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MSGSSAGSSFVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGMTDHGNMFGASEFYNSATKAGIKPII GVEAYIAPGSRFDTRRILWGDPSQKADDVSGSGSYTHLTMMAENATGLRNLFKLSSHASFEGQLSKWSRM DAELIAEHAEGIIITTGCPSGEVQTRLRLGQDREALEAAAKWREIVGPDNYFLELMDHGLTIERRVRDGL LEIGRALNIPPLATNDCHYVTRDAAHNHEALLCVQTGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDDEVP GACDSTLLIAERVQSYADVWTPRDRMPVFPVPDGHDQASWLRHEVDAGLRRRFPAGPPDGYRERAAYEID VICSKGFPSYFLIVADLISYARSAGIRVGPGRGSAAGSLVAYALGITDIDPIPHGLLFERFLNPERTSMP DIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPAIM AKDIPLSGITDPSHERYKEAAEVRGLIETDPDVRTIYQTARGLEGLIRNAGVHACAVIMSSEPLTEAIPL WKRPQDGAIITGWDYPACEAIGLLKMDFLGLRNLTIIGDAIDNVRANRGIDLDLESVPLDDKATYELLGR GDTLGVFQLDGGPMRDLLRRMQPTGFEDVVAVIALYRPGPMGMNAHNDYADRKNNRQAIKPIHPELEEPL REILAETYGLIVYQEQIMRIAQKVASYSLARADILRKAMGKKKREVLEKEFEGFSDGMQANGFSPAAIKA LWDTILPFADYAFNKSHAAGYGMVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLP PDVNESGLNFASVGQDIRYGLGAVRNVGANVVGSLLQTRNDKGKFTDFSDYLNKIDISACNKKVTESLIK AGAFDSLGHARKGLFLVHSDAVDSVLGTKKAEALGQFDLFGSNDDGTGTADPVFTIKVPDDEWEDKHKLA LEREMLGLYVSGHPLNGVAHLLAAQVDTAIPAILDGDVPNDAQVRVGGILASVNRRVNKNGMPWASAQLE DLTGGIEVMFFPHTYSSYGADIVDDAVVLVNAKVAVRDDRIALIANDLTVPDFSNAEVERPLAVSLPTRQ CTFDKVSALKQVLARHPGTSQVHLRLISGDRITTLALDQSLRVTPSPALMGDLKELLGPGCLGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1547 | dnaE | - | 100% (1184) | DNA polymerase III subunit alpha |
| M. tuberculosis H37Rv | Rv3370c | dnaE2 | e-116 | 29.35% (1104) | error-prone DNA polymerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1574 | dnaE | 0.0 | 100.00% (1184) | DNA polymerase III subunit alpha |
| M. gilvum PYR-GCK | Mflv_3636 | dnaE | 0.0 | 84.82% (1179) | DNA polymerase III subunit alpha |
| M. leprae Br4923 | MLBr_01207 | dnaE | 0.0 | 91.24% (1176) | DNA polymerase III subunit alpha |
| M. abscessus ATCC 19977 | MAB_2696c | dnaE | 0.0 | 83.43% (1183) | DNA polymerase III subunit alpha |
| M. marinum M | MMAR_2369 | dnaE | 0.0 | 90.29% (1184) | DNA polymerase III, alpha subunit, DnaE1 |
| M. avium 104 | MAV_3224 | dnaE | 0.0 | 91.41% (1176) | DNA polymerase III subunit alpha |
| M. smegmatis MC2 155 | MSMEG_3178 | dnaE | 0.0 | 86.42% (1186) | DNA polymerase III subunit alpha |
| M. thermoresistible (build 8) | TH_0581 | - | 0.0 | 86.65% (1176) | DNA polymerase III alpha subunit |
| M. ulcerans Agy99 | MUL_1545 | dnaE | 0.0 | 90.20% (1184) | DNA polymerase III subunit alpha |
| M. vanbaalenii PYR-1 | Mvan_2777 | dnaE | 0.0 | 85.48% (1178) | DNA polymerase III subunit alpha |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1547|M.tuberculosis_H37Rv --MSGSSAGSS---FVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGM
Mb1574|M.bovis_AF2122/97 --MSGSSAGSS---FVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGM
MLBr_01207|M.leprae_Br4923 ------MNQSS---FVHLHNHTEYSMLDGAAKITPMFAEVERLQMPAVGM
MMAR_2369|M.marinum_M ------MSGSSSRSFVHLHNHTEYSMLDGAAKITPMLAEVERLDMPAIGM
MUL_1545|M.ulcerans_Agy99 ------MSGSSSRSFVHLHNHTEYSMLDGAAKITPMLAEVERLDMPAIGM
MAV_3224|M.avium_104 ------MNHSS---FVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGM
TH_0581|M.thermoresistible__bu -------MSSS---FVHLHNHTEFSMLDGAAKIGPLLAEAQRLEMSAIGM
Mflv_3636|M.gilvum_PYR-GCK -------MSGS---FVHLHNHTEYSMLDGAAKVKPMLAEAQRLEMPAIGM
Mvan_2777|M.vanbaalenii_PYR-1 -------MSGS---FVHLHNHTEYSMLDGAAKVKPMLAEAQRLEMPAIGM
MSMEG_3178|M.smegmatis_MC2_155 MSGTDGRSSGS---FVHLHNHTEYSMLDGAAKITPMLAEAQRLEMPAIGM
MAB_2696c|M.abscessus_ATCC_199 ----MSSSNSS---FVHLHNHTEYSMLDGAAKIKPMLAEVERLGMSAVGM
.* *********:********: *::**.:** *.*:**
Rv1547|M.tuberculosis_H37Rv TDHGNMFGASEFYNSATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQK
Mb1574|M.bovis_AF2122/97 TDHGNMFGASEFYNSATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQK
MLBr_01207|M.leprae_Br4923 TDHGNMFGASEFYNTAIKAGIKPIIGVEAYIAPGSRFDTRRITWGDPSQK
MMAR_2369|M.marinum_M TDHGNMFGASEFYNSATKAGVKPIIGVEAYVAPGSRFDTRRITWGDPSQK
MUL_1545|M.ulcerans_Agy99 TDHGNMFGASEFYNSATKAGVKPIIGVEAYVAPGSRFDTRRITWGDPSQK
MAV_3224|M.avium_104 TDHGNMFGASEFYNAATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQK
TH_0581|M.thermoresistible__bu TDHGNMFGASEFYNAATDAGIKPIIGVEAYIAPGSRFDTKRVQWGDPSQK
Mflv_3636|M.gilvum_PYR-GCK TDHGNMFGASEFYNAATDAGIKPIIGIEAYIAPASRFDTKRVLWGDPGQK
Mvan_2777|M.vanbaalenii_PYR-1 TDHGNMFGASEFYNAATDAGIKPIIGIEAYIAPASRFETKRVLWGDPSQK
MSMEG_3178|M.smegmatis_MC2_155 TDHGNMFGASEFYNSATKAGIKPIIGIEAYIAPGSRFDTKRVTWGDPGQK
MAB_2696c|M.abscessus_ATCC_199 TDHGNMYGASEFYNVAAATGVKPIIGIEAYIAPASRFDTKRVFWGDPGQK
******:******* * :*:*****:***:**.***:*:*: ****.**
Rv1547|M.tuberculosis_H37Rv ADDVSGSGSYTHLTMMAENATGLRNLFKLSSHASFEGQLSKWSRMDAELI
Mb1574|M.bovis_AF2122/97 ADDVSGSGSYTHLTMMAENATGLRNLFKLSSHASFEGQLSKWSRMDAELI
MLBr_01207|M.leprae_Br4923 ADDVSAGGAYTHLTMVAENAAGLRNLFKLSSLASFEGQLSKWSRMDAELI
MMAR_2369|M.marinum_M GDDVSGSGSYTHLTMVAENATGLRNLFKLSSLASFEGQLGKWSRMDAELV
MUL_1545|M.ulcerans_Agy99 GDDVSGSGSYTHLTMVAENATGLRNLFKLSSLASFEGQLGKWSRMDAELV
MAV_3224|M.avium_104 ADDVSGSGSYTHLTMVAENAAGLRNLFKLSSLASFEGQLGKWSRMDAELI
TH_0581|M.thermoresistible__bu SDDVSGSGAYTHMTMVAETADGLRNMFKLSSLASFEGQLGKWSRMDAELI
Mflv_3636|M.gilvum_PYR-GCK SDDVSGSGSYTHMTMVAENATGLRNLFKLSSLASFEGQLGKWSRMDAEII
Mvan_2777|M.vanbaalenii_PYR-1 SDDVSGGGSYTHMTMVAENATGLRNLFKLSSLASFEGQLGKWARMDAEII
MSMEG_3178|M.smegmatis_MC2_155 GDDVSGSGAYTHMTMVAENATGLRNLFKLSSLASFEGQLGKWSRMDAEII
MAB_2696c|M.abscessus_ATCC_199 SDDVSGSGSYTHMTMVAENATGLRNLFKLSSLASFEGQLGKWARMDADLI
.****..*:***:**:**.* ****:***** *******.**:****:::
Rv1547|M.tuberculosis_H37Rv AEHAEGIIITTGCPSGEVQTRLRLGQDREALEAAAKWREIVGPDNYFLEL
Mb1574|M.bovis_AF2122/97 AEHAEGIIITTGCPSGEVQTRLRLGQDREALEAAAKWREIVGPDNYFLEL
MLBr_01207|M.leprae_Br4923 GEYAEGIIVTTGCPSGEVQTRLRLGHDREALESAAKWREIVGPDNYFLEL
MMAR_2369|M.marinum_M AEHAEGIIATTGCPSGEVQTRLRLGHDREALESAAKWREIFGADNYFLEL
MUL_1545|M.ulcerans_Agy99 AEHAEGIIATTGCPSGEVQTRLRLGHDREALESAAKWREIFGADNYFLEL
MAV_3224|M.avium_104 AEHADGIIATTGCPSGEVQTRLRLGQDREALESAAKWREIFGADNFFLEL
TH_0581|M.thermoresistible__bu AEHATGIIATTGCPSGEVQTRLRLGHHREALEAAAKWRDIFGPDNYFLEL
Mflv_3636|M.gilvum_PYR-GCK AEHAEGIIATTGCPSGEVQTRLRLGHDREALEAAARWREIFGPENFFLEL
Mvan_2777|M.vanbaalenii_PYR-1 AEHAEGIIATTGCPSGEVQTRLRLGHDREALEAAARWREIFGPENFFLEL
MSMEG_3178|M.smegmatis_MC2_155 AEHAEGIIATTGCPSGEVQTRLRLGHEREALEAAAKWREIFGPENFFLEL
MAB_2696c|M.abscessus_ATCC_199 AEHASGIIATTGCPSGEVQTRLRLGQESEALAAAAKWQDIFGKDNFFLEL
.*:* *** ****************:. *** :**:*::*.* :*:****
Rv1547|M.tuberculosis_H37Rv MDHGLTIERRVRDGLLEIGRALNIPPLATNDCHYVTRDAAHNHEALLCVQ
Mb1574|M.bovis_AF2122/97 MDHGLTIERRVRDGLLEIGRALNIPPLATNDCHYVTRDAAHNHEALLCVQ
MLBr_01207|M.leprae_Br4923 MDHGLSIEQRVREGLLNIGRKLNIPPLATNDCHYVTRDAVHNHEALLCVQ
MMAR_2369|M.marinum_M MDHGLSIERRVREGLIEIGRKLDIPPLATNDCHYVTRDAAHNHEALLCVQ
MUL_1545|M.ulcerans_Agy99 MDHGLSIERRVREGLIEIGRKLDIPPLATNDCHYVTRDAAHNHEALLCVQ
MAV_3224|M.avium_104 MDHGLSIEQRVRGGLLEIGRKLNIPPLATNDCHYVTRDAAHNHEALLCVQ
TH_0581|M.thermoresistible__bu MDHGLDIERRVRDGLLEIGRKLNIPPLATNDCHYVTRDAAQNHEALLCVQ
Mflv_3636|M.gilvum_PYR-GCK MDHGLDIERRVREGLLEIGQKLGIPPLATNDCHYVTRDASQNHEALLCIQ
Mvan_2777|M.vanbaalenii_PYR-1 MDHGLDIERRVREGLLDIGQKLGIPPLATNDCHYVTRDAAQNHEALLCIQ
MSMEG_3178|M.smegmatis_MC2_155 MDHGLDIERRVREGLLEIGRKLGIPPLATNDCHYVTREAARNHEALLCVQ
MAB_2696c|M.abscessus_ATCC_199 MDHGLSIERRVREGLLEVGKKLGIPPLATNDCHYVTKDHAHNHEALLCVQ
***** **:*** **:::*: *.*************:: :*******:*
Rv1547|M.tuberculosis_H37Rv TGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDDEVPGACDSTLLIAERVQS
Mb1574|M.bovis_AF2122/97 TGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDDEVPGACDSTLLIAERVQS
MLBr_01207|M.leprae_Br4923 TGKTLSDPNRFKFHGDGYYLKSAAEMRQLWDDEVPGACDSTLLIAERVQS
MMAR_2369|M.marinum_M TGKTLSDPNRFKFDGDGYYLKSAAEMRQLWDDDIPGACDSTLLIAERVQS
MUL_1545|M.ulcerans_Agy99 TGKTLSDPNRFKFDGDGYYLKSAAEMRQLWDDDIPGACDSTLLIAERVQS
MAV_3224|M.avium_104 TGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDAEVPGACDSTLLIAERVQS
TH_0581|M.thermoresistible__bu TGKTLSDPNRFKFDGDGYYLKSAAEMRALWDDEVPGACDNTLLIAERVQS
Mflv_3636|M.gilvum_PYR-GCK TGKTLSDPNRFKFDGDGYYLKSAAEMRALWDGQVPGACDSTLLIAERVQP
Mvan_2777|M.vanbaalenii_PYR-1 TGKTLSDPNRFKFDGDGYFLKSAAEMRALWDGQVPGACDSTLLIAERVQS
MSMEG_3178|M.smegmatis_MC2_155 TGKTLSDPTRFKFDGDGYFLKSAEEMRALWDSQVPGACDSTLLIGERVQS
MAB_2696c|M.abscessus_ATCC_199 TGKTLSDPTRFKFDGDGYYLKPASEMRDLWDDAVPGACDNTLLIAERVQS
********.****.****:**.* *** :** :*****.****.****.
Rv1547|M.tuberculosis_H37Rv YADVWTPRDRMPVFPVPDGHDQASWLRHEVDAGL-RRRFPAGP----PDG
Mb1574|M.bovis_AF2122/97 YADVWTPRDRMPVFPVPDGHDQASWLRHEVDAGL-RRRFPAGP----PDG
MLBr_01207|M.leprae_Br4923 YADVWEPRNRMPVFPVPVGHDQASWLRHEVDAGL-KRRFPDGP----PNG
MMAR_2369|M.marinum_M YADVWTPRDRMPIFPVPEGHDPASWLHHEVMAGL-RRRFPSGL----GQD
MUL_1545|M.ulcerans_Agy99 YADVWTPRDRMPIFPVPEGHDPASWLHHEVMAGL-RRRFPSGL----GQD
MAV_3224|M.avium_104 YAEVWTPRDRMPVFPVPEGHDQASWLHHEVMAGL-RRRFPDGV----GQD
TH_0581|M.thermoresistible__bu YADVWTPRDRMPVFPVPEGHTQESWLRHEVRAGL-QRRFPDGV----PQE
Mflv_3636|M.gilvum_PYR-GCK YTDVWAPKDRMPVFPVPEGHDQGSWLTHEVMAGL-ERRFSAAAGGQVPPE
Mvan_2777|M.vanbaalenii_PYR-1 YADVWTPKDRMPIFPVPEGHDQGSWLTHEVMTGLQERRFHGAP---VPQE
MSMEG_3178|M.smegmatis_MC2_155 YADVWEPRDRMPVFPVPEGHDQASWLTHEVKAGL-ERRFRGGP---VPEE
MAB_2696c|M.abscessus_ATCC_199 YEDVWNFKDRMPIFPVPEGEDQDSWLRKEVDRGL-ERRFEGVPGG-VPDE
* :** ::***:**** *. *** :** ** .***
Rv1547|M.tuberculosis_H37Rv YRERAAYEIDVICSKGFPSYFLIVADLISYARSAGIRVGPGRGSAAGSLV
Mb1574|M.bovis_AF2122/97 YRERAAYEIDVICSKGFPSYFLIVADLISYARSAGIRVGPGRGSAAGSLV
MLBr_01207|M.leprae_Br4923 YVERAAYEIDVICDKGFPAYFLIVADLVNHARSVGIRVGPGRGSAAGSLA
MMAR_2369|M.marinum_M YIDRAEYEIKVICDKGFPSYFLIVADLINYARSVDIRVGPGRGSAAGSLV
MUL_1545|M.ulcerans_Agy99 YIDRAEYEIKVICDKGFPSYFLIVADLINYARSVDIRVGPGRGSAAGSLV
MAV_3224|M.avium_104 YIDRAEYEIKVICDKGFPSYFLIVADLINYARSVDIRVGPGRGSAAGSLV
TH_0581|M.thermoresistible__bu YLDRAEYEIEVICAKGYPSYFLIVADLVNYARSVDIRVGPGRGSAAGSLV
Mflv_3636|M.gilvum_PYR-GCK YIERADYEIKVICDKGFPAYFLIVADLINYAKSVGIRVGPGRGSAAGSLV
Mvan_2777|M.vanbaalenii_PYR-1 YIDRAQYEIKVICDKGFPAYFLIVADLINYARSVGIRVGPGRGSAAGSLV
MSMEG_3178|M.smegmatis_MC2_155 YTTRAEYEIKVICDKGFPSYFLIVADLINYARSVGIRVGPGRGSAAGSLV
MAB_2696c|M.abscessus_ATCC_199 YFTRAHYELDVIKQKGFPAYFLVVGDLVSHAKEVGIRVGPGRGSAAGSLV
* ** **:.** **:*:***:*.**:.:*:...**************.
Rv1547|M.tuberculosis_H37Rv AYALGITDIDPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAAD
Mb1574|M.bovis_AF2122/97 AYALGITDIDPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAAD
MLBr_01207|M.leprae_Br4923 AYALGITDIDPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAAD
MMAR_2369|M.marinum_M AYAMGITNIDPIPHGLLFERFLNPERPSAPDIDIDFDDRRRGEMVRYAAD
MUL_1545|M.ulcerans_Agy99 AYAMGITNIDPIPHGLLFERFLNPERPSAPDIDIDFDDRRRGEMVRYAAD
MAV_3224|M.avium_104 AYALGITNIDPIPHGLLFERFLNPERPSAPDIDIDFDDRRRGEMVRYAAD
TH_0581|M.thermoresistible__bu AYALRITDIDPIEHGLLFERFLNPERASMPDIDIDFDDRRRGEMVRYAAE
Mflv_3636|M.gilvum_PYR-GCK AYAMGITNIDPIPHGLLFERFLNPERPSAPDIDIDFDDRRRGEMLRYAAN
Mvan_2777|M.vanbaalenii_PYR-1 AYAMGITNIDPIPHGLLFERFLNPERPSAPDIDIDFDDRRRGEMLRYAAN
MSMEG_3178|M.smegmatis_MC2_155 AYALGITNIDPIPHGLLFERFLNPERPSAPDIDIDFDDRRRGEMLRYAAN
MAB_2696c|M.abscessus_ATCC_199 AYALGITNIDPIPHGLLFERFLNPERPSAPDIDIDFDDRRRGEMVRYATE
***: **:**** *************.* ***************:***::
Rv1547|M.tuberculosis_H37Rv KWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPAIM
Mb1574|M.bovis_AF2122/97 KWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPAIM
MLBr_01207|M.leprae_Br4923 KWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAMADRITKALPPAIM
MMAR_2369|M.marinum_M KWGQDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPPIM
MUL_1545|M.ulcerans_Agy99 KWGQDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPPIM
MAV_3224|M.avium_104 KWGSDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPPIM
TH_0581|M.thermoresistible__bu KWGHERVAQVITFGTIKTKAALKDAARVHYGQPGFAIADRITKALPPPIM
Mflv_3636|M.gilvum_PYR-GCK KWGSDRVAQVITFGTIKTKAALKDSARVHYGQPGFAIADRITKALPPPIM
Mvan_2777|M.vanbaalenii_PYR-1 KWGSDRVAQVITFGTIKTKAALKDSARVHYGQPGFAIADRITKALPPPIM
MSMEG_3178|M.smegmatis_MC2_155 RWGSERVAQVITFGTIKTKAALKDSARVNFGQPGFAIADRITKALPPPIM
MAB_2696c|M.abscessus_ATCC_199 KWGSDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPPIM
:** :*******************:**:::******:**********.**
Rv1547|M.tuberculosis_H37Rv AKDIPLSGITDPSHERYKEAAEVRGLIETDPDVRTIYQTARGLEGLIRNA
Mb1574|M.bovis_AF2122/97 AKDIPLSGITDPSHERYKEAAEVRGLIETDPDVRTIYQTARGLEGLIRNA
MLBr_01207|M.leprae_Br4923 AKDIPLSGITDPAHERFKEAAEVRSLIETDSDVRIIYQTARGLEGLIRNA
MMAR_2369|M.marinum_M AKDIPLSGITDPAHERFKEAAEVRGLIETDPDVRTIYQTARGLEGLIRNA
MUL_1545|M.ulcerans_Agy99 AKDIPLSGITDPAHERFKEAAEVRGLIETDPDVRTIYQTARGLEGLIRNA
MAV_3224|M.avium_104 AKDIPLSGITDPSHERYKEAAEVRGLIETDPDVRTIYQTARGLEGLIRNA
TH_0581|M.thermoresistible__bu AKDIPLSGITDPNHERYKEAAEVRGLIESDPDVRRIYETALGLEGLVRNA
Mflv_3636|M.gilvum_PYR-GCK AKDIPVSGITDPTHERYKEAAEVRALIDTDPDVRTIYETARGLEGLVRNA
Mvan_2777|M.vanbaalenii_PYR-1 AKDIPVSGITDPTHERYKEAAEVRALIDTDPDVRTIYETARGLEGLVRNA
MSMEG_3178|M.smegmatis_MC2_155 AKDIPLSGITDPNHERYKEAAEVRGLIDTDPDVRTIYETARGLEGLVRNA
MAB_2696c|M.abscessus_ATCC_199 AKDIPVWGITNPEHERYKEAAEVRTLIDTDPDVRNIYQTALGLEGLIRNA
*****: ***:* ***:******* **::*.*** **:** *****:***
Rv1547|M.tuberculosis_H37Rv GVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLG
Mb1574|M.bovis_AF2122/97 GVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLG
MLBr_01207|M.leprae_Br4923 GVHACAVILSSEPLTEAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLG
MMAR_2369|M.marinum_M GVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYPSCEAIGLLKMDFLG
MUL_1545|M.ulcerans_Agy99 GVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYPSCEAIGLLKMDFLG
MAV_3224|M.avium_104 GVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYPSCEAIGLLKMDFLG
TH_0581|M.thermoresistible__bu GVHACAVIMSSEPLIDAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLG
Mflv_3636|M.gilvum_PYR-GCK GVHACAVIMSSEPLIDAIPLWKRPQDGAVITGWDYPSCEAIGLLKMDFLG
Mvan_2777|M.vanbaalenii_PYR-1 GVHACAVIMSSEPLIDAIPLWKRPQDGAVITGWDYPSCEAIGLLKMDFLG
MSMEG_3178|M.smegmatis_MC2_155 GVHACAVIMSSEPLIDAIPLWKRPQDGAIITGWDYPSCEAIGLLKMDFLG
MAB_2696c|M.abscessus_ATCC_199 GVHACAVIMSSEPLTDAIPLWKRAQDGAIITGWDYPSCEAIGLLKMDFLG
********:***** :*******.****:*******:*************
Rv1547|M.tuberculosis_H37Rv LRNLTIIGDAIDNVRANRGIDLDLESVPLDDKATYELLGRGDTLGVFQLD
Mb1574|M.bovis_AF2122/97 LRNLTIIGDAIDNVRANRGIDLDLESVPLDDKATYELLGRGDTLGVFQLD
MLBr_01207|M.leprae_Br4923 LRNLTIIGDAIENIKTNRGIDLDLESVPLDDQATYELLGRGDTLGVFQLD
MMAR_2369|M.marinum_M LRNLTIIGDAIENIKANRGIDLDLESLPLDDKPTYELLGRGETLGVFQLD
MUL_1545|M.ulcerans_Agy99 LRNLTIIGDAIENIEANRGIDLDLESLPLDDKPTYELLGRGETLGVFQLD
MAV_3224|M.avium_104 LRNLTIIGDALDNIKANRGIDLDLESVPLDDKATYELLGRGDTLGVFQLD
TH_0581|M.thermoresistible__bu LRNLTIIGDALENIKANRGIDLDLDTIPMDDPATYELLGRGDTLGVFQLD
Mflv_3636|M.gilvum_PYR-GCK LRNLTIIGDCIENIKANRGVDVDLESLALDDPKAYELLGRGDTLGVFQLD
Mvan_2777|M.vanbaalenii_PYR-1 LRNLTIIGDCIENIKANRGIDVDLESLTLDDPKAYELLGRGDTLGVFQLD
MSMEG_3178|M.smegmatis_MC2_155 LRNLTIIGDAIANIKANRGIDLDLETLPLDDPAAYELLSRGDTLGVFQLD
MAB_2696c|M.abscessus_ATCC_199 LRNLTVIGDALDNIKANRGIDLDLDHLPLDDPATYELLSRGDTLGVFQLD
*****:***.: *:.:***:*:**: :.:** :****.**:********
Rv1547|M.tuberculosis_H37Rv GGPMRDLLRRMQPTGFEDVVAVIALYRPGPMGMNAHNDYADRKNNRQAIK
Mb1574|M.bovis_AF2122/97 GGPMRDLLRRMQPTGFEDVVAVIALYRPGPMGMNAHNDYADRKNNRQAIK
MLBr_01207|M.leprae_Br4923 GGPMRDLLRRMQPTGFEDIVAVLALYRPGPMGMNAHNDYADRKNNRQVIK
MMAR_2369|M.marinum_M GGPMRDLLRRMQPTEFNDIVAVLALYRPGPMGMNAHNDYADRKNNRQAVK
MUL_1545|M.ulcerans_Agy99 GGPMRDLLRRMQPTEFNDIVAVLALYRPGPMGMNAHNDYADRKNNRQAVK
MAV_3224|M.avium_104 GGPMRDLLRRMQPTEFNDIVAVLALYRPGPMGMNAHNDYADRKNGRQPIK
TH_0581|M.thermoresistible__bu GGPMRDLLRRMQPTSFDDIVAVLALYRPGPMGMNAHNDYADRKNGRQPIT
Mflv_3636|M.gilvum_PYR-GCK GSAMRDLLRRMQPTEFNDIVAVLALYRPGPMGMNAHNDYADRKNGRQPIK
Mvan_2777|M.vanbaalenii_PYR-1 GGPMRDLLRRMQPTEFNDIVAVLALYRPGPMGMNAHNDYADRKNGRQAIK
MSMEG_3178|M.smegmatis_MC2_155 GGPMRDLLRRMQPTGFNDIVAVLALYRPGPMGMNAHNDYADRKNGRQPIK
MAB_2696c|M.abscessus_ATCC_199 GGPMRDLLRRMQPTGFNDIVAVLALYRPGPMGMNAHNDYADRKNGRQPIK
*..*********** *:*:***:*********************.** :.
Rv1547|M.tuberculosis_H37Rv PIHPELEEPLREILAETYGLIVYQEQIMRIAQKVASYSLARADILRKAMG
Mb1574|M.bovis_AF2122/97 PIHPELEEPLREILAETYGLIVYQEQIMRIAQKVASYSLARADILRKAMG
MLBr_01207|M.leprae_Br4923 PIHPELEEPLREILAETYGLIVYQEQIMRIAQKVAGYSLARADILRKAMG
MMAR_2369|M.marinum_M PIHPELEEPLREILSETYGLIVYQEQIMFIAQKVASYTMGKADALRKAMG
MUL_1545|M.ulcerans_Agy99 PIHPELEEPLREILSETYGLIVYQEQIMFIAQKVASYTMGKADALRKAMG
MAV_3224|M.avium_104 PIHPELEEPLREILAETYGLIVYQEQIMFIAQKVASYTMGKADALRKAMG
TH_0581|M.thermoresistible__bu PIHPELAEPLEEILAETYGLIVYQEQIMRIAQKVAGYSLARADILRKAMG
Mflv_3636|M.gilvum_PYR-GCK PIHPELEEPLKDILAETYGLIVYQEQIMFIAQKVASYSMGKADALRKAMG
Mvan_2777|M.vanbaalenii_PYR-1 PIHPELEEPLKDILSETYGLIVYQEQIMFIAQKVASYSMGKADALRKAMG
MSMEG_3178|M.smegmatis_MC2_155 PIHPELEEPLKDILAETYGLIVYQEQIMFIAQKVASYTMGKADALRKAMG
MAB_2696c|M.abscessus_ATCC_199 PIHPELEEPLKDILAETFGLIVYQEQIMFIAQKVASYSMGKADALRKAMG
****** ***.:**:**:********** ******.*::.:** ******
Rv1547|M.tuberculosis_H37Rv KKKREVLEKEFEGFSDGMQANGFSPAAIKALWDTILPFADYAFNKSHAAG
Mb1574|M.bovis_AF2122/97 KKKREVLEKEFEGFSDGMQANGFSPAAIKALWDTILPFADYAFNKSHAAG
MLBr_01207|M.leprae_Br4923 KKKREVLEKEFEGFSEGMQANGFSVHAIKALWDIILPFADYAFNKSHAAG
MMAR_2369|M.marinum_M KKKLEVLEAEYKGFYEGMTANGFSEKAVKALWDTILPFAGYAFNKSHAAG
MUL_1545|M.ulcerans_Agy99 KKKLEVLEAEYKGFYEGMTANGFSEKAVKALWDTILPFAGYAFNKSHAAG
MAV_3224|M.avium_104 KKKLEVLEAEYKGFYEGMTANGFSEKAVKALWDTILPFAGYAFNKSHAAG
TH_0581|M.thermoresistible__bu KKKREVLDKEYEGFSEGMKANGFSASAIKALWDTVLPFADYAFNKSHAAG
Mflv_3636|M.gilvum_PYR-GCK KKKLEVLEAEYKGFKEGMTANGFSEGAVKALWDTILPFAGYAFNKSHAAG
Mvan_2777|M.vanbaalenii_PYR-1 KKKLEVLEAEYQGFKEGMTANGFSEKAVKALWDTILPFAGYAFNKSHAAG
MSMEG_3178|M.smegmatis_MC2_155 KKKLEVLEAEYKGFKEGMTANGFSEGAVKALWDTILPFAGYAFNKSHAAG
MAB_2696c|M.abscessus_ATCC_199 KKKLEVLEAEYKGFYEGMTNNGFSEKAVKALWDTILPFAGYAFNKSHAAG
*** ***: *::** :** **** *:***** :****.**********
Rv1547|M.tuberculosis_H37Rv YGMVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLP
Mb1574|M.bovis_AF2122/97 YGMVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLP
MLBr_01207|M.leprae_Br4923 YGLISYWTAYLKANFAGEYMAGLLTSVGDDKDKAAVYLADCRKFGITVLP
MMAR_2369|M.marinum_M YGLVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLP
MUL_1545|M.ulcerans_Agy99 YGLVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLP
MAV_3224|M.avium_104 YGLVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLP
TH_0581|M.thermoresistible__bu YGLVSYWTAYLKANYPAEYMAGLLTSVRDDKDKAAVYLADCRRLGITVLP
Mflv_3636|M.gilvum_PYR-GCK YGLVSYWTAYLKANYQAEYMAGLLTSVGDDKDKAAIYLADCRRLGITVLP
Mvan_2777|M.vanbaalenii_PYR-1 YGLVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRRLGITVLP
MSMEG_3178|M.smegmatis_MC2_155 YGLVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRRLGITVLP
MAB_2696c|M.abscessus_ATCC_199 YGLVSFWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRRLGITVLP
**::*:********: .********** *******:******::******
Rv1547|M.tuberculosis_H37Rv PDVNESGLNFASVGQDIRYGLGAVRNVGANVVGSLLQTRNDKGKFTDFSD
Mb1574|M.bovis_AF2122/97 PDVNESGLNFASVGQDIRYGLGAVRNVGANVVGSLLQTRNDKGKFTDFSD
MLBr_01207|M.leprae_Br4923 PDVNESVLDFASVGADIRYGLGAVRNVGANVVGSLIKTRNAKGKFADFSD
MMAR_2369|M.marinum_M PDVNESLVNFASVGQDIRFGLGAVRNVGANVVGSLIGTRSGKGKFTDFSD
MUL_1545|M.ulcerans_Agy99 PDVNESLVNFASVGQDIRFGLGAVRNVGANVVGSLIGTRSGKGKFTDFSD
MAV_3224|M.avium_104 PDVNESLVNFASVGQDIRFGLGAVRNVGANVVGSLIKTREEKGKFTDFSD
TH_0581|M.thermoresistible__bu PDVNESAVNFTSVGKDIRYGLGAVRNVGANVVSSLIATRTEKGKFTDFSD
Mflv_3636|M.gilvum_PYR-GCK PDVNESVQNFASVGDDIRFGLGAVRNVGANVVASLVSTREEKGKYTDFSD
Mvan_2777|M.vanbaalenii_PYR-1 PDVNESVQNFASVGDDIRFGLGAVRNVGANVVSSLVATRKEKGKFADFSD
MSMEG_3178|M.smegmatis_MC2_155 PDVNESEHNFASVGDDIRFGLGAIRNVGANVVSSLIKTRTEKGKFTDFSD
MAB_2696c|M.abscessus_ATCC_199 PDVNESVHNFASVGEDIRYGLGGVRNVGANVVQSLIATREEKGAFTDFSD
****** :*:*** ***:***.:******** **: ** ** ::****
Rv1547|M.tuberculosis_H37Rv YLNKIDISACNKKVTESLIKAGAFDSLGHARKGLFLVHSDAVDSVLGTKK
Mb1574|M.bovis_AF2122/97 YLNKIDISACNKKVTESLIKAGAFDSLGHARKGLFLVHSDAVDSVLGTKK
MLBr_01207|M.leprae_Br4923 YLNKIDITSCNKKVTESLIKAGAFDSLGHSRKGLFLVHADAVDSVLGTKK
MMAR_2369|M.marinum_M YLNKIDISACNKKVTESLIKAGAFDSLGHPRKGLFLVHTDAVDSVLGTKK
MUL_1545|M.ulcerans_Agy99 YLNKIDISACNKKVTESLIKAGAFDSLGHPRKGLFLVHTDAVDSVLGTKK
MAV_3224|M.avium_104 YLNKIDISACNKKVTESLIKAGAFDSLKHARKGLFLVHTDAVDSVLGTKK
TH_0581|M.thermoresistible__bu YLNKIDISVCNKKVTESLIKAGAFDSLGHPRKGLFLVHGDAVESVLGTKK
Mflv_3636|M.gilvum_PYR-GCK YLNKIDITACTKKVTESLIKAGAFDSLGHPRKGLFLVHTDAVDSVLGTKK
Mvan_2777|M.vanbaalenii_PYR-1 YLNKIDIAACNKKVTESLVKAGAFDSLGHPRKGLFLVHTDAVDSVLGTKK
MSMEG_3178|M.smegmatis_MC2_155 YLNKIDITACNKKVTESLIKAGAFDSLGHPRKGLFLVHTDAVDSVLGTKK
MAB_2696c|M.abscessus_ATCC_199 YLHKIDIAACNKKVTESLVKAGAFDSLGHPRKGLFLVQSDAVDSVLGTKK
**:****: *.*******:******** *.*******: ***:*******
Rv1547|M.tuberculosis_H37Rv AEALGQFDLFGS-NDDGTGTADPVFTIKVPDDEWEDKHKLALEREMLGLY
Mb1574|M.bovis_AF2122/97 AEALGQFDLFGS-NDDGTGTADPVFTIKVPDDEWEDKHKLALEREMLGLY
MLBr_01207|M.leprae_Br4923 AEAIGQFDLFGG-TDGGT---DAVFTIKVPDDEWEDKHKLALEREMLGLY
MMAR_2369|M.marinum_M AEAMGQFDLFGG-SDSGA---DAVFTIKVPEDEWEDKHKLALEREMLGLY
MUL_1545|M.ulcerans_Agy99 AEAMGQFDLFGG-SDSGA---DAVFTIKVPEDEWEDKHKLALEREMLGLY
MAV_3224|M.avium_104 AEAMGQFDLFGG-DGGCT---ESVFTIKVPDDEWEDKHKLALEREMLGLY
TH_0581|M.thermoresistible__bu AEAMGQFDLFGG-DGSSEDSLDSVFTIKVPDEEWDDKHKLALEREMLGLY
Mflv_3636|M.gilvum_PYR-GCK AEAMGQFDLFGGGDDDG-DTGDSAFTIKVPDEEWEDKHKLALEREMLGLY
Mvan_2777|M.vanbaalenii_PYR-1 AEAMGQFDLFGGADGSGADAGDSAFTIKVPDEEWEDKHKLALEREMLGLY
MSMEG_3178|M.smegmatis_MC2_155 AEAMGQFDLFGGGEDTG---TDAVFTIKVPDEEWEDKHKLALEREMLGLY
MAB_2696c|M.abscessus_ATCC_199 AEAMGQFDLFGGGGEDS-VPASDIFAIKVPDDEWEEKHKLALEREMLGLY
***:*******. . *:****::**::**************
Rv1547|M.tuberculosis_H37Rv VSGHPLNGVAHLLAAQVDTAIPAILDGDVPNDAQVRVGGILASVNRRVNK
Mb1574|M.bovis_AF2122/97 VSGHPLNGVAHLLAAQVDTAIPAILDGDVPNDAQVRVGGILASVNRRVNK
MLBr_01207|M.leprae_Br4923 VSGHPLNGVAHLLAAQVDTAIPTILDGGVSNDTQVRVGGILAAVNRRVNK
MMAR_2369|M.marinum_M VSGHPLNGVAHLLAAQVDTAIPAILDGDVSNDAQVRVGGILAAVNRRVNK
MUL_1545|M.ulcerans_Agy99 VSGHPLNGVAHLLATQVDTAIPAILDGDVSNDAQVRVGGILAAVNRRVNK
MAV_3224|M.avium_104 VSGHPLNGVAHLLAAQVDTQIPAILDGDVPNETQVRVGGILASVNRRVNK
TH_0581|M.thermoresistible__bu VSGHPLEGVAHLLANQVDTQIPAILDGEVPNDAQVTVGGILNSVNRRVNK
Mflv_3636|M.gilvum_PYR-GCK VSGHPLNGIAHLLTAQVDTQIPAILEGAIPNDAQVRVGGILASVNRRVNK
Mvan_2777|M.vanbaalenii_PYR-1 VSGHPLNGVAHLLAAQVDTQIPAILDGDVANDTQVRVGGILASVNRRVNK
MSMEG_3178|M.smegmatis_MC2_155 VSGHPLNGVAHLLANQVDTQIPAILDGDVANDAQVLVGGILASVNRRVNK
MAB_2696c|M.abscessus_ATCC_199 VSGHPLNGVAHLLSRQTDTQIPAILDGEVANDAVVKVGGILASVNRRVNK
******:*:****: *.** **:**:* :.*:: * ***** :*******
Rv1547|M.tuberculosis_H37Rv NGMPWASAQLEDLTGGIEVMFFPHTYSSYGADIVDDAVVLVNAKVAVRDD
Mb1574|M.bovis_AF2122/97 NGMPWASAQLEDLTGGIEVMFFPHTYSSYGADIVDDAVVLVNAKVAVRDD
MLBr_01207|M.leprae_Br4923 NGIPWASAQLDDLTGGIEVMFFPHTYSSYGADIIDDAVVLVNAKVVVRDD
MMAR_2369|M.marinum_M NGMPWASAQLEDLTGGIEVMFFPHTYSNYGADIADDAVVLVNAKVAIRDD
MUL_1545|M.ulcerans_Agy99 NGMPWASAQLEDLTGGIEVMFFPHTYSNYGADIADDAVVLVNAKVAIRDD
MAV_3224|M.avium_104 NGMPWASAQLEDLTGGIEVMFFPHAYSTYGADIADDAVVLINAKVAIRDD
TH_0581|M.thermoresistible__bu NGLPWASAQLEDLTGGIEVLFFPQTYSLYGAEIADDAVVLIKAKVAARDD
Mflv_3636|M.gilvum_PYR-GCK NGLPWASAQIEDLSGGIEVLFFPQTYSMFGAEIADDVVVLVGAKVAKRDD
Mvan_2777|M.vanbaalenii_PYR-1 NGLPWASAQIEDLTGGIEVLFFPQTYSMFGAEIADDVVVLVGAKVAIRDD
MSMEG_3178|M.smegmatis_MC2_155 NGLPWASAQLEDLTGGIEVLFFPQTYSLFGADIADDVVVLVKAKVAARDD
MAB_2696c|M.abscessus_ATCC_199 NGMPWASAQLEDLTGGIEVLFFPQAYSVYGADIADDAVVLVNAKVAIRDD
**:******::**:*****:***::** :**:* **.***: ***. ***
Rv1547|M.tuberculosis_H37Rv RIALIANDLTVPDFSNAEVERPLAVSLPTRQCTFDKVSALKQVLARHPGT
Mb1574|M.bovis_AF2122/97 RIALIANDLTVPDFSNAEVERPLAVSLPTRQCTFDKVSALKQVLARHPGT
MLBr_01207|M.leprae_Br4923 RIALIANQLVVPDFSNVQEDRPLAVSLLTRQCTFDKVNALKQVLARHPGT
MMAR_2369|M.marinum_M RISLIANELVVPDFSNAQADRPLAVSLPTRQCTIDKVTALKQVLARHPGT
MUL_1545|M.ulcerans_Agy99 RISLIANELVVPDFSNAQADRPLAVSLPTRQCTIDKVTALKQVLARHPGT
MAV_3224|M.avium_104 RIALIANELVVPDFSIAQVDRPLAVSLPTRQCTIDKVTALKQVLARHPGT
TH_0581|M.thermoresistible__bu RIALIAHELIVPDFSNASADRPIAVSLPTRQCTLDKVTALKQVLTNHPGT
Mflv_3636|M.gilvum_PYR-GCK RISLIANELIVPDFTSAQVNRPVAVSLPTRQCTVDKVTALKQVLARHPGT
Mvan_2777|M.vanbaalenii_PYR-1 RISLIANELVVPDFSSANVNRPVAVSLPTRQCTVDKVTALKQVLARHPGT
MSMEG_3178|M.smegmatis_MC2_155 RIALIAHELIVPDFSSAQADRPLSVSLPTRQCTIDKVTALKQVLANHPGT
MAB_2696c|M.abscessus_ATCC_199 RVSLIANDLVVPDFSQAADDRPVAVTMPTRQCTIDKVTALKQVLTRHPGT
*::***::* ****: . :**::*:: *****.***.******:.****
Rv1547|M.tuberculosis_H37Rv SQVHLRLISGDRITTLALDQSLRVTPSPALMGDLKELLGPGCLGS
Mb1574|M.bovis_AF2122/97 SQVHLRLISGDRITTLALDQSLRVTPSPALMGDLKELLGPGCLGS
MLBr_01207|M.leprae_Br4923 SQVHLRLISGDRITTLELDQSLRVTSSPALMGDLKALLGPGCLGD
MMAR_2369|M.marinum_M SQVHLRLISGDRITTLELDQSLRVTPSPALMGDLKELLGPGCLGS
MUL_1545|M.ulcerans_Agy99 SQVHLRLISGDRITTLELDQSLRVTPSPALMGDLKELLGPGCLGS
MAV_3224|M.avium_104 SQVHLRLISGDRITTLELDASLRVTPSPALMGDLKELLGPGCLGG
TH_0581|M.thermoresistible__bu AQVHLRLINGDRITTLELDPSLRVTPSLELMGDLKALLGPGCLG-
Mflv_3636|M.gilvum_PYR-GCK AQVHLRLISGERITTLELDQSLRVTPSSALMGDLKELLGPGCLGG
Mvan_2777|M.vanbaalenii_PYR-1 AQVHLRLISGERITTLELDQSLRVTPSSALMGDLKELLGPGCLGG
MSMEG_3178|M.smegmatis_MC2_155 SQVHLRLISGERITTLELDQSLRVTPSSALMGDLKALLGPGCLG-
MAB_2696c|M.abscessus_ATCC_199 NQVHLRLISGERVTTLELDQSLRVTPSSALMGDLKALLGPGCLGG
*******.*:*:*** ** *****.* ****** ********