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VSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERIPNLHFSVSATTRAPRPGEVDGVDYH FIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQPVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFL APPSWQDLQARLIGRGTETADVIQRRLDTARIELAAQGDFDKVVVNRRLESACAELVSLLVGTAPGSP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1389 | gmk | - | 100% (208) | guanylate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1424 | gmk | 1e-116 | 100.00% (208) | guanylate kinase |
| M. gilvum PYR-GCK | Mflv_3740 | gmk | 4e-80 | 73.17% (205) | guanylate kinase |
| M. leprae Br4923 | MLBr_00541 | gmk | 4e-90 | 77.78% (207) | guanylate kinase |
| M. abscessus ATCC 19977 | MAB_2823c | - | 1e-59 | 68.48% (165) | guanylate kinase |
| M. marinum M | MMAR_2202 | gmk | 5e-90 | 80.19% (207) | guanylate kinase Gmk |
| M. avium 104 | MAV_3385 | gmk | 1e-88 | 86.34% (183) | guanylate kinase |
| M. smegmatis MC2 155 | MSMEG_3051 | gmk | 1e-79 | 74.13% (201) | guanylate kinase |
| M. thermoresistible (build 8) | TH_0821 | gmk | 8e-56 | 74.64% (138) | PROBABLE GUANYLATE KINASE GMK |
| M. ulcerans Agy99 | MUL_1788 | gmk | 2e-90 | 80.49% (205) | guanylate kinase |
| M. vanbaalenii PYR-1 | Mvan_2667 | gmk | 2e-80 | 74.63% (205) | guanylate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3740|M.gilvum_PYR-GCK --MSEGRGPD--------SASGATVLVLSGPSAVGKSTVVRCLRERVADL
Mvan_2667|M.vanbaalenii_PYR-1 --MNEGGGPD--------SATGAAVLVLSGPSAVGKSTVVRCLRERVEDL
Rv1389|M.tuberculosis_H37Rv --MSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERIPNL
Mb1424|M.bovis_AF2122/97 --MSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERIPNL
MMAR_2202|M.marinum_M -------------MSAGGGPGTGHVVVLSGPSAVGKSTVVRCLRERIPNL
MUL_1788|M.ulcerans_Agy99 --MPGGGADSGAPMSAGGGPGTGHVVVLSGPSAVGKSTVVRCLRERIPNL
MLBr_00541|M.leprae_Br4923 MPVSARGAPDAEHWAWSEQTDKGRVVVLSGPSAVGKSTVVRCLRERVSNL
MAV_3385|M.avium_104 ------------------------MVVLSGPSAVGKSTVVRCLRERVPNL
MSMEG_3051|M.smegmatis_MC2_155 --MTVGRGAG---QRATDGPARARVVVLSGPSAVGKSTVVRCLRERLPDL
TH_0821|M.thermoresistible__bu --------------------------------------------------
MAB_2823c|M.abscessus_ATCC_199 ---------------------------------------MRRLRDEVDGL
Mflv_3740|M.gilvum_PYR-GCK YFSVSVTTRAPRPGEVDGVDYFFVTPERFQQLIDDNALLEWADIHGGLHR
Mvan_2667|M.vanbaalenii_PYR-1 FFSVSVTTRAPRPGEVDGVDYFFVTAEQFQQLIDEGALLEWAEIHGGLHR
Rv1389|M.tuberculosis_H37Rv HFSVSATTRAPRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHR
Mb1424|M.bovis_AF2122/97 HFSVSATTRAPRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHR
MMAR_2202|M.marinum_M HFSVSATTRAPRPGEVDGVDYHFVTPESFQQMIDQGELLEWAEIHGGLHR
MUL_1788|M.ulcerans_Agy99 HFSVSATTRAPRPGEVDGVDYHFVTPESFQQMIDQGELLEWAEIHGGLHR
MLBr_00541|M.leprae_Br4923 HFSVSATTREPRPDEMDGVDYHFVSPARFQQLIDQGALLEWAEIHGGMHR
MAV_3385|M.avium_104 HFSVSATTRAPRPGEVDGVDYHFVSPARFQQLIDEGALLEWAEIHSGLHR
MSMEG_3051|M.smegmatis_MC2_155 YFSVSVTTRAPRPGEVDGVDYTFVSPERFQQLIDDGELLEWAEIHGGLHR
TH_0821|M.thermoresistible__bu ---------------VDGVDYSFISPERFAELIDSGELLEWAEIHGGLHR
MAB_2823c|M.abscessus_ATCC_199 FFSVSATTRAPRPGEVDGVDYHFVTAEEFQRLIDTDALLEWADIHGGLQR
:***** *: . * .:** . *****:**.*::*
Mflv_3740|M.gilvum_PYR-GCK SGTPAAPVREAAAAGRPVLIEVDLAGARAVKKAMPEATSVFLAPPSWETL
Mvan_2667|M.vanbaalenii_PYR-1 SGTPAAPVRAAAAAGHPVLIEVDLAGARAVKKAMPEATTVFLAPPSWEVL
Rv1389|M.tuberculosis_H37Rv SGTLAQPVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFLAPPSWQDL
Mb1424|M.bovis_AF2122/97 SGTLAQPVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFLAPPSWQDL
MMAR_2202|M.marinum_M SGTPAQPVREATASGVPVLIEVDLAGARAVKKAMPEAISVFLAPPSWEDL
MUL_1788|M.ulcerans_Agy99 SGTPAQPVREATASGVPVLIEVDLAGGRAVKKAMPEAISVFLAPPSWEDL
MLBr_00541|M.leprae_Br4923 SGTLAEPVRVAAAAGFPVLIEVDLAGARAVKKAMPEAIAVFLAPPSWEDL
MAV_3385|M.avium_104 SGTLAAPVRAAVARGCPVLIEVDLAGARAVKKAMPEALTVFLAPPSWEDL
MSMEG_3051|M.smegmatis_MC2_155 SGTPAAPVREATRAGRPVLIEVDLAGARAVKQAMPEVVSVFLAPPSWDEL
TH_0821|M.thermoresistible__bu SGTPAEPIRRAVKDGRPVLIEVDLAGARAVKAAMPEAMTVFVAPPDWQTL
MAB_2823c|M.abscessus_ATCC_199 SGTPAAPVREAMEAGRPTLIEVDLAGARAIKAALPQALAVFLAPPSWEAL
*** * *:* * * *.********.**:* ::*:. :**:***.*: *
Mflv_3740|M.gilvum_PYR-GCK ESRLIGRGTETPEVIARRLETARAELAAQDDFDEIVVNSQLESACAELVA
Mvan_2667|M.vanbaalenii_PYR-1 ESRLVGRGTETPDVIARRLQTARDELAAQGDFDEVVVNGQLESACAELVS
Rv1389|M.tuberculosis_H37Rv QARLIGRGTETADVIQRRLDTARIELAAQGDFDKVVVNRRLESACAELVS
Mb1424|M.bovis_AF2122/97 QARLIGRGTETADVIQRRLDTARIELAAQGDFDKVVVNRRLESACAELVS
MMAR_2202|M.marinum_M KARLVGRGTETPDVIRRRLQTAQTELAAQPDFDKVVVNGRLESACAELVS
MUL_1788|M.ulcerans_Agy99 KARLVGRGTETPDVIRRRLQTAQTELAAQRDFDKVVVNGRLESACAELVS
MLBr_00541|M.leprae_Br4923 EARLVGRGTETPEAIRRRLETARIELAAQDDFDEVVVNRRLESACAELVS
MAV_3385|M.avium_104 EARLIGRGTETPEVIARRLQTARVEMAAQHDFDRVVVNSRLESACAELVS
MSMEG_3051|M.smegmatis_MC2_155 VRRLSGRGTETPEVMARRLDTARAEMAAQSDFDRVVVNRQLDSACAELVS
TH_0821|M.thermoresistible__bu EERLVGRGTETPEVIARRLDTARAELAAQSEFDRIVVNSDLETACAELVS
MAB_2823c|M.abscessus_ATCC_199 VDRLTGRGTESESVIARRLETATVEMAAQTDFDVVIVNDQLENACAKLVS
** *****: ..: ***:** *:*** :** ::** *:.***:**:
Mflv_3740|M.gilvum_PYR-GCK LLVAHAPERRDQP------------
Mvan_2667|M.vanbaalenii_PYR-1 LLVAHTPVQHDQS------------
Rv1389|M.tuberculosis_H37Rv LLVGTAPG----SP-----------
Mb1424|M.bovis_AF2122/97 LLVGTAPG----SP-----------
MMAR_2202|M.marinum_M LLVRTVPG----SG-----------
MUL_1788|M.ulcerans_Agy99 LLVRTVPG----SG-----------
MLBr_00541|M.leprae_Br4923 LLVGAVSG----SA-----------
MAV_3385|M.avium_104 LLVGTAPDRHDTSGRTGRQSTSHPD
MSMEG_3051|M.smegmatis_MC2_155 LLVDS--------------------
TH_0821|M.thermoresistible__bu LLVDP--------------------
MAB_2823c|M.abscessus_ATCC_199 LLVGR--------------------
***