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VDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFGRPSGVQGSFV AERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPA AAAALGTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFT TSKVTLSTTGNAQEPAGRFTKVAAAVADSVVTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPS QFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLGLRSTVTQ GIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIGINTAGKSLSDSASGLGFAIP VNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRAVADS DEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1223 | htrA | - | 100% (528) | PROBABLE SERINE PROTEASE HTRA (DEGP PROTEIN) |
| M. tuberculosis H37Rv | Rv0983 | pepD | 8e-66 | 43.31% (344) | serine protease PepD |
| M. tuberculosis H37Rv | Rv0125 | pepA | 2e-22 | 33.60% (250) | serine protease PepA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1255 | htrA | 0.0 | 99.62% (528) | serine protease HtrA |
| M. gilvum PYR-GCK | Mflv_2202 | - | 0.0 | 72.87% (494) | peptidase S1 and S6, chymotrypsin/Hap |
| M. leprae Br4923 | MLBr_01078 | htrA | 0.0 | 81.80% (533) | possinble serine protease |
| M. abscessus ATCC 19977 | MAB_1364 | - | 0.0 | 70.35% (489) | serine protease HtrA |
| M. marinum M | MMAR_4214 | htrA | 0.0 | 87.90% (504) | serine protease HtrA (DegP protein) |
| M. avium 104 | MAV_1366 | - | 0.0 | 81.94% (504) | trypsin |
| M. smegmatis MC2 155 | MSMEG_5070 | - | 0.0 | 70.14% (489) | trypsin |
| M. thermoresistible (build 8) | TH_4008 | - | 1e-110 | 75.19% (262) | PUTATIVE Trypsin |
| M. ulcerans Agy99 | MUL_4517 | htrA | 0.0 | 87.50% (504) | serine protease HtrA (DegP protein) |
| M. vanbaalenii PYR-1 | Mvan_4494 | - | 0.0 | 73.08% (494) | peptidase S1 and S6, chymotrypsin/Hap |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1223|M.tuberculosis_H37Rv MDTRVDTDNAMP-----ARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRP
Mb1255|M.bovis_AF2122/97 MDTRVDTDNAMP-----ARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRP
MMAR_4214|M.marinum_M -----------------------------MTSDQGNNSGQDGGPRLAPRP
MUL_4517|M.ulcerans_Agy99 -----------------------------MTSDQGNNSGQDGGPRLAPRP
MLBr_01078|M.leprae_Br4923 MNTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHHLATRP
MAV_1366|M.avium_104 -----------------------------MTSDPGYDQAKDSANRLAPRP
MAB_1364|M.abscessus_ATCC_1997 -----------------------------MTAN------QDTAPRLAPRP
Mflv_2202|M.gilvum_PYR-GCK -----------------------------MTNLD----ETG-RKRLEPRP
Mvan_4494|M.vanbaalenii_PYR-1 -----------------------------MTNLD----QTG-RERLEPRP
MSMEG_5070|M.smegmatis_MC2_155 -----------------------------MTNQE----QSGDGGRLAPRP
TH_4008|M.thermoresistible__bu --------------------------------------------------
Rv1223|M.tuberculosis_H37Rv VFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPV
Mb1255|M.bovis_AF2122/97 VFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPV
MMAR_4214|M.marinum_M ISRPPVDSAARQTFGRPSGVQGSFVAERVRPQRYRDQSEYEPHDQPADPV
MUL_4517|M.ulcerans_Agy99 ISRPPVDSAARQTFGRPSGVQGSFVAERVRPQRYRDQSEYEPHDQPADPV
MLBr_01078|M.leprae_Br4923 VARPPVDAASREAFGRPCGFSGSFVAEYVRPQKYRDRSEFRPDDQPADPV
MAV_1366|M.avium_104 ISRPPVDPASRREFGRPAGLRGSFVAERVRPKKYREQSEFRPSEQSADPV
MAB_1364|M.abscessus_ATCC_1997 VDRPPVDPASQRAFGRPSGVSGSFQGA----DKYRDQGEYTPRVGPPDPV
Mflv_2202|M.gilvum_PYR-GCK VSRPPVDPSAQRAFGRPSGVSGSFLGA----EKHRDQGEFTPKDQPPDPV
Mvan_4494|M.vanbaalenii_PYR-1 VSRPPVDPAAQRAFGRPTGVNGSFLGA----DQHRDQGEYTPKDQAPDPV
MSMEG_5070|M.smegmatis_MC2_155 VERPPVDPAAQRTFGRPAGVEGSFLGA----GQYQDQGEYAPKDQPPDPV
TH_4008|M.thermoresistible__bu --------------------------------------------------
Rv1223|M.tuberculosis_H37Rv LQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAAL
Mb1255|M.bovis_AF2122/97 LQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAAL
MMAR_4214|M.marinum_M LEEAFSRPVGGADSLQRHPIDAGALDAEKDGGQADEADDPWRDPGAAAAL
MUL_4517|M.ulcerans_Agy99 LEEAFSRPVGGADSLQRHPIDAGALDAEKDGGQADEADDPWRDPGAAAAL
MLBr_01078|M.leprae_Br4923 LAEAFSRPFGSVDSLQRHPIDAGALAAEKDATQLDEPDDPWRDPAAAATL
MAV_1366|M.avium_104 LQEAFSRPDGSPETLQRHPVDSGALAAEKDGVEPDHADDPWRDPGAPAAL
MAB_1364|M.abscessus_ATCC_1997 LAQAFGRPDNVTTSLQRHPADAGKLDAADEG--PDAAEDPWRDPTAQVQL
Mflv_2202|M.gilvum_PYR-GCK LAEAFGRPYQGGDSLQRHPTDAGALDAERDG-DDADQDDPWRNPGAPVAL
Mvan_4494|M.vanbaalenii_PYR-1 LAEAFGRPYQGGDSLQRHPTDAGALDAERDG-DADELDDPWRNPGAAAAL
MSMEG_5070|M.smegmatis_MC2_155 LAEAFGRPRGTSETLQRHPTDAGALEAERLG-DEDVTDDPWRDPSAPVAL
TH_4008|M.thermoresistible__bu --------------------------------------------------
Rv1223|M.tuberculosis_H37Rv GTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIG
Mb1255|M.bovis_AF2122/97 GTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIG
MMAR_4214|M.marinum_M GTPAVAAPLPQGALGRTGKLGVRDVLFGGQVSYLALIVLAVIALVIGALG
MUL_4517|M.ulcerans_Agy99 GTPAVAAPLPQGALGRTGKLGVRDVLFGGQVSYLALIVLAVIALVIGALG
MLBr_01078|M.leprae_Br4923 ASPAVASPVPHTELGQCGKLGVRDVLFGGRVSYLALVILVFIALALGAIG
MAV_1366|M.avium_104 GTPAVAPSPSRSALGYGGKLGVRDVLFGGKVSYLALLVLLLIALVIGLIG
MAB_1364|M.abscessus_ATCC_1997 GRPAVNKAPVSLSGAPAPKLGVRDVLFGGRVSIPALAILAAVALLIGLVG
Mflv_2202|M.gilvum_PYR-GCK GTPAVAATAPVQAAGPVGKLGVRDVLFGGKVSFVALMVLGLIALVIGVAG
Mvan_4494|M.vanbaalenii_PYR-1 GTPALAPAGPTQAAAPLGKLGVRDVLFGGKVSYVALVVLGLVALVIGVAG
MSMEG_5070|M.smegmatis_MC2_155 GTPAQPPPPPVYVNAPTGKLGLREVLFGGRVSWIALLTLALVAVLIAFVG
TH_4008|M.thermoresistible__bu --------------------------------------------------
Rv1223|M.tuberculosis_H37Rv GVIGRKTAEVVDAFTTSKVTLSTT--GNAQEPAGRFTKVAAAVADSVVTI
Mb1255|M.bovis_AF2122/97 GVIGRKTAEVVDAFTTSKVTLSTT--GNAQEPAGRFTKVAAAVADSVVTI
MMAR_4214|M.marinum_M GVIGRKTAEVVEAFTTSKVTLSTN--GNAQEPAGRFTKVAAAVADSVVTI
MUL_4517|M.ulcerans_Agy99 GVIGRKTAEVVEAFTTSKVTLSTN--GNAQEPAGLFTKVAAAVADSVVTI
MLBr_01078|M.leprae_Br4923 GVIGRKTAEIVDAFTTSKVTLATT--NNTEEPAGRFAKVAAAVADSVVTI
MAV_1366|M.avium_104 GVVGRKTAEVAEAFTTSKVTLSTN--GNGEAPAGRFAKVAAATAGAVVTI
MAB_1364|M.abscessus_ATCC_1997 GIIGRKTAEVVEAFTTSKVTLTTD--DSTQPDESRFTAVANAVKSSVVTI
Mflv_2202|M.gilvum_PYR-GCK GWVGRTTAEVVSAFTTSKVTLETSGGDDNGEPRGQFAEVAAAVADSVVTI
Mvan_4494|M.vanbaalenii_PYR-1 GWVGRTTAEVVSAFTTSKVTLETS-DTGGAESEGQFAKVAAAVADSVVTI
MSMEG_5070|M.smegmatis_MC2_155 GWVGQKTAGTVQAFTTSKVTLETG--DHPDPDAGRFEQVAAAVADSVVTI
TH_4008|M.thermoresistible__bu --------------------------------------------------
Rv1223|M.tuberculosis_H37Rv ESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKE
Mb1255|M.bovis_AF2122/97 ESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVLNDGKE
MMAR_4214|M.marinum_M ETKSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKE
MUL_4517|M.ulcerans_Agy99 ETKSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKE
MLBr_01078|M.leprae_Br4923 ESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAANKPSQFKTTVVFNDGKD
MAV_1366|M.avium_104 ESKSDQEGMQGSGVVIDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKE
MAB_1364|M.abscessus_ATCC_1997 EASSDDEVAQGSGVVIDPKGYIITNNHVISDAAKNPGKFKIEVIFNDSKK
Mflv_2202|M.gilvum_PYR-GCK EATSDREGSQGSGVVVDGRGYIVTNNHVISEAATNPSEFKMSVVFNDGKE
Mvan_4494|M.vanbaalenii_PYR-1 EATSKTEGSQGSGVVVDGRGYIVTNNHVISEAATNPSEFKMSVVFNDGTE
MSMEG_5070|M.smegmatis_MC2_155 EAKSKTEGSQGSGVVVDGKGYIVTNNHVISEAATKPADFQITVVFNDGKE
TH_4008|M.thermoresistible__bu ---------------MPGRX-XXTNNHVISEAATKPADFQIQVVFNDGTK
: : *******:**.:*..*: *::**...
Rv1223|M.tuberculosis_H37Rv VPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLG
Mb1255|M.bovis_AF2122/97 VPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLG
MMAR_4214|M.marinum_M VPASLVGRDPKTDLAVLKVDNVDNLTVARLGNSDKVRVGDEVLAVGAPLG
MUL_4517|M.ulcerans_Agy99 VPASLVGRDPKTDLAVLKVDNVDNLTVARLGNSDKVRVGDEVLAVGAPLG
MLBr_01078|M.leprae_Br4923 VPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSGKVRVGDEVIAAGAPLG
MAV_1366|M.avium_104 VPANLVGRDPKTDLAVLKVDNVDNLSVARLGDSDKVRVGDEVLAAGAPLG
MAB_1364|M.abscessus_ATCC_1997 VPANLVGRDPKTDIAVLKVDNVDNLTVARLGDSDKVAVGAEVIAFGSPLG
Mflv_2202|M.gilvum_PYR-GCK VPANLVGRDPKTDLAVLKVDNVDNLSVARMGDSEKLQVGEEVIAAGAPLG
Mvan_4494|M.vanbaalenii_PYR-1 VPANLVGRDPKTDLAVLKVDNVDNLSVARMGDSEKIRVGEEVIAAGAPLG
MSMEG_5070|M.smegmatis_MC2_155 VPANLVGRDPKTDLAVLKVDNVDNLTVAKLGDSEKIRVGEEVIAAGAPLG
TH_4008|M.thermoresistible__bu VPANLVGRDPKTDLAVLKVDNVDNLTVARMGDSDKLQVGEEVIAAGAPLG
***.*********:***********:**::*:* *: ** **:* *:***
Rv1223|M.tuberculosis_H37Rv LRSTVTQGIVSALHRPVPLSGE--GSDTDTVIDAIQTDASINHGNSGGPL
Mb1255|M.bovis_AF2122/97 LRSTVTQGIVSALHRPVPLSGE--GSDTDTVIDAIQTDASINHGNSGGPL
MMAR_4214|M.marinum_M LRSTVTEGIVSALHRPVPLSGE--GSDTDTVIDAIQTDASINHGNSGGPL
MUL_4517|M.ulcerans_Agy99 LRSTVTEGIVSALHRPVPLSGE--GSDTDTVIDAIQTDASINHGNSGGPL
MLBr_01078|M.leprae_Br4923 LRSTVTHGIVSALHRPVPLSGE--GSDTDTVIDAIQTDASINHGNSGGPL
MAV_1366|M.avium_104 LRSTVTHGIVSALHRPVPLSGE--GSDTDTVIDAVQTDASINHGNSGGPL
MAB_1364|M.abscessus_ATCC_1997 LRSTVTGGIISALHRPVPLSGE--GSDTDTVIDALQTDAAINHGNSGGPL
Mflv_2202|M.gilvum_PYR-GCK LRSTVTHGIISALHRPVPLSGD--GSDTDTVIDGVQTDASINHGNSGGPL
Mvan_4494|M.vanbaalenii_PYR-1 LRSTVTHGIVSALHRPVPLSGD--GSDTDTVIDGVQTDASINHGNSGGPL
MSMEG_5070|M.smegmatis_MC2_155 LRSTVTHGIVSALHRPVPLSGD--GSDTDTVIDGVQTDASINHGNSGGPL
TH_4008|M.thermoresistible__bu LRSTVTRGIISALNRPVPLSGNRSGTDTDTVIDGVQTDASINHGNSGGPL
****** **:***:*******: *:*******.:****:**********
Rv1223|M.tuberculosis_H37Rv IDMDAQVIGINTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPT
Mb1255|M.bovis_AF2122/97 IDMDAQVIGINTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPT
MMAR_4214|M.marinum_M IDMDSQVIGINTAGKSLSDSASGLGFAIPVNEMKFVAETLIKDGKIVHPT
MUL_4517|M.ulcerans_Agy99 IDMDSQVIGINTAGKSLSDSASGLGFAIPVNEMEFVAETLIKDGKIVHPT
MLBr_01078|M.leprae_Br4923 IDMDSQVIGINTAGKSLSDSASGLSFAIPVDEMKSVVQTLIKDGKIVHPT
MAV_1366|M.avium_104 IDMDSQVIGIDTAGKSLSDSASGLGFAIPINEAKEVAQTLIRDGKIVHPT
MAB_1364|M.abscessus_ATCC_1997 IDMKSQVIGINTAGKSLSDSSSGLGFAIPINEAADVAQTLIRDGKIVHAT
Mflv_2202|M.gilvum_PYR-GCK INMDAEVIGINTAGKSLSDSASGLGFAIPVNEVKQVVETLIQSGKIAHPT
Mvan_4494|M.vanbaalenii_PYR-1 INMNSEVIGINTAGKSLSDSASGLGFAIPVNEVKQVVETLIKNGKIAHPT
MSMEG_5070|M.smegmatis_MC2_155 INMNAEVIGINTAGKSLSDSASGLGFAIPVNEVKEVVETLVKDGKVAHPT
TH_4008|M.thermoresistible__bu INMNAEVIGINTAGKSLSDSASGLGFAIPVNEVKTVVETLIRDGHISHPT
*:*.::****:*********:***.****::* *.::*::.*:: *.*
Rv1223|M.tuberculosis_H37Rv LGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRAVADSD
Mb1255|M.bovis_AF2122/97 LGINTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRAVADSD
MMAR_4214|M.marinum_M IGITTRSVSNAIASGAQVANVKAGSPAQKAGILENDVIVKIGNRSVADSD
MUL_4517|M.ulcerans_Agy99 IGITTRSVSNAIASGAQVANVKAGSPAQKAGILENDVIVKIGNRSVADSD
MLBr_01078|M.leprae_Br4923 LGVSTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRKVADAD
MAV_1366|M.avium_104 LGVSTRSVSNAIASGAQVANVKAGSPAQKGGVLENDVVVKVGNRKVADAD
MAB_1364|M.abscessus_ATCC_1997 LGISSRTVSNATATGAEVANVKAGSPAEKGGMLENDVVVKVGNRTVADAD
Mflv_2202|M.gilvum_PYR-GCK LGLTARSVSNDVAKGAQIADVKPGSPAEQAGLLENDVVVKVGDREVADAD
Mvan_4494|M.vanbaalenii_PYR-1 LGLTARSVSNDVAKGAQIADISPNSPAERAGLLENDVVIKVGDREVADAD
MSMEG_5070|M.smegmatis_MC2_155 LLVNAVTVSNSVASGAQIKNVVENGPAGKAGMLENDVVVKVGDRKVADAD
TH_4008|M.thermoresistible__bu LGVSAVSVSNDLASGALVRDVKVGGPADRGGLVENDVVVKVGDRTVADAD
: :.: :*** *.** : :: ..** :.*::****::*:*:* ***:*
Rv1223|M.tuberculosis_H37Rv EFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST-----
Mb1255|M.bovis_AF2122/97 EFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST-----
MMAR_4214|M.marinum_M EFVVAVRQLTIGQDAPVEVVRDGRHVTLTVKPDPDSS-----
MUL_4517|M.ulcerans_Agy99 EFVVAVRQLTIGQDAPVEVVRDGRHVTLTVKPDPDSS-----
MLBr_01078|M.leprae_Br4923 EFIVAVRQLTIGQDASVEVVRDGRHVTLTVKSDPDSS-----
MAV_1366|M.avium_104 EFVVAVRQLTIGQDSPIEVVRDGRHVTLTVKPDPDGS-----
MAB_1364|M.abscessus_ATCC_1997 EFVVAVRQLKIGQEATITVLRQGRPVELKVTPGPDGS-----
Mflv_2202|M.gilvum_PYR-GCK EMIVAVRQLKIGQPSPVEVVRDGRVVTLTVTPTGDDST----
Mvan_4494|M.vanbaalenii_PYR-1 EFIVAVRQLAIGQPAPIEVLRDGRPVTLTVTPNGDDST----
MSMEG_5070|M.smegmatis_MC2_155 EFVVAVRQLKIGQEAPIEVVRDGRPLTLMVTPIGDDQKAQ--
TH_4008|M.thermoresistible__bu EFVVAVRQLKVGEEAPIEVLREGRPVTLMITPDAEPSTRDKE
*::****** :*: :.: *:*:** : * :.. :