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VSLSLGIVGLPNVGKSTLFNALTRNNVVAANYPFATIEPNEGVVSLPDPRLDKLAELFGSQRVVPAPVTF VDIAGLVKGASEGAGLGNKFLAHIRECDAICQVVRVFVDDDVTHVTGRVDPQSDIEVVETELILADLQTL ERATGRLEKEARTNKARKPVYDAALRAQQVLDAGKTLFAAGVDAAALRELNLLTTKPFLYVFNADEAVLT DPARVGELRALVAPADAVFLDAAIESELTELDDESAAELLESIGQSERGLDALARAGFHTLKLQTFLTAG PKEARAWTIHQGDTAPKAAGVIHSDFEKGFIKAEIVSYDDLVAAGSMAAAKAAGKVRIEGKDYVMADGDV VEFRFNV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1112 | - | - | 100% (357) | translation-associated GTPase |
| M. tuberculosis H37Rv | Rv2440c | obgE | 2e-16 | 39.84% (128) | GTPase ObgE |
| M. tuberculosis H37Rv | Rv2725c | hflX | 1e-05 | 30.14% (146) | GTP-binding protein HflX |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1142 | - | 0.0 | 99.72% (357) | GTP-dependent nucleic acid-binding protein EngD |
| M. gilvum PYR-GCK | Mflv_2082 | - | 1e-172 | 84.59% (357) | translation-associated GTPase |
| M. leprae Br4923 | MLBr_01936 | - | 1e-171 | 86.16% (354) | GTP-dependent nucleic acid-binding protein EngD |
| M. abscessus ATCC 19977 | MAB_1266 | - | 1e-171 | 84.03% (357) | GTP-dependent nucleic acid-binding protein EngD |
| M. marinum M | MMAR_4353 | - | 1e-179 | 89.30% (355) | GTP binding protein |
| M. avium 104 | MAV_1232 | ychF | 1e-179 | 90.00% (350) | translation-associated GTPase |
| M. smegmatis MC2 155 | MSMEG_5222 | ychF | 1e-173 | 86.03% (358) | translation-associated GTPase |
| M. thermoresistible (build 8) | TH_1238 | - | 1e-172 | 84.59% (357) | Probable GTP binding protein |
| M. ulcerans Agy99 | MUL_0166 | - | 1e-178 | 89.01% (355) | GTP-dependent nucleic acid-binding protein EngD |
| M. vanbaalenii PYR-1 | Mvan_4625 | - | 1e-174 | 85.43% (357) | translation-associated GTPase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1112|M.tuberculosis_H37Rv ---MSLSLGIVGLPNVGKSTLFNALTRNNVVAANYPFATIEPNEGVVSLP
Mb1142|M.bovis_AF2122/97 ---MSLSLGIVGLPNVGKSTLFNALTRNNVVAANYPFATIEPNEGVVSLP
MAB_1266|M.abscessus_ATCC_1997 ---MSLNLGIVGLPNVGKSTLFNALTRNNVLAANYPFATIEPNEGVVPLP
MSMEG_5222|M.smegmatis_MC2_155 ---MSLNLGIVGLPNVGKSTLFNALTRNDVLAANYPFATIEPNEGVVPLP
Mflv_2082|M.gilvum_PYR-GCK MDPVGLNLGIVGLPNVGKSTLFNALTRNDVLAANYPFATIEPNEGVVALP
Mvan_4625|M.vanbaalenii_PYR-1 MVPVGLNLGIVGLPNVGKSTLFNALTRNDVLAANYPFATIEPNEGVVALP
TH_1238|M.thermoresistible__bu ---VGLNLGIVGLPNVGKSTLFNALTRNNVLAANYPFATIEPNEGVVPLP
MAV_1232|M.avium_104 ----------MGLPNVGKSTLFNALTRNNVVAANYPFATIEPNEGVVPLP
MMAR_4353|M.marinum_M ---MSLSLGIVGLPNVGKSTLFNALTRNDVLAANYPFATIEPNEGVVSLP
MUL_0166|M.ulcerans_Agy99 ---MSLSLGIVGLPNVGKSTLFNALTRNDVLAANYPFATIEPNEGVVSLP
MLBr_01936|M.leprae_Br4923 ---MSLSLGIVGLPNVGKSTLFNALTRSNVVVANYPFATIEPNEGVVSLP
:****************.:*:.***************.**
Rv1112|M.tuberculosis_H37Rv DPRLDKLAELFGSQRVVPAPVTFVDIAGLVKGASEGAGLGNKFLAHIREC
Mb1142|M.bovis_AF2122/97 DPRLDKLAELFGSQRVVPAPVTFVDIAGLIKGASEGAGLGNKFLAHIREC
MAB_1266|M.abscessus_ATCC_1997 DPRLDKLAEVFGSARTLPATVTFVDIAGIVKGASEGAGLGNKFLANIREC
MSMEG_5222|M.smegmatis_MC2_155 DPRLDKLAELFGSEKTVPAPVTFVDIAGIVKGASEGAGLGNKFLANIREC
Mflv_2082|M.gilvum_PYR-GCK DPRLTELARMFGSEKIVPAPVTFVDIAGIVKGASEGAGLGNKFLANIRES
Mvan_4625|M.vanbaalenii_PYR-1 DPRLTELARIFGSEKILPAPVTFVDIAGIVKGASEGAGLGNKFLANIREC
TH_1238|M.thermoresistible__bu DPRLEKLAEIFGSEKIVPATVTFVDIAGIVKGASEGAGLGNKFLANIREC
MAV_1232|M.avium_104 DPRLDKLAEMFKSERIVAAPVTFVDIAGLVKGASEGAGLGNKFLAHIREC
MMAR_4353|M.marinum_M DPRLDKLAELFGSERIVAAPVTFVDIAGLVKGASEGAGLGNKFLAHIREC
MUL_0166|M.ulcerans_Agy99 DPRLDKLAELFGSERIVAAPVTFVDIAGLVKGASEGAGLGNKFLAHIREC
MLBr_01936|M.leprae_Br4923 DPRLAKLAELFGSERILPAQVTFVDIAGLVKGASEGAGLGNKFLAHIREC
**** :**.:* * : :.* ********::***************:***.
Rv1112|M.tuberculosis_H37Rv DAICQVVRVFVDDDVTHVTGRVDPQSDIEVVETELILADLQTLERATGRL
Mb1142|M.bovis_AF2122/97 DAICQVVRVFVDDDVTHVTGRVDPQSDIEVVETELILADLQTLERATGRL
MAB_1266|M.abscessus_ATCC_1997 DAICQVVRVFADDDVVHVDGRVDPAADIEVIETELILADMQTLEKAVPRL
MSMEG_5222|M.smegmatis_MC2_155 DAICQVVRVFNDDDVVHVDGRVDPRSDIEVIETELILADMQTLEKAVPRL
Mflv_2082|M.gilvum_PYR-GCK DAICQVVRVFADDDVVHVDGRVDPKSDIEVIETELILADMQTLEKAVPRL
Mvan_4625|M.vanbaalenii_PYR-1 DAICQVVRVFADDDVVHVDGRVDPKSDIEVIETELILADMQTLERALPRL
TH_1238|M.thermoresistible__bu DAICQVVRVFSDDDVAHVDGRIDPKADIEVIETELILADLQTLEKALPRL
MAV_1232|M.avium_104 DAICQVVRVFADDDVTHVAGQVDPRSDIEVVETELILADLQTLERAAGRL
MMAR_4353|M.marinum_M DAICQVVRVFHDDDVTHVSGRVDPRSDIEVVETELILADMQTLERAVPRL
MUL_0166|M.ulcerans_Agy99 DAICQVVRVFHDDDVTHVSGRVDPRSDIEVVETELILADMQTLERAVPRL
MLBr_01936|M.leprae_Br4923 DAICQVVRVFSGDDITHVTGRVDPQSDIGIIDTELILADLDTLERALPRL
********** .**:.** *::** :** :::*******::***:* **
Rv1112|M.tuberculosis_H37Rv EKEARTNKARKPVYDAALRAQQVLDAGKTLFA----AGVDAAALRELNLL
Mb1142|M.bovis_AF2122/97 EKEARTNKARKPVYDAALRAQQVLDAGKTLFA----AGVDAAALRELNLL
MAB_1266|M.abscessus_ATCC_1997 EKEAKNKKDRQPLLDAAKAAQEVLDGGKTLFS----TGKDWSSVRELNLM
MSMEG_5222|M.smegmatis_MC2_155 EKEARNNKERKPVLEAAVAAQAVLDSGKTLFAGAAAAGIDVTLLRELNLM
Mflv_2082|M.gilvum_PYR-GCK EKEARNNKDRKPVLEAALAAQEILNTGKTLFA----AGMDTTLLRELNLM
Mvan_4625|M.vanbaalenii_PYR-1 EKEARTHKDRRPVYDAAVAAGKILDTGKTLFS----AGFDVSELRELNLL
TH_1238|M.thermoresistible__bu EKEARTHKDRRPTYEAAVAAQEILNSGKTLFA----AGFDATLLRELNLL
MAV_1232|M.avium_104 EKEARTSKERRPVYEAALAAQETLNGGKTLFS----AGTDTSLLRELNLL
MMAR_4353|M.marinum_M EKEARNNKERKPVHEAALAAQEVLDSGKTLFA----AGVDTSLLRELNLL
MUL_0166|M.ulcerans_Agy99 EKEARNNKERKPVHEAALAAQEVLDSGKTLFA----AGVDTSLLRELNLL
MLBr_01936|M.leprae_Br4923 EKEARNHKERKPIYAAAINAQQVLNVGTTLFA----AGVDGSALRELNLL
****:. * *:* ** * *: *.***: :* * : :*****:
Rv1112|M.tuberculosis_H37Rv TTKPFLYVFNADEAVLTDPARVGELRALVAPADAVFLDAAIESELTELDD
Mb1142|M.bovis_AF2122/97 TTKPFLYVFNADEAVLTDPARVGELRALVAPADAVFLDAAIESELTELDD
MAB_1266|M.abscessus_ATCC_1997 TTKPFLYVFNADESVLGDEARVAQLRALVAPADAVFLDAKIESELQELDE
MSMEG_5222|M.smegmatis_MC2_155 TTKPFLYVFNADESVLTDEARQAELREMVAPADAVFLDAKIEAELLELDD
Mflv_2082|M.gilvum_PYR-GCK TTKPFLYVFNADETVLTDEKRVAELRELVAPADAVFLDAKIEAELQELDE
Mvan_4625|M.vanbaalenii_PYR-1 TAKPFLYVFNADEAVLTDTERVAALRELVAPADAVFLDAKIEAELQELDE
TH_1238|M.thermoresistible__bu TTKPFLYVFNCDEEVLTDEARKAELRELVAPADCVFLDAKIEAELQELDD
MAV_1232|M.avium_104 TTKPFLYVFNADESVLTDPARIAELRELVAPADAVFLDAAIESELIELDD
MMAR_4353|M.marinum_M TTKPFLYVFNADESVLTDAARVAQLRELVAPADAVFLDAAIEAELVELDE
MUL_0166|M.ulcerans_Agy99 TTKPFLYVFNADESVLTGAARVAQLRELVAPADAVFLDAAIEAELVELDE
MLBr_01936|M.leprae_Br4923 TNKPFLYVFNADEAVLTAAAWVAELRQLVAPADAVFLDAAIEAELAELDD
* ********.** ** . ** :*****.***** **:** ***:
Rv1112|M.tuberculosis_H37Rv ESAAELLESIGQSERGLDALARAGFHTLKLQTFLTAGPKEARAWTIHQGD
Mb1142|M.bovis_AF2122/97 ESAAELLESIGQSERGLDALARAGFHTLKLQTFLTAGPKEARAWTIHQGD
MAB_1266|M.abscessus_ATCC_1997 ESAAELLESIGQAERGLDALARAGFHTLKLQTYLTAGPKEARAWTIHQGD
MSMEG_5222|M.smegmatis_MC2_155 ESAAELLESIGQTERGLDALARAGFHTLKLQTYLTAGPKEARAWTIHQGD
Mflv_2082|M.gilvum_PYR-GCK ESAAELLESIGQTERGLDALARAGFHTLKLQTYLTAGPKEARAWTIHQGD
Mvan_4625|M.vanbaalenii_PYR-1 ESAAELLESIGQTERGLDALARAGFHTLKLQTYLTAGPKEARAWTIHQGD
TH_1238|M.thermoresistible__bu ESARELLESIGQTERGLDALARAGFHTLKLQTFLTAGPKEARAWTIRQGT
MAV_1232|M.avium_104 ESAAELLESIGQTERGLDALARAGFHTLRLQTFLTAGPKEARAWVIHQGD
MMAR_4353|M.marinum_M ESAAELLESIGQTERGLDALARAGFHTLNLQTYLTVGPKEARAWTIHRGD
MUL_0166|M.ulcerans_Agy99 ESAAELLESIGQTERGLDALARAGFHTLNLQTYLTVGPKEARAWTIHRGD
MLBr_01936|M.leprae_Br4923 ESAAELLESIGQTERGLDALARAGFRTLALQTFLTVGPKEVRAWTIHQGD
*** ********:************:** ***:**.****.***.*::*
Rv1112|M.tuberculosis_H37Rv TAPKAAGVIHSDFEKGFIKAEIVSYDDLVAAGSMAAAKAAGKVRIEGKDY
Mb1142|M.bovis_AF2122/97 TAPKAAGVIHSDFEKGFIKAEIVSYDDLVAAGSMAAAKAAGKVRIEGKDY
MAB_1266|M.abscessus_ATCC_1997 TAPKAAGVIHTDFEKGFIKAEVVSYEDLIEAGSMAAAKAAGKVRMEGKEY
MSMEG_5222|M.smegmatis_MC2_155 TAPKAAGVIHSDFEKGFIKAEVVSFDDLVEAGSMAAAKAAGKVRMEGKDY
Mflv_2082|M.gilvum_PYR-GCK TAPKAAGVIHTDFEKGFIKAEVVSFDDLMEAGSMAAAKAAGKVRMEGKDY
Mvan_4625|M.vanbaalenii_PYR-1 TAPKAAGVIHSDFEKGFIKAEVVSFDDLVEAGSMAAAKAAGKVRIEGKDY
TH_1238|M.thermoresistible__bu TAPKAAGVIHSDFEKGFIKAEVVSFDDLVEAGSMAAAKAAGKVRMEGKDY
MAV_1232|M.avium_104 TAPKAAGVIHSDFEKGFIKAEIVSYDDLIAAGSMAAAKAAGKVRMEGKDY
MMAR_4353|M.marinum_M TAPKAAGVIHTDFEKGFIKAEIVSFDDLLAAGSMAAAKAAGKVRMEGKDY
MUL_0166|M.ulcerans_Agy99 TAPKAAGVIHTDFEKGFIKAEIVSFDDLLAAGSMAAAKAAGKVRMEGKDY
MLBr_01936|M.leprae_Br4923 TASKAAGVIHTDFEKRFIKAEIVSYDDLIATGSMSAAKAAGKVRTEGKDY
**.*******:**** *****:**::**: :***:********* ***:*
Rv1112|M.tuberculosis_H37Rv VMADGDVVEFRFNV---------
Mb1142|M.bovis_AF2122/97 VMADGDVVEFRFNV---------
MAB_1266|M.abscessus_ATCC_1997 VMVDGDVVEFRFNV---------
MSMEG_5222|M.smegmatis_MC2_155 VMADGDVVEFRHGGTSGSGKK--
Mflv_2082|M.gilvum_PYR-GCK VMADGDVVEFRFNV---------
Mvan_4625|M.vanbaalenii_PYR-1 VMADGDVVEFRFNV---------
TH_1238|M.thermoresistible__bu VMQDGDVVEFRFNV---------
MAV_1232|M.avium_104 VMADGDVVEFRFNV---------
MMAR_4353|M.marinum_M VMADGDVVEFRFQTSSGGKAAGR
MUL_0166|M.ulcerans_Agy99 VMADGDVVEFRFRTSSGGKAAGR
MLBr_01936|M.leprae_Br4923 VMADGDVVEFRHG----------
** ********.