For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARLLVASALARQGPLLVVTATGR EADDLAAELRGVFGDAVALLPSWETLPHERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSL LQPMTPQLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEF WGDEITEMRMFSVADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKL AEGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASWSVAALGTAE NQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVRAAPSARGHQRDIDEIFAMLRA HIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPGQAPKPGVVGVLQGPLRDGVIIPGANLVVITET DLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRG GGAKNTDKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHA FSPDTPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQV AVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKD LGLVVVDEEQRFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGP HDDKQIAAALRRELLRDGQAFYVHNRVSSIDAAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREH DILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTETAYDRLAT IAQNNELGAGMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVRTA EEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVDELTDRYGALPEPARRLAAVARL RLLCRGSGITDVTAASAATVRLSPLTLPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGGLGAPRIRDVE LVQMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1020 | mfd | - | 100% (1234) | PROBABLE TRANSCRIPTION-REPAIR COUPLING FACTOR MFD (TRCF) |
M. tuberculosis H37Rv | Rv2973c | recG | 4e-51 | 31.63% (528) | ATP-dependent DNA helicase RecG |
M. tuberculosis H37Rv | Rv1633 | uvrB | 1e-11 | 39.22% (102) | excinuclease ABC subunit B |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1048 | mfd | 0.0 | 100.00% (1234) | transcription-repair coupling factor Mfd (TRCF) |
M. gilvum PYR-GCK | Mflv_1948 | - | 0.0 | 79.45% (1207) | transcription-repair coupling factor |
M. leprae Br4923 | MLBr_00252 | mfd | 0.0 | 84.38% (1229) | putative transcription-repair coupling factor |
M. abscessus ATCC 19977 | MAB_1157 | - | 0.0 | 73.53% (1224) | transcription-repair coupling factor |
M. marinum M | MMAR_4465 | mfd | 0.0 | 85.89% (1233) | transcription-repair coupling factor Mfd (TrcF) |
M. avium 104 | MAV_3818 | recG | 6e-52 | 33.76% (465) | ATP-dependent DNA helicase RecG |
M. smegmatis MC2 155 | MSMEG_5423 | mfd | 0.0 | 79.17% (1224) | transcription-repair coupling factor |
M. thermoresistible (build 8) | TH_0914 | mfd | 0.0 | 79.88% (1153) | transcription-repair coupling factor |
M. ulcerans Agy99 | MUL_4634 | mfd | 0.0 | 85.48% (1233) | transcription-repair coupling factor Mfd (TrcF) |
M. vanbaalenii PYR-1 | Mvan_4777 | - | 0.0 | 78.87% (1216) | transcription-repair coupling factor |
CLUSTAL 2.0.9 multiple sequence alignment Rv1020|M.tuberculosis_H37Rv MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARL Mb1048|M.bovis_AF2122/97 MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARL MLBr_00252|M.leprae_Br4923 MTAPGPACLDTPIAGLVELALTAPTFGQLMERAGTRPAELILAGPACARL MMAR_4465|M.marinum_M MTAPGAASPDTPIAGLVDLALTAPTFQQLIARASDRPDELTLVGPASARS MUL_4634|M.ulcerans_Agy99 MTAPGAASPDTPIAGLVDLALTAPTFQQLIARASDRPDELTLVGPASARS Mflv_1948|M.gilvum_PYR-GCK MTASGTLHVHTPIAGLVGLALRDPSLQEIARRGVDRPADLHFVGPASARL Mvan_4777|M.vanbaalenii_PYR-1 MTVSGTLHVHTPIAGLVDLALRDPALQEIARRAGDRPADLNLVGPASARV MSMEG_5423|M.smegmatis_MC2_155 MTAPGHTSVQTPIAGLVELALSDPSLQDVIRRAADRPADLALVGPASARV TH_0914|M.thermoresistible__bu -------------------------------------------------- MAB_1157|M.abscessus_ATCC_1997 MTAT-----TPPLAGVIRTALRDPAFDVLAPAIAAKTG-LDLTAPTCARA MAV_3818|M.avium_104 -------------------------------------------------- Rv1020|M.tuberculosis_H37Rv LVASALARQ--GPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPH Mb1048|M.bovis_AF2122/97 LVASALARQ--GPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPH MLBr_00252|M.leprae_Br4923 FVASALARL--GPLLVVTATGREASNLTAELRGVFGAAVAMFPSWETLPH MMAR_4465|M.marinum_M FVASALAQQ--GPLLVVTATGREADDVTAELRGVFGEAVALFPSWETLPH MUL_4634|M.ulcerans_Agy99 FVASALAQQ--GPLLVVTATGREADDVTAELRGVFGEAVALFPSWETLPH Mflv_1948|M.gilvum_PYR-GCK FVASALAQA--GLLLVVTATGREADDLTAELRGVFGDAVAMFPSWETLPH Mvan_4777|M.vanbaalenii_PYR-1 FVASALAQP--GLLLVVTATGREADDLTAELRGVFGDAVALFPSWETLPH MSMEG_5423|M.smegmatis_MC2_155 LVAAALAQN--GPLLVVAATGREADELTAELRGVFGDSVALFPSWETLPH TH_0914|M.thermoresistible__bu ---------------VVTATGREAEELTAELRGVYGDEVAMFPSWETLPH MAB_1157|M.abscessus_ATCC_1997 FVVTGMADASDAPVLVVTATTREAQDLTAELRDVYGDAVTLLPSWETLPH MAV_3818|M.avium_104 -------------------------------------------------- Rv1020|M.tuberculosis_H37Rv ERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTP-- Mb1048|M.bovis_AF2122/97 ERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTP-- MLBr_00252|M.leprae_Br4923 ERLSPGVDTVGARLMVLRRLAHPDDARLGPPLQVVVTAVRSLLQPMTA-- MMAR_4465|M.marinum_M ERLSPGVDTVGARLLLLRRLAHPEDTRLGPPLRVVVTAVRSLLQPMTP-- MUL_4634|M.ulcerans_Agy99 ERLSPGVDTVGARLLLLRRLAHPDDTRLGPPLRVVVTAVRSLLQPMTP-- Mflv_1948|M.gilvum_PYR-GCK ERLSPGVDTVGARMMLLRRLAFPDDARLGEPLRVVVTTARSLLQPMAP-- Mvan_4777|M.vanbaalenii_PYR-1 ERLSPGVDTVGARMMLLRRLTHPDDARLGPPLRIVVTTARSLLQPMAP-- MSMEG_5423|M.smegmatis_MC2_155 ERLSPGVETVGARLMLLRRLARPDDETLGAPLRVVVTTTRSLLQPMAP-- TH_0914|M.thermoresistible__bu ERLSPGVDTVGTRLMVLRRLAHPDDARLGPPLRVVVTTTRSLVQPMAQRP MAB_1157|M.abscessus_ATCC_1997 ERLSPGVDTVGARLQVLHRLAHPEDSRMGVPLRVVITTVRSLLQPMSP-- MAV_3818|M.avium_104 ------MASLTDRLDFVVGAKAAEQLEELFGIRTVDDLLRHYPRSYTEG- : :: *: : .:: : * * :. : Rv1020|M.tuberculosis_H37Rv -QLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGIL Mb1048|M.bovis_AF2122/97 -QLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGIL MLBr_00252|M.leprae_Br4923 -QLGLVEPVTLSVGDEIGFERVIARLVELAYTRVDMVGRRGEFAVRGGIL MMAR_4465|M.marinum_M -QLGRQEPVSLSVGQEIGFDEVIARLVELAYTRVDMVGRRGEFAVRGGIL MUL_4634|M.ulcerans_Agy99 -QLGRQEPVSLSVGQEIGFDEVIARLVELAYTRVDMVGRRGEFAVRGGIL Mflv_1948|M.gilvum_PYR-GCK -DLARIDPVTLTVGGEADFDETVARLVDLAYTRVDMVGKRGEFAVRGGIL Mvan_4777|M.vanbaalenii_PYR-1 -DLAEVDPVTLTVGGEADFDAVVARLVDLAYSRVDMVGKRGEFAVRGGIL MSMEG_5423|M.smegmatis_MC2_155 -DLVDIEPVTLSVGAEMEFEDVVARLVDLSYTRVDMVGKRGEFAVRGGIL TH_0914|M.thermoresistible__bu DEVRQTEPVTLTVGADADFDETIARLVELAYTRVDMVGRRGEFAVRGGIL MAB_1157|M.abscessus_ATCC_1997 -ELFDLEPVELAVGAELEFDGVIARLVELAYTRVDMVAGRGEFAVRGGIL MAV_3818|M.avium_104 -------------------------------------------ASRWGAD * * * Rv1020|M.tuberculosis_H37Rv DIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACREL Mb1048|M.bovis_AF2122/97 DIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACREL MLBr_00252|M.leprae_Br4923 DIFGPTAEHPVRVEFWGDEITEMRMFSVVDQRSIPEIGVDTLVAIACREL MMAR_4465|M.marinum_M DLFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIEVSTLVAVACREL MUL_4634|M.ulcerans_Agy99 DLFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIEVSTLVAVACREL Mflv_1948|M.gilvum_PYR-GCK DLFPPTAEHPVRVEFWGDEISEMRMFSVADQRSIPEIEIDTVIAVPCREL Mvan_4777|M.vanbaalenii_PYR-1 DVFPPTAEHPVRVEFWGDEVSEMRMFSVADQRSIPEIEIDTLIAVPCREL MSMEG_5423|M.smegmatis_MC2_155 DVFPPTAEHPVRVEFWGDEISEMRAFAIADQRSIPEVPVQTVVAVPCREL TH_0914|M.thermoresistible__bu DVFPPTAEHPVRIEFWGDEVSEMRMFSVADQRSIPEISIDTVVAMPCREL MAB_1157|M.abscessus_ATCC_1997 DVFSPTADHPVRVEFWGDEVSEMRYFSVADQRSIPELQVDSVLAMPCREL MAV_3818|M.avium_104 DERPPAGEHIT----IIDTITETKTWPMKKT---PKKVCHRITLGAGRNK * *:.:* . * ::* : :.: . *: : . *: Rv1020|M.tuberculosis_H37Rv LLSEDVRAR----AAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEA Mb1048|M.bovis_AF2122/97 LLSEDVRAR----AAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEA MLBr_00252|M.leprae_Br4923 LLSDDVRARAVELAAQAAARRPTEEPAISGSVTDVLAKLAEGIPVDGMEA MMAR_4465|M.marinum_M LLTEDVRAR----AAALAAQHPASENTVTGSVIDMLAKLAEGIPTDGMEA MUL_4634|M.ulcerans_Agy99 LLTEDVRAR----AAALAAQHPASENTVTGSVIDMLAKLAEGIPTDGMEA Mflv_1948|M.gilvum_PYR-GCK LLTADVRER----AAALAEEHPVSENNVPGSVPDMLARLAEGIPVDGMEA Mvan_4777|M.vanbaalenii_PYR-1 LLTAEVRDR----AAALASEHPVLENSVTGSVPDMLAKLAEGIPVDGMEA MSMEG_5423|M.smegmatis_MC2_155 LMTDDVRER----AAALAAEHPTTENTVPGTVPDMLAKLAEGIPVDGMEA TH_0914|M.thermoresistible__bu LLTDEVRER----AVKLAEQHPRQENTLPGTLPDMLAKLAEGIPVDGMEA MAB_1157|M.abscessus_ATCC_1997 LLTDQVRARAAELASAAGVSGSEEGHRLGAGVGEMLAKLADGICVDGMES MAV_3818|M.avium_104 VTATFFNAN----------------------------------------- : : .. . Rv1020|M.tuberculosis_H37Rv VLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASW Mb1048|M.bovis_AF2122/97 VLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASW MLBr_00252|M.leprae_Br4923 LLPVLCPDDYALLTDQFAADTPVLLCDPEKVRIQAADLIKTDRAFLEASW MMAR_4465|M.marinum_M LLPVLRPDDHALLTDQLAEGTPVLVCDPEKVRTRAADLIKTGREFLEASW MUL_4634|M.ulcerans_Agy99 LLPVLRPDDHALLTDQLAEGTPVLVCDPEKVRTRAADLIKTGREFLEASW Mflv_1948|M.gilvum_PYR-GCK LLPLLRPSDFATLPDHLPEGTPLLVCDPEKVRTRAADLIKTGREFLEASW Mvan_4777|M.vanbaalenii_PYR-1 LLPLLRPSDFATLPDHLPEGTPLLVCDPEKVRTRAADLIKTGREFLEASW MSMEG_5423|M.smegmatis_MC2_155 LLPLLHPIEPTTLTRHLPEGAPVLVCDPEKVRTRAADLIKTGREFLEASW TH_0914|M.thermoresistible__bu LLPLLRPGELSMLTDHLPAGAPVLVCDPEKVRTRAADLISTGQEFLEASW MAB_1157|M.abscessus_ATCC_1997 LLPVLHSGKLTMLVDHLPDHAPVLVCDPEKVRTRAADLERTGREFLEASW MAV_3818|M.avium_104 -----------YLKKGLTEGTKVMLSGEVGFFKNVMQLTHPAFLILDS-- * :. : :::.. . .. :* . :*:: Rv1020|M.tuberculosis_H37Rv SVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDE Mb1048|M.bovis_AF2122/97 SVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDE MLBr_00252|M.leprae_Br4923 SVAAIG-ADNAAPVDVEQLYGSGFVELGDVQAAAIRSGHPWWTLSQLSDE MMAR_4465|M.marinum_M SVAAMG---TDAPVDVEALGGSGFAELEQVQTAASSSGHPWWTLSQLSEE MUL_4634|M.ulcerans_Agy99 SVAAMG---TDAPVDVEALGGSGFAELEQVQTAASSSGHPWWTLSQLSEE Mflv_1948|M.gilvum_PYR-GCK STAAVG---GDVPIDLEALGASGYVTYNEARDAARDGGHGWWTLSQLDSG Mvan_4777|M.vanbaalenii_PYR-1 STAAVG---GDVPIDIEALGVSGYVGYGDARDAARAGGHPWWTLSQLDSG MSMEG_5423|M.smegmatis_MC2_155 STAAVG---GDAPIDLEALGASGFVTFEEAREAAREGGHPWWTLSQLSDE TH_0914|M.thermoresistible__bu SAAAIG---GDAPIDLDALGASGFLDLDDARASAAEAGHPWWTLSQLSSE MAB_1157|M.abscessus_ATCC_1997 SVAAIG---SDAPIDVEALADSGFRELDDVKHAAGEAGYPWWSLSPLGMD MAV_3818|M.avium_104 ----------------PDGRNKGTRSLMNIANASGASG------------ .* : :: * Rv1020|M.tuberculosis_H37Rv S--AIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAH Mb1048|M.bovis_AF2122/97 S--AIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAH MLBr_00252|M.leprae_Br4923 S--ALELDIRAAPSTRGHQHAIDGIFAMLRAHVATGGYAAIVTPGTGTAH MMAR_4465|M.marinum_M S--ATELEVRAAPSARGHQKDIDDIFAMLRAHVSTGGYAVMVEPGTGTAH MUL_4634|M.ulcerans_Agy99 S--ATELEVRAAPSARGHQKDIDDIFAMLRAHVSTGGYAVMVEPGTGTAH Mflv_1948|M.gilvum_PYR-GCK AGESTALDIRPAPSARG-QHNLEEIFAMLRAHVATGGCGVVVTPGAGTCQ Mvan_4777|M.vanbaalenii_PYR-1 AGESTALDIRPAPSARGQQHNLDEIFAMLRAHVATGGFGVVVTPGSGTAM MSMEG_5423|M.smegmatis_MC2_155 S--AVELDIRSAPSARGSQHNLEEIFAMLRAHVATGGYAAVVTPGIGTAH TH_0914|M.thermoresistible__bu S--AIELDLRPVPAART-KSAVTEIFAMLRAHVTTGGYAAVVTPGAGTAQ MAB_1157|M.abscessus_ATCC_1997 NDQAIGLAVRPSPSARGHKEGAAEIFAMLRAHVMTGGRAAVVAAGAGTTH MAV_3818|M.avium_104 ----------------------EEVLDAYERHFFP-------IYPASTKM :: . *. . .* Rv1020|M.tuberculosis_H37Rv RVVERLSESDTPAGMLDPGQAP----KPGVVGVLQGPLRDGVIIPGANLV Mb1048|M.bovis_AF2122/97 RVVERLSESDTPAGMLDPGQAP----KPGVVGVLQGPLRDGVIIPGANLV MLBr_00252|M.leprae_Br4923 RVVERLAESDIPGAMLEPAAAPGLGLRPGLVGVLKGPLLDGVVIPGANLV MMAR_4465|M.marinum_M RMVERLAESDIPAAMLEPGAAP----KLGVVGVLKGPLRDGVIVPGANLV MUL_4634|M.ulcerans_Agy99 RMVERLAESDIPAAMLEPGAAP----KLGVVGVLKGPLRDGVIVPGANLV Mflv_1948|M.gilvum_PYR-GCK RVVEQLSESDTPAMILEPGMAP----KDGVVGVLKGPLHDGVVIPGANLV Mvan_4777|M.vanbaalenii_PYR-1 RVVEQLSESDIPATVLEPGAVP----GEGVVGVIKGPLHDGVVIPGANLV MSMEG_5423|M.smegmatis_MC2_155 RVVEQLGEADTAATILEPGTAP----KAGVVGVLKGPLCSGVVLPGANLV TH_0914|M.thermoresistible__bu RIVEQLGESETPARRLEPGAGL----EPGVVGVLQGPLHDGLVLPGANLV MAB_1157|M.abscessus_ATCC_1997 RIIEQLAETETPATLLEPGAEP----AEGVVGVLRGHLTDGVVLTGANIV MAV_3818|M.avium_104 QSWDIFSCVRLVLDVLDPVPDP-----------LPEPLR------AKFDL : : :. *:* : * . : Rv1020|M.tuberculosis_H37Rv VITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFV Mb1048|M.bovis_AF2122/97 VITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFV MLBr_00252|M.leprae_Br4923 IITEADLTGSRATPVEGKRLAAKRRSAADPLALTAGDLVVHDQHGIGRFV MMAR_4465|M.marinum_M VVTETNLTGNRATAVEGKRLAAKRRNTVDPLALTAGDLVVHDQHGIGRFV MUL_4634|M.ulcerans_Agy99 VVTETNLTGNRATAVEGKRLAAKRRNTVDPLALTAGDLVVHDQHGIGRFV Mflv_1948|M.gilvum_PYR-GCK VITETDLTGNRAAATEGKKLAAKRRNVVDPLALTAGDLVVHDQHGIGRFV Mvan_4777|M.vanbaalenii_PYR-1 VITETDLTGNRAAATEGKKLAAKRRNVVDPLALTAGDLVVHDQHGIGRFV MSMEG_5423|M.smegmatis_MC2_155 IITETDLTGNRVTANEGRKLAAKRRNVVDPLALTAGDLVVHDQHGIGKFV TH_0914|M.thermoresistible__bu VITEADLTGNRVTAQQGRKLAPKRRNVVDPLALTAGDLVVHDQHGIGRFV MAB_1157|M.abscessus_ATCC_1997 IVTETDLTGSRVAATDGKRLPAKRRNQVDPLALSAGDLVVHDQHGIGRFV MAV_3818|M.avium_104 VCEDQALRDIHLAESEARRQRARERLTFD--------------EAVGLQW : : * . : : :.:: .:.* * ..:* Rv1020|M.tuberculosis_H37Rv EMVERTVGGARREYLVLEYASAKRGGG-AKNTDKLYVPMDSLDQLSRYVG Mb1048|M.bovis_AF2122/97 EMVERTVGGARREYLVLEYASAKRGGG-AKNTDKLYVPMDSLDQLSRYVG MLBr_00252|M.leprae_Br4923 EMVERTVGGARREYLVLEYASNKK----SKQADKLYVPMDSLDQLSRYVG MMAR_4465|M.marinum_M EMVERTVGGARREYLVLEYASAKR----GGGSDKLYVPMDSLDQLSRYVG MUL_4634|M.ulcerans_Agy99 EMVERTVGGARREYLVLEYASARR----GGGSDKLYVPMDSLDQLSRYVG Mflv_1948|M.gilvum_PYR-GCK EMTERVIGGARREYLVLEYASAKR----GGGADRLYVPMDSLDQLSRYVG Mvan_4777|M.vanbaalenii_PYR-1 EMTERVIGGARREYLVLEYASAKR----GGGSDRLYVPMDSLDQLSRYVG MSMEG_5423|M.smegmatis_MC2_155 EMTERVVGGARREYLVLEYASSKR----GGGTDKLYVPMDSLDQLSRYVG TH_0914|M.thermoresistible__bu EMVERTVGGARREYLVLEYASNRRGTG-GGHTDKLYVPMDSLDQLSRYVG MAB_1157|M.abscessus_ATCC_1997 EMVERTVGGARREYLVLEYASGKRGAAAGGQSDRLYVPMDSLDQLSRYVG MAV_3818|M.avium_104 ALVARRHG--------------------------------------ELSE :. * * . Rv1020|M.tuberculosis_H37Rv GQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPD Mb1048|M.bovis_AF2122/97 GQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPD MLBr_00252|M.leprae_Br4923 GQAPALSRLGGSDWANTKTKARCAVREIAGELVSLYAKRQASPGHAFGPD MMAR_4465|M.marinum_M GQAPALSRLGGSDWTNTKTKARKAVREIAGELVALYAKRQASPGHAFAPD MUL_4634|M.ulcerans_Agy99 GQAPALSRLGGSDWTNTKTKARKAVREIAGELVALYAKRQASPGHAFAPD Mflv_1948|M.gilvum_PYR-GCK GEAPTLSRLGGSDWANTKTKARRAVREIAAELVTLYAKRQASPGHAFSPD Mvan_4777|M.vanbaalenii_PYR-1 GEAPTLSRLGGSDWANTKTKARKAVREIAAELVALYAKRQASAGHAFAPD MSMEG_5423|M.smegmatis_MC2_155 GEAPSLSRLGGSDWANTKTKARRAVREIASELVALYAKRQSAPGHAFGPD TH_0914|M.thermoresistible__bu GDSPSLSRLGGSDWTNTKTKARKAVREIAAELVALYAKRQSAPGHAFSPD MAB_1157|M.abscessus_ATCC_1997 GESPGLSRLGGSDWTNTKTKARKAVREIAGELVALYAARQAAPGHAFAPD MAV_3818|M.avium_104 SGPPAPPRPDG--------------------------------------- . .* .* .* Rv1020|M.tuberculosis_H37Rv TPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTE Mb1048|M.bovis_AF2122/97 TPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTE MLBr_00252|M.leprae_Br4923 TPWQAEMEDAFGFTETVDQLTAITEVKGDMEKSVPMDRVICGDVGYGKTE MMAR_4465|M.marinum_M TPWQAEMEDAFGFTETVDQLTAITEVKGDMEKSIPMDRVICGDVGYGKTE MUL_4634|M.ulcerans_Agy99 TPWQAEMEDAFGFTETVDQLTAITEVKRDMEKSIPMDRVICGDVGYGKTE Mflv_1948|M.gilvum_PYR-GCK TPWQVEMEDAFGFTETVDQLTAITEVKSDMEKPVPMDRVICGDVGYGKTE Mvan_4777|M.vanbaalenii_PYR-1 TPWQREMEDAFGFTETVDQLTAITEVKSDMEKPVPMDRVICGDVGYGKTE MSMEG_5423|M.smegmatis_MC2_155 TPWQAEMEDAFGFTETIDQLTAIQEVKSDMEKPVPMDRVICGDVGYGKTE TH_0914|M.thermoresistible__bu TPWQREMEDAFGFTETVDQLTAIEEVKADMEKPVPMDRVICGDVGYGKTE MAB_1157|M.abscessus_ATCC_1997 TPWQREMEDAFGFVETVDQLTAITEVKSDMEKPVPMDRVVCGDVGYGKTE MAV_3818|M.avium_104 --LAAELLRRLPFELTAGQREVLDVLSDGLASTRPLNRLLQGEVGSGKTI *: : * * .* .: :. .: .. *::*:: *:** *** Rv1020|M.tuberculosis_H37Rv IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVT------- Mb1048|M.bovis_AF2122/97 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVT------- MLBr_00252|M.leprae_Br4923 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLRTFTERMAGFPVT------- MMAR_4465|M.marinum_M IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTDRMAGFPVT------- MUL_4634|M.ulcerans_Agy99 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTDRMAGFPVT------- Mflv_1948|M.gilvum_PYR-GCK IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTARMTGFPVT------- Mvan_4777|M.vanbaalenii_PYR-1 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTNRMTGFPVT------- MSMEG_5423|M.smegmatis_MC2_155 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTNRMAGFPVT------- TH_0914|M.thermoresistible__bu IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTERMAGFPVT------- MAB_1157|M.abscessus_ATCC_1997 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTNRTAGFPVK------- MAV_3818|M.avium_104 VSVLAMLQMVDAGYQCALLAPTEVLAAQHLRSIRDVLGPLAMAGQLGGAD ::* * :: *: * * *:*.** :** ***::: :.: Rv1020|M.tuberculosis_H37Rv ----IKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGL Mb1048|M.bovis_AF2122/97 ----IKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGL MLBr_00252|M.leprae_Br4923 ----VKGLSRFTDAAESRAVIDGLAEGSVDIVIGTHRLLQTGVCWKDLGL MMAR_4465|M.marinum_M ----VKGLSRFTDPAESRTVIEGMADGSVDVVIGTHRLLQTGVRWKDLGL MUL_4634|M.ulcerans_Agy99 ----VKGLSRFTDPAESRTVIEGMADGSVDVVIGTHRLLQTGVRWKDLGL Mflv_1948|M.gilvum_PYR-GCK ----VRGLSRFTDPASSRATLEGMKDGSVDIVIGTHRLIQTGVTWKDLGL Mvan_4777|M.vanbaalenii_PYR-1 ----VKGLSRFTDPAESRATIEGMKDGSVDIVIGTHRLLQTGVTWKDLGL MSMEG_5423|M.smegmatis_MC2_155 ----VKGLSRFTDPAESRAVIEGLKDGSVDVVIGTHRLLQTGVTWKDLGL TH_0914|M.thermoresistible__bu ----IKGLSRFTSPSESRAVLEGMADGSVDIVIGTHRLLQTGVRWKDLGL MAB_1157|M.abscessus_ATCC_1997 ----VAGLSRFTDPLTSKLVVEGMADGSVDIVIGTHRLLQTGVRWKDLGL MAV_3818|M.avium_104 NATRLALLSGSMTAAQKKQVRDEVAGGQVGIVVGTHALLQDAVEFHNLGM : ** . .: . : : *.*.:*:*** *:* .* :::**: Rv1020|M.tuberculosis_H37Rv VVVDEEQRFGVEHKEHIKSLR---THVDVLTMSATPIPRTLEMSLAGIRE Mb1048|M.bovis_AF2122/97 VVVDEEQRFGVEHKEHIKSLR---THVDVLTMSATPIPRTLEMSLAGIRE MLBr_00252|M.leprae_Br4923 VVVDEEQWFGVEHKEHIKSLR---THVDVLTMSATPIPRTLEMSLAGIRE MMAR_4465|M.marinum_M VVVDEEQRFGVEHKEHIKSLR---SHVDVLTMSATPIPRTLEMSLAGIRE MUL_4634|M.ulcerans_Agy99 VVVDEEQRFGVEHKEHIKSLR---SHVDVLTMSATPIPRTLEMSLAGIRE Mflv_1948|M.gilvum_PYR-GCK VIVDEEQRFGVEHKEHIKSMR---THVDVLTMSATPIPRTLEMSLAGIRE Mvan_4777|M.vanbaalenii_PYR-1 VIVDEEQRFGVEHKEHIKSMR---THVDVLTMSATPIPRTLEMSLAGIRE MSMEG_5423|M.smegmatis_MC2_155 IIVDEEQRFGVEHKEHIKSMR---THVDVLTMSATPIPRTLEMSLAGIRE TH_0914|M.thermoresistible__bu VIIDEEQRFGVEHKEHIKSMR---THVDVLTMSATPIPRTLEMSLAGIRE MAB_1157|M.abscessus_ATCC_1997 VIVDEEQRFGVEHKEHIKALR---THVDVLTMSATPIPRTLEMSLAGIRE MAV_3818|M.avium_104 VVVDEQHRFGVEQRDRLRAKARPGVTPHLLVMTATPIPRTVALTVYGDLE :::**:: ****::::::: .:*.*:*******: ::: * * Rv1020|M.tuberculosis_H37Rv MSTILTPPEERYPVLTYVGPHDDK-----QIAAALRRELLRDGQAFYVHN Mb1048|M.bovis_AF2122/97 MSTILTPPEERYPVLTYVGPHDDK-----QIAAALRRELLRDGQAFYVHN MLBr_00252|M.leprae_Br4923 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYVHN MMAR_4465|M.marinum_M MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYVHN MUL_4634|M.ulcerans_Agy99 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYVHN Mflv_1948|M.gilvum_PYR-GCK MSTILTPPEERYPVLTYVGQHDDK-----QVAAALRREMLRDGQAFYIHN Mvan_4777|M.vanbaalenii_PYR-1 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRREMLRDGQAFYIHN MSMEG_5423|M.smegmatis_MC2_155 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYIHN TH_0914|M.thermoresistible__bu MSTILTPPEERYPVLTYVGPYDDK-----QIAAALRRELLRDGQAFYIHN MAB_1157|M.abscessus_ATCC_1997 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYVHN MAV_3818|M.avium_104 TSTLRELPRGRQPITSNVIFVKDKPAWLGRAWRRIGEEVAAGRQAYVVAA **: *. * *: : * .** : : .*: . **: : Rv1020|M.tuberculosis_H37Rv RVSSIDAAAARVR-----------------ELVPEARVVVAHGQMPEDLL Mb1048|M.bovis_AF2122/97 RVSSIDAAAARVR-----------------ELVPEARVVVAHGQMPEDLL MLBr_00252|M.leprae_Br4923 RVSSIYQAAARVC-----------------GLVPEARVVVAHGQMPEDLL MMAR_4465|M.marinum_M RVSSIDDTAARIR-----------------KLVPEARVVVAHGQMPEDLL MUL_4634|M.ulcerans_Agy99 RASSIDDTAARIR-----------------KLVPEARVVAAHGQMPEDLL Mflv_1948|M.gilvum_PYR-GCK RVRTIDSAAAKIR-----------------QLVPEARVVVAHGQMPEEQL Mvan_4777|M.vanbaalenii_PYR-1 RVRTIDSAAAKVR-----------------QLVPEARVVVAHGQMPEEQL MSMEG_5423|M.smegmatis_MC2_155 RVRTIDEAAARVR-----------------QLVPEARVVVAHGQMNEETL TH_0914|M.thermoresistible__bu RVSTIDKAAARVR-----------------ELVPEARVVVAHGQMNEEAL MAB_1157|M.abscessus_ATCC_1997 RVSTIDKAAARIR-----------------DLVPEARVVVAHGQMPEEML MAV_3818|M.avium_104 RIDESDDDGAADQNAKAPETAEGLYARLRSQELAQLRLGLMHGRLSAEEK * .* :.: *: **:: : Rv1020|M.tuberculosis_H37Rv ETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR Mb1048|M.bovis_AF2122/97 ETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR MLBr_00252|M.leprae_Br4923 ETTMRGFWNREYDILVCTTIVETGLDIPNANTLVVERADTFGLSQLHQLR MMAR_4465|M.marinum_M ERTVQGFWQREFDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR MUL_4634|M.ulcerans_Agy99 ERTVQGFWQREFDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR Mflv_1948|M.gilvum_PYR-GCK EKTVEGFWNREYDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR Mvan_4777|M.vanbaalenii_PYR-1 EKTVEGFWNREYDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR MSMEG_5423|M.smegmatis_MC2_155 EKTVEGFWNREYDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR TH_0914|M.thermoresistible__bu ERTVEGFWNREYDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR MAB_1157|M.abscessus_ATCC_1997 ERTVQGFWNREYDILVCTTIIETGLDISNANTLIVERADIFGLSQLHQLR MAV_3818|M.avium_104 DAVMAAFRAGDIDVLVCTTVIEVGVDVPNATVMLVMDADRFGISQLHQLR : .: * : *:*****::*.*:*:.**..::* ** **:******* Rv1020|M.tuberculosis_H37Rv GRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDL Mb1048|M.bovis_AF2122/97 GRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDL MLBr_00252|M.leprae_Br4923 GRVGRSHERGYAYFLYPPQAPLTEIAYDRLVTIAQNNELGAGMAVALKDL MMAR_4465|M.marinum_M GRVGRSRERGYAYFLYPPQAPLTETAYDRLATIAQNNELGAGMAVALKDL MUL_4634|M.ulcerans_Agy99 GRVGRSRERGYAYFLYPPQAPLTETAYDRLATIAQNNELGAGMAVALKDL Mflv_1948|M.gilvum_PYR-GCK GRVGRSRERGYAYFLYPPEVPLTETAYDRLATIAQNNELGAGMAVAMKDL Mvan_4777|M.vanbaalenii_PYR-1 GRVGRSRERGYAYFLYPPEVPLTETAYDRLATIAQNNELGAGMAVAMKDL MSMEG_5423|M.smegmatis_MC2_155 GRVGRSRERGYAYFLYPPNKPLTETAYDRLATIAQNNELGAGMAVAMKDL TH_0914|M.thermoresistible__bu GRVGRSRERGYAYFLYPPDAPLTETAYDRLATVAQNNELGAGMAVAMKDL MAB_1157|M.abscessus_ATCC_1997 GRVGRSRERGYAYFLYSPEVPLTETAYDRLSTIAQNNDLGAGMAVAMKDL MAV_3818|M.avium_104 GRIGRGEHP--SLCLFASWAAPDSPAGRRLTAVAET---MDGFALADLDL **:**... : *:.. . . * ** ::*:. *:*:* ** Rv1020|M.tuberculosis_H37Rv EIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVR Mb1048|M.bovis_AF2122/97 EIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVR MLBr_00252|M.leprae_Br4923 EIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYR----AVADGKTAI MMAR_4465|M.marinum_M EIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVT MUL_4634|M.ulcerans_Agy99 EIRGAGNVLGVEQSGHVAGVGFDLYLRLVGEAVEAYR----AAADGKMVT Mflv_1948|M.gilvum_PYR-GCK EIRGAGNVLGAEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVA Mvan_4777|M.vanbaalenii_PYR-1 EIRGAGNVLGAEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVA MSMEG_5423|M.smegmatis_MC2_155 EIRGAGNVLGAEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVA TH_0914|M.thermoresistible__bu EIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYR----AAAEGKTVA MAB_1157|M.abscessus_ATCC_1997 EIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVL MAV_3818|M.avium_104 KERREGDVLGRNQSGRAVTL------------------------------ : * *:*** :***:.. : Rv1020|M.tuberculosis_H37Rv TAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVD Mb1048|M.bovis_AF2122/97 TAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVD MLBr_00252|M.leprae_Br4923 TPEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDTEVAAVVD MMAR_4465|M.marinum_M TPEEPKDVRIDLPVDAHLPPDYIGSDRLRLEAYRRLAAATSDSGVAAVVD MUL_4634|M.ulcerans_Agy99 TPEEPKDVRIDLPVDAHLPPDYIGSDRLRLEAYRRLATATSDSGVAAVVD Mflv_1948|M.gilvum_PYR-GCK TPEEPKDVRIDLPVDAHLPPDYIGSDRLRLEGYRRLAAAPDDAAVDAVVE Mvan_4777|M.vanbaalenii_PYR-1 APEEPKDVRIDLPVDAHLPPDYIGSDRLRLEAYRRLAAAPDDAAVDAVIE MSMEG_5423|M.smegmatis_MC2_155 TPQEQKDVRIDLPVDAHLPPEYIGSDRLRLEAYRRLAAAADDDAVASVVD TH_0914|M.thermoresistible__bu TPEEPKDIRIDLPIDAHLPPEYIASDRLRLEAYRRLASAPDDDGIAAVVD MAB_1157|M.abscessus_ATCC_1997 TAEEPKEVRIDLPVDAHLPTDYIGSDRLRLEAYRRLAAAADAAQINAAVE MAV_3818|M.avium_104 -------------------------RLLSLADHQEYIEAARDFCVQAYAG * * ::. *. : : Rv1020|M.tuberculosis_H37Rv ELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAA--SAATVRLSPLT Mb1048|M.bovis_AF2122/97 ELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAA--SAATVRLSPLT MLBr_00252|M.leprae_Br4923 ELIDRYGALPEPAQRLVAVAQLRLLCRGSGIIEVTAP--SASTMRLSPIR MMAR_4465|M.marinum_M ELIDRYGALPEPALRLVAVARLRLLCRASGITDVSAP--SSATVRLAPMD MUL_4634|M.ulcerans_Agy99 ELIDRYGALPEPALRLVAVARLRLLCRASGITDVSAP--SSATVRLAPMD Mflv_1948|M.gilvum_PYR-GCK ELVDRYGPLPEPAELLVAVARLRLLARAAGITEVGAVSASASTLRISPLT Mvan_4777|M.vanbaalenii_PYR-1 ELVDRYGPLPEPAQRLVAVARLRLLARAHGVTEIGAP--SATTLRISPMT MSMEG_5423|M.smegmatis_MC2_155 ELIDRYGPLPEPAQRLVAVARLRLLCREFGITEIGAV--SASTVRLSPMV TH_0914|M.thermoresistible__bu ELVDRYGPLPEPAQRLVAVARLRLLCRRFGVTEVSAP--SEATVRVAPLT MAB_1157|M.abscessus_ATCC_1997 ELADRYGPLPLPVQRLVAVASLRLLCREMGITDLSVVG---TNIRIQPLP MAV_3818|M.avium_104 NRFDPG--LSVLAARFTDTDRIEYLDKS---------------------- : * *. . :. . :. * : Rv1020|M.tuberculosis_H37Rv LPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGG----LGAPRIRDVELV Mb1048|M.bovis_AF2122/97 LPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGG----LGAPRIRDVELV MLBr_00252|M.leprae_Br4923 LIDSAQVRLKRMYPGAQYRATAATVQVPIPRAGSSGGTLGVPCIRDVELV MMAR_4465|M.marinum_M LPDSAQVRLKRMYPGGHYRATTSTVQVPIPRDGG----VGAPRIRDVELV MUL_4634|M.ulcerans_Agy99 LPDSAQVRLKRMYPGGHYRATTSTVQVPIPRDGG----VGAPRIRDVELV Mflv_1948|M.gilvum_PYR-GCK LPDSAQLRLKRLYSGANYRATTSTVQVPIPRAGQG---VGAPRIRDRELV Mvan_4777|M.vanbaalenii_PYR-1 LPDSAQLRLKRLYSGANYRATTSTVQVPVPRAGSG---VGSPRIRDLELV MSMEG_5423|M.smegmatis_MC2_155 LPDSAQLRLKRMYPGGHYRATTSTVQVPLPRAGEG---VGAPRIRDLELV TH_0914|M.thermoresistible__bu LQDSQQVRLKRLYPGAHYRATTSTVQVTIPRSGG----IGSPRIRDLELA MAB_1157|M.abscessus_ATCC_1997 LLDSAQLRLKRLHPAAQYRATTSVVQVPIPRAGDGG--VGSDRIRDLELV MAV_3818|M.avium_104 -------------------------------------------------- Rv1020|M.tuberculosis_H37Rv QMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP Mb1048|M.bovis_AF2122/97 QMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP MLBr_00252|M.leprae_Br4923 QAVADLITALQGLPRKVIGITGPEPTSK-------------- MMAR_4465|M.marinum_M QMVANLVTALAGKPQQDIGRTSLSEDDAAATASGKERQAR-- MUL_4634|M.ulcerans_Agy99 QMVANLVTALAGKLQQDIGRTSLSEDDAGATASGKERQAR-- Mflv_1948|M.gilvum_PYR-GCK DFVAGLIKVLGE------------------------------ Mvan_4777|M.vanbaalenii_PYR-1 AFVAGLLLAIDGKPGEEVDITKFGGGA--------------- MSMEG_5423|M.smegmatis_MC2_155 QWVAGLVLVLNGKGQGDVDMSKFSNPAGEAKR---------- TH_0914|M.thermoresistible__bu QMVAGLLLMLHGDTEGEVDITRFGGAAAVTSDKRRPR----- MAB_1157|M.abscessus_ATCC_1997 HMIAELLVALSGRPAGSVDITPLEVSK--------------- MAV_3818|M.avium_104 ------------------------------------------