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TVSGTLHVHTPIAGLVDLALRDPALQEIARRAGDRPADLNLVGPASARVFVASALAQPGLLLVVTATGRE ADDLTAELRGVFGDAVALFPSWETLPHERLSPGVDTVGARMMLLRRLTHPDDARLGPPLRIVVTTARSLL QPMAPDLAEVDPVTLTVGGEADFDAVVARLVDLAYSRVDMVGKRGEFAVRGGILDVFPPTAEHPVRVEFW GDEVSEMRMFSVADQRSIPEIEIDTLIAVPCRELLLTAEVRDRAAALASEHPVLENSVTGSVPDMLAKLA EGIPVDGMEALLPLLRPSDFATLPDHLPEGTPLLVCDPEKVRTRAADLIKTGREFLEASWSTAAVGGDVP IDIEALGVSGYVGYGDARDAARAGGHPWWTLSQLDSGAGESTALDIRPAPSARGQQHNLDEIFAMLRAHV ATGGFGVVVTPGSGTAMRVVEQLSESDIPATVLEPGAVPGEGVVGVIKGPLHDGVVIPGANLVVITETDL TGNRAAATEGKKLAAKRRNVVDPLALTAGDLVVHDQHGIGRFVEMTERVIGGARREYLVLEYASAKRGGG SDRLYVPMDSLDQLSRYVGGEAPTLSRLGGSDWANTKTKARKAVREIAAELVALYAKRQASAGHAFAPDT PWQREMEDAFGFTETVDQLTAITEVKSDMEKPVPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVP TTLLADQHLQTFTNRMTGFPVTVKGLSRFTDPAESRATIEGMKDGSVDIVIGTHRLLQTGVTWKDLGLVI VDEEQRFGVEHKEHIKSMRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQ VAAALRREMLRDGQAFYIHNRVRTIDSAAAKVRQLVPEARVVVAHGQMPEEQLEKTVEGFWNREYDILVC TTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPEVPLTETAYDRLATIAQNN ELGAGMAVAMKDLEIRGAGNVLGAEQSGHVAGVGFDLYVRLVGEAVEAYRAAADGKTVAAPEEPKDVRID LPVDAHLPPDYIGSDRLRLEAYRRLAAAPDDAAVDAVIEELVDRYGPLPEPAQRLVAVARLRLLARAHGV TEIGAPSATTLRISPMTLPDSAQLRLKRLYSGANYRATTSTVQVPVPRAGSGVGSPRIRDLELVAFVAGL LLAIDGKPGEEVDITKFGGGA*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_4777 | - | - | 100% (1212) | transcription-repair coupling factor |
M. vanbaalenii PYR-1 | Mvan_2155 | - | 4e-47 | 30.71% (420) | ATP-dependent DNA helicase RecG |
M. vanbaalenii PYR-1 | Mvan_3350 | - | 1e-10 | 29.13% (206) | excinuclease ABC subunit B |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1048 | mfd | 0.0 | 78.87% (1216) | transcription-repair coupling factor Mfd (TRCF) |
M. gilvum PYR-GCK | Mflv_1948 | - | 0.0 | 93.13% (1194) | transcription-repair coupling factor |
M. tuberculosis H37Rv | Rv1020 | mfd | 0.0 | 78.87% (1216) | transcription-repair coupling factor Mfd (TRCF) |
M. leprae Br4923 | MLBr_00252 | mfd | 0.0 | 77.03% (1219) | putative transcription-repair coupling factor |
M. abscessus ATCC 19977 | MAB_1157 | - | 0.0 | 75.70% (1206) | transcription-repair coupling factor |
M. marinum M | MMAR_4465 | mfd | 0.0 | 81.51% (1206) | transcription-repair coupling factor Mfd (TrcF) |
M. avium 104 | MAV_3818 | recG | 8e-50 | 31.40% (465) | ATP-dependent DNA helicase RecG |
M. smegmatis MC2 155 | MSMEG_5423 | mfd | 0.0 | 84.74% (1212) | transcription-repair coupling factor |
M. thermoresistible (build 8) | TH_0914 | mfd | 0.0 | 81.90% (1155) | transcription-repair coupling factor |
M. ulcerans Agy99 | MUL_4634 | mfd | 0.0 | 81.01% (1206) | transcription-repair coupling factor Mfd (TrcF) |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_4777|M.vanbaalenii_PYR-1 MTVSGTLHVHTPIAGLVDLALRDPALQEIARRAGDRPADLNLVGPASARV Mflv_1948|M.gilvum_PYR-GCK MTASGTLHVHTPIAGLVGLALRDPSLQEIARRGVDRPADLHFVGPASARL MSMEG_5423|M.smegmatis_MC2_155 MTAPGHTSVQTPIAGLVELALSDPSLQDVIRRAADRPADLALVGPASARV Mb1048|M.bovis_AF2122/97 MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARL Rv1020|M.tuberculosis_H37Rv MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARL MLBr_00252|M.leprae_Br4923 MTAPGPACLDTPIAGLVELALTAPTFGQLMERAGTRPAELILAGPACARL MMAR_4465|M.marinum_M MTAPGAASPDTPIAGLVDLALTAPTFQQLIARASDRPDELTLVGPASARS MUL_4634|M.ulcerans_Agy99 MTAPGAASPDTPIAGLVDLALTAPTFQQLIARASDRPDELTLVGPASARS TH_0914|M.thermoresistible__bu -------------------------------------------------- MAB_1157|M.abscessus_ATCC_1997 MTAT-----TPPLAGVIRTALRDPAFDVLAPAIAAKTG-LDLTAPTCARA MAV_3818|M.avium_104 -------------------------------------------------- Mvan_4777|M.vanbaalenii_PYR-1 FVASALAQP--GLLLVVTATGREADDLTAELRGVFGDAVALFPSWETLPH Mflv_1948|M.gilvum_PYR-GCK FVASALAQA--GLLLVVTATGREADDLTAELRGVFGDAVAMFPSWETLPH MSMEG_5423|M.smegmatis_MC2_155 LVAAALAQN--GPLLVVAATGREADELTAELRGVFGDSVALFPSWETLPH Mb1048|M.bovis_AF2122/97 LVASALARQ--GPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPH Rv1020|M.tuberculosis_H37Rv LVASALARQ--GPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPH MLBr_00252|M.leprae_Br4923 FVASALARL--GPLLVVTATGREASNLTAELRGVFGAAVAMFPSWETLPH MMAR_4465|M.marinum_M FVASALAQQ--GPLLVVTATGREADDVTAELRGVFGEAVALFPSWETLPH MUL_4634|M.ulcerans_Agy99 FVASALAQQ--GPLLVVTATGREADDVTAELRGVFGEAVALFPSWETLPH TH_0914|M.thermoresistible__bu ---------------VVTATGREAEELTAELRGVYGDEVAMFPSWETLPH MAB_1157|M.abscessus_ATCC_1997 FVVTGMADASDAPVLVVTATTREAQDLTAELRDVYGDAVTLLPSWETLPH MAV_3818|M.avium_104 -------------------------------------------------- Mvan_4777|M.vanbaalenii_PYR-1 ERLSPGVDTVGARMMLLRRLTHPDDARLGPPLRIVVTTARSLLQPMAP-- Mflv_1948|M.gilvum_PYR-GCK ERLSPGVDTVGARMMLLRRLAFPDDARLGEPLRVVVTTARSLLQPMAP-- MSMEG_5423|M.smegmatis_MC2_155 ERLSPGVETVGARLMLLRRLARPDDETLGAPLRVVVTTTRSLLQPMAP-- Mb1048|M.bovis_AF2122/97 ERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTP-- Rv1020|M.tuberculosis_H37Rv ERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTP-- MLBr_00252|M.leprae_Br4923 ERLSPGVDTVGARLMVLRRLAHPDDARLGPPLQVVVTAVRSLLQPMTA-- MMAR_4465|M.marinum_M ERLSPGVDTVGARLLLLRRLAHPEDTRLGPPLRVVVTAVRSLLQPMTP-- MUL_4634|M.ulcerans_Agy99 ERLSPGVDTVGARLLLLRRLAHPDDTRLGPPLRVVVTAVRSLLQPMTP-- TH_0914|M.thermoresistible__bu ERLSPGVDTVGTRLMVLRRLAHPDDARLGPPLRVVVTTTRSLVQPMAQRP MAB_1157|M.abscessus_ATCC_1997 ERLSPGVDTVGARLQVLHRLAHPEDSRMGVPLRVVITTVRSLLQPMSP-- MAV_3818|M.avium_104 ------MASLTDRLDFVVGAKAAEQLEELFGIRTVDDLLRHYPRSYTEG- : :: *: : .:: : * * :. : Mvan_4777|M.vanbaalenii_PYR-1 -DLAEVDPVTLTVGGEADFDAVVARLVDLAYSRVDMVGKRGEFAVRGGIL Mflv_1948|M.gilvum_PYR-GCK -DLARIDPVTLTVGGEADFDETVARLVDLAYTRVDMVGKRGEFAVRGGIL MSMEG_5423|M.smegmatis_MC2_155 -DLVDIEPVTLSVGAEMEFEDVVARLVDLSYTRVDMVGKRGEFAVRGGIL Mb1048|M.bovis_AF2122/97 -QLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGIL Rv1020|M.tuberculosis_H37Rv -QLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGIL MLBr_00252|M.leprae_Br4923 -QLGLVEPVTLSVGDEIGFERVIARLVELAYTRVDMVGRRGEFAVRGGIL MMAR_4465|M.marinum_M -QLGRQEPVSLSVGQEIGFDEVIARLVELAYTRVDMVGRRGEFAVRGGIL MUL_4634|M.ulcerans_Agy99 -QLGRQEPVSLSVGQEIGFDEVIARLVELAYTRVDMVGRRGEFAVRGGIL TH_0914|M.thermoresistible__bu DEVRQTEPVTLTVGADADFDETIARLVELAYTRVDMVGRRGEFAVRGGIL MAB_1157|M.abscessus_ATCC_1997 -ELFDLEPVELAVGAELEFDGVIARLVELAYTRVDMVAGRGEFAVRGGIL MAV_3818|M.avium_104 -------------------------------------------ASRWGAD * * * Mvan_4777|M.vanbaalenii_PYR-1 DVFPPTAEHPVRVEFWGDEVSEMRMFSVADQRSIPEIEIDTLIAVPCREL Mflv_1948|M.gilvum_PYR-GCK DLFPPTAEHPVRVEFWGDEISEMRMFSVADQRSIPEIEIDTVIAVPCREL MSMEG_5423|M.smegmatis_MC2_155 DVFPPTAEHPVRVEFWGDEISEMRAFAIADQRSIPEVPVQTVVAVPCREL Mb1048|M.bovis_AF2122/97 DIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACREL Rv1020|M.tuberculosis_H37Rv DIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACREL MLBr_00252|M.leprae_Br4923 DIFGPTAEHPVRVEFWGDEITEMRMFSVVDQRSIPEIGVDTLVAIACREL MMAR_4465|M.marinum_M DLFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIEVSTLVAVACREL MUL_4634|M.ulcerans_Agy99 DLFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIEVSTLVAVACREL TH_0914|M.thermoresistible__bu DVFPPTAEHPVRIEFWGDEVSEMRMFSVADQRSIPEISIDTVVAMPCREL MAB_1157|M.abscessus_ATCC_1997 DVFSPTADHPVRVEFWGDEVSEMRYFSVADQRSIPELQVDSVLAMPCREL MAV_3818|M.avium_104 DERPPAGEHIT----IIDTITETKTWPMKKT---PKKVCHRITLGAGRNK * *:.:* . * ::* : :.: . *: : . *: Mvan_4777|M.vanbaalenii_PYR-1 LLTAEVRDR----AAALASEHPVLENSVTGSVPDMLAKLAEGIPVDGMEA Mflv_1948|M.gilvum_PYR-GCK LLTADVRER----AAALAEEHPVSENNVPGSVPDMLARLAEGIPVDGMEA MSMEG_5423|M.smegmatis_MC2_155 LMTDDVRER----AAALAAEHPTTENTVPGTVPDMLAKLAEGIPVDGMEA Mb1048|M.bovis_AF2122/97 LLSEDVRAR----AAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEA Rv1020|M.tuberculosis_H37Rv LLSEDVRAR----AAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEA MLBr_00252|M.leprae_Br4923 LLSDDVRARAVELAAQAAARRPTEEPAISGSVTDVLAKLAEGIPVDGMEA MMAR_4465|M.marinum_M LLTEDVRAR----AAALAAQHPASENTVTGSVIDMLAKLAEGIPTDGMEA MUL_4634|M.ulcerans_Agy99 LLTEDVRAR----AAALAAQHPASENTVTGSVIDMLAKLAEGIPTDGMEA TH_0914|M.thermoresistible__bu LLTDEVRER----AVKLAEQHPRQENTLPGTLPDMLAKLAEGIPVDGMEA MAB_1157|M.abscessus_ATCC_1997 LLTDQVRARAAELASAAGVSGSEEGHRLGAGVGEMLAKLADGICVDGMES MAV_3818|M.avium_104 VTATFFNAN----------------------------------------- : : .. . Mvan_4777|M.vanbaalenii_PYR-1 LLPLLRPSDFATLPDHLPEGTPLLVCDPEKVRTRAADLIKTGREFLEASW Mflv_1948|M.gilvum_PYR-GCK LLPLLRPSDFATLPDHLPEGTPLLVCDPEKVRTRAADLIKTGREFLEASW MSMEG_5423|M.smegmatis_MC2_155 LLPLLHPIEPTTLTRHLPEGAPVLVCDPEKVRTRAADLIKTGREFLEASW Mb1048|M.bovis_AF2122/97 VLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASW Rv1020|M.tuberculosis_H37Rv VLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASW MLBr_00252|M.leprae_Br4923 LLPVLCPDDYALLTDQFAADTPVLLCDPEKVRIQAADLIKTDRAFLEASW MMAR_4465|M.marinum_M LLPVLRPDDHALLTDQLAEGTPVLVCDPEKVRTRAADLIKTGREFLEASW MUL_4634|M.ulcerans_Agy99 LLPVLRPDDHALLTDQLAEGTPVLVCDPEKVRTRAADLIKTGREFLEASW TH_0914|M.thermoresistible__bu LLPLLRPGELSMLTDHLPAGAPVLVCDPEKVRTRAADLISTGQEFLEASW MAB_1157|M.abscessus_ATCC_1997 LLPVLHSGKLTMLVDHLPDHAPVLVCDPEKVRTRAADLERTGREFLEASW MAV_3818|M.avium_104 -----------YLKKGLTEGTKVMLSGEVGFFKNVMQLTHPAFLILDS-- * :. : :::.. . .. :* . :*:: Mvan_4777|M.vanbaalenii_PYR-1 STAAVG---GDVPIDIEALGVSGYVGYGDARDAARAGGHPWWTLSQLDSG Mflv_1948|M.gilvum_PYR-GCK STAAVG---GDVPIDLEALGASGYVTYNEARDAARDGGHGWWTLSQLDSG MSMEG_5423|M.smegmatis_MC2_155 STAAVG---GDAPIDLEALGASGFVTFEEAREAAREGGHPWWTLSQLSDE Mb1048|M.bovis_AF2122/97 SVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDE Rv1020|M.tuberculosis_H37Rv SVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDE MLBr_00252|M.leprae_Br4923 SVAAIG-ADNAAPVDVEQLYGSGFVELGDVQAAAIRSGHPWWTLSQLSDE MMAR_4465|M.marinum_M SVAAMG---TDAPVDVEALGGSGFAELEQVQTAASSSGHPWWTLSQLSEE MUL_4634|M.ulcerans_Agy99 SVAAMG---TDAPVDVEALGGSGFAELEQVQTAASSSGHPWWTLSQLSEE TH_0914|M.thermoresistible__bu SAAAIG---GDAPIDLDALGASGFLDLDDARASAAEAGHPWWTLSQLSSE MAB_1157|M.abscessus_ATCC_1997 SVAAIG---SDAPIDVEALADSGFRELDDVKHAAGEAGYPWWSLSPLGMD MAV_3818|M.avium_104 ----------------PDGRNKGTRSLMNIANASGASG------------ .* : :: * Mvan_4777|M.vanbaalenii_PYR-1 AGESTALDIRPAPSARGQQHNLDEIFAMLRAHVATGGFGVVVTPGSGTAM Mflv_1948|M.gilvum_PYR-GCK AGESTALDIRPAPSARG-QHNLEEIFAMLRAHVATGGCGVVVTPGAGTCQ MSMEG_5423|M.smegmatis_MC2_155 S--AVELDIRSAPSARGSQHNLEEIFAMLRAHVATGGYAAVVTPGIGTAH Mb1048|M.bovis_AF2122/97 S--AIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAH Rv1020|M.tuberculosis_H37Rv S--AIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAH MLBr_00252|M.leprae_Br4923 S--ALELDIRAAPSTRGHQHAIDGIFAMLRAHVATGGYAAIVTPGTGTAH MMAR_4465|M.marinum_M S--ATELEVRAAPSARGHQKDIDDIFAMLRAHVSTGGYAVMVEPGTGTAH MUL_4634|M.ulcerans_Agy99 S--ATELEVRAAPSARGHQKDIDDIFAMLRAHVSTGGYAVMVEPGTGTAH TH_0914|M.thermoresistible__bu S--AIELDLRPVPAART-KSAVTEIFAMLRAHVTTGGYAAVVTPGAGTAQ MAB_1157|M.abscessus_ATCC_1997 NDQAIGLAVRPSPSARGHKEGAAEIFAMLRAHVMTGGRAAVVAAGAGTTH MAV_3818|M.avium_104 ----------------------EEVLDAYERHFFP-------IYPASTKM :: . *. . .* Mvan_4777|M.vanbaalenii_PYR-1 RVVEQLSESDIPATVLEPGAVP----GEGVVGVIKGPLHDGVVIPGANLV Mflv_1948|M.gilvum_PYR-GCK RVVEQLSESDTPAMILEPGMAP----KDGVVGVLKGPLHDGVVIPGANLV MSMEG_5423|M.smegmatis_MC2_155 RVVEQLGEADTAATILEPGTAP----KAGVVGVLKGPLCSGVVLPGANLV Mb1048|M.bovis_AF2122/97 RVVERLSESDTPAGMLDPGQAP----KPGVVGVLQGPLRDGVIIPGANLV Rv1020|M.tuberculosis_H37Rv RVVERLSESDTPAGMLDPGQAP----KPGVVGVLQGPLRDGVIIPGANLV MLBr_00252|M.leprae_Br4923 RVVERLAESDIPGAMLEPAAAPGLGLRPGLVGVLKGPLLDGVVIPGANLV MMAR_4465|M.marinum_M RMVERLAESDIPAAMLEPGAAP----KLGVVGVLKGPLRDGVIVPGANLV MUL_4634|M.ulcerans_Agy99 RMVERLAESDIPAAMLEPGAAP----KLGVVGVLKGPLRDGVIVPGANLV TH_0914|M.thermoresistible__bu RIVEQLGESETPARRLEPGAGL----EPGVVGVLQGPLHDGLVLPGANLV MAB_1157|M.abscessus_ATCC_1997 RIIEQLAETETPATLLEPGAEP----AEGVVGVLRGHLTDGVVLTGANIV MAV_3818|M.avium_104 QSWDIFSCVRLVLDVLDPVPDP-----------LPEPLR------AKFDL : : :. *:* : * . : Mvan_4777|M.vanbaalenii_PYR-1 VITETDLTGNRAAATEGKKLAAKRRNVVDPLALTAGDLVVHDQHGIGRFV Mflv_1948|M.gilvum_PYR-GCK VITETDLTGNRAAATEGKKLAAKRRNVVDPLALTAGDLVVHDQHGIGRFV MSMEG_5423|M.smegmatis_MC2_155 IITETDLTGNRVTANEGRKLAAKRRNVVDPLALTAGDLVVHDQHGIGKFV Mb1048|M.bovis_AF2122/97 VITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFV Rv1020|M.tuberculosis_H37Rv VITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFV MLBr_00252|M.leprae_Br4923 IITEADLTGSRATPVEGKRLAAKRRSAADPLALTAGDLVVHDQHGIGRFV MMAR_4465|M.marinum_M VVTETNLTGNRATAVEGKRLAAKRRNTVDPLALTAGDLVVHDQHGIGRFV MUL_4634|M.ulcerans_Agy99 VVTETNLTGNRATAVEGKRLAAKRRNTVDPLALTAGDLVVHDQHGIGRFV TH_0914|M.thermoresistible__bu VITEADLTGNRVTAQQGRKLAPKRRNVVDPLALTAGDLVVHDQHGIGRFV MAB_1157|M.abscessus_ATCC_1997 IVTETDLTGSRVAATDGKRLPAKRRNQVDPLALSAGDLVVHDQHGIGRFV MAV_3818|M.avium_104 VCEDQALRDIHLAESEARRQRARERLTFD--------------EAVGLQW : : * . : : :.:: .:.* * ..:* Mvan_4777|M.vanbaalenii_PYR-1 EMTERVIGGARREYLVLEYASAKR----GGGSDRLYVPMDSLDQLSRYVG Mflv_1948|M.gilvum_PYR-GCK EMTERVIGGARREYLVLEYASAKR----GGGADRLYVPMDSLDQLSRYVG MSMEG_5423|M.smegmatis_MC2_155 EMTERVVGGARREYLVLEYASSKR----GGGTDKLYVPMDSLDQLSRYVG Mb1048|M.bovis_AF2122/97 EMVERTVGGARREYLVLEYASAKRGGG-AKNTDKLYVPMDSLDQLSRYVG Rv1020|M.tuberculosis_H37Rv EMVERTVGGARREYLVLEYASAKRGGG-AKNTDKLYVPMDSLDQLSRYVG MLBr_00252|M.leprae_Br4923 EMVERTVGGARREYLVLEYASNKK----SKQADKLYVPMDSLDQLSRYVG MMAR_4465|M.marinum_M EMVERTVGGARREYLVLEYASAKR----GGGSDKLYVPMDSLDQLSRYVG MUL_4634|M.ulcerans_Agy99 EMVERTVGGARREYLVLEYASARR----GGGSDKLYVPMDSLDQLSRYVG TH_0914|M.thermoresistible__bu EMVERTVGGARREYLVLEYASNRRGTG-GGHTDKLYVPMDSLDQLSRYVG MAB_1157|M.abscessus_ATCC_1997 EMVERTVGGARREYLVLEYASGKRGAAAGGQSDRLYVPMDSLDQLSRYVG MAV_3818|M.avium_104 ALVARRHG--------------------------------------ELSE :. * * . Mvan_4777|M.vanbaalenii_PYR-1 GEAPTLSRLGGSDWANTKTKARKAVREIAAELVALYAKRQASAGHAFAPD Mflv_1948|M.gilvum_PYR-GCK GEAPTLSRLGGSDWANTKTKARRAVREIAAELVTLYAKRQASPGHAFSPD MSMEG_5423|M.smegmatis_MC2_155 GEAPSLSRLGGSDWANTKTKARRAVREIASELVALYAKRQSAPGHAFGPD Mb1048|M.bovis_AF2122/97 GQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPD Rv1020|M.tuberculosis_H37Rv GQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPD MLBr_00252|M.leprae_Br4923 GQAPALSRLGGSDWANTKTKARCAVREIAGELVSLYAKRQASPGHAFGPD MMAR_4465|M.marinum_M GQAPALSRLGGSDWTNTKTKARKAVREIAGELVALYAKRQASPGHAFAPD MUL_4634|M.ulcerans_Agy99 GQAPALSRLGGSDWTNTKTKARKAVREIAGELVALYAKRQASPGHAFAPD TH_0914|M.thermoresistible__bu GDSPSLSRLGGSDWTNTKTKARKAVREIAAELVALYAKRQSAPGHAFSPD MAB_1157|M.abscessus_ATCC_1997 GESPGLSRLGGSDWTNTKTKARKAVREIAGELVALYAARQAAPGHAFAPD MAV_3818|M.avium_104 SGPPAPPRPDG--------------------------------------- . .* .* .* Mvan_4777|M.vanbaalenii_PYR-1 TPWQREMEDAFGFTETVDQLTAITEVKSDMEKPVPMDRVICGDVGYGKTE Mflv_1948|M.gilvum_PYR-GCK TPWQVEMEDAFGFTETVDQLTAITEVKSDMEKPVPMDRVICGDVGYGKTE MSMEG_5423|M.smegmatis_MC2_155 TPWQAEMEDAFGFTETIDQLTAIQEVKSDMEKPVPMDRVICGDVGYGKTE Mb1048|M.bovis_AF2122/97 TPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTE Rv1020|M.tuberculosis_H37Rv TPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTE MLBr_00252|M.leprae_Br4923 TPWQAEMEDAFGFTETVDQLTAITEVKGDMEKSVPMDRVICGDVGYGKTE MMAR_4465|M.marinum_M TPWQAEMEDAFGFTETVDQLTAITEVKGDMEKSIPMDRVICGDVGYGKTE MUL_4634|M.ulcerans_Agy99 TPWQAEMEDAFGFTETVDQLTAITEVKRDMEKSIPMDRVICGDVGYGKTE TH_0914|M.thermoresistible__bu TPWQREMEDAFGFTETVDQLTAIEEVKADMEKPVPMDRVICGDVGYGKTE MAB_1157|M.abscessus_ATCC_1997 TPWQREMEDAFGFVETVDQLTAITEVKSDMEKPVPMDRVVCGDVGYGKTE MAV_3818|M.avium_104 --LAAELLRRLPFELTAGQREVLDVLSDGLASTRPLNRLLQGEVGSGKTI *: : * * .* .: :. .: .. *::*:: *:** *** Mvan_4777|M.vanbaalenii_PYR-1 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTNRMTGFPVT------- Mflv_1948|M.gilvum_PYR-GCK IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTARMTGFPVT------- MSMEG_5423|M.smegmatis_MC2_155 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTNRMAGFPVT------- Mb1048|M.bovis_AF2122/97 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVT------- Rv1020|M.tuberculosis_H37Rv IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVT------- MLBr_00252|M.leprae_Br4923 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLRTFTERMAGFPVT------- MMAR_4465|M.marinum_M IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTDRMAGFPVT------- MUL_4634|M.ulcerans_Agy99 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTDRMAGFPVT------- TH_0914|M.thermoresistible__bu IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTERMAGFPVT------- MAB_1157|M.abscessus_ATCC_1997 IAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFTNRTAGFPVK------- MAV_3818|M.avium_104 VSVLAMLQMVDAGYQCALLAPTEVLAAQHLRSIRDVLGPLAMAGQLGGAD ::* * :: *: * * *:*.** :** ***::: :.: Mvan_4777|M.vanbaalenii_PYR-1 ----VKGLSRFTDPAESRATIEGMKDGSVDIVIGTHRLLQTGVTWKDLGL Mflv_1948|M.gilvum_PYR-GCK ----VRGLSRFTDPASSRATLEGMKDGSVDIVIGTHRLIQTGVTWKDLGL MSMEG_5423|M.smegmatis_MC2_155 ----VKGLSRFTDPAESRAVIEGLKDGSVDVVIGTHRLLQTGVTWKDLGL Mb1048|M.bovis_AF2122/97 ----IKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGL Rv1020|M.tuberculosis_H37Rv ----IKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGL MLBr_00252|M.leprae_Br4923 ----VKGLSRFTDAAESRAVIDGLAEGSVDIVIGTHRLLQTGVCWKDLGL MMAR_4465|M.marinum_M ----VKGLSRFTDPAESRTVIEGMADGSVDVVIGTHRLLQTGVRWKDLGL MUL_4634|M.ulcerans_Agy99 ----VKGLSRFTDPAESRTVIEGMADGSVDVVIGTHRLLQTGVRWKDLGL TH_0914|M.thermoresistible__bu ----IKGLSRFTSPSESRAVLEGMADGSVDIVIGTHRLLQTGVRWKDLGL MAB_1157|M.abscessus_ATCC_1997 ----VAGLSRFTDPLTSKLVVEGMADGSVDIVIGTHRLLQTGVRWKDLGL MAV_3818|M.avium_104 NATRLALLSGSMTAAQKKQVRDEVAGGQVGIVVGTHALLQDAVEFHNLGM : ** . .: . : : *.*.:*:*** *:* .* :::**: Mvan_4777|M.vanbaalenii_PYR-1 VIVDEEQRFGVEHKEHIKSMR---THVDVLTMSATPIPRTLEMSLAGIRE Mflv_1948|M.gilvum_PYR-GCK VIVDEEQRFGVEHKEHIKSMR---THVDVLTMSATPIPRTLEMSLAGIRE MSMEG_5423|M.smegmatis_MC2_155 IIVDEEQRFGVEHKEHIKSMR---THVDVLTMSATPIPRTLEMSLAGIRE Mb1048|M.bovis_AF2122/97 VVVDEEQRFGVEHKEHIKSLR---THVDVLTMSATPIPRTLEMSLAGIRE Rv1020|M.tuberculosis_H37Rv VVVDEEQRFGVEHKEHIKSLR---THVDVLTMSATPIPRTLEMSLAGIRE MLBr_00252|M.leprae_Br4923 VVVDEEQWFGVEHKEHIKSLR---THVDVLTMSATPIPRTLEMSLAGIRE MMAR_4465|M.marinum_M VVVDEEQRFGVEHKEHIKSLR---SHVDVLTMSATPIPRTLEMSLAGIRE MUL_4634|M.ulcerans_Agy99 VVVDEEQRFGVEHKEHIKSLR---SHVDVLTMSATPIPRTLEMSLAGIRE TH_0914|M.thermoresistible__bu VIIDEEQRFGVEHKEHIKSMR---THVDVLTMSATPIPRTLEMSLAGIRE MAB_1157|M.abscessus_ATCC_1997 VIVDEEQRFGVEHKEHIKALR---THVDVLTMSATPIPRTLEMSLAGIRE MAV_3818|M.avium_104 VVVDEQHRFGVEQRDRLRAKARPGVTPHLLVMTATPIPRTVALTVYGDLE :::**:: ****::::::: .:*.*:*******: ::: * * Mvan_4777|M.vanbaalenii_PYR-1 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRREMLRDGQAFYIHN Mflv_1948|M.gilvum_PYR-GCK MSTILTPPEERYPVLTYVGQHDDK-----QVAAALRREMLRDGQAFYIHN MSMEG_5423|M.smegmatis_MC2_155 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYIHN Mb1048|M.bovis_AF2122/97 MSTILTPPEERYPVLTYVGPHDDK-----QIAAALRRELLRDGQAFYVHN Rv1020|M.tuberculosis_H37Rv MSTILTPPEERYPVLTYVGPHDDK-----QIAAALRRELLRDGQAFYVHN MLBr_00252|M.leprae_Br4923 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYVHN MMAR_4465|M.marinum_M MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYVHN MUL_4634|M.ulcerans_Agy99 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYVHN TH_0914|M.thermoresistible__bu MSTILTPPEERYPVLTYVGPYDDK-----QIAAALRRELLRDGQAFYIHN MAB_1157|M.abscessus_ATCC_1997 MSTILTPPEERYPVLTYVGPHDDK-----QVAAALRRELLRDGQAFYVHN MAV_3818|M.avium_104 TSTLRELPRGRQPITSNVIFVKDKPAWLGRAWRRIGEEVAAGRQAYVVAA **: *. * *: : * .** : : .*: . **: : Mvan_4777|M.vanbaalenii_PYR-1 RVRTIDSAAAKVR-----------------QLVPEARVVVAHGQMPEEQL Mflv_1948|M.gilvum_PYR-GCK RVRTIDSAAAKIR-----------------QLVPEARVVVAHGQMPEEQL MSMEG_5423|M.smegmatis_MC2_155 RVRTIDEAAARVR-----------------QLVPEARVVVAHGQMNEETL Mb1048|M.bovis_AF2122/97 RVSSIDAAAARVR-----------------ELVPEARVVVAHGQMPEDLL Rv1020|M.tuberculosis_H37Rv RVSSIDAAAARVR-----------------ELVPEARVVVAHGQMPEDLL MLBr_00252|M.leprae_Br4923 RVSSIYQAAARVC-----------------GLVPEARVVVAHGQMPEDLL MMAR_4465|M.marinum_M RVSSIDDTAARIR-----------------KLVPEARVVVAHGQMPEDLL MUL_4634|M.ulcerans_Agy99 RASSIDDTAARIR-----------------KLVPEARVVAAHGQMPEDLL TH_0914|M.thermoresistible__bu RVSTIDKAAARVR-----------------ELVPEARVVVAHGQMNEEAL MAB_1157|M.abscessus_ATCC_1997 RVSTIDKAAARIR-----------------DLVPEARVVVAHGQMPEEML MAV_3818|M.avium_104 RIDESDDDGAADQNAKAPETAEGLYARLRSQELAQLRLGLMHGRLSAEEK * .* :.: *: **:: : Mvan_4777|M.vanbaalenii_PYR-1 EKTVEGFWNREYDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR Mflv_1948|M.gilvum_PYR-GCK EKTVEGFWNREYDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR MSMEG_5423|M.smegmatis_MC2_155 EKTVEGFWNREYDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR Mb1048|M.bovis_AF2122/97 ETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR Rv1020|M.tuberculosis_H37Rv ETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR MLBr_00252|M.leprae_Br4923 ETTMRGFWNREYDILVCTTIVETGLDIPNANTLVVERADTFGLSQLHQLR MMAR_4465|M.marinum_M ERTVQGFWQREFDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR MUL_4634|M.ulcerans_Agy99 ERTVQGFWQREFDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR TH_0914|M.thermoresistible__bu ERTVEGFWNREYDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLR MAB_1157|M.abscessus_ATCC_1997 ERTVQGFWNREYDILVCTTIIETGLDISNANTLIVERADIFGLSQLHQLR MAV_3818|M.avium_104 DAVMAAFRAGDIDVLVCTTVIEVGVDVPNATVMLVMDADRFGISQLHQLR : .: * : *:*****::*.*:*:.**..::* ** **:******* Mvan_4777|M.vanbaalenii_PYR-1 GRVGRSRERGYAYFLYPPEVPLTETAYDRLATIAQNNELGAGMAVAMKDL Mflv_1948|M.gilvum_PYR-GCK GRVGRSRERGYAYFLYPPEVPLTETAYDRLATIAQNNELGAGMAVAMKDL MSMEG_5423|M.smegmatis_MC2_155 GRVGRSRERGYAYFLYPPNKPLTETAYDRLATIAQNNELGAGMAVAMKDL Mb1048|M.bovis_AF2122/97 GRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDL Rv1020|M.tuberculosis_H37Rv GRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDL MLBr_00252|M.leprae_Br4923 GRVGRSHERGYAYFLYPPQAPLTEIAYDRLVTIAQNNELGAGMAVALKDL MMAR_4465|M.marinum_M GRVGRSRERGYAYFLYPPQAPLTETAYDRLATIAQNNELGAGMAVALKDL MUL_4634|M.ulcerans_Agy99 GRVGRSRERGYAYFLYPPQAPLTETAYDRLATIAQNNELGAGMAVALKDL TH_0914|M.thermoresistible__bu GRVGRSRERGYAYFLYPPDAPLTETAYDRLATVAQNNELGAGMAVAMKDL MAB_1157|M.abscessus_ATCC_1997 GRVGRSRERGYAYFLYSPEVPLTETAYDRLSTIAQNNDLGAGMAVAMKDL MAV_3818|M.avium_104 GRIGRGEHP--SLCLFASWAAPDSPAGRRLTAVAET---MDGFALADLDL **:**... : *:.. . . * ** ::*:. *:*:* ** Mvan_4777|M.vanbaalenii_PYR-1 EIRGAGNVLGAEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVA Mflv_1948|M.gilvum_PYR-GCK EIRGAGNVLGAEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVA MSMEG_5423|M.smegmatis_MC2_155 EIRGAGNVLGAEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVA Mb1048|M.bovis_AF2122/97 EIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVR Rv1020|M.tuberculosis_H37Rv EIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVR MLBr_00252|M.leprae_Br4923 EIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYR----AVADGKTAI MMAR_4465|M.marinum_M EIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVT MUL_4634|M.ulcerans_Agy99 EIRGAGNVLGVEQSGHVAGVGFDLYLRLVGEAVEAYR----AAADGKMVT TH_0914|M.thermoresistible__bu EIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYR----AAAEGKTVA MAB_1157|M.abscessus_ATCC_1997 EIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYR----AAADGKTVL MAV_3818|M.avium_104 KERREGDVLGRNQSGRAVTL------------------------------ : * *:*** :***:.. : Mvan_4777|M.vanbaalenii_PYR-1 APEEPKDVRIDLPVDAHLPPDYIGSDRLRLEAYRRLAAAPDDAAVDAVIE Mflv_1948|M.gilvum_PYR-GCK TPEEPKDVRIDLPVDAHLPPDYIGSDRLRLEGYRRLAAAPDDAAVDAVVE MSMEG_5423|M.smegmatis_MC2_155 TPQEQKDVRIDLPVDAHLPPEYIGSDRLRLEAYRRLAAAADDDAVASVVD Mb1048|M.bovis_AF2122/97 TAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVD Rv1020|M.tuberculosis_H37Rv TAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVD MLBr_00252|M.leprae_Br4923 TPEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDTEVAAVVD MMAR_4465|M.marinum_M TPEEPKDVRIDLPVDAHLPPDYIGSDRLRLEAYRRLAAATSDSGVAAVVD MUL_4634|M.ulcerans_Agy99 TPEEPKDVRIDLPVDAHLPPDYIGSDRLRLEAYRRLATATSDSGVAAVVD TH_0914|M.thermoresistible__bu TPEEPKDIRIDLPIDAHLPPEYIASDRLRLEAYRRLASAPDDDGIAAVVD MAB_1157|M.abscessus_ATCC_1997 TAEEPKEVRIDLPVDAHLPTDYIGSDRLRLEAYRRLAAAADAAQINAAVE MAV_3818|M.avium_104 -------------------------RLLSLADHQEYIEAARDFCVQAYAG * * ::. *. : : Mvan_4777|M.vanbaalenii_PYR-1 ELVDRYGPLPEPAQRLVAVARLRLLARAHGVTEIGAP--SATTLRISPMT Mflv_1948|M.gilvum_PYR-GCK ELVDRYGPLPEPAELLVAVARLRLLARAAGITEVGAVSASASTLRISPLT MSMEG_5423|M.smegmatis_MC2_155 ELIDRYGPLPEPAQRLVAVARLRLLCREFGITEIGAV--SASTVRLSPMV Mb1048|M.bovis_AF2122/97 ELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAA--SAATVRLSPLT Rv1020|M.tuberculosis_H37Rv ELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAA--SAATVRLSPLT MLBr_00252|M.leprae_Br4923 ELIDRYGALPEPAQRLVAVAQLRLLCRGSGIIEVTAP--SASTMRLSPIR MMAR_4465|M.marinum_M ELIDRYGALPEPALRLVAVARLRLLCRASGITDVSAP--SSATVRLAPMD MUL_4634|M.ulcerans_Agy99 ELIDRYGALPEPALRLVAVARLRLLCRASGITDVSAP--SSATVRLAPMD TH_0914|M.thermoresistible__bu ELVDRYGPLPEPAQRLVAVARLRLLCRRFGVTEVSAP--SEATVRVAPLT MAB_1157|M.abscessus_ATCC_1997 ELADRYGPLPLPVQRLVAVASLRLLCREMGITDLSVVG---TNIRIQPLP MAV_3818|M.avium_104 NRFDPG--LSVLAARFTDTDRIEYLDKS---------------------- : * *. . :. . :. * : Mvan_4777|M.vanbaalenii_PYR-1 LPDSAQLRLKRLYSGANYRATTSTVQVPVPRAGSG---VGSPRIRDLELV Mflv_1948|M.gilvum_PYR-GCK LPDSAQLRLKRLYSGANYRATTSTVQVPIPRAGQG---VGAPRIRDRELV MSMEG_5423|M.smegmatis_MC2_155 LPDSAQLRLKRMYPGGHYRATTSTVQVPLPRAGEG---VGAPRIRDLELV Mb1048|M.bovis_AF2122/97 LPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGG----LGAPRIRDVELV Rv1020|M.tuberculosis_H37Rv LPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGG----LGAPRIRDVELV MLBr_00252|M.leprae_Br4923 LIDSAQVRLKRMYPGAQYRATAATVQVPIPRAGSSGGTLGVPCIRDVELV MMAR_4465|M.marinum_M LPDSAQVRLKRMYPGGHYRATTSTVQVPIPRDGG----VGAPRIRDVELV MUL_4634|M.ulcerans_Agy99 LPDSAQVRLKRMYPGGHYRATTSTVQVPIPRDGG----VGAPRIRDVELV TH_0914|M.thermoresistible__bu LQDSQQVRLKRLYPGAHYRATTSTVQVTIPRSGG----IGSPRIRDLELA MAB_1157|M.abscessus_ATCC_1997 LLDSAQLRLKRLHPAAQYRATTSVVQVPIPRAGDGG--VGSDRIRDLELV MAV_3818|M.avium_104 -------------------------------------------------- Mvan_4777|M.vanbaalenii_PYR-1 AFVAGLLLAIDGKPGEEVDITKFGGGA--------------- Mflv_1948|M.gilvum_PYR-GCK DFVAGLIKVLGE------------------------------ MSMEG_5423|M.smegmatis_MC2_155 QWVAGLVLVLNGKGQGDVDMSKFSNPAGEAKR---------- Mb1048|M.bovis_AF2122/97 QMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP Rv1020|M.tuberculosis_H37Rv QMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP MLBr_00252|M.leprae_Br4923 QAVADLITALQGLPRKVIGITGPEPTSK-------------- MMAR_4465|M.marinum_M QMVANLVTALAGKPQQDIGRTSLSEDDAAATASGKERQAR-- MUL_4634|M.ulcerans_Agy99 QMVANLVTALAGKLQQDIGRTSLSEDDAGATASGKERQAR-- TH_0914|M.thermoresistible__bu QMVAGLLLMLHGDTEGEVDITRFGGAAAVTSDKRRPR----- MAB_1157|M.abscessus_ATCC_1997 HMIAELLVALSGRPAGSVDITPLEVSK--------------- MAV_3818|M.avium_104 ------------------------------------------