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VGPPHRSRPPLPSPGPTCQVLPTTAVIHTVTAEALGRIGIDAPRIPGSLDVAAHAAIGLLPLVAGCDRRH RRPVRGARAGRAAQVSLCMTAIRVEPVSSNAVCTGPAAQVGDQSRSPQRDYAHQALQPDVPRRRARRHRP RRCSAKTGSSSSTMRCTCHQNQCLWSSGVSWALAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0745 | - | - | 100% (175) | hypothetical protein Rv0745 |
| M. tuberculosis H37Rv | Rv3649 | - | 2e-14 | 72.92% (48) | helicase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0766 | - | 1e-102 | 100.00% (175) | hypothetical protein Mb0766 |
| M. gilvum PYR-GCK | Mflv_1391 | - | 3e-10 | 60.00% (50) | DEAD/DEAH box helicase domain-containing protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0486c | - | 2e-10 | 64.58% (48) | DEAD-box ATP dependent DNA helicase |
| M. marinum M | MMAR_5141 | - | 3e-14 | 73.47% (49) | DEAD/DEAH box helicase |
| M. avium 104 | MAV_0515 | - | 3e-13 | 70.83% (48) | ATP-dependent rna helicase, dead/deah box family protein |
| M. smegmatis MC2 155 | MSMEG_6160 | - | 3e-09 | 56.00% (50) | ATP-dependent rna helicase, dead/deah box family protein |
| M. thermoresistible (build 8) | TH_0854 | - | 6e-11 | 64.00% (50) | PROBABLE HELICASE |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_5399 | - | 2e-10 | 64.58% (48) | DEAD/DEAH box helicase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5141|M.marinum_M ----MISFGRELLAVALAGTPTGEHPLHHVAELPPRAGQPSAWPQWAEPD
MAV_0515|M.avium_104 ----MASFGSELLAAALAGTTADEQPLRHVAELPPRSGRPHDWPAWAEPE
Mflv_1391|M.gilvum_PYR-GCK MTEPVPEFGRELLACAVEGTAADEHPLRHVADLPPRRATSHPWPPWADPD
Mvan_5399|M.vanbaalenii_PYR-1 MTDPGPDFGRELLACAVDGTAAGEYPLRHVADLPPRRARAQAWPHWADPD
MSMEG_6160|M.smegmatis_MC2_155 MSDRGLEFGRELLNCAVEGTPGDDNPLRHVADLAPRTGKPVPWPAWAHPD
TH_0854|M.thermoresistible__bu VEETGPNFGRELLACAVAGTAPDERPVRHIADVPPRRGRTRPWPSWADPD
MAB_0486c|M.abscessus_ATCC_199 ---MTVGYGRELLDLIVAGTPSGETPVRHICDIPARNAEVTSWPQWAHPD
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M VVRTFTQRGITAPWSHQSTAAELAHDGRHVVVSTGTASGKSLAYQLPVLA
MAV_0515|M.avium_104 VVGAFAARGIKSPWSHQFTAADLAWSGRHVVVSTGTASGKSLAYQLPALN
Mflv_1391|M.gilvum_PYR-GCK VVQAFHDQGIRSLWSHQLAAADLAHDGRHVVLSTGTASGKSLAYQLPIAT
Mvan_5399|M.vanbaalenii_PYR-1 VVRAFHDRGVEALWSHQLAAAELARDGRHVVLSTGTASGKSLAYQLPILT
MSMEG_6160|M.smegmatis_MC2_155 VVRALHDHGITAPWSHQLSAAQLAHDGRHVVISTGTASGKSLAYQLPILS
TH_0854|M.thermoresistible__bu VVRVFGDRGITEPWEHQAVAADLAHSGRHVVLSTGTASGKSLAYQLPILS
MAB_0486c|M.abscessus_ATCC_199 AIAAFAAQGVTAPWSHQVAAATLAFAGRHVVVATGTASGKSVAYQLPILT
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M ALAADPRARVLYLSPTKALGHDQLRTAQALVANVERLRD----VAPTAYD
MAV_0515|M.avium_104 ALATDPRARVLYLSPTKALGHDQLRAAHALTAAIPRLREPGFAVAPTAYD
Mflv_1391|M.gilvum_PYR-GCK ELKRNPRSRVLYLSPTKALGHDQLRAAAALTASVPGLDD----VAPTPYD
Mvan_5399|M.vanbaalenii_PYR-1 ALKENPRSRALYLSPTKALGHDQLRAAAALTAAVPGLAD----VAPTPYD
MSMEG_6160|M.smegmatis_MC2_155 ALADDPRARVLYLSPTKALGHDQLRAAHALTESVAALRD----VAPAPYD
TH_0854|M.thermoresistible__bu ALAADPRARVLYLSPTKALGHDQLRAAQELTGAVERLAT----VAPTAYD
MAB_0486c|M.abscessus_ATCC_199 ALASEPRARALYLAPTKALGHDQLRAVRELITGVDNFER----VQPCTYD
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M GDSSDEVRRFARERSRWLFSNPDMIHLSILRNHARWAVLLRNLRYLIVDE
MAV_0515|M.avium_104 GDSPTEVRRFARERSRWVFSNPDMIHLSTLRNHARWAVLLRGLRFVIVDE
Mflv_1391|M.gilvum_PYR-GCK GDSPSEVRRFARERSRWIFSNPDMIHLSLLRNHARWAVFLRNLRYVVVDE
Mvan_5399|M.vanbaalenii_PYR-1 GDSPTEVRRFARERSRWIFSNPDMIHLSMLRNHARWAVFLRHLQYLVIDE
MSMEG_6160|M.smegmatis_MC2_155 GDSATEVRRFARERSRWIFSNPDMIHLSLLRNHSRWAVFLRNLRYIVVDE
TH_0854|M.thermoresistible__bu GDSPTEVRRFARERSRWIFSNPDMVHLAMLRNHGRWAVFLRHLRYVVVDE
MAB_0486c|M.abscessus_ATCC_199 GDSSNELRRFARESSRWIFTNPDMIHVSLLHNHTRWSAFLRGLRYLVVDE
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M CHYYRGVFGSNVAMVLRRLLRLCARYSAHP------TVIFASATTDSPGA
MAV_0515|M.avium_104 CHYYRGVFGSHVAMVLRRLLRLCARYASAP------AVIFASATTDSPGA
Mflv_1391|M.gilvum_PYR-GCK CHYYRGIFGSNVAMVLRRLLRLCARYAPAG-DVSGPTVVFASATTAQPAI
Mvan_5399|M.vanbaalenii_PYR-1 CHYYRGIFGSNVAMVLRRLLRLCARYSATGADFSGPTVIFASATTAQPAA
MSMEG_6160|M.smegmatis_MC2_155 CHYYRGIFGSNVAMVLRRLLRLCERYSANG---ATPTVIFASATTSSPAE
TH_0854|M.thermoresistible__bu CHYYRGIFGSNVAMVLRRLLRLCQRYSAGG----SPTVFFASATTAAPAD
MAB_0486c|M.abscessus_ATCC_199 CHYYRGVFGSNVALILQRLLRLCERYGSHP------TVVFASATTANPGA
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M TAAELIGQPVAEVTEDGSPQGARTVALWEPALRTDLTGENGAPVRRSAGT
MAV_0515|M.avium_104 TAAELIGLPVREVTEDGSPQGARTVALWEPALRADLVGENGAPVRRSAGG
Mflv_1391|M.gilvum_PYR-GCK TASELIGQTVAEVTEDGSPQGARTIALWEPALIPDLLGENGAPVRRSAGA
Mvan_5399|M.vanbaalenii_PYR-1 TASELIGQTVAEVTEDGSPQGARTVALWEPALIADLVGENGAPVRRSAGA
MSMEG_6160|M.smegmatis_MC2_155 TAAELIGQTVVEVTEDGSPQGARTIALWEPALLPDLAGENGAPVRRSAGS
TH_0854|M.thermoresistible__bu TASELIGQSVTEVTDDASPHGARTIALWEPPLLPDLVGENGAPVRRPAGA
MAB_0486c|M.abscessus_ATCC_199 AAQALIGQPVEEVVADGSPHGMRTVALWEPPLLP-ITGENGAPVRRPVST
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M EAARVMADLIVEGAQTLTFVRSRRAAELTALGAQARLQDIAPQLSHTVAS
MAV_0515|M.avium_104 EAARVMADLIAEGAQTLTFVRSRRAAELTALGAQARLDEIAPELSAQVAS
Mflv_1391|M.gilvum_PYR-GCK EAARVMADLIAEGARTLTFVRSRRGAELAALGARTRLADTAPDLADQVAS
Mvan_5399|M.vanbaalenii_PYR-1 EASRVMADLIAEGARTLTFVRSRRGAELAALGARARLADTAPELAQQVAS
MSMEG_6160|M.smegmatis_MC2_155 EAGRVMADLVAEGARTLTFVRSRRGAELTALGARARLSETAPDLVEQVAS
TH_0854|M.thermoresistible__bu EAARVMADLVAEGARTLTFVRSRRGAELTALGARSRLEEIAPELAQRVAS
MAB_0486c|M.abscessus_ATCC_199 ETSRLLADLVQEGARTLAFVRSRRGAEMTALGAAHRLSEVDPGLVSQVAA
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M YRAGYLPEDRNCLEHALTEGRLRGLATTNALELGVDIAGLDAVVLAGFPG
MAV_0515|M.avium_104 YRAGYLAEDRTALERALAEGRLRGLATTNALELGVDIAGLDAVVLAGFPG
Mflv_1391|M.gilvum_PYR-GCK YRAGYLAEDRRRLERALADGELRGMATTNALELGVDIAGLDAVVLAGFPG
Mvan_5399|M.vanbaalenii_PYR-1 YRAGYLAEDRRALERALAEGELRGVATTNALELGMDIAGLDAVVLAGFPG
MSMEG_6160|M.smegmatis_MC2_155 YRAGYLAEDRRELEHALSDGRLRGLATTNALELGIDIAGLDAVVMAGFPG
TH_0854|M.thermoresistible__bu YRAGYLAEDRRALEQALANGELRALATTNALELGIDIAGLDAVVLAGFPG
MAB_0486c|M.abscessus_ATCC_199 YRAGYLPEDRRALEQALSSGTLTGAATTNALELGVDIAGLDAVVVAGFPG
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M TVASFWQQAGRSGRRGQGALVVLIARDDPLDTYLVHHPAALLDKPVERVV
MAV_0515|M.avium_104 TVASFWQQAGRSGRRGQGALVVLIARDDPLDTYLVHNPAALLGKPVERVV
Mflv_1391|M.gilvum_PYR-GCK TVASFWQQAGRAGRRGQGALVVLIARDDPLDTYLVHHPAALLDKPIERVV
Mvan_5399|M.vanbaalenii_PYR-1 TVASFWQQAGRAGRRGQGALIVLIARDDPLDTYLVHHPAALLDKPIERVV
MSMEG_6160|M.smegmatis_MC2_155 TVASFWQQAGRSGRRGQGALVVLIARDDPLDTYLVHHPAALLDKPIERVV
TH_0854|M.thermoresistible__bu TVTSFWQQAGRSGRRGQSALIVLIARDDPLDTYLVHHPSALLDRPIERVV
MAB_0486c|M.abscessus_ATCC_199 TVASFWQQAGRSGRRGQGSLVVLVARDDPLDTYLVHHPEALLDKPIEAVV
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M IDPGNPYLLGPQLLCAATELPLDAVEVHELRAVEVVEALVDDGLLRRRGD
MAV_0515|M.avium_104 IDPRNPYILGPQLLCAATELPLQEAEVRELDATEVAEGLVDDGLLRRRNG
Mflv_1391|M.gilvum_PYR-GCK IDPANPYVLGPQLLCAATELPLTEAEVRMWDAESVAAGLVDDGLLRRRPS
Mvan_5399|M.vanbaalenii_PYR-1 IDPANPYVLGPQLLCAATELPLTDAEVRMWGAEPVAESLVDDGLLRRRPS
MSMEG_6160|M.smegmatis_MC2_155 IDPTNPHVLGPQLLCAAAELPLTEAEVRRWDAEAVAQRLVDDGLLRKRPA
TH_0854|M.thermoresistible__bu IDPTNPHVLGPQLLCAAAELPLTIEEVRRWDAEEVAESLVDDGLLRRRAS
MAB_0486c|M.abscessus_ATCC_199 IDPTNPHVLRPHLLCAATELPLTEDDVRSLDAGQVVSDLVDDGLLRKRPG
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M KYFPAPGVQPHAAVDIRGSIGGQVVIVEADTGRLLGNVGADQAPASVHPG
MAV_0515|M.avium_104 KYFPAPGLQPHAAVDIRG-AGGQVVILEADTGRLLGSAGAGQAPASVHPG
Mflv_1391|M.gilvum_PYR-GCK GFFPAPGLDPHPAVDIRGSTGGQIAILEDGTGRMLGSTGAGQAPASVHPG
Mvan_5399|M.vanbaalenii_PYR-1 GFFPAPGLDPHPAVDIRGSTGGQIAILEAGTGRMLGSAGAGQAPASVHPG
MSMEG_6160|M.smegmatis_MC2_155 GYFPAPGVDPHPAVDIRGSTGGQIAILEADTGRMLGSAGAGQAASSVHPG
TH_0854|M.thermoresistible__bu GYFPSPGVDPHPAVDIRAAAGGQIAIVETGTGRLLGSAGVGQAPASVHPG
MAB_0486c|M.abscessus_ATCC_199 GYFAAPGLNPYAAVDIRGSIGGQVMILEADTGRVLGTVDTGRAPATVHPG
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M AVYLHQGESYVVDSLDTEEGLAFVHAADPGYATFARELTDIAVTGSGERL
MAV_0515|M.avium_104 AVYLHQGESYVVDSLDLQEGIAFVHAEDPGYATFAREITDIAVTGAGERL
Mflv_1391|M.gilvum_PYR-GCK AVYLHQGESYVVDSLDFEDGIAFVHAEDPGYTTFAREVTDISVTGAGERS
Mvan_5399|M.vanbaalenii_PYR-1 AVYLHQGESYVVDSLDFEDAVAFVHAEDPGYTTFARELTDINVTGAGERA
MSMEG_6160|M.smegmatis_MC2_155 AVYLHQGESYVVDSLDFEDGIAFVHAEDPGYTTFAREITDISVTGPGERV
TH_0854|M.thermoresistible__bu AVYLHQGESYLVDSLNFEEGVAFVHAEDPGYTTSAREITDISVTGVGERK
MAB_0486c|M.abscessus_ATCC_199 AVYLHSGETYVVDSLDFGDGIALVHNDRPDYSTFARSTIDIAITGEGERI
Rv0745|M.tuberculosis_H37Rv --------------------------------------------------
Mb0766|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5141|M.marinum_M EFGPVTVGLVPVTVTHQVVGYLRRRLSGEVIDFVELDMPEHVLPTTAVMY
MAV_0515|M.avium_104 VFGPVTLGLVPVRVTHRVVGYLRRRLSGEVIDFIELDMPEHTLATTAAMY
Mflv_1391|M.gilvum_PYR-GCK GHGPVTVGLVPVSVTNTVTGYLRRRLDGEVIDFIELDMPTRTLNTMAAMC
Mvan_5399|M.vanbaalenii_PYR-1 GYGPVTVGLVPVSVSNTVTGYLRRRMDGEVIDFVELDMPTRSLETMAVMC
MSMEG_6160|M.smegmatis_MC2_155 DHGPVTIGLVPVSVTNTVVGYLRRRMDGEVIDFVELDMPPRTLDTMAVMC
TH_0854|M.thermoresistible__bu TFGPVTIGLVPVSVTNTVTGYLRREMSGEVIDFVELDMPSRTLDTMAVMC
MAB_0486c|M.abscessus_ATCC_199 DLGDIQIGLVPVDVTHQVIGYLRTLTTGEILDFVELDMPSSTLSTKAVMY
Rv0745|M.tuberculosis_H37Rv -MGPPHRSRPPLPSPGPTC---------------------QVLPTTAVIH
Mb0766|M.bovis_AF2122/97 -MGPPHRSRPPLPSPGPTC---------------------QVLPTTAVIH
* . *: . . * * *.:
MMAR_5141|M.marinum_M TITAEELLRNGVDAVAIPGSLHAAEHAAIGLLPLVASCDR-------GDI
MAV_0515|M.avium_104 TITEEALRDNGIDGPRIPGSLHAAEHAAIGLLPLVASCDR-------GDI
Mflv_1391|M.gilvum_PYR-GCK TITPEALQDAGIDPLRIPGALHAAEHAAIGLLPLMASCDR-------GDI
Mvan_5399|M.vanbaalenii_PYR-1 TITPEALQDNGIDPLRLPGSLHAAEHAAIGLLPLMASCDR-------GDI
MSMEG_6160|M.smegmatis_MC2_155 TITPEALQDNGIEQLSVPGALHAAEHASIGLLPLVASCDR-------GDI
TH_0854|M.thermoresistible__bu TITPEALADNDIDPVRIPGSLHAAEHAAIGLLPLVASCDR-------GDI
MAB_0486c|M.abscessus_ATCC_199 TVTPEALAGIDIDPLSTPGALHAAEHAAIGLLPLVASCDR-------GDI
Rv0745|M.tuberculosis_H37Rv TVTAEALGRIGIDAPRIPGSLDVAAHAAIGLLPLVAGCDRRHRRPVRGAR
Mb0766|M.bovis_AF2122/97 TVTAEALGRIGIDAPRIPGSLDVAAHAAIGLLPLVAGCDRRHRRPVRGAR
*:* * * .:: **:*..* **:******:*.*** *
MMAR_5141|M.marinum_M GGISTAIGPE--GLPSVFVYDGYPGGAGFAERGFRRARTWLGATASAIEA
MAV_0515|M.avium_104 GGLSTAAGPEPAGLPSVFVYDGHPGGAGFAERGFRRASTWLGATAAAIEA
Mflv_1391|M.gilvum_PYR-GCK GGVSTAVGPV-DGLPTIFVYDGYPGGAGFAARGFRTLARWWEATASAIEA
Mvan_5399|M.vanbaalenii_PYR-1 GGVSTAVGPV-DGLPTIFVYDGYPGGAGFAARGFRTMDRWWEATASAIEA
MSMEG_6160|M.smegmatis_MC2_155 GGVSTAVGPV-DGLPSIFVYDGYPGGAGFADRGYRQLQTWWGATAAAIEA
TH_0854|M.thermoresistible__bu GGVSTAVGPD-SGLPTIFVYDGYPGGAGFADRGFDQFETWWGATADAIES
MAB_0486c|M.abscessus_ATCC_199 GGVSTALQPE-TGLPTVFVYDGHPGGAGFAARGYHKLATWLGATADAIDA
Rv0745|M.tuberculosis_H37Rv AGRAAQVSLCMTAIRVEPVSSNAVCTGPAAQVGDQSRSPQRDYAHQALQP
Mb0766|M.bovis_AF2122/97 AGRAAQVSLCMTAIRVEPVSSNAVCTGPAAQVGDQSRSPQRDYAHQALQP
.* :: .: * .. . * * : *::.
MMAR_5141|M.marinum_M CECPSGCPSCVQSPKCGNGNDPLDKAGAMQVLR---LVLSQVGDDLL-
MAV_0515|M.avium_104 CECPRGCPSCVQSPKCGNGNDPLDKAGAARVLR---LVLAELDGGPR-
Mflv_1391|M.gilvum_PYR-GCK CECPSGCPSCVQSPKCGNGNDPLDKDGAIRVLR---LVIGALEHRHR-
Mvan_5399|M.vanbaalenii_PYR-1 CECPSGCPSCVQSPKCGNGNDPLDKDGAILVLR---MVVRLLTGRTD-
MSMEG_6160|M.smegmatis_MC2_155 CECPSGCPSCVQSPKCGNGNDPLDKAGAVKVLR---LVLGALTK----
TH_0854|M.thermoresistible__bu CECPAGCPSCVQSPKCGNGNDPLDKAGAVRVLR---LVLDELEKGNT-
MAB_0486c|M.abscessus_ATCC_199 CECDAGCPSCVQSPKCGNGNSPLDKRAAVKVLR---LVLSRLPG----
Rv0745|M.tuberculosis_H37Rv -DVPRRRARRHRPRRCSAKTGSSSSTMRCTCHQNQCLWSSGVSWALAR
Mb0766|M.bovis_AF2122/97 -DVPRRRARRHRPRRCSAKTGSSSSTMRCTCHQNQCLWSSGVSWALAR
: . :. :*. ... .. : : :