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ALHLHRAERTDLLADGLGALLADPQPDPFAQELVLVAARGVERWLSQRLSLVLGCGPGRADGVCAGIAFR NPQSLIAEITGTLDDDPWSPEALAWPLLAVIDASLDEPWCRTLASHLGHFATTDAEAELRRGRRYSVARR LAGLFASYARQRPGLLAAWLDGDLGELPGDLAWQPPLWRALVTTVGADPPHVRHDKTIARLRDGPADLPA RLSLFGHTRLACTDVQLLDALAVHHDLHLWLPHPSDELWRALAGFQGADGLLPRRQDTSRRAAQHPLLET LGRDVRELQRALPAARATDEFLGATTKPDTLLGWLQADIAGNAPRPAGRSLSDADRSVQVHACHGPARQI DVLREVLLGLLEDDPTLQPRDIVVMCPDIDTYAPLIVAGFGLGEVAGDCHPAHRLRVRLADRALTQTNPL LSVAAELLTIAETRATASQLLNLAQAAPVRAKFGFADDDLDTITTWVRESNIRWGFDPTHRRRYGLDTVV HNTWRFGLDRILTGVAMSEDSQAWLDTALPLDDVGSNRVELAGRLAEFVERLHHVVGGLSGARPLVAWLD ALATGIDLLTACNDGWQRAQVQREFADVLARAGSRAAPLLRLPDVRALLDAQLAGRPTRANFRTGTLTVC TMVPMRSVPHRVVCLVGLDDGVFPRLSHPDGDDVLAREPMTGERDIRSEDRQLLLDAIGAATQTLVITYT GADERTGQPRPPAVPLAELLDALDQTTSAPVRERILVTHPLQPFDRKNVTPGALLGAKPFTFDPAALAAA QAAAGKRCPPTAFISGRLPAPPAADVTLADLLDFFKDPVKGFFRALDYTLPWDVDTVEDSIPVQVDALAE WTVGERMLRDMLRGLHPDDAAHSEWRRGTLPPGRLGVRRAKEIRNRARDLAAAALAHRDGHGQAHDVDVD LGDGRRLSGTVTPVFGGRTVSVTYSKLAPKHVLPAWIGLVTLAAQEPGREWSALCIGRSKTRNHIARRLF VPPPDPVAVLRELVLLYDAGRREPLPLPLKTSCAWAQARRDGQDPYPPARECWQTNRFRPGDDDAPAHVR AWGPRAPFEVLLGKPRAGEEVAGEETRLGALAARLWLPLLAAEGSV*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv0631c | recC | - | 100% (1097) | PROBABLE EXONUCLEASE V (GAMMA CHAIN) RECC (EXODEOXYRIBONUCLEASE V GAMMA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0648c | recC | 0.0 | 99.82% (1097) | exonuclease V gamma chain |
M. gilvum PYR-GCK | Mflv_5129 | - | 0.0 | 64.58% (1101) | exodeoxyribonuclease V, gamma subunit |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_0400c | - | 0.0 | 66.39% (1095) | exodeoxyribonuclease V, gamma subunit (RecC) |
M. marinum M | MMAR_0958 | recC | 0.0 | 68.15% (1102) | exodeoxyribonuclease V (gamma chain), RecC |
M. avium 104 | MAV_4542 | recC | 0.0 | 70.31% (1098) | exodeoxyribonuclease V, gamma subunit |
M. smegmatis MC2 155 | MSMEG_1328 | recC | 0.0 | 66.82% (1106) | exodeoxyribonuclease V, gamma subunit |
M. thermoresistible (build 8) | TH_1754 | recC | 0.0 | 67.18% (1112) | PROBABLE EXONUCLEASE V (GAMMA CHAIN) RECC |
M. ulcerans Agy99 | MUL_0709 | recC | 0.0 | 67.88% (1102) | exodeoxyribonuclease V (gamma chain), RecC |
M. vanbaalenii PYR-1 | Mvan_1210 | - | 0.0 | 66.15% (1099) | exodeoxyribonuclease V, gamma subunit |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_0958|M.marinum_M --MPLHLHRAERTDLLADGLGALLAQPLADPFAEELVLVPARGVERWLSQ MUL_0709|M.ulcerans_Agy99 --MPFHLHRAERTDLLADGLGALLAQPLADPFAEELVLVPARGVERWLSQ MAV_4542|M.avium_104 --MPLHLHRAERTDLLADGLGALLANPPADPFALELVVVPARGVERWLSQ MAB_0400c|M.abscessus_ATCC_199 --MALHLRRAERTDMLADGLARLLAVPAPDPFAEELVLVPAKGIERWLSQ MSMEG_1328|M.smegmatis_MC2_155 MSMALHLHRAERTDLLADGLAALLSDPLPDPFATELVLVPAKGVERWLSQ TH_1754|M.thermoresistible__bu --MALHLHRAERTDQLADGLAALLSEPLDDPFVEELVIVPAKGVERWLSQ Mflv_5129|M.gilvum_PYR-GCK --MALHLHRADRTDLLADGLGAMLSDPPADPFAEDLVLVSARGTERWLSQ Mvan_1210|M.vanbaalenii_PYR-1 --MALHLHRADRTDLLADGLGAMLADPPADPFAEDLVLVSARGTERWLSQ Rv0631c|M.tuberculosis_H37Rv --MALHLHRAERTDLLADGLGALLADPQPDPFAQELVLVAARGVERWLSQ Mb0648c|M.bovis_AF2122/97 --MALHLHRAERTDLLADGLGALLADPQPDPFAQELVLVAARGVERWLSQ *.:**:**:*** *****. :*: * ***. :**:*.*:* ****** MMAR_0958|M.marinum_M RLSHLLG-HAPGGGDGVCAGVSFRNPRSLIAEITG----TAADDPWSAEA MUL_0709|M.ulcerans_Agy99 RLSHLLG-HAPGGGDGVCAGVSFRNPRSLIAEITG----TAADDPWSAEA MAV_4542|M.avium_104 RLSHVLG-RARDG-DGVCAGVQFRSPGSLIAEITG----TAEDDPWSPDA MAB_0400c|M.abscessus_ATCC_199 RLSDRLG---------VCAGVRFRSPRSLIAEITG----TVDNDPWSPDA MSMEG_1328|M.smegmatis_MC2_155 RLSNRLG---------VCAAVEFRNPRSLIAELTG----TADDDPWSPDA TH_1754|M.thermoresistible__bu RLSHLLGRGADGNSDGVCAGVAFRNPHSLIAGLTGPLTGAADDDPWAPEA Mflv_5129|M.gilvum_PYR-GCK RLSHVLG--RGSGQDGICAGVTFRHPRSLIAELTG----TREHDPWSPDA Mvan_1210|M.vanbaalenii_PYR-1 RLSHILG--RGSGQDGICAGVTFRHPRSLMAELTG----TDEDDPWSPDA Rv0631c|M.tuberculosis_H37Rv RLSLVLG-CGPGRADGVCAGIAFRNPQSLIAEITG----TLDDDPWSPEA Mb0648c|M.bovis_AF2122/97 RLSLVLG-CGPGRADGVCAGIAFRNPQSLIAEITG----TLDDDPWSPEA *** ** :**.: ** * **:* :** : .***:.:* MMAR_0958|M.marinum_M MTWPLLEVIDGSLEQPWCATLARHLGHFDV-GPEAELRRGRRYSVARRLA MUL_0709|M.ulcerans_Agy99 MTWPLLEVIDGSLEEPWCATLARHLGHFDV-GPEAELRRGRRYSVARRLA MAV_4542|M.avium_104 LAWPLLEAIDCSLDEPWCRTLATHLGHFHS-GAEAELRRTRRYEAARRLA MAB_0400c|M.abscessus_ATCC_199 LVWPLLTVIDENLHQSWAVPLASHLGAFEA-GEERELRQGRRYAVARRLA MSMEG_1328|M.smegmatis_MC2_155 MVWPLLGVIDESLDEPWCATLATHLGHFEM-GEEYELRQGRRYAVARRLA TH_1754|M.thermoresistible__bu MVWPLLEVIDASCTEDWCSTLATHLGHFET-GAERELRQGRRYAVARRLA Mflv_5129|M.gilvum_PYR-GCK MVWPLLAVIDDCLAEPWCSTLGAHLGHFAD-GEERELRQGRRYAVARRLA Mvan_1210|M.vanbaalenii_PYR-1 MVWPLLDVIDGCITEPWCATLATHLGHFAD-GEEKVLRQGRRYAVARRLA Rv0631c|M.tuberculosis_H37Rv LAWPLLAVIDASLDEPWCRTLASHLGHFATTDAEAELRRGRRYSVARRLA Mb0648c|M.bovis_AF2122/97 LAWPLLAVIDASLDEPWCRTLASHLGHFATTDAEAELRRGRRYSVARRLA :.**** .** : *. .*. *** * . * **: *** .***** MMAR_0958|M.marinum_M GLFASYARQRPRVLSDWLDGGRGDLDPDLSWQPELWCALVAVVGADPPHL MUL_0709|M.ulcerans_Agy99 GLFASYARQRPRVLSDWLDGGRGDLDPDLSWQPELWCALVAVVGADPPHL MAV_4542|M.avium_104 GLFAGYARQRPRLLVDWLDGDPGDLDEDLRWQPPLWRALVARVAADPPHV MAB_0400c|M.abscessus_ATCC_199 GLFASYARQRPELLVSWLDGDP--AEPDLAWQPPLWRALVARVDAVPPHV MSMEG_1328|M.smegmatis_MC2_155 GLFASYARQRPQLLVDWDG-----LPDDLAWQKALWQALCERIDADPPHI TH_1754|M.thermoresistible__bu GLFASYARQRPQLLIDWLAGEVGDLDSDLRWQPPLWRALVDRVDADPPHV Mflv_5129|M.gilvum_PYR-GCK GLFASYATQRPRLLEDWLAGRTDGLDADLRWQPELYRALVDRVQADPPHV Mvan_1210|M.vanbaalenii_PYR-1 GLFDSYARQRPQLLIDWIDGRTGALDEDLRWQPELYRALLAHVDTEPPHI Rv0631c|M.tuberculosis_H37Rv GLFASYARQRPGLLAAWLDGDLGELPGDLAWQPPLWRALVTTVGADPPHV Mb0648c|M.bovis_AF2122/97 GLFASYARQRPGLLAAWLDGDLGELPGDLAWQPPLWRALVTTVGADPPHV *** .** *** :* * ** ** *: ** : : ***: MMAR_0958|M.marinum_M RHEKTLTALRARP-AGLPPRLSLFGHTRMAVTDIELLGAVATHHELHLWL MUL_0709|M.ulcerans_Agy99 RHEKTLTALRARP-AGLPPRLSLFGHTRMAVTDIELLGALATHHELHLWL MAV_4542|M.avium_104 RHAETIARLRRAP-SDLPQRLSLFGHTRLACTDVELLDALATHHDLHLWL MAB_0400c|M.abscessus_ATCC_199 RHDRVRARLREAP-SDLPPRISLFGHTRLPVTDIELLDALATHHDLYLWL MSMEG_1328|M.smegmatis_MC2_155 RHAKTLVQLHESP-TDLPQRLSLFGHTRLPATEVELLTALATHHDLHLWL TH_1754|M.thermoresistible__bu RHAEVLARLRESPVEELPPRLSLFGHTRLPSTEIELLEALATHHELHLWL Mflv_5129|M.gilvum_PYR-GCK RHAETVARLVDSP-TDLPERLSLFGHTRLPVTEIELLAAVATHHDLHLWL Mvan_1210|M.vanbaalenii_PYR-1 RHAETVARLRESP-SELPQRLSMFGHTRLPATEIELLAALSTHHDLHLWL Rv0631c|M.tuberculosis_H37Rv RHDKTIARLRDGP-ADLPARLSLFGHTRLACTDVQLLDALAVHHDLHLWL Mb0648c|M.bovis_AF2122/97 RHDKTIARLRDGP-ADLPARLSLFGHTRLACTDVQLLDALAVHHDLHLWL ** .. . * * ** *:*:*****:. *:::** *::.**:*:*** MMAR_0958|M.marinum_M PHPSAALWRSLADLH---GVVPRRADASHRRVVHPLLATLGRDLRELQRG MUL_0709|M.ulcerans_Agy99 PHPSAALWRSLADLH---GVVPRRADASHRRVVHPLLATLGRDLRELQRG MAV_4542|M.avium_104 PHPSDRLWRALAGTN---GVIPRRDDTSHRAVAHPLLATLGRDLRELQRG MAB_0400c|M.abscessus_ATCC_199 PHPSDALWQTLASDH---GPVPRREDIAHRSVRHPLLATLGRDVRELQRA MSMEG_1328|M.smegmatis_MC2_155 PHPSDTLWQALSTRK---GPLPRREDTSHRDVGHPLLATLGRDLREMQRL TH_1754|M.thermoresistible__bu PHPSNELWTRLAGHT---GPVPRRADLTHREVGHPLLATLGRDLRELQRS Mflv_5129|M.gilvum_PYR-GCK PHPSDALWTSLRDVR---DVIPRRDDTSHRRVGHPLLATLGRDLRELQRC Mvan_1210|M.vanbaalenii_PYR-1 PHPSDKLWTSLRGVH---GAAPRRTDTSHRDVDHPLLATLGRDLRELQRV Rv0631c|M.tuberculosis_H37Rv PHPSDELWRALAGFQGADGLLPRRQDTSRRAAQHPLLETLGRDVRELQRA Mb0648c|M.bovis_AF2122/97 PHPSDELWRALAGFQGADGLLPRRQDTSRRAAQHPLLETLGRDVRELQRA **** ** * . *** * ::* . **** *****:**:** MMAR_0958|M.marinum_M LPADPATDEALGA------TTRPDTLLGWLQSDLAANQVRPENRTLVAGD MUL_0709|M.ulcerans_Agy99 LPADPATDEALGA------TTRPDTLLGWLQSDLAANQVRPENRTLVAGD MAV_4542|M.avium_104 LPADPRTDEYLAG------DARPDTLLGWLQSDIAANAIRPVGRSLAAGD MAB_0400c|M.abscessus_ATCC_199 LP-EPTSDEYLSG------TTFSDSLLGWLQSDLAADEVRPQGRALAAHD MSMEG_1328|M.smegmatis_MC2_155 LP-EPDTDEFRGR------SEYPDTLLGWLQSDIAADAVRPQGRHHRRED TH_1754|M.thermoresistible__bu LPAERATDEFLGAPGPETDAGRPDTLLGWLQSDIAANAVRPAGRVLRPDD Mflv_5129|M.gilvum_PYR-GCK LPTDTVSDESLGS------VARPDTLLGWLQSDIGADRVRAEGRTHDAGD Mvan_1210|M.vanbaalenii_PYR-1 LPADAQTDESLGP------ADRPDTLLGWLQSDLGADAVRPQGRSCAPGD Rv0631c|M.tuberculosis_H37Rv LPAARATDEFLGA------TTKPDTLLGWLQADIAGNAPRPAGRSLSDAD Mb0648c|M.bovis_AF2122/97 LPAARATDEFLGA------TTKPDTLLGWLQADIAGNAPRPAERSLSDAD ** :** . .*:******:*:..: *. * * MMAR_0958|M.marinum_M RSIQVHSCHGPARQIDVLREVLLGLLADDPTLEPRDILVMCPDIETYAPL MUL_0709|M.ulcerans_Agy99 RSIQVHSCHGPARQIDVLREVLLGLLADDPTLEPRDILVMCPDIETYAPL MAV_4542|M.avium_104 RSVQIHNCHGPARQVDVLREVLLGLLADDPTLQPRDILVMCPDIESYAPL MAB_0400c|M.abscessus_ATCC_199 HTVQVHSCHGPARQIDVLREVLLGLLADDPTLEPRDILVMCPDIETYAPL MSMEG_1328|M.smegmatis_MC2_155 RSIQVHSCHGPSRQIDVLREVLLGLLADDPTLEPRDILVMCPDIETYAPL TH_1754|M.thermoresistible__bu DSVQVHSCHGAARQIDVLREVLLGLLAEDETLEPRDIVVMCPDIETYAPL Mflv_5129|M.gilvum_PYR-GCK RSVQVHSCHGPARQVDVLREVLLGMLEDDPTLEPRDILVMCPDIEAYAPL Mvan_1210|M.vanbaalenii_PYR-1 RSVQVHSCHGAARQIDVLREVLLGLLADDPTLEPRDILVMCPDIETYAPL Rv0631c|M.tuberculosis_H37Rv RSVQVHACHGPARQIDVLREVLLGLLEDDPTLQPRDIVVMCPDIDTYAPL Mb0648c|M.bovis_AF2122/97 RSVQVHACHGPARQIDVLREVLLGLLEDDPTLQPRDIVVMCPDIDTYAPL ::*:* ***.:**:*********:* :* **:****:******::**** MMAR_0958|M.marinum_M IVADFGLGDVMH---------GVHPAHRLRVRLADRSLLQTNPLLGVASQ MUL_0709|M.ulcerans_Agy99 IVADFGLGDVMH---------GVHPAHRLRVRLADRSLLQTNPLLGVASQ MAV_4542|M.avium_104 IMADFGLGDVVH---------GAHPAHQLRVRLADRSLIQTNPLLGVAAQ MAB_0400c|M.abscessus_ATCC_199 ISARFGLGESVP---------GAHPAHQLRVRLADRALVQTNPLLTVAGQ MSMEG_1328|M.smegmatis_MC2_155 ITAGFGLGDVVPRTRGAHINLSAHPAHKLRVRLADRALVQTNPLLAVAAQ TH_1754|M.thermoresistible__bu IMADFGLGDVVH---------GAHPAHRLRVRLADRALVQTNPLLGVAAQ Mflv_5129|M.gilvum_PYR-GCK IVAGFGLGDVVS---------GAHPAHRLRVKLADRALTQTNPLLGVARR Mvan_1210|M.vanbaalenii_PYR-1 IVAGFGLGDVVS---------GAHPAHRLRVTLADRALTQTNPLLGVARQ Rv0631c|M.tuberculosis_H37Rv IVAGFGLGEVAG---------DCHPAHRLRVRLADRALTQTNPLLSVAAE Mb0648c|M.bovis_AF2122/97 IVAGFGLGEVAG---------DCHPAHRLRVRLADRALTQTNPLLSVAAE * * ****: . ****:*** ****:* ****** ** . MMAR_0958|M.marinum_M LLMLAGSRVTASEVLNLAQAAPVRARFGFADDHLEDITRWVRQSNIRWGF MUL_0709|M.ulcerans_Agy99 LLMLAGSRVTASEVLNLAQAAPVRARFGFADDHLEDITRWVRQSNIRWGF MAV_4542|M.avium_104 LLALAGGRVRASEVLNLAQTPAVRARFGFTDDDLEAITGWVRQANIRWGL MAB_0400c|M.abscessus_ATCC_199 ILSLASGRATASEVLNLAESSPVRMRFGFTDDDLDAITAWVREANIRWGF MSMEG_1328|M.smegmatis_MC2_155 LLALAGGRATASEVLNLAESAPVRARFGFTDDDLDAITAWTREANIRWGF TH_1754|M.thermoresistible__bu LLQLAGGRATAGEVLNLAQAAPVRARFGFTDDDLEDITRWVRQANIRWGF Mflv_5129|M.gilvum_PYR-GCK LLELAGSRATAGEVLDVAEAAPVRARFGFSDDDLDAVGTWVRESNIRWGF Mvan_1210|M.vanbaalenii_PYR-1 LLGLAGGRATASEVLNLAEAAPVRLRFGFTDDDLDAIGDWVREANIRWGF Rv0631c|M.tuberculosis_H37Rv LLTIAETRATASQLLNLAQAAPVRAKFGFADDDLDTITTWVRESNIRWGF Mb0648c|M.bovis_AF2122/97 LLTIAETRATASQLLNLAQAAPVRAKFGFADDDLDTITTWVRESNIRWGF :* :* *. *.::*::*::..** :***:**.*: : *.*::*****: MMAR_0958|M.marinum_M DQEHRKPYGVD-FVHNTWRFGIDRVLAGVAMSEASHAWIDATLPLDDVGS MUL_0709|M.ulcerans_Agy99 DQEHRKPYGVD-FVHNTWRFGIDRVLAGVAMSEASHAWIDATLPLDDVGS MAV_4542|M.avium_104 DRQHRRPYHVD-FVHNTWRFGIDRILAGVAMSDDSNAWIDATLPLDDVSS MAB_0400c|M.abscessus_ATCC_199 DPEHRAPYGVD-FLHNTWRFGIDRVLAGVALSEDAHAWLGATLPLDDVSS MSMEG_1328|M.smegmatis_MC2_155 DQEHRRPYGVE-FLHNTWRFGIDRVLAGVAMSDDSHAWLGTTLPLDDVSS TH_1754|M.thermoresistible__bu DTEHRRPFGVE-FIQNTWRFGVDRVLAGVAMSDDAHSWVGTTLPLDDVSS Mflv_5129|M.gilvum_PYR-GCK DRDHRRPYGVD-FVQNTWRFGIDRVLAGVAMSDDSRAWLDTTLPLDDVSS Mvan_1210|M.vanbaalenii_PYR-1 DRGHRHPYGVD-FVQNTWRFGIDRVLAGVAMSDDSHAWLDTTLPLDDVSS Rv0631c|M.tuberculosis_H37Rv DPTHRRRYGLDTVVHNTWRFGLDRILTGVAMSEDSQAWLDTALPLDDVGS Mb0648c|M.bovis_AF2122/97 DPTHRRRYGLDTVVHNTWRFGLDRILTGVAMSEDSQAWLDTALPLDDVGS * ** : :: .::******:**:*:***:*: :.:*:.::******.* MMAR_0958|M.marinum_M NRVELAGRFAEYIDRLRQVVDSLTGTRPLREWLAALTDGIALLTRVDEGD MUL_0709|M.ulcerans_Agy99 NRVELAGRFAEYIDRLRQVVDSLTGTRPLREWLAALTDGIALLTRVDEGE MAV_4542|M.avium_104 NRVQLAGQLAEFVARLQHVLDSLTGARPLTEWLTAVADGIALLTRVRDAD MAB_0400c|M.abscessus_ATCC_199 NRVELAGRFAEFVSQLHTTVTALSGTRPLAEWLTILSTGIDALATDSED- MSMEG_1328|M.smegmatis_MC2_155 NRVELAGRFADFVEKLRRTVDQLSGTRPLHEWLDALTAGIDALALADED- TH_1754|M.thermoresistible__bu NRVELAGRLAEYVERLHRTVGALTGTQPLHAWLTALTEGVDLLTRVDDED Mflv_5129|M.gilvum_PYR-GCK NRVELAGRLAEFVDRLRDAVESLTGTAMLADWLARIRTGVSELTAVPDSD Mvan_1210|M.vanbaalenii_PYR-1 NRVELAGRLAEYVDRLRSVVESLSGAAALNDWLARLSEGLDALTAVSDAD Rv0631c|M.tuberculosis_H37Rv NRVELAGRLAEFVERLHHVVGGLSGARPLVAWLDALATGIDLLTACNDG- Mb0648c|M.bovis_AF2122/97 NRVELAGRLAEFVERLHHVVGGLSGARPLVAWLDALATGIDLLTACNDG- ***:***::*::: :*: .: *:*: * ** : *: *: : MMAR_0958|M.marinum_M AWQSDQMQREFAEVSRTAGRWVETMLRLPDIRALLQRHLAGRPTRANFRT MUL_0709|M.ulcerans_Agy99 AWQSDQMRREFAEVSRTAGRWVETMLRVPDIRALLQRHLAGRPTRANFRT MAV_4542|M.avium_104 EWQSGQLQREFAAVSAQAGSRADTVLRLPDVRALLTRHLSGRPTRANFRT MAB_0400c|M.abscessus_ATCC_199 -WPRAQMLREFAEIQDAA---VPVSLRLSDIRALLDRHLAGRPTRANFRT MSMEG_1328|M.smegmatis_MC2_155 -WPAAQMQREFAEITARAGD-TATSLRLADVRALLDRHLAGRPTRANFRT TH_1754|M.thermoresistible__bu AWQVSQLHREFGDILAKAGPRADMPLRLPDITALLERQLAGRPTRANFRT Mflv_5129|M.gilvum_PYR-GCK LWQHSQLERELADIAAAAGVHAGTELRLSDVRSLLDRHLAGRPTRANFRT Mvan_1210|M.vanbaalenii_PYR-1 LWQTSQVGRELADILAAAGAHADVELRLSDIRALLDRHLAGRPTRANFRT Rv0631c|M.tuberculosis_H37Rv -WQRAQVQREFADVLARAGSRAAPLLRLPDVRALLDAQLAGRPTRANFRT Mb0648c|M.bovis_AF2122/97 -WQRAQVQREFADVLARAGSRAAPLLRLPDVRALLDAQLAGRPTRANFRT * *: **:. : * . **:.*: :** :*:********** MMAR_0958|M.marinum_M GTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRQGVVDGDDVLARSPMTGER MUL_0709|M.ulcerans_Agy99 GTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRQGVVDGDDVLARSPMTGER MAV_4542|M.avium_104 GTLTVCTMVPMRSVPHRVVCLVGLDDGLFPRLGVVDGDDALSRCPMTGER MAB_0400c|M.abscessus_ATCC_199 GTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRLGAVDGDDALARDPMTGER MSMEG_1328|M.smegmatis_MC2_155 GTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRLGAVDGDDALARDPMTGER TH_1754|M.thermoresistible__bu GTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRVGVVDGDDVLARDPMTGER Mflv_5129|M.gilvum_PYR-GCK GTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRVGVVDGDDALARDPMTGER Mvan_1210|M.vanbaalenii_PYR-1 GTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRSGVVDGDDVLARDPMTGER Rv0631c|M.tuberculosis_H37Rv GTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRLSHPDGDDVLAREPMTGER Mb0648c|M.bovis_AF2122/97 GTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRLSHPDGDDVLAREPMTGER ***************************:*** . ****.*:* ****** MMAR_0958|M.marinum_M DIRSEDRQLLLDAIGAATENLVITYTGANEYSGQRKPPAVPLAELLDTLD MUL_0709|M.ulcerans_Agy99 DIRSEDRQLLLDAIGAATENLVITYTGANEYSGQRKPPAVPLAELLGTLD MAV_4542|M.avium_104 DIRSEDRQLLLDAIGAATEKLVITYTGANEYSGQPRPPAVPLAELLDTLD MAB_0400c|M.abscessus_ATCC_199 DIRSEDRQLLLDAIGAATETLVLTYTGANEYSGQARPPAVPLAELLDTLD MSMEG_1328|M.smegmatis_MC2_155 DIRSEDRQLLLDAILAATQTLVITYTGANEYSGQARPPAVPLAELIDTLK TH_1754|M.thermoresistible__bu DVRSEDRQLLLDAICAATEKLVITYTGANEYSGQVRPPAVPLAELLDTLD Mflv_5129|M.gilvum_PYR-GCK DIRSEDRQLLLDAIGAATEKLVITYTGANEYSGQRRPPAVPVVELLDTLD Mvan_1210|M.vanbaalenii_PYR-1 DIRSEDRQLLLDAIGAATEKLVITYTGANEYSGQRKPPAVPVMELLDTLD Rv0631c|M.tuberculosis_H37Rv DIRSEDRQLLLDAIGAATQTLVITYTGADERTGQPRPPAVPLAELLDALD Mb0648c|M.bovis_AF2122/97 DIRSEDRQLLLDAIGAATQTLVITYTGADERTGQPRPPAVPLAELLDALD *:************ ***:.**:*****:* :** :*****: **:.:*. MMAR_0958|M.marinum_M MTTTEQVRGRVVVEHPLQPFDVRNVTCGALMP--GVPFSFDPTVLRAARA MUL_0709|M.ulcerans_Agy99 MTTTEQVRGRVVVEHPLQPFDVRNVTRGALMP--GVPFSFDPTVLRAARA MAV_4542|M.avium_104 ITTAEPVRDRIVVRHPLQPFDIRNVIPDELVP--GVPFSFDPTVLRAARA MAB_0400c|M.abscessus_ATCC_199 ITTSQPVRDRIHITHPLQPFDIRNVTPGSVIP--GHPFTFDSTALIAARA MSMEG_1328|M.smegmatis_MC2_155 ITTEDSALD-VLTRHPLQPFDKRNVIPGALVP--DEPFTFDQTALVAARA TH_1754|M.thermoresistible__bu RTTEEPVRDRLVVQHPLQPFDVRNVEPGGLIP--GVPFTFDSTVLNAARI Mflv_5129|M.gilvum_PYR-GCK VTTSSPVRDRVHTSHPLQPFDIANVTPGELGMPVGTPFTFDPTTLTAARA Mvan_1210|M.vanbaalenii_PYR-1 VTTSAPVRETVLVEHPLQPFDVDNVTPGKLGMPAGRPFTFDPTALTAATA Rv0631c|M.tuberculosis_H37Rv QTTSAPVRERILVTHPLQPFDRKNVTPGALLG--AKPFTFDPAALAAAQA Mb0648c|M.bovis_AF2122/97 QTTSAPVRERILVTHPLQPFDRKNVTPGALLG--AKPFTFDPAALAAAQA ** . : ******* ** . : **:** :.* ** MMAR_0958|M.marinum_M AAGERAQQPRFIGAPLAPPPADDVALADLVAFFKDPVKGFFRALDYTLPW MUL_0709|M.ulcerans_Agy99 AAGERAQQPRFIGAPLAPPPADDVALADLVAFFKDPVKGFFRALDYTLPW MAV_4542|M.avium_104 ATGEHCEPPKFISAPLPPPPPADVILADLVGFFKDPVQGFFRALQFTLPH MAB_0400c|M.abscessus_ATCC_199 AAGARAERPPFICGPLPALDVTDVALTDLAAFFNHPIKGFFRALDYTLPW MSMEG_1328|M.smegmatis_MC2_155 SSGERAMRPAFFSDPLPPPLPDDVALEDLLNFFKDPVKGFFRALDYTLPW TH_1754|M.thermoresistible__bu RAEDRAARPPFVSGPLAPPPPEDVLLADLLAFFRDPVKGFFRALDYTLPW Mflv_5129|M.gilvum_PYR-GCK TTGDREEHRPLLAEPLPAPPADDVALDDLIGFFRDPVKGFFRALDFTLPW Mvan_1210|M.vanbaalenii_PYR-1 AAGHRGPRPHLLGRPLPAPPPADVALDELIGFFKDPVKGFFRALDYTLPW Rv0631c|M.tuberculosis_H37Rv AAGKRCPPTAFISGRLPAPPAADVTLADLLDFFKDPVKGFFRALDYTLPW Mb0648c|M.bovis_AF2122/97 AAGKRCPPTAFISGRLPAPPAADVTLADLLDFFKDPVKGFFRALDYTLPW : : :. *.. ** * :* **..*::******::*** MMAR_0958|M.marinum_M DVDGVEDAMPVDINALEEWTVGDRMLADILSGMAPDEARQAEWRRGTLPP MUL_0709|M.ulcerans_Agy99 DVDGVEDAMPVDINALEEWTVGDRMLADILSGMAPDEARQAEWRRGTLPP MAV_4542|M.avium_104 DVDGVQDAMPVDIDALQEWTVGDRMLRDMLRGMTPEDARQAEWRRGTLPP MAB_0400c|M.abscessus_ATCC_199 DVDGVSDDMPVEIDALEEWTVGDRLLADMLRGMTPADAQQAEWRRGTLPP MSMEG_1328|M.smegmatis_MC2_155 DVEGVSDVMPVDIDALEEWTVGDRMLSDILRGMTPAAAQQAEWRRGTLPP TH_1754|M.thermoresistible__bu EVDGVDDAMPVDLDALAEWTVGDRMLDDLLRGMRPEDARDAEWRRGTLPP Mflv_5129|M.gilvum_PYR-GCK DVDGLDDAIPVDVDALQEWKIGQRLLDDMQRGMSPAQAQQAEWRRGSLPP Mvan_1210|M.vanbaalenii_PYR-1 DVEAVEDAMPVEIDALQEWKIGDRMLDDMLRGMTPADAQQAEWRRGSLPP Rv0631c|M.tuberculosis_H37Rv DVDTVEDSIPVQVDALAEWTVGERMLRDMLRGLHPDDAAHSEWRRGTLPP Mb0648c|M.bovis_AF2122/97 DVDTVEDSIPVQVDALAEWTVGERMLRDMLRGLHLDDAAHSEWRRGTLPP :*: :.* :**:::** **.:*:*:* *: *: * .:*****:*** MMAR_0958|M.marinum_M GQLGWRKVTEIRDQAALLAAAALRHRRAD-AAAYDVDIDLG-SRRLTGTV MUL_0709|M.ulcerans_Agy99 GQLGWRKVTEIRDQAALLAAAAMRHRRDD-AAAYDVDIDLG-SRRLTGTV MAV_4542|M.avium_104 GQLGWRRVTEIRDQAARLAREAHQHRAEQPGGAHDVDIDLGRGRRLTGTV MAB_0400c|M.abscessus_ATCC_199 GQLGWRRVSELRERCAALAAETRGYQTDD-SRAFDIDIDLGDGRRLAGTV MSMEG_1328|M.smegmatis_MC2_155 GQLGWRRAIALRDQCALLAAEALGFRDTD-GQAYDVDIDLGGGRRLTGTV TH_1754|M.thermoresistible__bu GRLGWRKAGEILDQAVELARTAHQYRDEP-PRACDVDIDLGGGRRLTGTV Mflv_5129|M.gilvum_PYR-GCK GRLGWRRAQEITTRSAALAAAAQQYRTPD-PHAVDIDVAVGPARRLTGTV Mvan_1210|M.vanbaalenii_PYR-1 GRLGWRKAQEIASRSAALAAAARQHRTPD-PRAIDVDVAIGPARRVTGTV Rv0631c|M.tuberculosis_H37Rv GRLGVRRAKEIRNRARDLAAAALAHRDGH-GQAHDVDVDLGDGRRLSGTV Mb0648c|M.bovis_AF2122/97 GRLGVRRAKEIRNRARDLAAAALAHRDGH-GQAHDVDVDLGDGRRLSGTV *:** *:. : :. ** : .: * *:*: :* .**::*** MMAR_0958|M.marinum_M AQVFGDRLVSVTYSKLDGKHLLESWIPLLALFAHAGAHDWSAVCIGRQKR MUL_0709|M.ulcerans_Agy99 AQVFGDRLVSVTYSKLDGKHLLESWIPLLALFAHAGAHDWSAVCIGRQKR MAV_4542|M.avium_104 TPVYGNRLVAVTYSRLDGRHLLESWIPLLALAAHDRGRDWSAVCIGRMRR MAB_0400c|M.abscessus_ATCC_199 SPVFGERLVSVTYSRLDAKHLLQSWIPLVALSAHDHQRDWSAVCIGRARR MSMEG_1328|M.smegmatis_MC2_155 SPVFGDRLVSVTYSKLGGKHLLQSWIPLLALAAGYPDRDWLAVCIGRPAR TH_1754|M.thermoresistible__bu APVFGQRLVSVTYSKLDGRHLLQPWISLLALYAHDPHTAWSAVCVGRRKR Mflv_5129|M.gilvum_PYR-GCK PRLYGERMVAVTYSKLAGRHLLESWIRLVALTAHRPGTDWTAVCIGRGDR Mvan_1210|M.vanbaalenii_PYR-1 PRVYGSRTVAVTYSKLDGRHLLASWIRLVALTAHHPGTDWTAVCIGRGGR Rv0631c|M.tuberculosis_H37Rv TPVFGGRTVSVTYSKLAPKHVLPAWIGLVTLAAQEPGREWSALCIGR-SK Mb0648c|M.bovis_AF2122/97 TPVFGGRTVSVTYSKLAPKHVLPAWIGLVTLAAQEPGREWSALCIGR-SK . ::* * *:****:* :*:* .** *::* * * *:*:** : MMAR_0958|M.marinum_M GTVPRQAGLGRPREQPVELLRDLVAIYDAGRREPIPLPIKTSYAWGAARH MUL_0709|M.ulcerans_Agy99 GTVPRQAGLGRPRGQPVELLRDLVAIYDAGRREPIPLPIKTSYAWAAARH MAV_4542|M.avium_104 GTGIRVQRLGSPDDDPVELLHELVSIYDAGRREPIPLPLKTSYAWAAARY MAB_0400c|M.abscessus_ATCC_199 GPQPLVRSLGRPM-DPLGVLRGLVAIYDAGRREPLPLPLKTSYAWAQARR MSMEG_1328|M.smegmatis_MC2_155 GTTPRVEGLGGPD-NPVDLLADLVAIYDAGRREPLPLPVKTSYAWAEARH TH_1754|M.thermoresistible__bu GTTPREELVGRPDGSPVELLRDLVAIYDAGRREPLPLPVKTSFAWAEARH Mflv_5129|M.gilvum_PYR-GCK G-RPTRERLLGPPDSAAEVLADLIAMYDAGRRAPIPLPLKTSYAWAETDF Mvan_1210|M.vanbaalenii_PYR-1 GGNQTKERLLGPPEAAAEVLRDLVAMYDAGRCAPIPLPLKTSYAWAETEY Rv0631c|M.tuberculosis_H37Rv TRNHIARRLFVPPPDPVAVLRELVLLYDAGRREPLPLPLKTSCAWAQARR Mb0648c|M.bovis_AF2122/97 TRNHIARRLFVPPPDPVAVLRELVLLYDAGRREPLPLPLKTSCAWAQARR : * . :* *: :***** *:***:*** **. : MMAR_0958|M.marinum_M CGDDPVREASFRWKSSDRYPAEDQAPAHVRTWGRN---ARLTDLMQPVRA MUL_0709|M.ulcerans_Agy99 CGDDPVREASFRWKSSDRYPAEDQAPAHVRTWGRN---ARLTDLMQPVHA MAV_4542|M.avium_104 GGDDPVAEARYRWKSSDRYPGEDQAPAHVRAWGRG---APLDDLMQPVRP MAB_0400c|M.abscessus_ATCC_199 DRDDPELQAGYRWRSG-NFPGEDADPAVERAFGQG---VWLRHLMQPLRP MSMEG_1328|M.smegmatis_MC2_155 CGDDPEQKAGFRWRSG-RYPGEDAEPAHVRAWGRD---AWLRDLMQPLRP TH_1754|M.thermoresistible__bu SGGDPERAALYRWRSN-NYPGEDQEPAHVRAWGRNGRPAWLQDLMQPLRP Mflv_5129|M.gilvum_PYR-GCK HRGQPLREAGWKWKTG-RYPGEDQDPAHIRVWGPH---LPLEDLVAAG-- Mvan_1210|M.vanbaalenii_PYR-1 HRGTPLREAGWKWKTG-RFPGEDAEPAHVRVWGPH---FPLSGLVSAG-- Rv0631c|M.tuberculosis_H37Rv DGQDPYPPARECWQTNRFRPGDDDAPAHVRAWGPR---APFEVLLGKPRA Mb0648c|M.bovis_AF2122/97 DGQDPYPPARECWQTNRFRPGDDDAPAHVRAWGPR---APFEVLLGKPRA * * *::. *.:* ** *.:* : *: MMAR_0958|M.marinum_M ESERAACPNGEDNRLGAFAARLWLPMLRAERDPG MUL_0709|M.ulcerans_Agy99 ESERAACPNGEDNRLGAFAARLWLPMLRAERDPG MAV_4542|M.avium_104 GEE----CDGEDNRLGAYAARLWLPMLRAERTTA MAB_0400c|M.abscessus_ATCC_199 GEE----TEGETNRLGAYSARLWLPLLRAERGA- MSMEG_1328|M.smegmatis_MC2_155 GEE----FEGETHRLGAYSSRLWLPLLRAERPVR TH_1754|M.thermoresistible__bu GEE----SAGETHRLGAYSMRLWGPLLRAMDGPR Mflv_5129|M.gilvum_PYR-GCK --------------LPGFAARLWLPMLRAERSAR Mvan_1210|M.vanbaalenii_PYR-1 --------------LPDYSTRLWQPMLLAERNPA Rv0631c|M.tuberculosis_H37Rv GEE----VAGEETRLGALAARLWLPLLAAEGSV- Mb0648c|M.bovis_AF2122/97 GEE----VAGEETRLGALAARLWLPLLAAEGSV- * : *** *:* *