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AIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFLEAFRFDEQDLR YLRGLGQFSDEFLRWLAGVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVLASK AARVVAAARGRPVVDFGARRAHGTDAACKVARTSYLAGAAGTSNLLAARQYGIPTFGTMAHSFVQAFDSE VAAFEAFARLYPATMLLVDTYDTLRGVDHVIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTAGLE QVEIFASSGLDENRIAALLAARCPIDGFGVGTQLVVAQDAPALDMAYKLVAYDGSGRTKFSSGKVIYPGR KQVFRKLEHGVFCGDTLGEHGENLPGDPLLVPIMTNGRRIRQHAPTLDGARDWARQQIDALPPELRSLED TGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0573c | - | - | 100% (463) | nicotinate phosphoribosyltransferase |
| M. tuberculosis H37Rv | Rv1330c | - | 1e-58 | 37.39% (436) | nicotinate phosphoribosyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0588c | - | 0.0 | 100.00% (463) | nicotinate phosphoribosyltransferase |
| M. gilvum PYR-GCK | Mflv_2348 | - | 3e-65 | 41.59% (428) | nicotinate phosphoribosyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1474c | - | 7e-59 | 37.58% (447) | nicotinate phosphoribosyltransferase |
| M. marinum M | MMAR_4068 | pncB | 5e-57 | 40.11% (364) | nicotinic acid phosphoribosyltransferase PncB |
| M. avium 104 | MAV_1550 | pncB | 4e-60 | 37.65% (425) | nicotinate phosphoribosyltransferase |
| M. smegmatis MC2 155 | MSMEG_4911 | pncB | 4e-68 | 40.43% (423) | nicotinate phosphoribosyltransferase |
| M. thermoresistible (build 8) | TH_1207 | - | 2e-60 | 38.12% (425) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3932 | pncB | 2e-54 | 39.01% (364) | nicotinate phosphoribosyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4297 | - | 2e-63 | 41.40% (401) | nicotinate phosphoribosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4068|M.marinum_M ------------MNHSVLAGLLTDKYEMTMLAAALRDGTAERRTSWEVFA
MUL_3932|M.ulcerans_Agy99 ------------MNHSVLAGLLTDKYEMTMLAAALRDGTAERRTSWKVFA
MAV_1550|M.avium_104 ------------MNDPVVTGLLTDKYELTMLAAALRDGSAGRRTTFELFA
Mflv_2348|M.gilvum_PYR-GCK MTAPPPESSNRQ-VPVSSTALLTDKYELTMLAAALRDGTAHRRCSFEVFA
Mvan_4297|M.vanbaalenii_PYR-1 MTPSSPDLSDMSGLSGLSMAMLTDKYELTMLAAALRDGTAHRRATFEVFA
TH_1207|M.thermoresistible__bu ----------------VTVALLTDKYEFTMLAAALRGGTAHRRTTFEVFA
MSMEG_4911|M.smegmatis_MC2_155 ----------------MTVALLTDKYELTMLAAALRDGTAHRRTTFEVFA
MAB_1474c|M.abscessus_ATCC_199 -------------MTHPCTSLLTDKYELTMLAAALRDGTAGRRATFEVFA
Rv0573c|M.tuberculosis_H37Rv -----------MAIRQHVGALFTDLYEVTMAQAYWAERMSG-TAVFEIFF
Mb0588c|M.bovis_AF2122/97 -----------MAIRQHVGALFTDLYEVTMAQAYWAERMSG-TAVFEIFF
.::** **.** * : :::*
MMAR_4068|M.marinum_M RRLPAGRRYGVVAGTGRLLELLPRFGFDDQACELLA--QFLDPDTVAYLR
MUL_3932|M.ulcerans_Agy99 RRLPAGRRYGVVAGTGRLLELLPRFGFDDQACELLA--QFLGPDTVAYLR
MAV_1550|M.avium_104 RRLPEGRRYGVVGGTGRLLEALPQFTFGDEACQSLR--QFLDPDTLRYLR
Mflv_2348|M.gilvum_PYR-GCK RRLPEGRRYGVTAGTGRFVEALDAFRFGPDELAALG--NFLDPATLDYLA
Mvan_4297|M.vanbaalenii_PYR-1 RRLPDGRRYGVTAGTARFVEALQAFRFDDAELTALD--GFLDSATLGYLA
TH_1207|M.thermoresistible__bu RRLPEGRRYGVVAGTGRFVAALTRFTFDDATLDVLS--ADLDDDTLNFLS
MSMEG_4911|M.smegmatis_MC2_155 RRLPEGRRYGVVAGTARFLEALTQYRFDPADLGLLR--GFLDADTLDYLA
MAB_1474c|M.abscessus_ATCC_199 RRLPDGRRYGVVAGTGRLLEALAEFRFGPAELESVS--TFLDEDSLEYLA
Rv0573c|M.tuberculosis_H37Rv RKLPPGRSYIMAAGLADVVEFLEAFRFDEQDLRYLRGLGQFSDEFLRWLA
Mb0588c|M.bovis_AF2122/97 RKLPPGRSYIMAAGLADVVEFLEAFRFDEQDLRYLRGLGQFSDEFLRWLA
*:** ** * :..* . .: * : *. : :. : :*
MMAR_4068|M.marinum_M DFRFSGDIDGYAEGELYFPGSPVLSVHGSFAECVLLETLVLSILNHDSAI
MUL_3932|M.ulcerans_Agy99 DFRFSGDIDGYAEGELYFPGSPVLSVHGSFAECVLLETLVLSVLNHDSAI
MAV_1550|M.avium_104 DFRFGGDIDGYAEGELYFPGSPVLSVTGTFAECVVLETLALSIFNHDTAI
Mflv_2348|M.gilvum_PYR-GCK GYRFSGDVDGYGEGELYFPGSPVLSVHGTFGECVVLETLVLSIFNFDSAV
Mvan_4297|M.vanbaalenii_PYR-1 DYRFTGDVDGYGEGELYFPGSPVLSVHGTFGECVLLETLALSIFNHDTAV
TH_1207|M.thermoresistible__bu DYRFRGDVDGYAEGELYFPGSPILAVHGTFAECVLLETLALSILNHDTAV
MSMEG_4911|M.smegmatis_MC2_155 GYRFGGDIDGYPEGELYFPGSPILSVHGTFAECVLLETLVLSIFNHDTAI
MAB_1474c|M.abscessus_ATCC_199 AYRFGGDIDGYPEGELYFPGSPVLTLRGSFAECVILETLILSILNHDSAV
Rv0573c|M.tuberculosis_H37Rv GVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVL
Mb0588c|M.bovis_AF2122/97 GVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVL
** **: . ** : **..* : : ..: *. ::**: *. :: ::.:
MMAR_4068|M.marinum_M ASAAARMVSAAGDRPLIEMGSRRTH-ECAAVAAARAAYIAGCTGSSNLEA
MUL_3932|M.ulcerans_Agy99 VSAAARMVSAAGDRPLIEMGSPRTH-ECAAVATARAAYIAGCTGSSNLEA
MAV_1550|M.avium_104 ASAAARMVSAARGRPLIEMGSRRTH-EQAAVAAARAAYIAGFAASSNLEA
Mflv_2348|M.gilvum_PYR-GCK ASAAARMASVAAGRPLIEMGSRRAH-EQAAVAAARAAYLAGFAGSSNLEA
Mvan_4297|M.vanbaalenii_PYR-1 ASAAARMVSAAAGRPLIEMGSRRTH-EQAAVAAARAAYLAGFTGSSNLEA
TH_1207|M.thermoresistible__bu ASAAARMVTAAQGRTLIEMGSRRTH-EEAAVAAARAAYLAGFDGSSNVEA
MSMEG_4911|M.smegmatis_MC2_155 ASAAARMASAAQGRPLIEMGSRRTH-EHAAVAAARAAYLAGFAGSSNLEA
MAB_1474c|M.abscessus_ATCC_199 ASAAARMVSAAGDRPLIEMGSRRTH-ELAAVACARAAYLAGFESTSNLEA
Rv0573c|M.tuberculosis_H37Rv ASKAARVVAAARGRPVVDFGARRAHGTDAACKVARTSYLAGAAGTSNLLA
Mb0588c|M.bovis_AF2122/97 ASKAARVVAAARGRPVVDFGARRAHGTDAACKVARTSYLAGAAGTSNLLA
.* ***:.:.* .*.::::*: *:* ** **::*:** .:**: *
MMAR_4068|M.marinum_M RQLYGVPAEGTAAHAFTMVHIN-QDRTPALAELAAFRAQIDALGPDTTLL
MUL_3932|M.ulcerans_Agy99 RQLYGVPAEGTAAHAFTMVHIN-QDRTPALAELAAFRAQIDALGPDTTLL
MAV_1550|M.avium_104 QRCYGIPAEGTSAHAFTMLHAR-TDAAAESTELAAFRAQVQALGVDTTLL
Mflv_2348|M.gilvum_PYR-GCK ERRHGVPALGTSAHAFTLLHTTADGGTASDWEKAAFRAQVDALGVDTTLL
Mvan_4297|M.vanbaalenii_PYR-1 ERRHGVPALGTSAHAFTLLHTT-DGGTPSDWEKSAFRAQVDVLGVGTTLL
TH_1207|M.thermoresistible__bu YRRYGVPVLGTSAHAFTLLHTT-DGTSFADGEKAAFRAQVDTLGVGTTLL
MSMEG_4911|M.smegmatis_MC2_155 QRRYGVPALGTAAHAYTLLHTT---ASGPD-EQAAFRGQVAALGTDTTLL
MAB_1474c|M.abscessus_ATCC_199 QRRYGVPARGTAAHAFTLLHAK-DGMSPGEAEREAFRAQVEALGVGTTLL
Rv0573c|M.tuberculosis_H37Rv ARQYGIPTFGTMAHSFVQAFDS---------EVAAFEAFARLY-PATMLL
Mb0588c|M.bovis_AF2122/97 ARQYGIPTFGTMAHSFVQAFDS---------EVAAFEAFARLY-PATMLL
: :*:*. ** **::. . * **.. * **
MMAR_4068|M.marinum_M VDTYDVTTGVANAVAAAG-----TALGAVRIDSGELGVLARQARQQLDAL
MUL_3932|M.ulcerans_Agy99 VDTYDVTTGVANAVAAAG-----TALGAVRIDSGELGVLAWQARQQLDAL
MAV_1550|M.avium_104 VDTYDVTTGVANAVTAAG-----TGLGAVRIDSGELGVLARQVREQLDRL
Mflv_2348|M.gilvum_PYR-GCK VDTYDITAGVANAVEVAG-----PQLGAVRIDSGDLGVLARQVREQLDRL
Mvan_4297|M.vanbaalenii_PYR-1 VDTYDITAGVANAVEVAG-----TRLGAVRIDSGDLGVLARQVRDQLDGL
TH_1207|M.thermoresistible__bu VDTFDIAEGVAHAVEVAG-----TDLGAVRIDSGDLGVLARQVRDQLDRL
MSMEG_4911|M.smegmatis_MC2_155 VDTYDITAGVANAIAAAG-----PKLGAVRIDSGDLGVLARQVRAQLDDL
MAB_1474c|M.abscessus_ATCC_199 VDTYDITAGVENAIAVAG-----TALGAVRIDSGDLGMLARQVRAQLDAL
Rv0573c|M.tuberculosis_H37Rv VDTYDTLRGVDHVIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTA
Mb0588c|M.bovis_AF2122/97 VDTYDTLRGVDHVIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTA
***:* ** :.: * : ***:***:*. *: .* :**
MMAR_4068|M.marinum_M GATETQIMVSGDLDEFSIAALRAE--PVDRYGVGTSLVTGSGAPTASMVY
MUL_3932|M.ulcerans_Agy99 GATETQIMVSGDLDEFSIAALRAE--PVDRYGVGTSLVTGSGAPTASMVY
MAV_1550|M.avium_104 GATRTRIVVSGDLDEFSIAALAAE--PVDSYGVGTSVVTGSGAPTANMVY
Mflv_2348|M.gilvum_PYR-GCK GATGTEIVVSGDLDEFAIAALRAE--PVDRYGVGTSVVTGSGAPTAGMVY
Mvan_4297|M.vanbaalenii_PYR-1 GATQTRIVVSGDLDEFSIAALRAE--PVDVYGVGTSVVTGSGAPTAGMVY
TH_1207|M.thermoresistible__bu GATRTKIVVSGDLDEFAIAALRAE--PVDSYGVGTSVVTGSGAPAAGLVY
MSMEG_4911|M.smegmatis_MC2_155 GATETKIVVSGDLDEYAIAALRAE--PVDSYGVGTSVVTGSGAPTASMVY
MAB_1474c|M.abscessus_ATCC_199 GAHRTRIVVSGDLDEYSIAALRAE--PVDIYGVGTSVVTGSGIPTAGMVY
Rv0573c|M.tuberculosis_H37Rv GLEQVEIFASSGLDENRIAALLAARCPIDGFGVGTQLVVAQDAPALDMAY
Mb0588c|M.bovis_AF2122/97 GLEQVEIFASSGLDENRIAALLAARCPIDGFGVGTQLVVAQDAPALDMAY
* ..*..*..*** **** * *:* :****.:*.... *: .:.*
MMAR_4068|M.marinum_M KLVEVEGIPVQKRSSQKESRGGRKEALRLARPTGTVTEEIVHPAGR-PPA
MUL_3932|M.ulcerans_Agy99 KLVEVEGIPVQKRSSQKESRGGRKEALRLARPTGTVTEEIVHPAGR-PPA
MAV_1550|M.avium_104 KLVEVDGLPVQKRSSHKESRGGRKEALRLSRDTGIITEELVYPAGH-RPD
Mflv_2348|M.gilvum_PYR-GCK KLVEVDGIPVEKRSSHKQSHGGRKQALRLAKASGTVVEEVIHPAGH-PPE
Mvan_4297|M.vanbaalenii_PYR-1 KLVEVDGIPVEKRSSHKESHGGRKQASRLAKKSGTIVEEVVYPAGD-PPP
TH_1207|M.thermoresistible__bu KLVEVDGIPVEKRSTHKMSRGGRKQALRLMKPTGTMVEEVVHPYGR-PPE
MSMEG_4911|M.smegmatis_MC2_155 KLVEVDGMPVAKRSSSKESHGGRKEALRVAKASGTIVEEVVYPYGK-PPQ
MAB_1474c|M.abscessus_ATCC_199 KLVEIDGIPVAKRSSHKESHGGHKCALRIAKPTGTITEEVVYRADAGQPT
Rv0573c|M.tuberculosis_H37Rv KLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEHGVFCGDTLGEHGEN----
Mb0588c|M.bovis_AF2122/97 KLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEHGVFCGDTLGEHGEN----
*** :* * *: * *:* . * . : :
MMAR_4068|M.marinum_M TTGL--HRVLTTPLVRSGKPMVTTDPDTLAAARKLVASGLRSLPWEGLKL
MUL_3932|M.ulcerans_Agy99 TTGL--HRVLTTPLARSGKPMVTTDPDTLAAARKLVASGLRSLPWEGLKL
MAV_1550|M.avium_104 VAEP--ARAVTVPLVRGGE--LVSKPN-LAAARELVASGLRSLPWEGLNL
Mflv_2348|M.gilvum_PYR-GCK VPADLVARALTVPLVRRGEP-LATPG--LDAARDRVADGLRSLPWDGLKL
Mvan_4297|M.vanbaalenii_PYR-1 HPADLEARTLTVPLMRAGEP-VADIG--LAAARTRVGDGLLSLPWDGLSL
TH_1207|M.thermoresistible__bu IPAGLHARPLTVQLVRDGEP-VADLG--LPAARERVAAGLRSLPWDGLKL
MSMEG_4911|M.smegmatis_MC2_155 IESPLTARKLTVPLVAGGKP-VEGYSDDLSAARERVRAGLHSLPWDGLKL
MAB_1474c|M.abscessus_ATCC_199 VPEP--HRILTTALVRGGKP-VAYHS--LTEARNRVHAGLLSLPWEGLGL
Rv0573c|M.tuberculosis_H37Rv ----LPGDPLLVPIMTNGRR-IRQHAPTLDGARDWARQQIDALPPELRSL
Mb0588c|M.bovis_AF2122/97 ----LPGDPLLVPIMTNGRR-IRQHAPTLDGARDWARQQIDALPPELRSL
: . : *. : * ** . : :** : *
MMAR_4068|M.marinum_M APG----EPAIPTQTISA--------------------------
MUL_3932|M.ulcerans_Agy99 APG----EPAIPTQTISA--------------------------
MAV_1550|M.avium_104 SHG----EPAIPTTQIPADRRRPPGID-----------------
Mflv_2348|M.gilvum_PYR-GCK SRG----EAAVPSRMIAPA-RGRS--------------------
Mvan_4297|M.vanbaalenii_PYR-1 SRG----DAAVPTRMVAPR-RGRV--------------------
TH_1207|M.thermoresistible__bu SRG----EPTIPTRMIPPAPSGQNR-------------------
MSMEG_4911|M.smegmatis_MC2_155 SRG----EPAIPTRMTADER------------------------
MAB_1474c|M.abscessus_ATCC_199 SHG----DPAIATRLVG---------------------------
Rv0573c|M.tuberculosis_H37Rv EDTGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP
Mb0588c|M.bovis_AF2122/97 EDTGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP
::.