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TAPPPESSNRQVPVSSTALLTDKYELTMLAAALRDGTAHRRCSFEVFARRLPEGRRYGVTAGTGRFVEAL DAFRFGPDELAALGNFLDPATLDYLAGYRFSGDVDGYGEGELYFPGSPVLSVHGTFGECVVLETLVLSIF NFDSAVASAAARMASVAAGRPLIEMGSRRAHEQAAVAAARAAYLAGFAGSSNLEAERRHGVPALGTSAHA FTLLHTTADGGTASDWEKAAFRAQVDALGVDTTLLVDTYDITAGVANAVEVAGPQLGAVRIDSGDLGVLA RQVREQLDRLGATGTEIVVSGDLDEFAIAALRAEPVDRYGVGTSVVTGSGAPTAGMVYKLVEVDGIPVEK RSSHKQSHGGRKQALRLAKASGTVVEEVIHPAGHPPEVPADLVARALTVPLVRRGEPLATPGLDAARDRV ADGLRSLPWDGLKLSRGEAAVPSRMIAPARGRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2348 | - | - | 100% (454) | nicotinate phosphoribosyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1365c | - | 1e-173 | 70.25% (447) | nicotinate phosphoribosyltransferase |
| M. tuberculosis H37Rv | Rv1330c | - | 1e-173 | 70.25% (447) | nicotinate phosphoribosyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1474c | - | 1e-168 | 71.46% (431) | nicotinate phosphoribosyltransferase |
| M. marinum M | MMAR_4068 | pncB | 1e-168 | 71.06% (432) | nicotinic acid phosphoribosyltransferase PncB |
| M. avium 104 | MAV_1550 | pncB | 1e-176 | 73.39% (436) | nicotinate phosphoribosyltransferase |
| M. smegmatis MC2 155 | MSMEG_4911 | pncB | 0.0 | 77.80% (437) | nicotinate phosphoribosyltransferase |
| M. thermoresistible (build 8) | TH_1207 | - | 0.0 | 78.11% (434) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3932 | pncB | 1e-163 | 69.21% (432) | nicotinate phosphoribosyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4297 | - | 0.0 | 85.58% (437) | nicotinate phosphoribosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2348|M.gilvum_PYR-GCK -MTAPPPESSNRQ-VPVSSTALLTDKYELTMLAAALRDGTAHRRCSFEVF
Mvan_4297|M.vanbaalenii_PYR-1 -MTPSSPDLSDMSGLSGLSMAMLTDKYELTMLAAALRDGTAHRRATFEVF
TH_1207|M.thermoresistible__bu -----------------VTVALLTDKYEFTMLAAALRGGTAHRRTTFEVF
MSMEG_4911|M.smegmatis_MC2_155 -----------------MTVALLTDKYELTMLAAALRDGTAHRRTTFEVF
MAB_1474c|M.abscessus_ATCC_199 --------------MTHPCTSLLTDKYELTMLAAALRDGTAGRRATFEVF
Mb1365c|M.bovis_AF2122/97 MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVF
Rv1330c|M.tuberculosis_H37Rv MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVF
MMAR_4068|M.marinum_M -------------MNHSVLAGLLTDKYEMTMLAAALRDGTAERRTSWEVF
MUL_3932|M.ulcerans_Agy99 -------------MNHSVLAGLLTDKYEMTMLAAALRDGTAERRTSWKVF
MAV_1550|M.avium_104 -------------MNDPVVTGLLTDKYELTMLAAALRDGSAGRRTTFELF
.:******:********.*:* * ::::*
Mflv_2348|M.gilvum_PYR-GCK ARRLPEGRRYGVTAGTGRFVEALDAFRFGPDELAALGNFLDPATLDYLAG
Mvan_4297|M.vanbaalenii_PYR-1 ARRLPDGRRYGVTAGTARFVEALQAFRFDDAELTALDGFLDSATLGYLAD
TH_1207|M.thermoresistible__bu ARRLPEGRRYGVVAGTGRFVAALTRFTFDDATLDVLSADLDDDTLNFLSD
MSMEG_4911|M.smegmatis_MC2_155 ARRLPEGRRYGVVAGTARFLEALTQYRFDPADLGLLRGFLDADTLDYLAG
MAB_1474c|M.abscessus_ATCC_199 ARRLPDGRRYGVVAGTGRLLEALAEFRFGPAELESVSTFLDEDSLEYLAA
Mb1365c|M.bovis_AF2122/97 ARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLRE
Rv1330c|M.tuberculosis_H37Rv ARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLRE
MMAR_4068|M.marinum_M ARRLPAGRRYGVVAGTGRLLELLPRFGFDDQACELLAQFLDPDTVAYLRD
MUL_3932|M.ulcerans_Agy99 ARRLPAGRRYGVVAGTGRLLELLPRFGFDDQACELLAQFLGPDTVAYLRD
MAV_1550|M.avium_104 ARRLPEGRRYGVVGGTGRLLEALPQFTFGDEACQSLRQFLDPDTLRYLRD
***** ******..**.*:: * : *. : *. :: :*
Mflv_2348|M.gilvum_PYR-GCK YRFSGDVDGYGEGELYFPGSPVLSVHGTFGECVVLETLVLSIFNFDSAVA
Mvan_4297|M.vanbaalenii_PYR-1 YRFTGDVDGYGEGELYFPGSPVLSVHGTFGECVLLETLALSIFNHDTAVA
TH_1207|M.thermoresistible__bu YRFRGDVDGYAEGELYFPGSPILAVHGTFAECVLLETLALSILNHDTAVA
MSMEG_4911|M.smegmatis_MC2_155 YRFGGDIDGYPEGELYFPGSPILSVHGTFAECVLLETLVLSIFNHDTAIA
MAB_1474c|M.abscessus_ATCC_199 YRFGGDIDGYPEGELYFPGSPVLTLRGSFAECVILETLILSILNHDSAVA
Mb1365c|M.bovis_AF2122/97 FRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIA
Rv1330c|M.tuberculosis_H37Rv FRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIA
MMAR_4068|M.marinum_M FRFSGDIDGYAEGELYFPGSPVLSVHGSFAECVLLETLVLSILNHDSAIA
MUL_3932|M.ulcerans_Agy99 FRFSGDIDGYAEGELYFPGSPVLSVHGSFAECVLLETLVLSVLNHDSAIV
MAV_1550|M.avium_104 FRFGGDIDGYAEGELYFPGSPVLSVTGTFAECVVLETLALSIFNHDTAIA
:** **:*** **********:*:: *:*.***:**** **::*.*:*:.
Mflv_2348|M.gilvum_PYR-GCK SAAARMASVAAGRPLIEMGSRRAHEQAAVAAARAAYLAGFAGSSNLEAER
Mvan_4297|M.vanbaalenii_PYR-1 SAAARMVSAAAGRPLIEMGSRRTHEQAAVAAARAAYLAGFTGSSNLEAER
TH_1207|M.thermoresistible__bu SAAARMVTAAQGRTLIEMGSRRTHEEAAVAAARAAYLAGFDGSSNVEAYR
MSMEG_4911|M.smegmatis_MC2_155 SAAARMASAAQGRPLIEMGSRRTHEHAAVAAARAAYLAGFAGSSNLEAQR
MAB_1474c|M.abscessus_ATCC_199 SAAARMVSAAGDRPLIEMGSRRTHELAAVACARAAYLAGFESTSNLEAQR
Mb1365c|M.bovis_AF2122/97 SAAARMVSAAGGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQR
Rv1330c|M.tuberculosis_H37Rv SAAARMVSAAGGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQR
MMAR_4068|M.marinum_M SAAARMVSAAGDRPLIEMGSRRTHECAAVAAARAAYIAGCTGSSNLEARQ
MUL_3932|M.ulcerans_Agy99 SAAARMVSAAGDRPLIEMGSPRTHECAAVATARAAYIAGCTGSSNLEARQ
MAV_1550|M.avium_104 SAAARMVSAARGRPLIEMGSRRTHEQAAVAAARAAYIAGFAASSNLEAQR
******.:.* .*.****** *:** **** *****:** .:**: * :
Mflv_2348|M.gilvum_PYR-GCK RHGVPALGTSAHAFTLLHTTADGGTASDWEKAAFRAQVDALGVDTTLLVD
Mvan_4297|M.vanbaalenii_PYR-1 RHGVPALGTSAHAFTLLHTT-DGGTPSDWEKSAFRAQVDVLGVGTTLLVD
TH_1207|M.thermoresistible__bu RYGVPVLGTSAHAFTLLHTT-DGTSFADGEKAAFRAQVDTLGVGTTLLVD
MSMEG_4911|M.smegmatis_MC2_155 RYGVPALGTAAHAYTLLHTT---ASGPD-EQAAFRGQVAALGTDTTLLVD
MAB_1474c|M.abscessus_ATCC_199 RYGVPARGTAAHAFTLLHAK-DGMSPGEAEREAFRAQVEALGVGTTLLVD
Mb1365c|M.bovis_AF2122/97 RYGVPAHGTAAHAFTMLHAQ-HGGPTELAERAAFRAQVEALGPGTTLLVD
Rv1330c|M.tuberculosis_H37Rv RYGVPAHGTAAHAFTMLHAQ-HGGPTELAERAAFRAQVEALGPGTTLLVD
MMAR_4068|M.marinum_M LYGVPAEGTAAHAFTMVHIN-QDRTPALAELAAFRAQIDALGPDTTLLVD
MUL_3932|M.ulcerans_Agy99 LYGVPAEGTAAHAFTMVHIN-QDRTPALAELAAFRAQIDALGPDTTLLVD
MAV_1550|M.avium_104 CYGIPAEGTSAHAFTMLHAR-TDAAAESTELAAFRAQVQALGVDTTLLVD
:*:*. **:***:*::* . * ***.*: .** .******
Mflv_2348|M.gilvum_PYR-GCK TYDITAGVANAVEVAGPQLGAVRIDSGDLGVLARQVREQLDRLGATGTEI
Mvan_4297|M.vanbaalenii_PYR-1 TYDITAGVANAVEVAGTRLGAVRIDSGDLGVLARQVRDQLDGLGATQTRI
TH_1207|M.thermoresistible__bu TFDIAEGVAHAVEVAGTDLGAVRIDSGDLGVLARQVRDQLDRLGATRTKI
MSMEG_4911|M.smegmatis_MC2_155 TYDITAGVANAIAAAGPKLGAVRIDSGDLGVLARQVRAQLDDLGATETKI
MAB_1474c|M.abscessus_ATCC_199 TYDITAGVENAIAVAGTALGAVRIDSGDLGMLARQVRAQLDALGAHRTRI
Mb1365c|M.bovis_AF2122/97 TYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRI
Rv1330c|M.tuberculosis_H37Rv TYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRI
MMAR_4068|M.marinum_M TYDVTTGVANAVAAAGTALGAVRIDSGELGVLARQARQQLDALGATETQI
MUL_3932|M.ulcerans_Agy99 TYDVTTGVANAVAAAGTALGAVRIDSGELGVLAWQARQQLDALGATETQI
MAV_1550|M.avium_104 TYDVTTGVANAVTAAGTGLGAVRIDSGELGVLARQVREQLDRLGATRTRI
*:*:: ** :*: .**. ***:*****:**:** *.* *** *** *.*
Mflv_2348|M.gilvum_PYR-GCK VVSGDLDEFAIAALRAEPVDRYGVGTSVVTGSGAPTAGMVYKLVEVDGIP
Mvan_4297|M.vanbaalenii_PYR-1 VVSGDLDEFSIAALRAEPVDVYGVGTSVVTGSGAPTAGMVYKLVEVDGIP
TH_1207|M.thermoresistible__bu VVSGDLDEFAIAALRAEPVDSYGVGTSVVTGSGAPAAGLVYKLVEVDGIP
MSMEG_4911|M.smegmatis_MC2_155 VVSGDLDEYAIAALRAEPVDSYGVGTSVVTGSGAPTASMVYKLVEVDGMP
MAB_1474c|M.abscessus_ATCC_199 VVSGDLDEYSIAALRAEPVDIYGVGTSVVTGSGIPTAGMVYKLVEIDGIP
Mb1365c|M.bovis_AF2122/97 VVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVP
Rv1330c|M.tuberculosis_H37Rv VVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVP
MMAR_4068|M.marinum_M MVSGDLDEFSIAALRAEPVDRYGVGTSLVTGSGAPTASMVYKLVEVEGIP
MUL_3932|M.ulcerans_Agy99 MVSGDLDEFSIAALRAEPVDRYGVGTSLVTGSGAPTASMVYKLVEVEGIP
MAV_1550|M.avium_104 VVSGDLDEFSIAALAAEPVDSYGVGTSVVTGSGAPTANMVYKLVEVDGLP
:*******::**** .**** ******:***** *:*.:******::*:*
Mflv_2348|M.gilvum_PYR-GCK VEKRSSHKQSHGGRKQALRLAKASGTVVEEVIHPAGH-PPEVPADLVARA
Mvan_4297|M.vanbaalenii_PYR-1 VEKRSSHKESHGGRKQASRLAKKSGTIVEEVVYPAGD-PPPHPADLEART
TH_1207|M.thermoresistible__bu VEKRSTHKMSRGGRKQALRLMKPTGTMVEEVVHPYGR-PPEIPAGLHARP
MSMEG_4911|M.smegmatis_MC2_155 VAKRSSSKESHGGRKEALRVAKASGTIVEEVVYPYGK-PPQIESPLTARK
MAB_1474c|M.abscessus_ATCC_199 VAKRSSHKESHGGHKCALRIAKPTGTITEEVVYRADAGQPTVPEP--HRI
Mb1365c|M.bovis_AF2122/97 VQKRSSYKKSPGGRKEALRRSRATGTITEELVHPAGR-PPVIVEP--HRV
Rv1330c|M.tuberculosis_H37Rv VQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGR-PPVIVEP--HRV
MMAR_4068|M.marinum_M VQKRSSQKESRGGRKEALRLARPTGTVTEEIVHPAGR-PPATTGL--HRV
MUL_3932|M.ulcerans_Agy99 VQKRSSQKESRGGRKEALRLARPTGTVTEEIVHPAGR-PPATTGL--HRV
MAV_1550|M.avium_104 VQKRSSHKESRGGRKEALRLSRDTGIITEELVYPAGH-RPDVAEP--ARA
* ***: * * **:* * * : :* :.**::: . * *
Mflv_2348|M.gilvum_PYR-GCK LTVPLVRRGEPLATPG---LDAARDRVADGLRSLPWDGLKLSRGEAAVPS
Mvan_4297|M.vanbaalenii_PYR-1 LTVPLMRAGEPVADIG---LAAARTRVGDGLLSLPWDGLSLSRGDAAVPT
TH_1207|M.thermoresistible__bu LTVQLVRDGEPVADLG---LPAARERVAAGLRSLPWDGLKLSRGEPTIPT
MSMEG_4911|M.smegmatis_MC2_155 LTVPLVAGGKPVEGYSDD-LSAARERVRAGLHSLPWDGLKLSRGEPAIPT
MAB_1474c|M.abscessus_ATCC_199 LTTALVRGGKPVAYHS---LTEARNRVHAGLLSLPWEGLGLSHGDPAIAT
Mb1365c|M.bovis_AF2122/97 LTLPLVRAGQPVADTS---LAAARQLVASGLRSLPADGLKLAPGEPAIPT
Rv1330c|M.tuberculosis_H37Rv LTLPLVRAGQPVADTS---LAAARQLVASGLRSLPGDGLKLAPGEPAIPT
MMAR_4068|M.marinum_M LTTPLVRSGKPMVTTDPDTLAAARKLVASGLRSLPWEGLKLAPGEPAIPT
MUL_3932|M.ulcerans_Agy99 LTTPLARSGKPMVTTDPDTLAAARKLVASGLRSLPWEGLKLAPGEPAIPT
MAV_1550|M.avium_104 VTVPLVRGGELVSKPN---LAAARELVASGLRSLPWEGLNLSHGEPAIPT
:* * *: : . * ** * ** *** :** *: *:.::.:
Mflv_2348|M.gilvum_PYR-GCK RMIAPA-RGRS---
Mvan_4297|M.vanbaalenii_PYR-1 RMVAPR-RGRV---
TH_1207|M.thermoresistible__bu RMIPPAPSGQNR--
MSMEG_4911|M.smegmatis_MC2_155 RMTADER-------
MAB_1474c|M.abscessus_ATCC_199 RLVG----------
Mb1365c|M.bovis_AF2122/97 RTIPA---------
Rv1330c|M.tuberculosis_H37Rv RTIPA---------
MMAR_4068|M.marinum_M QTISA---------
MUL_3932|M.ulcerans_Agy99 QTISA---------
MAV_1550|M.avium_104 TQIPADRRRPPGID