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MHNNGRMLGVIGGSGFYTFFGSDTRTVNSDTPYGQPSAPITIGTIGVHDVAFLPRHGAHHQYSAHAVPYR ANMWALRALGVRRVFGPCAVGSLDPELEPGAVVVPDQLVDRTSGRADTYFDFGGVHAAFADPYCPTLRAA VTGLPGVVDGGTMVVIQGPRFSTRAESQWFAAAGCNLVNMTGYPEAVLARELELCYAAIALVTDVDAGVA AGDGVKAADVFAAFGENIELLKRLVRAAIDRVADERTCTHCQHHAGVPLPFELP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0535 | pnp | - | 100% (264) | 5'-methylthioadenosine phosphorylase |
| M. tuberculosis H37Rv | Rv3307 | deoD | 7e-10 | 28.14% (199) | purine nucleoside phosphorylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0549 | pnp | 1e-156 | 100.00% (264) | 5'-methylthioadenosine phosphorylase |
| M. gilvum PYR-GCK | Mflv_4828 | - | 2e-07 | 25.41% (185) | purine nucleoside phosphorylase |
| M. leprae Br4923 | MLBr_00707 | deoD | 1e-06 | 25.97% (181) | purine nucleoside phosphorylase |
| M. abscessus ATCC 19977 | MAB_3956c | - | 1e-104 | 70.16% (258) | 5'-methylthioadenosine phosphorylase |
| M. marinum M | MMAR_0881 | pnp | 1e-129 | 83.71% (264) | 5'-methylthioadenosine phosphorylase, Pnp |
| M. avium 104 | MAV_4610 | mtaP | 1e-121 | 78.79% (264) | 5'-methylthioadenosine phosphorylase |
| M. smegmatis MC2 155 | MSMEG_0990 | mtaP | 1e-117 | 75.97% (258) | 5'-methylthioadenosine phosphorylase |
| M. thermoresistible (build 8) | TH_0435 | pnp | 1e-114 | 74.42% (258) | PROBABLE 5'-METHYLTHIOADENOSINE PHOSPHORYLASE PNP (MTA |
| M. ulcerans Agy99 | MUL_0634 | pnp | 1e-129 | 83.71% (264) | 5'-methylthioadenosine phosphorylase |
| M. vanbaalenii PYR-1 | Mvan_0881 | - | 1e-118 | 77.13% (258) | 5'-methylthioadenosine phosphorylase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0535|M.tuberculosis_H37Rv ----------------------MHNNGRMLGVIGGSGFY----TFFGSDT
Mb0549|M.bovis_AF2122/97 ----------------------MHNNGRMLGVIGGSGFY----TFFGSDT
MMAR_0881|M.marinum_M ----------------------MHNNEPMLAVIGGSGFY----SFFESDV
MUL_0634|M.ulcerans_Agy99 ----------------------MHNNEPMLAVIGGSGFY----SFFESDV
MAV_4610|M.avium_104 ----------------------MHHNGRMLGVIGGSGFY----IFFGSDA
MSMEG_0990|M.smegmatis_MC2_155 ---------------------------MMLGVIGGSGFY----TFFGSDA
Mvan_0881|M.vanbaalenii_PYR-1 ----------------------------MLGVIGGSGFY----SFFGSDA
TH_0435|M.thermoresistible__bu ----------------------------MLAVIGGSGFY----SFFGPDA
MAB_3956c|M.abscessus_ATCC_199 ----------------------------MLAVIGGSGFY----SFFDKPV
Mflv_4828|M.gilvum_PYR-GCK ----MDDPGVLAQQAADELRRRTGVDTHDVAVVLGSGWAPAATSLGEPDA
MLBr_00707|M.leprae_Br4923 MTYTLLDPDELARRAAQVIGERTGILKHDVAVVLGSGWSSAVAALGSSRA
:.*: ***: : .
Rv0535|M.tuberculosis_H37Rv RTVNSDTP-YGQPSAPITIG---TIGVHDVAFLPRHGAHHQYSAHAVPYR
Mb0549|M.bovis_AF2122/97 RTVNSDTP-YGQPSAPITIG---TIGVHDVAFLPRHGAHHQYSAHAVPYR
MMAR_0881|M.marinum_M RTVNPDTP-YGRPSAPITIG---AVGEHEVAFLPRHGASHQYSAHTVPYR
MUL_0634|M.ulcerans_Agy99 RTVNPDTP-YGRPSAPITIG---AVGEHEVAFLPRHGASHQYSAHTVPYR
MAV_4610|M.avium_104 DDVTVDTP-YGPPSAPVTVG---AVGGHRVAFLPRHGARHEFSAHTVPYR
MSMEG_0990|M.smegmatis_MC2_155 RAVSVETP-YGPPSAPITVG---TVGDHEVAFLPRHGVKHEFSPHTVPYR
Mvan_0881|M.vanbaalenii_PYR-1 RSVTVDTP-YGPPSAAITVG---SVGAHEVAFLPRHGVRHEYSPHTVPYR
TH_0435|M.thermoresistible__bu RTVTPDTP-YGAPSGPITIG---RVGQHEVAFLPRHGVDHEYSPHTVPYR
MAB_3956c|M.abscessus_ATCC_199 RTVTPATP-YGEPSAPITIG---LVGGREVAFLPRHGSRHEFSPHTVPYR
Mflv_4828|M.gilvum_PYR-GCK AIPMADLPGFTPPSAQGHGGQVLSVRAGPHRVLVLLGRIHAYEGHNLRHV
MLBr_00707|M.leprae_Br4923 VFPQAELPGFITPNAAGHTGELLSVRIGAHRVLVLAGRIHPYEGHDLRHV
* : *.. * : .* * * :. * : :
Rv0535|M.tuberculosis_H37Rv AN-MWALRALGVRRVFGPCAVGSLDPELEPGAVVVPDQLVDRTSGRADTY
Mb0549|M.bovis_AF2122/97 AN-MWALRALGVRRVFGPCAVGSLDPELEPGAVVVPDQLVDRTSGRADTY
MMAR_0881|M.marinum_M AN-MWALRALGARRVFAPCAVGSLNPRLGPGTVVVPDQLVDRTRGRADTY
MUL_0634|M.ulcerans_Agy99 AN-MWALRALGARRVFAPCAVGSLNPRLRPGTVVVPDQLVDRTRGRADTY
MAV_4610|M.avium_104 AN-LWALRKLGVRRVLAPCAVGSLVPELGPGAVVVPDQLVDRTRGRADTY
MSMEG_0990|M.smegmatis_MC2_155 AN-LWALRSLGVRRVFAPCAVGSLTPDLGPGSIVVPDQLVDRTSGRDDTY
Mvan_0881|M.vanbaalenii_PYR-1 AN-MWALRALGVRRVFGPCAVGSLDPQLGPGAMVVPDQLVDRTSGRPDTY
TH_0435|M.thermoresistible__bu AN-MWALRALGVRRVFAPCAVGSLTPDLGPGSVVVPDQLVDRTAGRADTY
MAB_3956c|M.abscessus_ATCC_199 AN-MWALRAVGVRRVFAPCAVGSLTADLGPGAIVVPDQLVDRTSGRAQTY
Mflv_4828|M.gilvum_PYR-GCK VHPVRTACAAGARTVVLTNAAGGVREDMTVGQPVLISDHLNLTARSP---
MLBr_00707|M.leprae_Br4923 VHPVRTACAAGARIIVLTNAAGGLRADMAVGQLVLISDHLNLTTRSP---
.: : : *.* :. . *.*.: : * *: .: :: *
Rv0535|M.tuberculosis_H37Rv FDFGGVHAAFADPYCPTLRAAVTGLPGVVDGGTMVVIQGPRFSTRAESQW
Mb0549|M.bovis_AF2122/97 FDFGGVHAAFADPYCPTLRAAVTGLPGVVDGGTMVVIQGPRFSTRAESQW
MMAR_0881|M.marinum_M FDSGGVHAAFADPYCPTLRSAVTDLPDVVDGATMVVIQGPRFSTRAESRW
MUL_0634|M.ulcerans_Agy99 FDSGGVHAAFADPYCPTLRSAVTDLPDVVDGATMVVIQGPRFSTRAESRW
MAV_4610|M.avium_104 FDSGAVHVDFADPYCPALREAVTGLPGVVDGGTMVVIQGPRFSTRAESRW
MSMEG_0990|M.smegmatis_MC2_155 FDSGGIHVAFADPYCPTLRAAATGLPGVVDGGTMVVIQGPRFSTRAESRW
Mvan_0881|M.vanbaalenii_PYR-1 FDSGGIHVGFADPYCPSLRAAVTGLPGVVDGGAMVVIQGPRFSTRAESRW
TH_0435|M.thermoresistible__bu FDSGGIHVSFADPYCPELRAIAARQPGVVDGGTMVVIQGPRFSTRAESRW
MAB_3956c|M.abscessus_ATCC_199 FDSAGIHVEFADPYCPGLR-AVSLQPGTIDGGTMVVVQGPRFSTRAESRW
Mflv_4828|M.gilvum_PYR-GCK -LVGAQFVDMVDAYSPALRALARDIDPSLTEGVYAGLPGPHYETPAEIRM
MLBr_00707|M.leprae_Br4923 -LVGTHFVDLTNAYTTRLRKLASDTDPTLTEGVYAAQPGPHYETPAEIRM
. .. :.:.* . ** . : .. . **::.* ** :
Rv0535|M.tuberculosis_H37Rv FAAAGCNLVNMTGYPEAVLARELELCYAAIALVTDVDAGVAAGDGVKAAD
Mb0549|M.bovis_AF2122/97 FAAAGCNLVNMTGYPEAVLARELELCYAAIALVTDVDAGVAAGDGVKAAD
MMAR_0881|M.marinum_M FAGAGFSLVNMTGYPEAVLARELELCYAAVALVTDVDAGVAVGEGVKAAD
MUL_0634|M.ulcerans_Agy99 FAGAGFSLVNMTGYPEAVLARELELCYAAVALVTDVDAGVAVGEGVKAAD
MAV_4610|M.avium_104 FASAGFSLVNMTGYPEAVLARELEMCYAAIALVTDLDAGVSAGEGVKAVE
MSMEG_0990|M.smegmatis_MC2_155 FASQGFTLVNMTGYPEAVLARELEMCYAAVALVTDLDAGIEVGSGVRAVD
Mvan_0881|M.vanbaalenii_PYR-1 FADQGFRLVNMTGYPESVLARELEMCYAAIALVTDVDAGVEHGQGVRAVD
TH_0435|M.thermoresistible__bu YADQGFTLINMTGHPEAVLARELEMCYAAIALVTDLDAGVESGSGVRAVD
MAB_3956c|M.abscessus_ATCC_199 YASQGFTLVNMTGYPEAVLARELEICYAAIALVTDLDAGVEHGQGVRAVD
Mflv_4828|M.gilvum_PYR-GCK LRTLGADLVGMSTVHETIAARACGAAVLGVSLVTNLAAGMT-GQPLSHEE
MLBr_00707|M.leprae_Br4923 LRMLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGIT-GKPLNHAE
* *:.*: *:: ** .::***:: **: *. : :
Rv0535|M.tuberculosis_H37Rv VFAAFGENIELLKRLVRAAIDRVADERTCTHCQHHAGVPLPFELP
Mb0549|M.bovis_AF2122/97 VFAAFGENIELLKRLVRAAIDRVADERTCTHCQHHAGVPLPFELP
MMAR_0881|M.marinum_M VFAEFGENIEMLKKLVRAGIGRVAAERACTHCLMHAGVTLPFELP
MUL_0634|M.ulcerans_Agy99 VFAEFGENIEMLKKLVRAGIGRVAAERACTHCLMHAGVTLPFELP
MAV_4610|M.avium_104 VFAEFEKNIEPFKKLVRDAIGRVAAERSCTQCSPHAGVSLPIELP
MSMEG_0990|M.smegmatis_MC2_155 VFAEFERNMPPFKKLVFEALEAVEVERTCTHCLTHSGVQLPFELP
Mvan_0881|M.vanbaalenii_PYR-1 VFAEFERNLVPFKQLVHEAIEQVDAERTCTHCMPHEGVQLPFDLP
TH_0435|M.thermoresistible__bu VFAEFRRNMEPFKKLVHEALDQVPGERTCRHCLAHDGVKLPFELP
MAB_3956c|M.abscessus_ATCC_199 VFAEFERNIGGFKELVRSAVTATESVDTCGHCRAHDGVTLPIELP
Mflv_4828|M.gilvum_PYR-GCK VLAAGRQSATRMGSLLSAVIAGL----------------------
MLBr_00707|M.leprae_Br4923 VLAAGTASANRIGSLLADIIARF----------------------
*:* . : *: :