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M. tuberculosis H37Rv Rv0427c (xthA)

annotation: PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI)
coordinates: 516017 - 516892
length: 291

PDGTIDGGHPQRPASPRLRSPLLRLATWNVNSIRTRLDRVLDWLGRADVDVLAMQETKCPDGQFPALPLF
ELGYDVAHVGFDQWNGVAIASRVGLDDVRVGFDGQPSWSGKPEVAATTEARALGATCGGIRVWSLYVPNG
RALDDPHYTYKLDWLAALRDTAEGWLRDDPAAPIALMGDWNIAPTDDDVWSTEFFAGCTHVSEPERKAFN
AIVDAQFTDVVRPFTPGPGVYTYWDYTQLRFPKKQGMRIDFILGSPALAARVMDAQIVREERKGKAPSDH
APVLVDLHAG*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv0427c xthA - 100% (291) PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0435c xthA 1e-176 100.00% (291) exodeoxyribonuclease III protein
M. gilvum PYR-GCK Mflv_0177 - 1e-121 74.44% (270) exodeoxyribonuclease III Xth
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_4189 - 1e-116 72.45% (265) exodeoxyribonuclease III protein XthA
M. marinum M MMAR_0742 xthA 1e-143 87.69% (268) exodeoxyribonuclease III protein XthA
M. avium 104 MAV_4727 xth 1e-136 83.58% (268) exodeoxyribonuclease III
M. smegmatis MC2 155 MSMEG_0829 xth 1e-120 75.19% (266) exodeoxyribonuclease III
M. thermoresistible (build 8) TH_0019 xthA 1e-110 72.16% (255) PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA (EXONUCLEASE
M. ulcerans Agy99 MUL_1374 xthA 1e-135 85.82% (261) exodeoxyribonuclease III protein XthA
M. vanbaalenii PYR-1 Mvan_0730 - 1e-123 75.19% (270) exodeoxyribonuclease III Xth

CLUSTAL 2.0.9 multiple sequence alignment


Rv0427c|M.tuberculosis_H37Rv        MPDGTIDGGHPQRPASPRLRSPLLRLATWNVNSIRTRLDRVLDWLGRADV
Mb0435c|M.bovis_AF2122/97           MPDGTIDGGHPQRPASPRLRSPLLRLATWNVNSIRTRLDRVLDWLGRADV
MMAR_0742|M.marinum_M               MPDGTLR------------------LATWNVNSIRTRLPRVLDWLERADV
MUL_1374|M.ulcerans_Agy99           ------------------------------MNSIRTRLPRVLDWLERADV
MAV_4727|M.avium_104                -----------------------MRLATWNVNSIRSRLPRVLDWLARTDV
Mflv_0177|M.gilvum_PYR-GCK          -----------------------MRLATWNVNSIRARVDRVTDWLERADV
Mvan_0730|M.vanbaalenii_PYR-1       -----------------------MRLATWNVNSIRARVDRVTDWLERADV
TH_0019|M.thermoresistible__bu      -------------------------------------VERVTDWLQRADI
MSMEG_0829|M.smegmatis_MC2_155      -----------------------MRVATWNVNSIRARVDRVTDWLARADV
MAB_4189|M.abscessus_ATCC_1997      -----------------------MRLATWNVNSIRARADRVISWLERSGT
                                                                           ** .** *:. 

Rv0427c|M.tuberculosis_H37Rv        DVLAMQETKCPDGQFPALPLFELGYDVAHVGFDQWNGVAIASRVGLDDVR
Mb0435c|M.bovis_AF2122/97           DVLAMQETKCPDGQFPALPLFELGYDVAHVGFDQWNGVAIASRVGLDDVR
MMAR_0742|M.marinum_M               DVLAIQETKCSDTQFPALPLFELGYEVAHVGFNQWNGVAIASRVGIDDVQ
MUL_1374|M.ulcerans_Agy99           DVLAIQETKCSDTQFPALPLFELGYEVAHVGFNQWNGVAIASRVGIDDVQ
MAV_4727|M.avium_104                DVLAMQETKCADGQFPTLPFFELGYEVAHVGFNQWNGVAIASRVGLDDVR
Mflv_0177|M.gilvum_PYR-GCK          DVLAMQETKCSDEQFPTMPFAALGYDVVHCGFSQWNGVAIASRVGIDAVE
Mvan_0730|M.vanbaalenii_PYR-1       DVLAMQETKCSDDQFPTMPFAALGYEIVHCGFNQWNGVAIASRVGIDDVE
TH_0019|M.thermoresistible__bu      DVLAMQETKCADDQFPTMPFAALGYEVVHCGFNQWNGVAIASRVGIEDVE
MSMEG_0829|M.smegmatis_MC2_155      DVLAMQETKCSDDKFPAMPFVELGYEVAYHGLNQWNGVAIASRVGLENVQ
MAB_4189|M.abscessus_ATCC_1997      DVLAMQETKCSDKQFPMQAFTDAGYEVAHVGFSQWNGVAIASRVGLEDVT
                                    ****:*****.* :**  .:   **::.: *:.************:: * 

Rv0427c|M.tuberculosis_H37Rv        VGFDGQPSWSGKPEVAATTEARALGATCGGIRVWSLYVPNGRALDDPHYT
Mb0435c|M.bovis_AF2122/97           VGFDGQPSWSGKPEVAATTEARALGATCGGIRVWSLYVPNGRALDDPHYT
MMAR_0742|M.marinum_M               IGFDGQPAWSGKPEVAAAAEARAVGATCGGVRVWSLYVPNGRALEDPHYT
MUL_1374|M.ulcerans_Agy99           ISFDGQPAWSGKPEVAAAAEARAVGATCGGVRVWSLYVPNGRALEDPHYT
MAV_4727|M.avium_104                VGFEGQPSWSGKPEVAAAAEARALAATCAGVRIWSLYVPNGRAVGDPHYA
Mflv_0177|M.gilvum_PYR-GCK          VGFEGQPTWSDKPEAEAAAEARALGATCGGVRVWSLYVPNGRSIDSPHYT
Mvan_0730|M.vanbaalenii_PYR-1       VGFDGQPTWNDKPEVEAAAEARALGATCGGVRVWSLYVPNGRTVDSPHYV
TH_0019|M.thermoresistible__bu      VGFDGQPTWSDSPDAEAAAEARALGATCNGVRVWSLYVPNGRTVGSPHYH
MSMEG_0829|M.smegmatis_MC2_155      LGFDNQPAW------EAAAEARALAATCGGVRVWSLYVPNGRTVDSPHYA
MAB_4189|M.abscessus_ATCC_1997      VGFEGQPGWSSSEDIEEASEARALGATCNGVRVWSLYVPNGRTLEDPHYQ
                                    :.*:.** *        ::****:.*** *:*:*********:: .*** 

Rv0427c|M.tuberculosis_H37Rv        YKLDWLAALRDTAEGWLRDDPAAPIALMGDWNIAPTDDDVWSTEFFAGCT
Mb0435c|M.bovis_AF2122/97           YKLDWLAALRDTAEGWLRDDPAAPIALMGDWNIAPTDDDVWSTEFFAGCT
MMAR_0742|M.marinum_M               YKLDWLAALRDTAQCWLKNDPGAPIALAGDFNIAPTDEDVWSTEFFTGAT
MUL_1374|M.ulcerans_Agy99           YKLDWLAALRDTAQCWLKNDPGAPIALAGDFNIAPTDEDVWNTEFFTGAT
MAV_4727|M.avium_104                YKLDWLAALRDSAAGWLREDPAAQIALAGDWNIAPQDDDVWSMEFFAGAT
Mflv_0177|M.gilvum_PYR-GCK          YKLKWLAALHNTAQGWLADDPSTPVALVGDWNIAPVDDDVWDISLFSEST
Mvan_0730|M.vanbaalenii_PYR-1       YKLEWLAALRDTASSWLESNPSAPIALVGDWNIAPIDDDVWDISLFQDST
TH_0019|M.thermoresistible__bu      YKLEWLGALRDTASKWLAADPAAQIALTGDWNIAPTDEDVWDIESYRDST
MSMEG_0829|M.smegmatis_MC2_155      YKLEWLAALRDNAQKWLADDPQAQIALTGDWNIAPTDEDVWDIDFFAGST
MAB_4189|M.abscessus_ATCC_1997      YKLRWLSALRDTAAGWLADAPDQQVALVGDWNIAPTDDDIWSVEAYQGST
                                    *** **.**::.*  **   *   :** **:**** *:*:*. . :  .*

Rv0427c|M.tuberculosis_H37Rv        HVSEPERKAFNAIVDAQFTDVVRPFTPGPGVYTYWDYTQLRFPKKQGMRI
Mb0435c|M.bovis_AF2122/97           HVSEPERKAFNAIVDAQFTDVVRPFTPGPGVYTYWDYTQLRFPKKQGMRI
MMAR_0742|M.marinum_M               HVSEPERKAFNAIVDAQFTDLVRPFTPGPGVYTYWDYTQLRFPKKQGMRI
MUL_1374|M.ulcerans_Agy99           RVSEPERKAFNAIVDAQFTDLVRPFTPGPGVYTYWYYTQLRFPKKQGMRI
MAV_4727|M.avium_104                HVSEPERRAFNAILDAQFADLVRPFAPGPGVYTYWDYTALRFPKRQGMRI
Mflv_0177|M.gilvum_PYR-GCK          HVTAPERAAFNAIVDAGFTDVVRPFTPGPGTFTYWDYTQLRFPKNRGMRI
Mvan_0730|M.vanbaalenii_PYR-1       HVTEPERAAFNAVVDAGFTDVVRPFTPGPGTFTYWDYTQLRFPKNRGMRI
TH_0019|M.thermoresistible__bu      HVTEPERAAFRAVVDAGYIDVVRPFTPGPGVYTYWDYTQLRFPKNRGMRI
MSMEG_0829|M.smegmatis_MC2_155      HVTEKERAAFQAIVDAQFADVVRPFAPGPGVYTYWDYTQLRFPKRQGMRI
MAB_4189|M.abscessus_ATCC_1997      HVSEPERSAFTAMNDAGFADVVRPFTPGPGVYTYWDYTQLSFPKKRGMRI
                                    :*:  ** ** *: ** : *:****:****.:*** ** * ***.:****

Rv0427c|M.tuberculosis_H37Rv        DFILGSPALAARVMDAQIVREERKG-----KAPSDHAPVLVDLHAG----
Mb0435c|M.bovis_AF2122/97           DFILGSPALAARVMDAQIVREERKG-----KAPSDHAPVLVDLHAG----
MMAR_0742|M.marinum_M               DFILGSPALAGRVVDAQIVRDERKG-----KAPSDHAPVFVDLRPGPAA-
MUL_1374|M.ulcerans_Agy99           DFILGSPALAGRVVDAQIVRDERKG-----KAPSDHAPVFVDLRPGPAA-
MAV_4727|M.avium_104                DFILGSPALARRVTHAQIDREERKG-----KGASDHAPVLVDVSRGEPPS
Mflv_0177|M.gilvum_PYR-GCK          DFILGSPTLAELVTHAEIARDERKTGKNRVGSPSDHAPVVVDLRT-----
Mvan_0730|M.vanbaalenii_PYR-1       DFILGSPALAERVVHAEIARDERKTGKNRVGSPSDHAPVVVDLCD-----
TH_0019|M.thermoresistible__bu      DFILGSPALAARVTHAEIVRDERRS-KGKVGPPSDHAPVLVQLD------
MSMEG_0829|M.smegmatis_MC2_155      DFILGSPAFAQRVGHAEIVREERKG-----KSPSDHAPVLVELN------
MAB_4189|M.abscessus_ATCC_1997      DFVLGSPEFAKRVGNAHIDREERKG-----KGASDHAPVVVDLD------
                                    **:**** :*  * .*.* *:**:        .******.*::

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv0427c	xthA	-	100% (291)	PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI)