For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLSTGDHFDLYDTSGPYTDTDTVIDLTAGLP HRPGVVRDRGTQLQRARAGEITAEMAFIAAREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAV KVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVK GDPTELTWEIYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYT NFEELCDIFARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIEGPGHIPMHKIV ENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAMLCYVTPKEHLGLPDRKDVKDGV IAYKIAAHAADLAKGHPRAQERDDALSTARFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMC GPKFCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLPITQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0423c | thiC | - | 100% (547) | thiamine biosynthesis protein ThiC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0431c | thiC | 0.0 | 100.00% (547) | thiamine biosynthesis protein ThiC |
| M. gilvum PYR-GCK | Mflv_0754 | - | 0.0 | 83.83% (538) | thiamine biosynthesis protein ThiC |
| M. leprae Br4923 | MLBr_00294 | thiC | 0.0 | 90.62% (544) | thiamine biosynthesis protein ThiC |
| M. abscessus ATCC 19977 | MAB_4196 | - | 0.0 | 86.06% (538) | thiamine biosynthesis protein ThiC |
| M. marinum M | MMAR_0735 | thiC | 0.0 | 92.14% (547) | thiamine biosynthesis protein ThiC |
| M. avium 104 | MAV_4731 | thiC | 0.0 | 90.88% (548) | thiamine biosynthesis protein ThiC |
| M. smegmatis MC2 155 | MSMEG_0826 | thiC | 0.0 | 85.69% (538) | thiamine biosynthesis protein ThiC |
| M. thermoresistible (build 8) | TH_1215 | thiC | 0.0 | 83.55% (547) | PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC |
| M. ulcerans Agy99 | MUL_3600 | thiC | 0.0 | 91.96% (547) | thiamine biosynthesis protein ThiC |
| M. vanbaalenii PYR-1 | Mvan_0725 | - | 0.0 | 83.46% (538) | thiamine biosynthesis protein ThiC |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4196|M.abscessus_ATCC_1997 ----MSTPSSRSQAPETVTTGPIQGSEKIYQELPNGL------RVPQRRV
Mvan_0725|M.vanbaalenii_PYR-1 ----MSDVVN-------VTTGPIAGSTKVYRNG-----------VPFRRV
Rv0423c|M.tuberculosis_H37Rv ----MTITVEPS-----VTTGPIAGSAKAYREIEAPG-SGATLQVPFRRV
Mb0431c|M.bovis_AF2122/97 ----MTITVEPS-----VTTGPIAGSAKAYREIEAPG-SGATLQVPFRRV
MMAR_0735|M.marinum_M ----MTVTVEPS-----ITTGPIAGSSKAYREVAGP--DGVTLRVPLRRV
MUL_3600|M.ulcerans_Agy99 ----MTVTVEPS-----ITTGPIAGSSKAYREVAGP--DGVTLRVPLRRV
MAV_4731|M.avium_104 ----MTAIVEPS-----VTTGPIAGSSKVYRELDGV--PGA--RVPFRRV
MLBr_00294|M.leprae_Br4923 MTETLSKTTEPS-----VTTGPIPGSSKAYREVANPD-GGPSLRVPFRRV
Mflv_0754|M.gilvum_PYR-GCK ---MTAVSDTVS-----VTTGPITGSSKVYRELSDG------GRVPFRRV
MSMEG_0826|M.smegmatis_MC2_155 -----------------MTTGPITGSTKAYREVEHPGVDVP-LRVPFRRV
TH_1215|M.thermoresistible__bu -VSDQSVAINPT-----VTTGPIAGSTKVYRELEG----VPGARVPYRRV
:***** ** * *:: ** ***
MAB_4196|M.abscessus_ATCC_1997 NLTNGEYLDLYDTSGPYTDTNAVIDLHKGLPPRAGIVTDRGTQLQRARAG
Mvan_0725|M.vanbaalenii_PYR-1 NLTTGEHLDLYDTSGPYTDAGAVIDLEAGLPHRR-VTRNRGTQLQRARAG
Rv0423c|M.tuberculosis_H37Rv HLSTGDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAG
Mb0431c|M.bovis_AF2122/97 HLSTGDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAG
MMAR_0735|M.marinum_M HLSTGADFDLYDTSGPYTDPNAVIDLAVGLPARPGLVRDRGTQLQRARAG
MUL_3600|M.ulcerans_Agy99 HLSTGADFDLYDTSGPYTDPNAVIDLAVGLPARPGLVRDRGTQLQRARAG
MAV_4731|M.avium_104 HLSTGDHFDLYDTSGPYTDPDATIDLTAGLPARPGRVRDRGTQLQRARAG
MLBr_00294|M.leprae_Br4923 HLSTGAHFDLYDTSGPYTDPDAVINLTAGLPPRPGVIRDRGTQLQRARAG
Mflv_0754|M.gilvum_PYR-GCK HLTTGDHLDLYDTSGPYTDDTAVIDLAAGLPERSGVVRDSGTQLMRARKG
MSMEG_0826|M.smegmatis_MC2_155 HLSDGDHLDLYDTSGPYTDTDAVIDLDAGLTPRPGVVRDRGTQLQRARAG
TH_1215|M.thermoresistible__bu HLSNGEHLDLYDTSGPYTDPDAVIDLSAGLPPRPGVVRDRGTQLQRARAG
:*: * :*********** :.*:* **. * : **** *** *
MAB_4196|M.abscessus_ATCC_1997 EITAEMEFIAVREGVPAELVRTEVAAGRAVIPANHKHPESEPMIIGKAFG
Mvan_0725|M.vanbaalenii_PYR-1 EITAEMAFIAEREGVSPELVRDEVARGRAVIPANHNHPEAEPMIIGKAFA
Rv0423c|M.tuberculosis_H37Rv EITAEMAFIAAREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFA
Mb0431c|M.bovis_AF2122/97 EITAEMAFIAAREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFA
MMAR_0735|M.marinum_M EITAEMAFIAAREGMSAELVRDEVALGRAVIPANHNHPESEPMVIGKAFA
MUL_3600|M.ulcerans_Agy99 EITAEMAFIAAREGMSAELVRDEVALGRAVIPANHNHPESEPMVIGKAFA
MAV_4731|M.avium_104 EITAEMAFIAAREGMPAELVRDEVARGRAVIPANHNHPEIEPMIIGKAFA
MLBr_00294|M.leprae_Br4923 EITAEMAFIADREGMPAELVRVEVALGRAVIPANHNHPEIEPMIIGKAFA
Mflv_0754|M.gilvum_PYR-GCK EITAEMAFIAEREGLPVELVRDEVARGRAVIPANHNHPESEPMIIGKAFA
MSMEG_0826|M.smegmatis_MC2_155 EITAEMAFIAEREGVPAELVRSEVARGRAVIPANHNHPESEPMIIGKAFG
TH_1215|M.thermoresistible__bu EITAEMAFIAEREGVPAELVRREVAAGRAVIPANHNHPEAEPMIIGKAFS
****** *** **.:. **** *** *********:*** ***:*****.
MAB_4196|M.abscessus_ATCC_1997 VKINANIGNSAVTSSIAEEVEKMVWAIRWGADNIMDLSTGKDIHQTREWI
Mvan_0725|M.vanbaalenii_PYR-1 VKINANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGRDIHQTREWI
Rv0423c|M.tuberculosis_H37Rv VKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWI
Mb0431c|M.bovis_AF2122/97 VKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWI
MMAR_0735|M.marinum_M VKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWI
MUL_3600|M.ulcerans_Agy99 VKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWI
MAV_4731|M.avium_104 TKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWI
MLBr_00294|M.leprae_Br4923 VKVNANIGNSAVTSSIAEEIDKMVWATRWGADTIMDLSTGKNIHETREWI
Mflv_0754|M.gilvum_PYR-GCK VKVNANIGNSAVTSSVAEEVDKMVWATRWGADTIMDLSTGADIHLTREWI
MSMEG_0826|M.smegmatis_MC2_155 VKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGRDIHLTREWI
TH_1215|M.thermoresistible__bu VKVNANIGNSAVTSSIEEEVDKMVWATRWGADTVMDLSTGRNIHETREWI
.*:************: **::***** *****.:****** :** *****
MAB_4196|M.abscessus_ATCC_1997 LRNSPVPVGTVPIYQALEKTNGDPAALTWELYRDTVIEQAEQGVDYMTVH
Mvan_0725|M.vanbaalenii_PYR-1 LRNSPVPVGTVPMYQALEKVGGDPVKLTWEVYRDTVIEQCEQGVDYMTVH
Rv0423c|M.tuberculosis_H37Rv LRNSPVPVGTVPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVH
Mb0431c|M.bovis_AF2122/97 LRNSPVPVGTVPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVH
MMAR_0735|M.marinum_M LRNSPVPVGTVPIYQALEKVKGDPTELTWELYRDTVIEQCEQGVDYMTVH
MUL_3600|M.ulcerans_Agy99 LRNSPVPVGTVPIYQALEKVKGDPTELTWELYRDTVIEQCEQGVDYMTVH
MAV_4731|M.avium_104 LRNSPVPVGTVPIYQALEKVKGDPTLLTWEIYRDTVIEQCEQGVDYMTVH
MLBr_00294|M.leprae_Br4923 LRNSPVPVGTVPIYQALEKVKGDPTKLTWEIYRDTVIEQCEQGVDYMTVH
Mflv_0754|M.gilvum_PYR-GCK LRNSPVPVGTVPIYQALEKVDGDPTQLTWKVYRDTVIEQCEQGVDYMTVH
MSMEG_0826|M.smegmatis_MC2_155 LRNSPVPVGTVPMYQALEKVNGDPTKLSWDVYRDTVIEQCEQGVDYMTVH
TH_1215|M.thermoresistible__bu LRNSPVPVGTVPIYQALEKVDGDPVKLTWEVYRDTVIEQCEQGVDYMTVH
************:******. ***. *:*.:********.**********
MAB_4196|M.abscessus_ATCC_1997 AGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTHFEELCEIL
Mvan_0725|M.vanbaalenii_PYR-1 AGVLLRHIPLTVDRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCGIL
Rv0423c|M.tuberculosis_H37Rv AGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIF
Mb0431c|M.bovis_AF2122/97 AGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIF
MMAR_0735|M.marinum_M AGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIL
MUL_3600|M.ulcerans_Agy99 AGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIL
MAV_4731|M.avium_104 AGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFDELCEIF
MLBr_00294|M.leprae_Br4923 AGVLLRYVLLTAKRVTGIVSRGGSIMASWCLANHRESFLYTNFAELCDIF
Mflv_0754|M.gilvum_PYR-GCK AGVLLRYIPLTVNRVTGIVSRGGSIMAAWMLAHHTESFLYTHFAELCEIL
MSMEG_0826|M.smegmatis_MC2_155 AGVLLRHIPLTVDRVTGIVSRGGSIMAAWCLAHHTESFLYTNFEELCEIF
TH_1215|M.thermoresistible__bu AGVLLRYIPLTVDRVTGIVSRGGSIMAAWCLAHHQESFLYTHFEELCEIL
******:: **..**************:* **:* ******:* *** *:
MAB_4196|M.abscessus_ATCC_1997 ARYDVTFSLGDGLRPGSIADANDEAQFAELRTLGELTKIAKSHGVQVMIE
Mvan_0725|M.vanbaalenii_PYR-1 ARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTGMAKSHGVQVMIE
Rv0423c|M.tuberculosis_H37Rv ARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIE
Mb0431c|M.bovis_AF2122/97 ARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIE
MMAR_0735|M.marinum_M ARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGVQVMIE
MUL_3600|M.ulcerans_Agy99 ARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGVQVMIE
MAV_4731|M.avium_104 ARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKSHGVQVMIE
MLBr_00294|M.leprae_Br4923 ARYDVTFSLGDGLRPGSIADANDTAQFAELRTLGELSKIAKVHGAQVMIE
Mflv_0754|M.gilvum_PYR-GCK ARYDVTFSLGDGLRPGSIADANDEAQFAELRTLGELTKIAKAHGVQVMIE
MSMEG_0826|M.smegmatis_MC2_155 ARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTTIAKNHGVQVMIE
TH_1215|M.thermoresistible__bu ARYDVTFSLGDGLRPGSIADANDEAQFAELRTLGELTKIAKSHGAQVMIE
*********************** ************: :** **.*****
MAB_4196|M.abscessus_ATCC_1997 GPGHVPMHKIVENVKLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAA
Mvan_0725|M.vanbaalenii_PYR-1 GPGHVPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAA
Rv0423c|M.tuberculosis_H37Rv GPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAA
Mb0431c|M.bovis_AF2122/97 GPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAA
MMAR_0735|M.marinum_M GPGHVPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAA
MUL_3600|M.ulcerans_Agy99 GPGHVPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAA
MAV_4731|M.avium_104 GPGHVPMHKIVENVRLEEEWCEEAPFYTLGPLATDIAPAYDHITSAIGAA
MLBr_00294|M.leprae_Br4923 GPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAA
Mflv_0754|M.gilvum_PYR-GCK GPGHVPMHKIVENVRLEEELCEEAPFYTLGPLTTDIAPAYDHITSAIGAA
MSMEG_0826|M.smegmatis_MC2_155 GPGHVPMHKIVENVRLEEELCDDAPFYTLGPLATDIAPAYDHITSAIGAA
TH_1215|M.thermoresistible__bu GPGHVPMHKIAENVRLEEEWCEEAPFYTLGPLATDIAPGYDHITSAIGAS
****:*****.***:**** *::*********:*****.**********:
MAB_4196|M.abscessus_ATCC_1997 IIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHSADLAKGHPRA
Mvan_0725|M.vanbaalenii_PYR-1 IIAQAGTAMLCYVTPKEHLGLPNRKDVKDGVIAYKIAAHAADLAKGHPGA
Rv0423c|M.tuberculosis_H37Rv IIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRA
Mb0431c|M.bovis_AF2122/97 IIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRA
MMAR_0735|M.marinum_M IIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAGDLAKGHPHA
MUL_3600|M.ulcerans_Agy99 IIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAGDLAKGHPHA
MAV_4731|M.avium_104 IIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAGDLAKGHPHA
MLBr_00294|M.leprae_Br4923 VIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGYPRA
Mflv_0754|M.gilvum_PYR-GCK IIAQAGTAMLCYVTPKEHLGLPDRSDVKTGVITYKIAAHAADLAKAHPRA
MSMEG_0826|M.smegmatis_MC2_155 IIAQAGTAMLCYVTPKEHLGLPNRQDVKDGVIAYKIAAHSADLAKGHPRA
TH_1215|M.thermoresistible__bu IIAQAGTAMLCYVTPKEHLGLPNRQDVKDGVIAYKIAAHAADLAKGHPRA
:*********************:*.*** ***:******:.****.:* *
MAB_4196|M.abscessus_ATCC_1997 QLRDNALSKARFEFRWEDQFNLSLDPDTAREFHDETLPAEPAKTAHFCSM
Mvan_0725|M.vanbaalenii_PYR-1 QARDDALSKARFEFRWEDQFNLSLDPDTAREFHDETLPATPAKTAHFCSM
Rv0423c|M.tuberculosis_H37Rv QERDDALSTARFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSM
Mb0431c|M.bovis_AF2122/97 QERDDALSTARFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSM
MMAR_0735|M.marinum_M QERDNALSQARFEFRWNDQFALSLDPDTAREYHDETLPAEPAKTAHFCSM
MUL_3600|M.ulcerans_Agy99 QERDNALSQARFEFRWNDQFALSLDPDTAREYHDETLPAEPAKTAHFCSM
MAV_4731|M.avium_104 QERDNALSQARFEFRWNDQFALSLDPDTAREYHDETLPAEPAKTAHFCSM
MLBr_00294|M.leprae_Br4923 QERDDALSTARFEFRWNDQFALSLDPPTAREFHDETLPAEPAKTAHFCSM
Mflv_0754|M.gilvum_PYR-GCK QERDDALSTARFEFRWNDQFALSLDPDSACGFHDETLPAVPAKTAHFCSM
MSMEG_0826|M.smegmatis_MC2_155 QQRDDALSKARFEFRWHDQFALSLDPDTAREFHDETLPAEPAKTAHFCSM
TH_1215|M.thermoresistible__bu QQRDDALSKARFEFRWHDQFALSLDPDTAREYHDETLPAEPAKTAHFCSM
* **:*** *******.*** ***** :* :******* **********
MAB_4196|M.abscessus_ATCC_1997 CGPKFCSMRITADIREFAAENGLETQEDIDAMLARGMEEKSAEFAEHGNR
Mvan_0725|M.vanbaalenii_PYR-1 CGPKFCSMRISHEVQE-------------------AMKEKSREFADQGNK
Rv0423c|M.tuberculosis_H37Rv CGPKFCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNR
Mb0431c|M.bovis_AF2122/97 CGPKFCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNR
MMAR_0735|M.marinum_M CGPKFCSMRITQDVRDYAAKHGLDSEEAIEAALEAGMAEKSAEFADHGNR
MUL_3600|M.ulcerans_Agy99 CGPKFCSMRITRDVRDYAAKHGLDSEEAIEAALEAGMAEKSAEFADHGNR
MAV_4731|M.avium_104 CGPKFCSMRITQDVRDYAAKHGLDSEEAIEAA----MADKSREFAEHGNR
MLBr_00294|M.leprae_Br4923 CGPKFCSMRITADIRVYAAKHGLDTEEAIEMG----MTEKSAEFAEHGNR
Mflv_0754|M.gilvum_PYR-GCK CGPKFCSMRISRDVRDAYEKG---------------MTDKSQEFAKHGNR
MSMEG_0826|M.smegmatis_MC2_155 CGPKFCSMRITADLKDS---------------IREAMDQKSAEFAEQGNR
TH_1215|M.thermoresistible__bu CGPRFCSMRITADIRD-------------------AMAQKSREFAEHGNQ
***:******: ::: * :** ***.:**:
MAB_4196|M.abscessus_ATCC_1997 VYLPIA----
Mvan_0725|M.vanbaalenii_PYR-1 VYLPVVTS--
Rv0423c|M.tuberculosis_H37Rv VYLPITQ---
Mb0431c|M.bovis_AF2122/97 VYLPITQ---
MMAR_0735|M.marinum_M VYLPITQ---
MUL_3600|M.ulcerans_Agy99 VYLPITQ---
MAV_4731|M.avium_104 VYLPLAQ---
MLBr_00294|M.leprae_Br4923 VYLPLTQ---
Mflv_0754|M.gilvum_PYR-GCK IYLPLHP---
MSMEG_0826|M.smegmatis_MC2_155 VYLPLTS---
TH_1215|M.thermoresistible__bu VYLPLEEVRP
:***: