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SDVVNVTTGPIAGSTKVYRNGVPFRRVNLTTGEHLDLYDTSGPYTDAGAVIDLEAGLPHRRVTRNRGTQL QRARAGEITAEMAFIAEREGVSPELVRDEVARGRAVIPANHNHPEAEPMIIGKAFAVKINANIGNSAVTS SIAEEVDKMVWATRWGADTIMDLSTGRDIHQTREWILRNSPVPVGTVPMYQALEKVGGDPVKLTWEVYRD TVIEQCEQGVDYMTVHAGVLLRHIPLTVDRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCGILARYD VTFSLGDGLRPGSIADANDAAQFAELRTLGELTGMAKSHGVQVMIEGPGHVPMHKIVENVRLEEELCEEA PFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAMLCYVTPKEHLGLPNRKDVKDGVIAYKIAAHAADLA KGHPGAQARDDALSKARFEFRWEDQFNLSLDPDTAREFHDETLPATPAKTAHFCSMCGPKFCSMRISHEV QEAMKEKSREFADQGNKVYLPVVTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0725 | - | - | 100% (516) | thiamine biosynthesis protein ThiC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0431c | thiC | 0.0 | 83.46% (538) | thiamine biosynthesis protein ThiC |
| M. gilvum PYR-GCK | Mflv_0754 | - | 0.0 | 84.70% (523) | thiamine biosynthesis protein ThiC |
| M. tuberculosis H37Rv | Rv0423c | thiC | 0.0 | 83.46% (538) | thiamine biosynthesis protein ThiC |
| M. leprae Br4923 | MLBr_00294 | thiC | 0.0 | 81.27% (534) | thiamine biosynthesis protein ThiC |
| M. abscessus ATCC 19977 | MAB_4196 | - | 0.0 | 83.08% (532) | thiamine biosynthesis protein ThiC |
| M. marinum M | MMAR_0735 | thiC | 0.0 | 82.50% (537) | thiamine biosynthesis protein ThiC |
| M. avium 104 | MAV_4731 | thiC | 0.0 | 84.02% (532) | thiamine biosynthesis protein ThiC |
| M. smegmatis MC2 155 | MSMEG_0826 | thiC | 0.0 | 86.64% (524) | thiamine biosynthesis protein ThiC |
| M. thermoresistible (build 8) | TH_1215 | thiC | 0.0 | 87.38% (515) | PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC |
| M. ulcerans Agy99 | MUL_3600 | thiC | 0.0 | 82.50% (537) | thiamine biosynthesis protein ThiC |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0826|M.smegmatis_MC2_155 -------------MTTGPITGSTKAYREVEHPGVDVP-LRVPFRRVHLSD
TH_1215|M.thermoresistible__bu --VSDQSVAINPTVTTGPIAGSTKVYRELEG----VPGARVPYRRVHLSN
Mb0431c|M.bovis_AF2122/97 -----MTITVEPSVTTGPIAGSAKAYREIEAPG-SGATLQVPFRRVHLST
Rv0423c|M.tuberculosis_H37Rv -----MTITVEPSVTTGPIAGSAKAYREIEAPG-SGATLQVPFRRVHLST
MMAR_0735|M.marinum_M -----MTVTVEPSITTGPIAGSSKAYREVAGP--DGVTLRVPLRRVHLST
MUL_3600|M.ulcerans_Agy99 -----MTVTVEPSITTGPIAGSSKAYREVAGP--DGVTLRVPLRRVHLST
MAV_4731|M.avium_104 -----MTAIVEPSVTTGPIAGSSKVYRELDGV--PGA--RVPFRRVHLST
MLBr_00294|M.leprae_Br4923 -MTETLSKTTEPSVTTGPIPGSSKAYREVANPD-GGPSLRVPFRRVHLST
Mflv_0754|M.gilvum_PYR-GCK ----MTAVSDTVSVTTGPITGSSKVYRELSDG------GRVPFRRVHLTT
Mvan_0725|M.vanbaalenii_PYR-1 -------MSDVVNVTTGPIAGSTKVYR-----------NGVPFRRVNLTT
MAB_4196|M.abscessus_ATCC_1997 MSTPSSRSQAPETVTTGPIQGSEKIYQELPNG------LRVPQRRVNLTN
:***** ** * *: ** ***:*:
MSMEG_0826|M.smegmatis_MC2_155 GDHLDLYDTSGPYTDTDAVIDLDAGLTPRPGVVRDRGTQLQRARAGEITA
TH_1215|M.thermoresistible__bu GEHLDLYDTSGPYTDPDAVIDLSAGLPPRPGVVRDRGTQLQRARAGEITA
Mb0431c|M.bovis_AF2122/97 GDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITA
Rv0423c|M.tuberculosis_H37Rv GDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITA
MMAR_0735|M.marinum_M GADFDLYDTSGPYTDPNAVIDLAVGLPARPGLVRDRGTQLQRARAGEITA
MUL_3600|M.ulcerans_Agy99 GADFDLYDTSGPYTDPNAVIDLAVGLPARPGLVRDRGTQLQRARAGEITA
MAV_4731|M.avium_104 GDHFDLYDTSGPYTDPDATIDLTAGLPARPGRVRDRGTQLQRARAGEITA
MLBr_00294|M.leprae_Br4923 GAHFDLYDTSGPYTDPDAVINLTAGLPPRPGVIRDRGTQLQRARAGEITA
Mflv_0754|M.gilvum_PYR-GCK GDHLDLYDTSGPYTDDTAVIDLAAGLPERSGVVRDSGTQLMRARKGEITA
Mvan_0725|M.vanbaalenii_PYR-1 GEHLDLYDTSGPYTDAGAVIDLEAGLPHRR-VTRNRGTQLQRARAGEITA
MAB_4196|M.abscessus_ATCC_1997 GEYLDLYDTSGPYTDTNAVIDLHKGLPPRAGIVTDRGTQLQRARAGEITA
* :*********** :.*:* **. * : **** *** *****
MSMEG_0826|M.smegmatis_MC2_155 EMAFIAEREGVPAELVRSEVARGRAVIPANHNHPESEPMIIGKAFGVKVN
TH_1215|M.thermoresistible__bu EMAFIAEREGVPAELVRREVAAGRAVIPANHNHPEAEPMIIGKAFSVKVN
Mb0431c|M.bovis_AF2122/97 EMAFIAAREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVN
Rv0423c|M.tuberculosis_H37Rv EMAFIAAREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVN
MMAR_0735|M.marinum_M EMAFIAAREGMSAELVRDEVALGRAVIPANHNHPESEPMVIGKAFAVKVN
MUL_3600|M.ulcerans_Agy99 EMAFIAAREGMSAELVRDEVALGRAVIPANHNHPESEPMVIGKAFAVKVN
MAV_4731|M.avium_104 EMAFIAAREGMPAELVRDEVARGRAVIPANHNHPEIEPMIIGKAFATKVN
MLBr_00294|M.leprae_Br4923 EMAFIADREGMPAELVRVEVALGRAVIPANHNHPEIEPMIIGKAFAVKVN
Mflv_0754|M.gilvum_PYR-GCK EMAFIAEREGLPVELVRDEVARGRAVIPANHNHPESEPMIIGKAFAVKVN
Mvan_0725|M.vanbaalenii_PYR-1 EMAFIAEREGVSPELVRDEVARGRAVIPANHNHPEAEPMIIGKAFAVKIN
MAB_4196|M.abscessus_ATCC_1997 EMEFIAVREGVPAELVRTEVAAGRAVIPANHKHPESEPMIIGKAFGVKIN
** *** **.:. **** *** *********:*** ***:*****..*:*
MSMEG_0826|M.smegmatis_MC2_155 ANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGRDIHLTREWILRNS
TH_1215|M.thermoresistible__bu ANIGNSAVTSSIEEEVDKMVWATRWGADTVMDLSTGRNIHETREWILRNS
Mb0431c|M.bovis_AF2122/97 ANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNS
Rv0423c|M.tuberculosis_H37Rv ANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNS
MMAR_0735|M.marinum_M ANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNS
MUL_3600|M.ulcerans_Agy99 ANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNS
MAV_4731|M.avium_104 ANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNS
MLBr_00294|M.leprae_Br4923 ANIGNSAVTSSIAEEIDKMVWATRWGADTIMDLSTGKNIHETREWILRNS
Mflv_0754|M.gilvum_PYR-GCK ANIGNSAVTSSVAEEVDKMVWATRWGADTIMDLSTGADIHLTREWILRNS
Mvan_0725|M.vanbaalenii_PYR-1 ANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGRDIHQTREWILRNS
MAB_4196|M.abscessus_ATCC_1997 ANIGNSAVTSSIAEEVEKMVWAIRWGADNIMDLSTGKDIHQTREWILRNS
***********: **::***** *****.:****** :** *********
MSMEG_0826|M.smegmatis_MC2_155 PVPVGTVPMYQALEKVNGDPTKLSWDVYRDTVIEQCEQGVDYMTVHAGVL
TH_1215|M.thermoresistible__bu PVPVGTVPIYQALEKVDGDPVKLTWEVYRDTVIEQCEQGVDYMTVHAGVL
Mb0431c|M.bovis_AF2122/97 PVPVGTVPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVHAGVL
Rv0423c|M.tuberculosis_H37Rv PVPVGTVPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVHAGVL
MMAR_0735|M.marinum_M PVPVGTVPIYQALEKVKGDPTELTWELYRDTVIEQCEQGVDYMTVHAGVL
MUL_3600|M.ulcerans_Agy99 PVPVGTVPIYQALEKVKGDPTELTWELYRDTVIEQCEQGVDYMTVHAGVL
MAV_4731|M.avium_104 PVPVGTVPIYQALEKVKGDPTLLTWEIYRDTVIEQCEQGVDYMTVHAGVL
MLBr_00294|M.leprae_Br4923 PVPVGTVPIYQALEKVKGDPTKLTWEIYRDTVIEQCEQGVDYMTVHAGVL
Mflv_0754|M.gilvum_PYR-GCK PVPVGTVPIYQALEKVDGDPTQLTWKVYRDTVIEQCEQGVDYMTVHAGVL
Mvan_0725|M.vanbaalenii_PYR-1 PVPVGTVPMYQALEKVGGDPVKLTWEVYRDTVIEQCEQGVDYMTVHAGVL
MAB_4196|M.abscessus_ATCC_1997 PVPVGTVPIYQALEKTNGDPAALTWELYRDTVIEQAEQGVDYMTVHAGVL
********:******. ***. *:*.:********.**************
MSMEG_0826|M.smegmatis_MC2_155 LRHIPLTVDRVTGIVSRGGSIMAAWCLAHHTESFLYTNFEELCEIFARYD
TH_1215|M.thermoresistible__bu LRYIPLTVDRVTGIVSRGGSIMAAWCLAHHQESFLYTHFEELCEILARYD
Mb0431c|M.bovis_AF2122/97 LRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIFARYD
Rv0423c|M.tuberculosis_H37Rv LRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIFARYD
MMAR_0735|M.marinum_M LRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDILARYD
MUL_3600|M.ulcerans_Agy99 LRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDILARYD
MAV_4731|M.avium_104 LRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFDELCEIFARYD
MLBr_00294|M.leprae_Br4923 LRYVLLTAKRVTGIVSRGGSIMASWCLANHRESFLYTNFAELCDIFARYD
Mflv_0754|M.gilvum_PYR-GCK LRYIPLTVNRVTGIVSRGGSIMAAWMLAHHTESFLYTHFAELCEILARYD
Mvan_0725|M.vanbaalenii_PYR-1 LRHIPLTVDRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCGILARYD
MAB_4196|M.abscessus_ATCC_1997 LRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTHFEELCEILARYD
**:: **..**************:* **:* ******:* *** *:****
MSMEG_0826|M.smegmatis_MC2_155 VTFSLGDGLRPGSIADANDAAQFAELRTLGELTTIAKNHGVQVMIEGPGH
TH_1215|M.thermoresistible__bu VTFSLGDGLRPGSIADANDEAQFAELRTLGELTKIAKSHGAQVMIEGPGH
Mb0431c|M.bovis_AF2122/97 VTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIEGPGH
Rv0423c|M.tuberculosis_H37Rv VTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIEGPGH
MMAR_0735|M.marinum_M VTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGVQVMIEGPGH
MUL_3600|M.ulcerans_Agy99 VTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGVQVMIEGPGH
MAV_4731|M.avium_104 VTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKSHGVQVMIEGPGH
MLBr_00294|M.leprae_Br4923 VTFSLGDGLRPGSIADANDTAQFAELRTLGELSKIAKVHGAQVMIEGPGH
Mflv_0754|M.gilvum_PYR-GCK VTFSLGDGLRPGSIADANDEAQFAELRTLGELTKIAKAHGVQVMIEGPGH
Mvan_0725|M.vanbaalenii_PYR-1 VTFSLGDGLRPGSIADANDAAQFAELRTLGELTGMAKSHGVQVMIEGPGH
MAB_4196|M.abscessus_ATCC_1997 VTFSLGDGLRPGSIADANDEAQFAELRTLGELTKIAKSHGVQVMIEGPGH
******************* ************: :** **.*********
MSMEG_0826|M.smegmatis_MC2_155 VPMHKIVENVRLEEELCDDAPFYTLGPLATDIAPAYDHITSAIGAAIIAQ
TH_1215|M.thermoresistible__bu VPMHKIAENVRLEEEWCEEAPFYTLGPLATDIAPGYDHITSAIGASIIAQ
Mb0431c|M.bovis_AF2122/97 IPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQ
Rv0423c|M.tuberculosis_H37Rv IPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQ
MMAR_0735|M.marinum_M VPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQ
MUL_3600|M.ulcerans_Agy99 VPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQ
MAV_4731|M.avium_104 VPMHKIVENVRLEEEWCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQ
MLBr_00294|M.leprae_Br4923 IPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAVIAQ
Mflv_0754|M.gilvum_PYR-GCK VPMHKIVENVRLEEELCEEAPFYTLGPLTTDIAPAYDHITSAIGAAIIAQ
Mvan_0725|M.vanbaalenii_PYR-1 VPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQ
MAB_4196|M.abscessus_ATCC_1997 VPMHKIVENVKLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQ
:*****.***:**** *::*********:*****.**********::***
MSMEG_0826|M.smegmatis_MC2_155 AGTAMLCYVTPKEHLGLPNRQDVKDGVIAYKIAAHSADLAKGHPRAQQRD
TH_1215|M.thermoresistible__bu AGTAMLCYVTPKEHLGLPNRQDVKDGVIAYKIAAHAADLAKGHPRAQQRD
Mb0431c|M.bovis_AF2122/97 AGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERD
Rv0423c|M.tuberculosis_H37Rv AGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERD
MMAR_0735|M.marinum_M AGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAGDLAKGHPHAQERD
MUL_3600|M.ulcerans_Agy99 AGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAGDLAKGHPHAQERD
MAV_4731|M.avium_104 AGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAGDLAKGHPHAQERD
MLBr_00294|M.leprae_Br4923 AGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGYPRAQERD
Mflv_0754|M.gilvum_PYR-GCK AGTAMLCYVTPKEHLGLPDRSDVKTGVITYKIAAHAADLAKAHPRAQERD
Mvan_0725|M.vanbaalenii_PYR-1 AGTAMLCYVTPKEHLGLPNRKDVKDGVIAYKIAAHAADLAKGHPGAQARD
MAB_4196|M.abscessus_ATCC_1997 AGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHSADLAKGHPRAQLRD
******************:*.*** ***:******:.****.:* ** **
MSMEG_0826|M.smegmatis_MC2_155 DALSKARFEFRWHDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPK
TH_1215|M.thermoresistible__bu DALSKARFEFRWHDQFALSLDPDTAREYHDETLPAEPAKTAHFCSMCGPR
Mb0431c|M.bovis_AF2122/97 DALSTARFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPK
Rv0423c|M.tuberculosis_H37Rv DALSTARFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPK
MMAR_0735|M.marinum_M NALSQARFEFRWNDQFALSLDPDTAREYHDETLPAEPAKTAHFCSMCGPK
MUL_3600|M.ulcerans_Agy99 NALSQARFEFRWNDQFALSLDPDTAREYHDETLPAEPAKTAHFCSMCGPK
MAV_4731|M.avium_104 NALSQARFEFRWNDQFALSLDPDTAREYHDETLPAEPAKTAHFCSMCGPK
MLBr_00294|M.leprae_Br4923 DALSTARFEFRWNDQFALSLDPPTAREFHDETLPAEPAKTAHFCSMCGPK
Mflv_0754|M.gilvum_PYR-GCK DALSTARFEFRWNDQFALSLDPDSACGFHDETLPAVPAKTAHFCSMCGPK
Mvan_0725|M.vanbaalenii_PYR-1 DALSKARFEFRWEDQFNLSLDPDTAREFHDETLPATPAKTAHFCSMCGPK
MAB_4196|M.abscessus_ATCC_1997 NALSKARFEFRWEDQFNLSLDPDTAREFHDETLPAEPAKTAHFCSMCGPK
:*** *******.*** ***** :* :******* *************:
MSMEG_0826|M.smegmatis_MC2_155 FCSMRITADLKDS---------------IREAMDQKSAEFAEQGNRVYLP
TH_1215|M.thermoresistible__bu FCSMRITADIRD-------------------AMAQKSREFAEHGNQVYLP
Mb0431c|M.bovis_AF2122/97 FCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLP
Rv0423c|M.tuberculosis_H37Rv FCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLP
MMAR_0735|M.marinum_M FCSMRITQDVRDYAAKHGLDSEEAIEAALEAGMAEKSAEFADHGNRVYLP
MUL_3600|M.ulcerans_Agy99 FCSMRITRDVRDYAAKHGLDSEEAIEAALEAGMAEKSAEFADHGNRVYLP
MAV_4731|M.avium_104 FCSMRITQDVRDYAAKHGLDSEEAIEAA----MADKSREFAEHGNRVYLP
MLBr_00294|M.leprae_Br4923 FCSMRITADIRVYAAKHGLDTEEAIEMG----MTEKSAEFAEHGNRVYLP
Mflv_0754|M.gilvum_PYR-GCK FCSMRISRDVRDAYEKG---------------MTDKSQEFAKHGNRIYLP
Mvan_0725|M.vanbaalenii_PYR-1 FCSMRISHEVQEA-------------------MKEKSREFADQGNKVYLP
MAB_4196|M.abscessus_ATCC_1997 FCSMRITADIREFAAENGLETQEDIDAMLARGMEEKSAEFAEHGNRVYLP
******: ::: * :** ***.:**::***
MSMEG_0826|M.smegmatis_MC2_155 LTS---
TH_1215|M.thermoresistible__bu LEEVRP
Mb0431c|M.bovis_AF2122/97 ITQ---
Rv0423c|M.tuberculosis_H37Rv ITQ---
MMAR_0735|M.marinum_M ITQ---
MUL_3600|M.ulcerans_Agy99 ITQ---
MAV_4731|M.avium_104 LAQ---
MLBr_00294|M.leprae_Br4923 LTQ---
Mflv_0754|M.gilvum_PYR-GCK LHP---
Mvan_0725|M.vanbaalenii_PYR-1 VVTS--
MAB_4196|M.abscessus_ATCC_1997 IA----
: