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VRSIDVVVEAVVTFAGAAGFAHTLAPLRRGQQDPCFRVPGDGTIWRTSLLPTGPVTARISRAGRDAARCV AWGSGAEEFVDMAPAMLGAADDASDFVPLHPAVAAAHRRLPNLRLGRTGQVLEALIPAVIEQRVPGADAF RSWRLLVSKYGTQAPGPAPPGMRVPPSAEVWRHIPSWEFHRANVDPGRARAVVGCAQRAASLERLVSLPA ARAAEALTSLPGVGVWTAAETTQRVFGDADAVSVGDYHIPKMIGWTLVGRPVDDAGMLELLEPMRPHRHR VVRLLEASGLAREPRRGPRLPVQNIRAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0142 | - | - | 100% (308) | hypothetical protein Rv0142 |
| M. tuberculosis H37Rv | Rv1317c | alkA | 5e-06 | 27.76% (263) | bifunctional methylated-DNA--protein-cysteine |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0147 | - | 1e-179 | 100.00% (308) | hypothetical protein Mb0147 |
| M. gilvum PYR-GCK | Mflv_1111 | - | 1e-110 | 63.21% (299) | hypothetical protein Mflv_1111 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0395c | - | 4e-57 | 43.86% (285) | hypothetical protein MAB_0395c |
| M. marinum M | MMAR_0352 | - | 1e-149 | 82.84% (303) | DNA glycosylase |
| M. avium 104 | MAV_5154 | - | 1e-143 | 82.49% (297) | hypothetical protein MAV_5154 |
| M. smegmatis MC2 155 | MSMEG_6468 | - | 1e-115 | 68.35% (297) | hypothetical protein MSMEG_6468 |
| M. thermoresistible (build 8) | TH_0074 | - | 3e-23 | 52.63% (95) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3945 | alkA | 1e-07 | 29.00% (269) | Ada regulatory protein AlkA |
| M. vanbaalenii PYR-1 | Mvan_5701 | - | 1e-114 | 64.78% (301) | hypothetical protein Mvan_5701 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0142|M.tuberculosis_H37Rv --------------------------------------------------
Mb0147|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0352|M.marinum_M --------------------------------------------------
MAV_5154|M.avium_104 --------------------------------------------------
Mflv_1111|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5701|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6468|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0395c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0074|M.thermoresistible__bu --------------------------------------------------
MUL_3945|M.ulcerans_Agy99 MHEDFERCYRAVQSKDARFDGWFVTAVLTTRIYCRPSCPVRPPFARNVRF
Rv0142|M.tuberculosis_H37Rv --------------------------------------------------
Mb0147|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0352|M.marinum_M --------------------------------------------------
MAV_5154|M.avium_104 --------------------------------------------------
Mflv_1111|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5701|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6468|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0395c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0074|M.thermoresistible__bu --------------------------------------------------
MUL_3945|M.ulcerans_Agy99 LPTAAAAQREGFRACKRCRPDASPGSPEWNMRGDIVARAMRLVADGTVDR
Rv0142|M.tuberculosis_H37Rv --------------------------------------------------
Mb0147|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0352|M.marinum_M --------------------------------------------------
MAV_5154|M.avium_104 --------------------------------------------------
Mflv_1111|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5701|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6468|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0395c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0074|M.thermoresistible__bu --------------------------------------------------
MUL_3945|M.ulcerans_Agy99 EGVTGLAARLGYTTRQLERLLQAEVGAGPLALARAQRMQTARVLIETTDL
Rv0142|M.tuberculosis_H37Rv --------------------------------MRSIDVVVEAVVTFAGAA
Mb0147|M.bovis_AF2122/97 --------------------------------MRSIDVVVEAVVTFAGAA
MMAR_0352|M.marinum_M -------------------------------------MKIERTVTFAGAA
MAV_5154|M.avium_104 ------------------------------------MKSSARTVVFPGAV
Mflv_1111|M.gilvum_PYR-GCK ------------------------------------MTGSTAGVVFPGPV
Mvan_5701|M.vanbaalenii_PYR-1 ------------------------------------MR-ISASVEFAGPV
MSMEG_6468|M.smegmatis_MC2_155 -------------------------------------------MVFSGPA
MAB_0395c|M.abscessus_ATCC_199 -------------------------------------------------M
TH_0074|M.thermoresistible__bu -----------------------------------VDAAVRRSVVFAGPV
MUL_3945|M.ulcerans_Agy99 PFGDVAFAAGFSSIRQFNDTIRLVCDSTPTALRRHAAARFGAPATSPGTV
Rv0142|M.tuberculosis_H37Rv GFAHTLAP---------LRRGQQDPCFRVPGDGTIWRTSLLPTGPVTARI
Mb0147|M.bovis_AF2122/97 GFAHTLAP---------LRRGQQDPCFRVPGDGTIWRTSLLPTGPVTARI
MMAR_0352|M.marinum_M GFGHTLAP---------LRRGRGDPCFRVPGDGTIWRTSLLGSGPVAARF
MAV_5154|M.avium_104 SFGHTLAP---------LRRGLGDPCFLAPGDGSIWRTSLLPTGPVTARI
Mflv_1111|M.gilvum_PYR-GCK RPGWTLSP---------LRRGRADPCYHDAPDGAIWRTSLMRSGPVTARI
Mvan_5701|M.vanbaalenii_PYR-1 NPGWTLSP---------LRRGRGDPCYHDASDGAIWRTSLMRSGPVTARL
MSMEG_6468|M.smegmatis_MC2_155 SPGLTLAP---------LRRGGIDPCYRVDAAGAIWRTSLMPSGPVTARI
MAB_0395c|M.abscessus_ATCC_199 DIRRTLGI---------HRRGSGDPAYRVSPGGSIIRGSYTPDGPGVLAI
TH_0074|M.thermoresistible__bu SPGLTLAP---------LRRGRGDPCHHDSPDGSIWRTSLMADGPVTVRI
MUL_3945|M.ulcerans_Agy99 SLRLPVRTPFAYQGVFGHLAAGAVPGCEEVRDGAYRRTLRLSSGNGIVTL
.: . * *: * * :
Rv0142|M.tuberculosis_H37Rv SRAGRDAARCVAWGSG-----AEEFVDMAPAMLGAADDASDFVPLHPAVA
Mb0147|M.bovis_AF2122/97 SRAGRDAARCVAWGSG-----AEEFVDMAPAMLGAADDASDFVPLHPAVA
MMAR_0352|M.marinum_M SRCAPDTAHCQAWGSG-----AEEFIDRLPALLGADDDAADFVPRDPTVA
MAV_5154|M.avium_104 SRAGTNAVQCVAWGAG-----AAQFVDMLPAMLGSEDDASDFVPRHPTVA
Mflv_1111|M.gilvum_PYR-GCK SHSARDTIDCEAWGPG-----AAEFTEGLPALLGADDDATGFDPADPTIA
Mvan_5701|M.vanbaalenii_PYR-1 SRSAPATVDCEAWGPG-----AAEFTDTLPGLLGADDDAAGFDPQEPTVA
MSMEG_6468|M.smegmatis_MC2_155 TRAATDAADCQAWGEG-----ADEFIDRLPALLGVDDDASDFAPAEPTIA
MAB_0395c|M.abscessus_ATCC_199 SRADKTVVG-RAYGDG-----AEWLLDRLPRLLGADDEPEALTPKHDTVA
TH_0074|M.thermoresistible__bu ARTGERSVECRMWGAG-----ATEFAESLPAFLGADDDPSGFRPHX---X
MUL_3945|M.ulcerans_Agy99 TPAPDHVRCLLVLDDFRDLAAATARCRRLLDLGADPEAVVEALSGDPALS
: . * : . : .
Rv0142|M.tuberculosis_H37Rv AAHRRLPNLRLGRTGQVLEALIPAVIEQRVPGADAFRSWRLLVSKYGTQA
Mb0147|M.bovis_AF2122/97 AAHRRLPNLRLGRTGQVLEALIPAVIEQRVPGADAFRSWRLLVSKYGTQA
MMAR_0352|M.marinum_M AAHRRLPNLRLGRTGQVLEAVLPAVIEQRVPGAEAFRSWRLLVTRYGTPA
MAV_5154|M.avium_104 AAQRRVPHLRLGRTGLVLEALIPAIIEQRVPGADAFRSWRVLVSKYGTPA
Mflv_1111|M.gilvum_PYR-GCK KAAGRAAHLRLGRTGRVLEALVPAILEQRVVGKDARRSWRQLVTEYGAPA
Mvan_5701|M.vanbaalenii_PYR-1 AALRKAPHLRLGRTGRVLEAIIPAVLEQRVVGKDAFRAWRLLVTRYGAPA
MSMEG_6468|M.smegmatis_MC2_155 KARRQVPHLRLGRTGRMLEALIPAIIEQRVYGLDAWRAWRALVTKFGTPA
MAB_0395c|M.abscessus_ATCC_199 RLVHGGTGVRLGATDRVWEALVPAVLEQKVPGAEAWRAWRYLINNVGIDL
TH_0074|M.thermoresistible__bu XSVRRSAHAR-GAT-------------PVTVGSGSRSRLNAVVLFF----
MUL_3945|M.ulcerans_Agy99 PVVATAPGQRIPRTVDEAELAVRAVLAQQVSTKAARTHAARLVTAYGRPI
. * * . : ::
Rv0142|M.tuberculosis_H37Rv PGPAPPGMRVPPSAEVWRHIPSWEFHRANVDPGRARAVVGCAQRAASLER
Mb0147|M.bovis_AF2122/97 PGPAPPGMRVPPSAEVWRHIPSWEFHRANVDPGRARAVVGCAQRAASLER
MMAR_0352|M.marinum_M PGPAPDGMRVPPSADAWRAIPSWEFHRANVDPGRARTVVGCAQRASALQR
MAV_5154|M.avium_104 PGPAPERMRVPPSAQAWRSIPSWEFHRANVDPRRAQTVVTCARRAASLER
Mflv_1111|M.gilvum_PYR-GCK PGPAPAHMRVPPTPETWRRIPSWKFHLANVDPGRARTVVGCAQRADALER
Mvan_5701|M.vanbaalenii_PYR-1 PGPAPAHMRIPPTAEAWRRIPSWEFHRANVDPRRARTVVGCAQRADALER
MSMEG_6468|M.smegmatis_MC2_155 PGPAPDGMRVVPSAEVWRRIPSWEFHRANVDPGRARTIVMCAQRADSLER
MAB_0395c|M.abscessus_ATCC_199 GG-----AKTPPPQRQWLDIPSWEWHKSGAEPVRMRTIRAAAT-------
TH_0074|M.thermoresistible__bu --------------------------------------------------
MUL_3945|M.ulcerans_Agy99 HDQGGTLTHTFPSVQDLAEIDPIHLVVPKTRQRTLSMMVDAIADR-RVNL
Rv0142|M.tuberculosis_H37Rv LVSLPAARAAEALTSLPGVGVWTAAETTQRVFGDADAVSVGDYHIPKMIG
Mb0147|M.bovis_AF2122/97 LVSLPAARAAEALTSLPGVGVWTAAETTQRVFGDADAVSVGDYHIPKMIG
MMAR_0352|M.marinum_M LVTRPVGEALAALTSLPGVGVWTAAETVQRAFGDADAVSVGDYHIPKMIG
MAV_5154|M.avium_104 LVSRPAAQARAALTSLPGVGEWTAAETAQRAFGDADAVSVGDYHIPKMVG
Mflv_1111|M.gilvum_PYR-GCK LVGRSPEAARTAMMSLPGIGVWTAAETAQRAFGDADALSVGDYHLAKIVG
Mvan_5701|M.vanbaalenii_PYR-1 LVDRPGEAARTAMMSLPGVGIWTAAETAQRALGDADALSVGDYHLSGVVG
MSMEG_6468|M.smegmatis_MC2_155 LT---HERAAVTLRSLPGVGEWTAAETMQRVFGDADALSAGDYHLATLVG
MAB_0395c|M.abscessus_ATCC_199 ---IDVETKPEHLTAVHGIGPWTEAEIRIRALGDPDAVPVGDYHIPAQVG
TH_0074|M.thermoresistible__bu ---------EILLVACVVLVTWFALYALYRLITDES--------------
MUL_3945|M.ulcerans_Agy99 DAGFDWTRAREQLLDIPGVGPWTAEVIAMRGLGDPDAFPVADLGVR--LA
: : * * : * .
Rv0142|M.tuberculosis_H37Rv WTLVGRPVDDAGMLELLEPMRPHRHRVVRLLEASGLAREPRRGPRLPVQN
Mb0147|M.bovis_AF2122/97 WTLVGRPVDDAGMLELLEPMRPHRHRVVRLLEASGLAREPRRGPRLPVQN
MMAR_0352|M.marinum_M WTLLGHPVDDAGMLELLEPMRPHRHRVVRLLEASGLAREPRRGPRLPVQN
MAV_5154|M.avium_104 WTLLGRPVDDAGMLELLEPMRPHRQRVVRLLEASGLAREPRRGPRLPVQQ
Mflv_1111|M.gilvum_PYR-GCK WTLLGHPIDDAAMVELLEPLRPHRHRAVRMLEVSGMTVNPRFGPRLSIPN
Mvan_5701|M.vanbaalenii_PYR-1 WTLLGYPIDDPQMVELLEPLRPHRHRAVRLLEVSGLAFKPRFGPRLPIPH
MSMEG_6468|M.smegmatis_MC2_155 QALTGEPVDDAGMVELLEPMRPHRHRAVRLLEASGMFVYRRRGARQAIPK
MAB_0395c|M.abscessus_ATCC_199 FALTGQKTDDAGMLELLEPYAGQRYRIIRLIELVAPKP-ARRGSRMPVRD
TH_0074|M.thermoresistible__bu --------------------------------------------------
MUL_3945|M.ulcerans_Agy99 AKQLGLPQRQPDLLDRSARWRPWRSYATQHLWTTLEHSVNDWPPREVA--
Rv0142|M.tuberculosis_H37Rv IRAL
Mb0147|M.bovis_AF2122/97 IRAL
MMAR_0352|M.marinum_M IRSL
MAV_5154|M.avium_104 IHSL
Mflv_1111|M.gilvum_PYR-GCK LADL
Mvan_5701|M.vanbaalenii_PYR-1 LADL
MSMEG_6468|M.smegmatis_MC2_155 LRTL
MAB_0395c|M.abscessus_ATCC_199 YRNF
TH_0074|M.thermoresistible__bu ----
MUL_3945|M.ulcerans_Agy99 ----