For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. tuberculosis H37Rv Rv0091 (mtn)

annotation: PROBABLE BIFUNCTIONAL MTA/SAH NUCLEOSIDASE MTN: 5'-METHYLTHIOADENOSINE NUCLEOSIDASE (METHYLTHIOADENOSINE METHYLTHIORIBOHYDROLASE) + S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (S-ADENOSYL-L-HOMOCYSTEINE HOMOCYSTEINYLRIBOHYDROLASE)
coordinates: 99684 - 100451
length: 255

MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRVVLAAAGMGKVNTGLTATLLADRFGC
RTIVFTGVAGGLDPELCIGDIVIADRVVQHDFGLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVK
HRLDGFTLAPLSTAAGGGGRQPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGAVAQICASFDI
PWLVIRALSDLAGADSGVDFNRFVGEVAASSARVLLRLLPVLTAC

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv0091 mtn - 100% (255) PROBABLE BIFUNCTIONAL MTA/SAH NUCLEOSIDASE MTN: 5'-METHYLTHIOADENOSINE NUCLEOSIDASE (METHYLTHIOADENOSINE METHYLTHIORIBOHYDROLASE) + S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (S-ADENOSYL-L-HOMOCYSTEINE HOMOCYSTEINYLRIBOHYDROLASE)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0094 mtn 1e-146 100.00% (255) bifunctional 5'-methylthioadenosine
M. gilvum PYR-GCK - - - - -
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 - - - - -
M. marinum M MMAR_0251 mtn 1e-104 74.00% (250) bifunctional Mta/Sah nucleosidase Mtn
M. avium 104 - - - - -
M. smegmatis MC2 155 MSMEG_1753 mtnN 3e-83 60.00% (250) MTA/SAH nucleosidase
M. thermoresistible (build 8) - - - - -
M. ulcerans Agy99 MUL_4862 mtn 1e-102 72.40% (250) bifunctional Mta/Sah nucleosidase Mtn
M. vanbaalenii PYR-1 - - - - -

CLUSTAL 2.0.9 multiple sequence alignment


Rv0091|M.tuberculosis_H37Rv         MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRVVLAAA
Mb0094|M.bovis_AF2122/97            MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRVVLAAA
MMAR_0251|M.marinum_M               --MTIGVICAIPQELAYLRTNLVAADQQEIAQICFYAGQLGDRRVVLTAA
MUL_4862|M.ulcerans_Agy99           --MTIGVICAIPQELAYLRTNLVATDQQEIARICFYAGQLGDRRVVLTAA
MSMEG_1753|M.smegmatis_MC2_155      --MTIGLICALPQELAHLCDLMGDVDVVHHAHTSFETGTLDGREVVVAGT
                                      :*:*:***:*****:*   :  ..  . *:  * :* *. :.**::.:

Rv0091|M.tuberculosis_H37Rv         GMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQH
Mb0094|M.bovis_AF2122/97            GMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQH
MMAR_0251|M.marinum_M               GMGKVNAGLVATLLADRFDCHTVIFTGVAGGLDPALSIGDIVIADRVVQH
MUL_4862|M.ulcerans_Agy99           GMGKVNAGLVATLLADRFDCHTVIFTGVAGGLDPALSIGDIVIADRVVQH
MSMEG_1753|M.smegmatis_MC2_155      GMGKVNAALVTTLLIHGFGCRTIVFSGVAGGLDPDLNVGDVIVAERVVQH
                                    ******:.*.:*** . *.*:*::*:******** * :**:::*:*****

Rv0091|M.tuberculosis_H37Rv         DFGLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAP
Mb0094|M.bovis_AF2122/97            DFGLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAP
MMAR_0251|M.marinum_M               DCGLLTDDGLQPYQPGHVPFIKPTEQLGYRVDPELLDRVKHRLEDFTLPA
MUL_4862|M.ulcerans_Agy99           DCGLLTDDGLQPYQPGHVPFIKPTEQLGYRVDPELLDRVKHRLEDFTLPA
MSMEG_1753|M.smegmatis_MC2_155      DAGLIENEQLQTYQAGHVPFINPTDRLGYDVDPALLGKVRAALEGLRLPA
                                    * **: :: *:.**.**:***:**::*** *** ::.:*:  *:.: *..

Rv0091|M.tuberculosis_H37Rv         LSTAAGGGGRQPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGA
Mb0094|M.bovis_AF2122/97            LSTAAGGGGRQPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGA
MMAR_0251|M.marinum_M               LSAAAGGGARPPRINYGTILTGDQYLHSARTRDQLYNDFAGMAIEMEGGA
MUL_4862|M.ulcerans_Agy99           LSAAAGGGARPPRINYGTILTGDQYLHSARTRDQLYNDFAGMAIEMEGGA
MSMEG_1753|M.smegmatis_MC2_155      LSTRAGGQGRPARIAYGTVLSGDQYLHSVPTRDRLHAQFGGRAVEMEGGA
                                    **: *** .* .** ***:*:******.  **::*: ::.* *:******

Rv0091|M.tuberculosis_H37Rv         VAQICASFDIPWLVIRALSDLAGADSGVDFNRFVGEVAASSARVLLRLLP
Mb0094|M.bovis_AF2122/97            VAQICASFDIPWLVIRALSDLAGADSGVDFNRFVGEVAASSARVLLRLLP
MMAR_0251|M.marinum_M               LAQVCESFAIPWLVIRALSDLAGAGSGLDFNRFVDEVSVSSARILLHLLS
MUL_4862|M.ulcerans_Agy99           LAQVCESFAISWLVIRAPSDLAGAGSGLDFNRFVDEVSVSSARILLHLLS
MSMEG_1753|M.smegmatis_MC2_155      VAQVAEAFGAEWLVIRALSDLAGEDSRFEFDQFAGEVAAASCAVLRALLP
                                    :**:. :*   ****** ***** .* .:*::*..**:.:*. :*  **.

Rv0091|M.tuberculosis_H37Rv         VLTAC
Mb0094|M.bovis_AF2122/97            VLTAC
MMAR_0251|M.marinum_M               VVD--
MUL_4862|M.ulcerans_Agy99           VVD--
MSMEG_1753|M.smegmatis_MC2_155      VL---
                                    *:

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv0091	mtn	-	100% (255)	PROBABLE BIFUNCTIONAL MTA/SAH NUCLEOSIDASE MTN: 5'-METHYLTHIOADENOSINE NUCLEOSIDASE (METHYLTHIOADENOSINE METHYLTHIORIBOHYDROLASE) + S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (S-ADENOSYL-L-HOMOCYSTEINE HOMOCYSTEINYLRIBOHYDROLASE)