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M. bovis AF2122 / 97 Mb0094 (mtn)

annotation: bifunctional 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase
coordinates: 99719 - 100486
length: 255

MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRVVLAAAGMGKVNTGLTATLLADRFGC
RTIVFTGVAGGLDPELCIGDIVIADRVVQHDFGLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVK
HRLDGFTLAPLSTAAGGGGRQPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGAVAQICASFDI
PWLVIRALSDLAGADSGVDFNRFVGEVAASSARVLLRLLPVLTAC
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0094mtn-100% (255)bifunctional 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCK-----
M. tuberculosis H37RvRv0091mtn1e-146100.00% (255) bifunctional 5'-methylthioadenosine
M. leprae Br4923-----
M. abscessus ATCC 19977-----
M. marinum MMMAR_0251mtn1e-10474.00% (250) bifunctional Mta/Sah nucleosidase Mtn
M. avium 104-----
M. smegmatis MC2 155MSMEG_1753mtnN3e-8360.00% (250) MTA/SAH nucleosidase
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_4862mtn1e-10272.40% (250) bifunctional Mta/Sah nucleosidase Mtn
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


Mb0094|M.bovis_AF2122/97            MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRVVLAAA
Rv0091|M.tuberculosis_H37Rv         MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRVVLAAA
MMAR_0251|M.marinum_M               --MTIGVICAIPQELAYLRTNLVAADQQEIAQICFYAGQLGDRRVVLTAA
MUL_4862|M.ulcerans_Agy99           --MTIGVICAIPQELAYLRTNLVATDQQEIARICFYAGQLGDRRVVLTAA
MSMEG_1753|M.smegmatis_MC2_155      --MTIGLICALPQELAHLCDLMGDVDVVHHAHTSFETGTLDGREVVVAGT
                                      :*:*:***:*****:*   :  ..  . *:  * :* *. :.**::.:

Mb0094|M.bovis_AF2122/97            GMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQH
Rv0091|M.tuberculosis_H37Rv         GMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQH
MMAR_0251|M.marinum_M               GMGKVNAGLVATLLADRFDCHTVIFTGVAGGLDPALSIGDIVIADRVVQH
MUL_4862|M.ulcerans_Agy99           GMGKVNAGLVATLLADRFDCHTVIFTGVAGGLDPALSIGDIVIADRVVQH
MSMEG_1753|M.smegmatis_MC2_155      GMGKVNAALVTTLLIHGFGCRTIVFSGVAGGLDPDLNVGDVIVAERVVQH
                                    ******:.*.:*** . *.*:*::*:******** * :**:::*:*****

Mb0094|M.bovis_AF2122/97            DFGLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAP
Rv0091|M.tuberculosis_H37Rv         DFGLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAP
MMAR_0251|M.marinum_M               DCGLLTDDGLQPYQPGHVPFIKPTEQLGYRVDPELLDRVKHRLEDFTLPA
MUL_4862|M.ulcerans_Agy99           DCGLLTDDGLQPYQPGHVPFIKPTEQLGYRVDPELLDRVKHRLEDFTLPA
MSMEG_1753|M.smegmatis_MC2_155      DAGLIENEQLQTYQAGHVPFINPTDRLGYDVDPALLGKVRAALEGLRLPA
                                    * **: :: *:.**.**:***:**::*** *** ::.:*:  *:.: *..

Mb0094|M.bovis_AF2122/97            LSTAAGGGGRQPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGA
Rv0091|M.tuberculosis_H37Rv         LSTAAGGGGRQPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGA
MMAR_0251|M.marinum_M               LSAAAGGGARPPRINYGTILTGDQYLHSARTRDQLYNDFAGMAIEMEGGA
MUL_4862|M.ulcerans_Agy99           LSAAAGGGARPPRINYGTILTGDQYLHSARTRDQLYNDFAGMAIEMEGGA
MSMEG_1753|M.smegmatis_MC2_155      LSTRAGGQGRPARIAYGTVLSGDQYLHSVPTRDRLHAQFGGRAVEMEGGA
                                    **: *** .* .** ***:*:******.  **::*: ::.* *:******

Mb0094|M.bovis_AF2122/97            VAQICASFDIPWLVIRALSDLAGADSGVDFNRFVGEVAASSARVLLRLLP
Rv0091|M.tuberculosis_H37Rv         VAQICASFDIPWLVIRALSDLAGADSGVDFNRFVGEVAASSARVLLRLLP
MMAR_0251|M.marinum_M               LAQVCESFAIPWLVIRALSDLAGAGSGLDFNRFVDEVSVSSARILLHLLS
MUL_4862|M.ulcerans_Agy99           LAQVCESFAISWLVIRAPSDLAGAGSGLDFNRFVDEVSVSSARILLHLLS
MSMEG_1753|M.smegmatis_MC2_155      VAQVAEAFGAEWLVIRALSDLAGEDSRFEFDQFAGEVAAASCAVLRALLP
                                    :**:. :*   ****** ***** .* .:*::*..**:.:*. :*  **.

Mb0094|M.bovis_AF2122/97            VLTAC
Rv0091|M.tuberculosis_H37Rv         VLTAC
MMAR_0251|M.marinum_M               VVD--
MUL_4862|M.ulcerans_Agy99           VVD--
MSMEG_1753|M.smegmatis_MC2_155      VL---
                                    *: