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NTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEFV DGVEQLAIDRVKALFGAEYANVQPHSGATANAATMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYH ATAYEVSKEDYLVDMDAVAEAARTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMAHFAGLVAA GVHPSPVPHAHVVTSTTHKTLGGPRGGIILCNDPAIAKKINSAVFPGQQGGPLEHVIAAKATAFKMAAQP EFAQRQQRCLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDGQQAEDRLAAVDITVNRN AVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADLIAAALTATNDDQLGPLRAQVQRLAARYPLYPE LHRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0070c | glyA2 | - | 100% (425) | PROBABLE SERINE HYDROXYMETHYLTRANSFERASE GLYA2 (SERINE METHYLASE 2) (SHMT 2) |
| M. tuberculosis H37Rv | Rv1093 | glyA | e-158 | 68.43% (415) | serine hydroxymethyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0071c | glyA | 0.0 | 99.76% (425) | serine hydroxymethyltransferase |
| M. gilvum PYR-GCK | Mflv_2060 | glyA | 4e-90 | 42.89% (464) | serine hydroxymethyltransferase |
| M. leprae Br4923 | MLBr_01953 | glyA | 1e-154 | 66.99% (412) | serine hydroxymethyltransferase |
| M. abscessus ATCC 19977 | MAB_1236 | - | 2e-92 | 43.10% (464) | serine hydroxymethyltransferase |
| M. marinum M | MMAR_0208 | glyA | 0.0 | 90.50% (421) | serine hydroxymethyltransferase GlyA2 |
| M. avium 104 | MAV_1215 | glyA | 1e-156 | 67.95% (415) | serine hydroxymethyltransferase |
| M. smegmatis MC2 155 | MSMEG_5249 | glyA | 1e-93 | 43.32% (464) | serine hydroxymethyltransferase |
| M. thermoresistible (build 8) | TH_2160 | glyA | 2e-94 | 43.75% (464) | serine hydroxymethyltransferase |
| M. ulcerans Agy99 | MUL_4902 | glyA | 0.0 | 89.62% (424) | serine hydroxymethyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4656 | glyA | 2e-90 | 42.74% (468) | serine hydroxymethyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2060|M.gilvum_PYR-GCK -------MTSVSASGQGAEYAATASEAYQAALRVIETVEPRIAEATRKEL
Mvan_4656|M.vanbaalenii_PYR-1 -------MTSSSPSGQGADYAATASEAYRAALRVIESVEPRVAEATRKEL
MSMEG_5249|M.smegmatis_MC2_155 MAADPSSNSSSVPAANGADYADTASAAYQAALQVIESVEPRVAAATRKEL
TH_2160|M.thermoresistible__bu --MTSDSTTTASAATPGAEYADTASAAYRAALQVIESVEPRIAEATRKEL
MAB_1236|M.abscessus_ATCC_1997 -----MTTSASSDIAQGAQYAETASAAYRSALQVIETIEPRIADATRKEL
Rv0070c|M.tuberculosis_H37Rv ---------------------------MNTLNDSLTAFDPDIAALIDGEL
Mb0071c|M.bovis_AF2122/97 ---------------------------MNTLNDSLTAFDPDIAALIDGEL
MMAR_0208|M.marinum_M ---------------------------MTILNESLSTFDPDIAALIDSEL
MUL_4902|M.ulcerans_Agy99 ---------------------------MSILNESLSTFDPDIAALIDSEL
MLBr_01953|M.leprae_Br4923 ------------------------------MVAPLAEVDPDIAELLGKEL
MAV_1215|M.avium_104 -------------MTAAPDARPTASDTASLMSAPLADIDPDIAGLLGQEL
: .:* :* **
Mflv_2060|M.gilvum_PYR-GCK ADQRDSLKLIASENYASPAVLLTMGTWFSDKYAEGTVGHRFYAACQNVDT
Mvan_4656|M.vanbaalenii_PYR-1 ADQRGSLKLIASENYASPAVLLTMGTWFSDKYAEGTVGHRFYAACQNVDT
MSMEG_5249|M.smegmatis_MC2_155 ADQRDSLKLIASENYASPAVLLTMGTWFSDKYAEGTIGHRFYAGCQNVDT
TH_2160|M.thermoresistible__bu ADQRESLKLIASENYASPATLLTMGTWLSDKYAEGTVGHRFYAGCQNVDT
MAB_1236|M.abscessus_ATCC_1997 ADQRDSLKLIASENYASPAVLLTMGTWLSDKYAEGTIGHRFYAGCQNIDT
Rv0070c|M.tuberculosis_H37Rv RRQESGLEMIASENYAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEFVDG
Mb0071c|M.bovis_AF2122/97 RRQESGLEMIASENYAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEFVDG
MMAR_0208|M.marinum_M NRQETGLEMIASENYAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEFVDG
MUL_4902|M.ulcerans_Agy99 NRQETGLEMIASENYAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEFVDG
MLBr_01953|M.leprae_Br4923 GRQRDTLEMIASENFVPRSVLQAQGSVLTNKYAEGLPGRRYYDGCEHVDV
MAV_1215|M.avium_104 GRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEYVDV
*. *::*****:.. :.: : *: :::***** *:*:* .*: :*
Mflv_2060|M.gilvum_PYR-GCK VEALAAEHARELFGAPYAYAQPHSGIDANLVAYWAILATRVEAPGLAEMG
Mvan_4656|M.vanbaalenii_PYR-1 VEALAAEHARELFGAPYAYAQPHSGIDANLVAYWAILATRVEAPGLAELG
MSMEG_5249|M.smegmatis_MC2_155 VESVAAEHARELFGAPYAYVQPHSGIDANLVAFWAILATRVEAPELANFG
TH_2160|M.thermoresistible__bu VESVAAEHARELFGAPYAYVQPHSGIDANLVAFWAILATRVEAPALAEHG
MAB_1236|M.abscessus_ATCC_1997 VEALAAEHARELFGAPYAYAQPHSGIDANLVAYWAILATRVEAPALADKG
Rv0070c|M.tuberculosis_H37Rv VEQLAIDRVKALFGAEYANVQPHSGATANAATMHALLNP-----------
Mb0071c|M.bovis_AF2122/97 VEQLAIDRVKALFGAEYANVQPHSGATANAATMHALLNP-----------
MMAR_0208|M.marinum_M VEQLAIDRVKALFGAEYANVQPHSGATANASAMHALLNP-----------
MUL_4902|M.ulcerans_Agy99 VEQLAIDRVKALFGAEYANVQPHSGATANASSMHALLNP-----------
MLBr_01953|M.leprae_Br4923 VENIARDRAKALFGADFANVQPHSGAQANAAVLHALMSP-----------
MAV_1215|M.avium_104 VENIARDRAKALFGADFANVQPHSGAQANAAVLHALMTP-----------
** :* ::.: **** :* .***** ** *:: .
Mflv_2060|M.gilvum_PYR-GCK AKHINDLSEADWEKLRAKLGNQRLLGMSLDTGGHLTHGFRPNISGKMFHQ
Mvan_4656|M.vanbaalenii_PYR-1 AKHVNDLSEGDWEKLRAKLGNQRLLGMSLDTGGHLTHGFRPNISGKMFHQ
MSMEG_5249|M.smegmatis_MC2_155 AKHINDLSEADWETLRNKLGNQRLLGMSLDAGGHLTHGFRPNISGKMFHQ
TH_2160|M.thermoresistible__bu VKHINDLSEADWEKLRNKLGNQRLLGMSLDAGGHLTHGFRPNISGKMFHQ
MAB_1236|M.abscessus_ATCC_1997 VRNVNDLSETDWEELRHQYGNQRLMGMSLDAGGHLTHGFRPNISGKMFHQ
Rv0070c|M.tuberculosis_H37Rv --------------------GDTILGLSLAHGGHLTHGMRINFSGKLYHA
Mb0071c|M.bovis_AF2122/97 --------------------GDTILGLSLAHGGHLTHGMRINFSGKLYHA
MMAR_0208|M.marinum_M --------------------GDTILGLSLAHGGHLTHGMRINFSGKLYNV
MUL_4902|M.ulcerans_Agy99 --------------------GDTILGLSLAHGGHLTHGMRINFSGKLYNV
MLBr_01953|M.leprae_Br4923 --------------------GERLLGLDLANGGHLTHGMRLNFSGKLYET
MAV_1215|M.avium_104 --------------------GERLLGLDLANGGHLTHGMKLNFSGKLYDV
.: ::*:.* *******:: *:***::.
Mflv_2060|M.gilvum_PYR-GCK RQYGTDPTTGFIDYDAVAASAREFKPLVLVAGYSAYPRRVNFAKMREIAD
Mvan_4656|M.vanbaalenii_PYR-1 RQYGTDPATGFIDYDAVAAAAREFKPLVLVAGYSAYPRRVNFAKMREIAD
MSMEG_5249|M.smegmatis_MC2_155 RSYGTNPETGFLDYDAVAAAAREFKPLVLVAGYSAYPRRVNFAKMREIAD
TH_2160|M.thermoresistible__bu RSYGTDPQTGLLDYDAVAAAAREFKPLIIVAGYSAYPRRINFAKMREIAD
MAB_1236|M.abscessus_ATCC_1997 RSYGTDPETGLLDYDALAAAAREFKPLVLVGGYSAYPRRVNFAKLREIAD
Rv0070c|M.tuberculosis_H37Rv TAYEVSKEDYLVDMDAVAEAARTHRPKMIIAGWSAYPRQLDFARFRAIAD
Mb0071c|M.bovis_AF2122/97 TAYEVSKEDYLVDMDAVAEAARTHRPKMIIAGWSAYPRQLDFARFRAIAD
MMAR_0208|M.marinum_M AAYEVSKDDYLIDMDAVAQAARDHQPKMIIAGWSAYPRQLDFARFREIAD
MUL_4902|M.ulcerans_Agy99 AAYEVSKDDYLIDMDAVAQAARDHQPKMIIAGWSAYPRQLDFARFREIAD
MLBr_01953|M.leprae_Br4923 GFYGVDATTHLIDMDAVRAKALEFRPKVLIAGWSAYPRILDFAAFRSIAD
MAV_1215|M.avium_104 GFYGVDPTTHLIDMDAVRAKALEFRPKVIIAGWSAYPRVLDFAAFASIAD
* .. ::* **: * .:* :::.*:***** ::** : ***
Mflv_2060|M.gilvum_PYR-GCK EVGATLMVDMAHFAGLVAGKVFTGDEDPVPHAHVVTTTTHKSLRGPRGGL
Mvan_4656|M.vanbaalenii_PYR-1 EVGATLMVDMAHFAGLVAGKVFTGDEDPVPHAHITTTTTHKSLRGPRGGL
MSMEG_5249|M.smegmatis_MC2_155 EVGATLMVDMAHFAGLVAGKVFTGDEDPVPHAHVTTTTTHKSLRGPRGGM
TH_2160|M.thermoresistible__bu EVGATLMVDMAHFAGLVAGKVFTGDEDPVPHAHVTTTTTHKSLRGPRGGM
MAB_1236|M.abscessus_ATCC_1997 EVGATLFVDMAHFAGLVAGKVFTGDENPVPHAHITTTTTHKSLRGPRGGL
Rv0070c|M.tuberculosis_H37Rv EVDAVLMVDMAHFAGLVAAGVHPS---PVPHAHVVTSTTHKTLGGPRGGI
Mb0071c|M.bovis_AF2122/97 EVDAVLMVDMAHFAGLVAAGVHPS---PVPHAHVVTSTTHKTLGGPRGGI
MMAR_0208|M.marinum_M EVGAVLMVDMAHFAGLVATGLHPS---PVPHAHVVTSTTHKTLGGPRGGI
MUL_4902|M.ulcerans_Agy99 EVGAVLMVDMAHFAGLVATGLHPS---PVPHAHVVTSTTHKTLGGPRGGI
MLBr_01953|M.leprae_Br4923 EVGAKLWVDMAHFAGLVAVGLHPS---PVPHADVVSTTVHKTLGGGRSGL
MAV_1215|M.avium_104 EVGAKLWVDMAHFAGLVAAGLHPS---PVPHADVVSTTVHKTLGGPRSGL
**.* * *********** :... *****.:.::*.**:* * *.*:
Mflv_2060|M.gilvum_PYR-GCK VLA-TEEFAPAVDKG-CPMVLGGPLSHVMAAKAVALAEARQPEFRTYAQA
Mvan_4656|M.vanbaalenii_PYR-1 VLA-TEEYAPAVDKG-CPMVLGGPLSHVMAAKAVALAEARRPEFRAYAQA
MSMEG_5249|M.smegmatis_MC2_155 VLA-TEEYAPAVDKG-CPMVLGGPLSHVMAAKAVALAEARQPAFQQYAQQ
TH_2160|M.thermoresistible__bu VLA-TEEYAPAVDKG-CPMVLGGPLSHVMAAKAVALAEARQPSFRAYAQR
MAB_1236|M.abscessus_ATCC_1997 VLA-TAEYSDAVDKG-CPMVLGGPLSHVMAAKAVALAEARQPSFQAYAQR
Rv0070c|M.tuberculosis_H37Rv ILCNDPAIAKKINSAVFPGQQGGPLEHVIAAKATAFKMAAQPEFAQRQQR
Mb0071c|M.bovis_AF2122/97 ILCNDPAIAKKINSAVFPGQQGGPLGHVIAAKATAFKMAAQPEFAQRQQR
MMAR_0208|M.marinum_M ILSNDAAIAKKINSAVFPGQQGGPLEHVIAAKATAFKMAAQPEFVQRQQR
MUL_4902|M.ulcerans_Agy99 ILSNDAAIAKKINSAVFPGQQGGPLEHVIAAKATAFKMAAQPEFVQRQQR
MLBr_01953|M.leprae_Br4923 ILG-KQEFATAINSAVFPGQQGGPLMHVIAGKAVALKIATTPEFTDRQQR
MAV_1215|M.avium_104 ILG-KQEYAKSINSAVFPGQQGGPLMHVIAAKAVALKIAGTEEFADRQRR
:* : ::.. * **** **:*.**.*: * * :
Mflv_2060|M.gilvum_PYR-GCK VADNAQTLADGFVK-----RDAGLVTGGTDNHLVLLDVTSFGLTGRQAES
Mvan_4656|M.vanbaalenii_PYR-1 VADNAQALADGFIK-----RDGSLVTGGTDNHLVLLDVTSFGLTGRQAES
MSMEG_5249|M.smegmatis_MC2_155 VADNAQALADGFVK-----RDAGLVTGGTDNHIVLLDVTSFGLTGRQAES
TH_2160|M.thermoresistible__bu VADNAKAFADGLLK-----RGARLVTGGTDNHIVLLDVTSFGLTGRQAEA
MAB_1236|M.abscessus_ATCC_1997 VADNAKSLAEGFLK-----RGARLVTGGTDNHLVLLDVQSFGLTGRQAES
Rv0070c|M.tuberculosis_H37Rv CLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDGQQAED
Mb0071c|M.bovis_AF2122/97 CLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDGQQAED
MMAR_0208|M.marinum_M CLDGARILADRLNQPDVAERGITVLTGGTDVHLVLVDLRNADLDGQQAED
MUL_4902|M.ulcerans_Agy99 CLDGAQILADRLNQPDVAERGITVLTGGTDVHLVLVDLRNADLDGQQAED
MLBr_01953|M.leprae_Br4923 TLAGARILADRLTAADVTKAGVSVVSGGTDVHLVLVDLRNSPFDGQAAED
MAV_1215|M.avium_104 TLSGARILAERLSGADVAAAGVSVVSGGTDVHLVLVDLRNSELDGQAAED
.*: :* : . :::**** *:**:*: . : *: **
Mflv_2060|M.gilvum_PYR-GCK ALLDSGIVTNRNAIPADPNGAWYTSGIRFGSPALTTRGFGADEFDRVSEL
Mvan_4656|M.vanbaalenii_PYR-1 ALLDSGIVTNRNAVPADPNGAWYTSGIRFGSPALTTRGFGADDFDRVAEL
MSMEG_5249|M.smegmatis_MC2_155 ALLDAGIVTNRNSIPADPNGAWYTSGVRLGTPALTSRGFGADDFDRVAEL
TH_2160|M.thermoresistible__bu ALLESGVVTNRNAIPADPNGAWYTSGIRFGTPALTSRGFDAADFDRVAEL
MAB_1236|M.abscessus_ATCC_1997 ALLDAGVVTNRNAIPADPNGAWYTSGIRFGTPALTSRGFGADEFDKVAEL
Rv0070c|M.tuberculosis_H37Rv RLAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADL
Mb0071c|M.bovis_AF2122/97 RLAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADL
MMAR_0208|M.marinum_M RLAAVDITVNRNAVPFDPRPPMVTSGLRIGTPALASRGFSHDDFGAVADI
MUL_4902|M.ulcerans_Agy99 RLAAVDITVNRNAVPFDPRPPMVTSGLRIGTPALASRGFSHDDFGAVADI
MLBr_01953|M.leprae_Br4923 LLHEVGITVNRNVVPNDPRPPMVTSGLRIGTPALATRGFGEAEFTEVADI
MAV_1215|M.avium_104 LLHEIGITVNRNAVPNDPRPPMVTSGLRVGTPALATRGFGDAEFSEVADV
* .:..*** :* **. . ***:*.*:***::***. :* *:::
Mflv_2060|M.gilvum_PYR-GCK VVEVLSNTQPAAGPNGPSKAKYTIADGVAERVHAAASELLEANPLYPGLT
Mvan_4656|M.vanbaalenii_PYR-1 VVEVLSNTQPAAGPNGPSKAKYTLADGTAERVRAAAAELLDANPLYPGLT
MSMEG_5249|M.smegmatis_MC2_155 IVEVLANTQ----PEGTSKAKYKLADGTAERVHAASSELLSANPLYPGLT
TH_2160|M.thermoresistible__bu VVEVLENTQ----PDATSKARYTLAEGTAARVQAAADELLTANPLYPGLT
MAB_1236|M.abscessus_ATCC_1997 VVDVLTNTE----ADGSSKAKYTLADAVAERVKAASAELLAANPLYPGLT
Rv0070c|M.tuberculosis_H37Rv IAAALTATN----------------DDQLGPLRAQVQRLAARYPLYPELH
Mb0071c|M.bovis_AF2122/97 IAAALTATN----------------DDQLGPLRAQVQRLAARYPLYPELH
MMAR_0208|M.marinum_M VAAALTAAD----------------DDQLGELRKQVQELAARYPLYPELH
MUL_4902|M.ulcerans_Agy99 VAAALTAAD----------------DDQLGELRKQVQELAARYPLYPELH
MLBr_01953|M.leprae_Br4923 IATVLTTGG----------------SVDVAALRQQVTRLARDFPLYGGLE
MAV_1215|M.avium_104 IATALAGGR----------------GADLAALRDRVTRLARDFPLYEGLE
:. .* :: .* *** *
Mflv_2060|M.gilvum_PYR-GCK L------
Mvan_4656|M.vanbaalenii_PYR-1 L------
MSMEG_5249|M.smegmatis_MC2_155 L------
TH_2160|M.thermoresistible__bu L------
MAB_1236|M.abscessus_ATCC_1997 L------
Rv0070c|M.tuberculosis_H37Rv RT-----
Mb0071c|M.bovis_AF2122/97 RT-----
MMAR_0208|M.marinum_M KP-----
MUL_4902|M.ulcerans_Agy99 KP-----
MLBr_01953|M.leprae_Br4923 DWSLAGR
MAV_1215|M.avium_104 DWALVGR