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METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWLWFGEVGFRSVWITVLLTRLAIVAAVA LVVAGIVLAALLLAYRSRPFFVPDEPQRDPVAPLRSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQL FVHGGTFGIVDPEFGYDIGFFVFDLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTTGRGMLTQAAR VQLAVFAGAVVLLKAVAYWLDRYELLSSGRKEPTFTGAGYTDIHAELPAKLVLVAIAVLCAVSFFTAIFL RDLRIPAMAAALLVLSAILVGGLWPLLMEQFSVRPNAADVERPYIQRNIEATREAYRIGGDWVQYRSYPG IGTKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFSFAEILDIDRYRIDGELQDYIVGVRELSP KSLTGNQTDWINKHTVYTHGNGFVAAPANRVNAAARGAENISDSNSGYPIYAVSDIASLGSGRQVIPVEQ PRVYYGEVIAQADPDYAIVGGAPGSAPREYDTDTSKYTYTGAGGVSIGNWFNRTVFATKVAQHKFLFSRE IGSESKVLIHRDPKERVQRVAPWLTTDDNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPVTSPTGI VRQGKQVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSEDQIPDELRAHFRYPEDLFE VQRSLLAKYHVDEPREFFTTNAFWSVPSDPTNNANATQPPFYVLVGDQQSAQPSFRLASAMVGYNREFLS AYISAHSDPANYGKLTVLELPTDTLTQGPQQIQNSMISDTRVASERTLLERSNRIHYGNLLSLPIADGGV LYVEPLYTERISTSPSSSTFPQLSRVLVSVREPRTEGGVRVGYAPTLAESLDQVFGPGTGRVATARGGDA ASAPPPGAGGPAPPQAVPPPRTTQPPAAPPRGPDVPPATVAELRETLADLRAVLDRLEKAIDAAETPGG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv0064 | - | - | 100% (979) | hypothetical protein Rv0064 |
M. tuberculosis H37Rv | Rv3193c | - | 0.0 | 50.41% (986) | hypothetical protein Rv3193c |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0065 | - | 0.0 | 99.49% (979) | hypothetical protein Mb0065 |
M. gilvum PYR-GCK | Mflv_4654 | - | 0.0 | 51.51% (994) | hypothetical protein Mflv_4654 |
M. leprae Br4923 | MLBr_00644 | - | 0.0 | 49.29% (980) | hypothetical protein MLBr_00644 |
M. abscessus ATCC 19977 | MAB_3498c | - | 0.0 | 50.21% (974) | hypothetical protein MAB_3498c |
M. marinum M | MMAR_1371 | - | 0.0 | 50.81% (986) | transmembrane protein |
M. avium 104 | MAV_4137 | - | 0.0 | 50.96% (985) | hypothetical protein MAV_4137 |
M. smegmatis MC2 155 | MSMEG_1959 | - | 0.0 | 51.51% (996) | hypothetical protein MSMEG_1959 |
M. thermoresistible (build 8) | - | - | - | - | - |
M. ulcerans Agy99 | MUL_2505 | - | 0.0 | 50.51% (986) | hypothetical protein MUL_2505 |
M. vanbaalenii PYR-1 | Mvan_1814 | - | 0.0 | 51.36% (991) | hypothetical protein Mvan_1814 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_4654|M.gilvum_PYR-GCK MGMRPAARMPSLTQRSRFLIAVSAVLVLLLLLGPRFIDTYVDWLWFGELG Mvan_1814|M.vanbaalenii_PYR-1 --MRPAARMPNLTRRSRVMIAVALAVVVLLLLGPRLVDTYVNWLWFGELG MSMEG_1959|M.smegmatis_MC2_155 MGMRPTARMPKLTRRSRVLIAFALVAVLLLLLGPRLIDTYVDWLWFGELG MMAR_1371|M.marinum_M MGMRPTARMPKLTRRSRVLILIALGVIALLLAGPRLIDAYVDWLWFGELG MUL_2505|M.ulcerans_Agy99 MGMRPTARMPKLTRRSRVLILIALGVIALLLAGPRLIDAYVDWLWFGELG MAV_4137|M.avium_104 MGMRPTARMPKLTRRSRILILIALGVIALLLAGPRLIDAYVDWLWFGELG MLBr_00644|M.leprae_Br4923 MGMRPAARMPKLTRRSRTLIMVALGVIVLLLAGPRLVDAYVEWLWFGELG MAB_3498c|M.abscessus_ATCC_199 MGMRPNGALPRLTRRSRRLVAASLVIVVLLLIGPRLVDTYINWLWFGELG Rv0064|M.tuberculosis_H37Rv METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWLWFGEVG Mb0065|M.bovis_AF2122/97 METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWLWFGEVG . . * *.:*:* :: . : *** ***::* *::******:* Mflv_4654|M.gilvum_PYR-GCK YRSVFTTQIITRLVIFFVVAILVGAVVFAGLALAYRTRPVFVPTAGPNDP Mvan_1814|M.vanbaalenii_PYR-1 YRSVFTTQIVTRLLLFLAVAVVFGAVVFAAMALAYRTRPVFVPTAGPNDP MSMEG_1959|M.smegmatis_MC2_155 YRSVFTTVLATRLIVFVVVALAIGAIVFAGLALAYRTRPVFVPTAGPNDP MMAR_1371|M.marinum_M YRSVFTTVLVTRFLVFLVAGVLVGGIVFAGLALAYRTRPVFVPNND-NDP MUL_2505|M.ulcerans_Agy99 YLSVFTTVLVTRFLVFLVAGVLVGGIVFAGLALAYRTRPVFVPNND-NDP MAV_4137|M.avium_104 YRSVFSTVLVTRFVVFLIAGLLVGGIVFAGLAVAYRTRPVFVPSND-NDP MLBr_00644|M.leprae_Br4923 YRSVFSTVLVTRVVVFLVAGLVVGGIVFAGLAVAYRTRPVFVPSHD-NDP MAB_3498c|M.abscessus_ATCC_199 FRGVFTTVLLTRLALFLIVGTLVAAVVFAGFGLAYRARPVFVPAKGPGDA Rv0064|M.tuberculosis_H37Rv FRSVWITVLLTRLAIVAAVALVVAGIVLAALLLAYRSRPFFVPDEPQRDP Mb0065|M.bovis_AF2122/97 FRSVWITVLLTRLAIVAAVALVVAGIVLAALLLAYRSRPFFVPDEPQRDP : .*: * : **. :. .. ...:*:*.: :***:**.*** *. Mflv_4654|M.gilvum_PYR-GCK IARYRTAVMARLRLIGIGVPLAIGVLAGFVGQSYWQRVQLFLHGGDFGVS Mvan_1814|M.vanbaalenii_PYR-1 IARYRTAVMARLRLVGIGVPVAVGLLAGLIAQNYWQRVQLFLHGGSFGVS MSMEG_1959|M.smegmatis_MC2_155 VARYRTTVMARLRLFGIGVPVFIGLLAGIVAQSYWVKIQLFLHGGDFGIT MMAR_1371|M.marinum_M VARYRTVVLARLRLFGIGIPAAIGLLAGIVAQSYWVRIQLFLHGGDFGIT MUL_2505|M.ulcerans_Agy99 VARYRTVVLARLRLFGIGIPAAIGLLAGIVAQSYWVRIQLFLHGGDFGIT MAV_4137|M.avium_104 VARYRALVLSRLRLVSIGVPVAIGLLAGIIAQSYWVRIQLFLHGGDFGIK MLBr_00644|M.leprae_Br4923 VARYRAMALSRLRLIGVGIPAAIGLLAGIIAQSYWVRIQLFLHGDNFGIR MAB_3498c|M.abscessus_ATCC_199 LAQYRALILSRVRLFLIGVPILIGVLAGVVAQSYWMPVQLFLEGGDFGIK Rv0064|M.tuberculosis_H37Rv VAPLRSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQLFVHGGTFGIV Mb0065|M.bovis_AF2122/97 VAPLRSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQLFVHGGTFGIV :* *: : * **. *:. :*::.*.:.. * :***:.*. **: Mflv_4654|M.gilvum_PYR-GCK DPQFGIDLGFYAFDLPFYRLVLTYLFVGVFLAFLANLLGHYLFGGIRLAG Mvan_1814|M.vanbaalenii_PYR-1 DPQFGIDLGFYAFDLPFYRLMLTYLFAATFLAFIANLLGHYLFGGIRLAG MSMEG_1959|M.smegmatis_MC2_155 DPEFGKDLGFYAFDLPFYRLVLTYLFVATFLAFVANLLGHYLFGGIRLTG MMAR_1371|M.marinum_M DPQFGKDLGFYAFELPFYRLLLSYLFVAIFLAFVANVVSHYLFGGIRLTG MUL_2505|M.ulcerans_Agy99 DPQFGKDLGFYAFELPFYRLLLSYLFVAIFLAFVANVVSHYLFGGIRLTG MAV_4137|M.avium_104 DPQFGKDLGFYAFELPFYRLLLSYLFVAVFLAFVANLLAHYIFGGIRLSG MLBr_00644|M.leprae_Br4923 DPQFGKDLGFYAFELPFYRLVLSYVFVAVFLAFVVNLLAHYIFGGIRLSG MAB_3498c|M.abscessus_ATCC_199 DPQFGLDLGFFAFDLPFYRFVLTYLFIAASIALIVNGLVHYIFGGIRLSG Rv0064|M.tuberculosis_H37Rv DPEFGYDIGFFVFDLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTT Mb0065|M.bovis_AF2122/97 DPEFGYDIGFFVFDLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTT **:** *:**:.*:***** :*.::* . :*::.. : **:***:**: Mflv_4654|M.gilvum_PYR-GCK RSGALSRAARIQLITLVGLLMLLKAVAYWFDRYELLSHTRGGKPFTGAGY Mvan_1814|M.vanbaalenii_PYR-1 RSGALSRAARIQLIALVGFLMLLKAVAYWLDRYELLSHTRGGKPFTGAGY MSMEG_1959|M.smegmatis_MC2_155 RVGALSRAARIQLISLAGTLIVLKAFAYWLDRYELLSNDRSAKPFTGAGY MMAR_1371|M.marinum_M RSGALSRSARIQLVSLVGVLVLLKAVAYWLDRYELLSHTRGGKPFTGAGY MUL_2505|M.ulcerans_Agy99 RSGALSRSARIQLVSLVGVLVLLKTVAYWLNRYELLSHTRGGKPFTGAGY MAV_4137|M.avium_104 RTGALSRSARIQLVTLVGLLVLLKAVAYWLDRYELLSHTRGGKPFTGAGY MLBr_00644|M.leprae_Br4923 RTGALSRLARLQLVSLVGVLVLLKAVAYWLDRYELLSRTRSSKPFTGAGY MAB_3498c|M.abscessus_ATCC_199 RSGTLSRPARIQLITFAGILVLLKVAAYWLDRYELLSHTRAGKPFTGAGY Rv0064|M.tuberculosis_H37Rv GRGMLTQAARVQLAVFAGAVVLLKAVAYWLDRYELLSSGRKEPTFTGAGY Mb0065|M.bovis_AF2122/97 GRGMLTQAARVQLAVFAGAVVLLKAVAYWLDRYELLSSGRKEPTFTGAGY * *:: **:** :.* :::**. ***::****** * .****** Mflv_4654|M.gilvum_PYR-GCK TDINAVLPAKLILMAIAVICAVAVFSAIFLRDLRIPAIGVVLLLLSSLVV Mvan_1814|M.vanbaalenii_PYR-1 TDINAVLPAKLILMVIAVICAAAVFSAIVLRDLRIPAIGVVLLLLSSLIV MSMEG_1959|M.smegmatis_MC2_155 TDINAVLPAKLIMLAIAVICAVAVFSALVLRDLRIPAIGVALLLLSSLVV MMAR_1371|M.marinum_M TDINAVLPAKLILMAIAVICAAAVFSAIVLRDLRIPAIGLVLLLLSSLIV MUL_2505|M.ulcerans_Agy99 TDINAVLPAKLILMAIAVICAAAVFSAIVLRDLRIPAIGLVLLLLSSLIV MAV_4137|M.avium_104 TDINAVLPAKLILMAIALICAAAVFSAITMRDLRIPAIGLVLLLLSSLIV MLBr_00644|M.leprae_Br4923 TDINAVQPAKLILIAIALICAAAVFSAITLRDFRIPAIGLVLLMLSSLIV MAB_3498c|M.abscessus_ATCC_199 TDINAVLPAKLILLAIAVICAVAVFSALVLKDLRIPAIGLALLLLSSLVV Rv0064|M.tuberculosis_H37Rv TDIHAELPAKLVLVAIAVLCAVSFFTAIFLRDLRIPAMAAALLVLSAILV Mb0065|M.bovis_AF2122/97 TDIHAELPAKLVLVAIAVLCAVSFFTAIFLRDLRIPAMAAALLVLSAILV ***:* ****:::.**::**.:.*:*: ::*:****:. .**:**:::* Mflv_4654|M.gilvum_PYR-GCK GAGWPLVVEQISVRPNAAQKESEYISRSITATRQAYGLTEESVTYRDYPG Mvan_1814|M.vanbaalenii_PYR-1 GAGWPLVVEQISVRPNAAQKESEYISRSITATRQAYGLTDEAVEYRDYPG MSMEG_1959|M.smegmatis_MC2_155 GAGWPLIVEQFSVKPNAAQKEAEYISRSIEATRHAYGLTDETVTYRNYEN MMAR_1371|M.marinum_M GAAWPMIVEQISVKPNAAQKESEYISRSITATRQAYGLTSNVVTYRNYTG MUL_2505|M.ulcerans_Agy99 GAAWPMIVEQISVKPNAAQKESEYISRSITATRQAYGLTSNVVTYRNYTG MAV_4137|M.avium_104 GAGWPLIVEQISVKPNAAQKESEYISRSITATRQAYGLTSDVVTYRNYTG MLBr_00644|M.leprae_Br4923 GTGWPLIVEQLIAKPDAVRKESEYIRRSITATRHAYGLTEDVVTYRNYIG MAB_3498c|M.abscessus_ATCC_199 GAGWPLIVEQFSVKPNAAQKESEYIARSIKATRDAYGLTDDVVTYRDYSG Rv0064|M.tuberculosis_H37Rv GGLWPLLMEQFSVRPNAADVERPYIQRNIEATREAYRIGGDWVQYRSYPG Mb0065|M.bovis_AF2122/97 GGLWPLLMEQFSVRPNAADVERPYIQRNIEATREAYRIGGDWVQYRSYPG * **:::**: .:*:*. * ** *.* ***.** : : * **.* . Mflv_4654|M.gilvum_PYR-GCK NA------SATAQQVAADRATTSNIRVLDPNIVAPAFTQFQQGKNFYFFP Mvan_1814|M.vanbaalenii_PYR-1 NA------TATAQQVAADRATTSNIRVLDPNIVSPAFTQFQQGKNFYFFP MSMEG_1959|M.smegmatis_MC2_155 TG------QTTAAQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFP MMAR_1371|M.marinum_M DG------EATAQQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFP MUL_2505|M.ulcerans_Agy99 DG------EATAQQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFP MAV_4137|M.avium_104 DA------QATAQQVADDRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFP MLBr_00644|M.leprae_Br4923 DA------PAIAQQIATDHATTSNIRLLDPTIVSPAFTQFQRGKNFYYFP MAB_3498c|M.abscessus_ATCC_199 TASSPAGSQQLAKQVAADRSTIANIRVLDPNIISPAFTQLQQGKNFYAFP Rv0064|M.tuberculosis_H37Rv IG------TKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFSFA Mb0065|M.bovis_AF2122/97 IG------TKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFSFA . . ::. * :* :::*:*** *:: :*** *: ***: *. Mflv_4654|M.gilvum_PYR-GCK DQLNMDRYRDDSGNLRDYVVAARELNPDRLIDNQRDWINRHTVFTHGNGF Mvan_1814|M.vanbaalenii_PYR-1 DQLNMDRYRDEDGNLRDYVVAARELNPDRLIDNQRDWINRHSVYTHGNGF MSMEG_1959|M.smegmatis_MC2_155 DQLSIDRYIGPDGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGF MMAR_1371|M.marinum_M DQLSIDRYFDRNNNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGF MUL_2505|M.ulcerans_Agy99 DQLSIDRYFDRNNNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGF MAV_4137|M.avium_104 DQLSIDRYLDRNGALRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGF MLBr_00644|M.leprae_Br4923 DQLSIDRYLDKKGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGF MAB_3498c|M.abscessus_ATCC_199 DALSIDRYQDKNGSLRDYVVAARELDPAKLRDNQRDWINRHTVYTHGNGF Rv0064|M.tuberculosis_H37Rv EILDIDRYR-IDGELQDYIVGVRELSPKSLTGNQTDWINKHTVYTHGNGF Mb0065|M.bovis_AF2122/97 EILDIDRYR-IDGELQDYIVGVRELSPKSLTGNQTDWINKHIVYTHGNGF : *.:*** .. *:**:*..***.* * .** ****:* *:****** Mflv_4654|M.gilvum_PYR-GCK IASPAN----TVRGIANDPNQNGGYPEFLASVVGANGEVSSPGPAPLAQP Mvan_1814|M.vanbaalenii_PYR-1 IASPAN----TVRGIANDPNQNGGYPEFLASVVGANGEVVSPGPAPLDQP MSMEG_1959|M.smegmatis_MC2_155 IASPAN----TVRGVANDPNQNGGYPEFLASVVGANGSVISPGPAPLDQP MMAR_1371|M.marinum_M IASPAN----TVRGIANDPNQNGGYPEFLVNVVGANGTVVSDGPAPLDQP MUL_2505|M.ulcerans_Agy99 IASPAN----TVRGIANDPNQNGGYPEFLVNVVGANGTVVSDGPAPLDQP MAV_4137|M.avium_104 IASPAN----TVRGIANDPNQNGGYPEFLVNVVGANGNVVSDGPAPLDQP MLBr_00644|M.leprae_Br4923 IASPAN----TVRGIANDPNQNGGYPQFLVNVVG-NGTVVSEGPARLDQP MAB_3498c|M.abscessus_ATCC_199 IAAPAN----TVRGVADKPDENGGYPEFLVNAVDDNGKVLSDGPAPLAQP Rv0064|M.tuberculosis_H37Rv VAAPANRVNAAARGAENISDSNSGYPIYAVSDIASLGSGRQ--VIPVEQP Mb0065|M.bovis_AF2122/97 VAAPANRVNAAARDAENISDSNSGYPIYAVSDIASLGSGRQ--VIPVEQP :*:*** :.*. : .:.*.*** : .. : * . : ** Mflv_4654|M.gilvum_PYR-GCK RIYFGPVIASAADDYAIVG-ESG-TPREYDYETNTDTRNYTYTGSGGVPI Mvan_1814|M.vanbaalenii_PYR-1 RIYFGPVIANTPADYAIVG-ESG-TPREYDYETNTATRNYTYTGSGGVPI MSMEG_1959|M.smegmatis_MC2_155 RIYFGPVISNTPADYAIVG-KTGDTDREYDYETNTETKNYTYGGKGGVPI MMAR_1371|M.marinum_M RIYYGPVISNTPADYAIVG-KTG-ADREYDYETSADTKNYTYTGSGGVSV MUL_2505|M.ulcerans_Agy99 RIYYGPVISNTPADYAIVG-KTG-ADREYDYETSADTKNYTYTGSGGVSV MAV_4137|M.avium_104 RVYFGPVISNTSADYAIVG-RNG-ADREYDYETSTETKNYTYTGLGGVPI MLBr_00644|M.leprae_Br4923 RVYFGPVISNTSADYAIVG-KNG-DDREYDYETNTDTKRYTYAGSGGVPI MAB_3498c|M.abscessus_ATCC_199 RVYYGPIIASDTNDYAIVG-KNG-NDREYDYENNAGTKNSTYTGSGGVPV Rv0064|M.tuberculosis_H37Rv RVYYGEVIAQADPDYAIVGGAPGSAPREYD----TDTSKYTYTGAGGVSI Mb0065|M.bovis_AF2122/97 RVYYGEVIAQADPDYAIVGGAPGSAPREYD----TDTSKYTYTGAGGVSI *:*:* :*:. ****** * **** : * . ** * ***.: Mflv_4654|M.gilvum_PYR-GCK GNWLTRSVFAAKYAERNFLFSNVINENSKILFNRDPADRVEAVAPWLTTD Mvan_1814|M.vanbaalenii_PYR-1 GNWLTRSVFAAKYAERNFLFSNVIGENSKILFNRDPADRVEAVAPWLTTD MSMEG_1959|M.smegmatis_MC2_155 GNWLNRSVFAAKFAERNFLFSNVIGENSKILFNRDPAERVEAVAPWLTTD MMAR_1371|M.marinum_M GSWISRTVFAAKFAERNFLFSNVIGSNSKILFNRDPAQRVEAVAPWLTTD MUL_2505|M.ulcerans_Agy99 GSWISRTVFAAKFAERNFLFSNVIGSNSKILFNRDPAQRVEAVAPWLTTD MAV_4137|M.avium_104 GDWLSRSVFAAKFAERNFLFSNVIGSNSKILFNRDPARRVEAVAPWLTTD MLBr_00644|M.leprae_Br4923 GSWLSRSVFAAKFAERNFLFSSVIGSNSKILFNRDPAQRVEAVAPWLTTD MAB_3498c|M.abscessus_ATCC_199 GGALARTVFGLKYAERNFLFSNVIGDNSKILFNRDPSRRVEAVAPWLTVD Rv0064|M.tuberculosis_H37Rv GNWFNRTVFATKVAQHKFLFSREIGSESKVLIHRDPKERVQRVAPWLTTD Mb0065|M.bovis_AF2122/97 GNWFNRTVFATKFAQHKFLFSREIGSESKVLIHRDPKERVQRVAPWLTTD *. : *:**. * *:::**** *..:**:*::*** **: ******.* Mflv_4654|M.gilvum_PYR-GCK TTVYPAIVNERIVWIVDGYTTLDNYPYSELSTLSSVTTDSNEVAQNRLQL Mvan_1814|M.vanbaalenii_PYR-1 TAVYPAIVNKRIVWIVDGYTTLDNYPYSELMSLSSATTDSNEVALNRLQP MSMEG_1959|M.smegmatis_MC2_155 TSVYPAIVNKRMVWIVDGYTTLDNYPYSELTTLSSATADSNEVAVNRLAP MMAR_1371|M.marinum_M SAVYPAIVNKRMVWILDGYTTLDNYPYSQLTSLSSATADSNEVAFNRLLP MUL_2505|M.ulcerans_Agy99 SAVYPAIVNKRMVWILDGYTTLDNYPYSQLTSLSSATADSNEVAFNRLLP MAV_4137|M.avium_104 SSVYPAIVNKRLVWIIDGYTTLDNYPYSELTSLESATADSNEVAFNKLAP MLBr_00644|M.leprae_Br4923 SSVYPAIVNKRLVWIIDGYTTLDNYPYSERTSLSSATADSTEVAFNRLAP MAB_3498c|M.abscessus_ATCC_199 SGTYPAIVDKRLVWIVDGYTTLDNYPYSQQTSLSEATFDSQVGRTGGALP Rv0064|M.tuberculosis_H37Rv DNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPVTSPTGIVR----Q Mb0065|M.bovis_AF2122/97 DNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPVTSPTGIVR----Q **.:*: *:***:*.*****.***:: :*. . .. Mflv_4654|M.gilvum_PYR-GCK DKQVSYIRNSVKATVDAYDGTVTLYAQDEQDPVLQAWMKVFPDSVKPKSD Mvan_1814|M.vanbaalenii_PYR-1 DKQVSYIRNSVKATVDAYDGTVTLYAQDEQDPVLQAWMKVFPDTVKPKAD MSMEG_1959|M.smegmatis_MC2_155 DKKVSYIRNSVKATVDAYDGTVTLYAQDENDPVLKAWMDVFPGTVKPKAD MMAR_1371|M.marinum_M DKQVSYIRNSVKATVDAYDGTVTLYQQDEQDPVLKAWMQVFPGTVKPKGD MUL_2505|M.ulcerans_Agy99 DKQVSYIRNSVKATVDAYDGTVTLYQQDEQDPVLKAWMQVFPGTVKPKGD MAV_4137|M.avium_104 DKRVSYIRNSVKATVDAYDGTVTLYQQDEQDPVLKAWMQVFPGTVKPKSD MLBr_00644|M.leprae_Br4923 DKRVAYIRNSVKATVDAYDGAVTLYQQDEYDPVLKVWMKVFPGTVRPKGD MAB_3498c|M.abscessus_ATCC_199 NQQVSYIRNSVKATVDAYDGTVTLYQQDEKDPVLKAWMKIFPGTVKPKAD Rv0064|M.tuberculosis_H37Rv GKQVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSEDQ Mb0065|M.bovis_AF2122/97 GKQVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSEDQ .::*:*:*************:***: *. ****:.** **.:*:.: : Mflv_4654|M.gilvum_PYR-GCK ITPELQEHLRYPEDLFKVQRALLAKYHVDDPVTFFSTSDFWDVPLDPNPT Mvan_1814|M.vanbaalenii_PYR-1 ITPELQEHLRYPEDLFKVQRALLAKYHVDDPVTFFSTSDFWDVPLDPNPT MSMEG_1959|M.smegmatis_MC2_155 ITPELQAHLRYPEDLFKVQRALLAKYHVDNPVTFFSAQDFWDVPLDPNPT MMAR_1371|M.marinum_M ISPELAAHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPT MUL_2505|M.ulcerans_Agy99 ISPELAAHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPT MAV_4137|M.avium_104 ISPELAEHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPT MLBr_00644|M.leprae_Br4923 ITPELAEHLRYPEDLFKVQRMLLAKYHVNDPGTFFNTSDFWDVPLDPNPT MAB_3498c|M.abscessus_ATCC_199 ISDDLKRHLRYPEDLFKVQRTLLARYHVNDPVTFFSTSDFWQVPDDPNAP Rv0064|M.tuberculosis_H37Rv IPDELRAHFRYPEDLFEVQRSLLAKYHVDEPREFFTTNAFWSVPSDPTNN Mb0065|M.bovis_AF2122/97 IPDELRAHFRYPEDLFEVQRSLLAKYHVDEPREFFTTNAFWSVPSDPTND *. :* *:*******:*** ***:***::* **.:. **.** **. Mflv_4654|M.gilvum_PYR-GCK ASSYQPPYYIVAKDLAENNGSASFQLTSAMNRFRRDFLAAYISASSDPET Mvan_1814|M.vanbaalenii_PYR-1 ASSYQPPYYIVAKDLAENNNSSSFQLTSAMNRFRRDFLAAYISASSDPET MSMEG_1959|M.smegmatis_MC2_155 ASSFQPPYYIVAKDLVKNDNSASFQLTSALNRFQRDFLAAYVSASSDPET MMAR_1371|M.marinum_M ASSYQPPYYIVAKNIAKNDNSASYQLISAMNRFKRDYLAAYISASSDPAT MUL_2505|M.ulcerans_Agy99 ASSYQPPYYIVAKNIAKNDNSASYQLISAMNRFKRDYLAAYISASSDPAT MAV_4137|M.avium_104 ASSYQPPYYIVAKNIAKNDNSSSYQLTSAMNRFKRDYLAAYISASSDPAT MLBr_00644|M.leprae_Br4923 ASSYQPPYYIVAKNILKNDRSASYQLTSAMNRFKQDFLAAYISASSDPET MAB_3498c|M.abscessus_ATCC_199 TGS-QPPYYIVAKDITKNDNSASFQLTSALNRFQRDFLAAYVSASSDPET Rv0064|M.tuberculosis_H37Rv ANATQPPFYVLVGDQQ--SAQPSFRLASAMVGYNREFLSAYISAHSDPAN Mb0065|M.bovis_AF2122/97 ANATQPPFYVLVGDQQ--SAQPSFRLASAMVGYNREFLSAYISAHSDPAN :.: ***:*::. : . ..*::* **: :.:::*:**:** *** . Mflv_4654|M.gilvum_PYR-GCK YGRLTVLTVPG--QVNGPKLAFNAISTDTAISTELGQIGRDGQNRIRWGN Mvan_1814|M.vanbaalenii_PYR-1 YGKLTVLTIPG--QVNGPKLAFNAISTDTAVSQDLGVIGRDNQNRIRWGN MSMEG_1959|M.smegmatis_MC2_155 YGKLTVLTIPG--QVNGPKLAFNAISTDTAVSQDLGVIGRDNQNRIRWGN MMAR_1371|M.marinum_M YGKITVLTIPG--QVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGN MUL_2505|M.ulcerans_Agy99 YGKITVLTIPG--QVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGN MAV_4137|M.avium_104 YGRITVLTIPG--QVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGN MLBr_00644|M.leprae_Br4923 YGKITVLTIPG--NVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGN MAB_3498c|M.abscessus_ATCC_199 YGKITVLTVPG--TVQGPKLVNNAITTDNQVSSHVGIIK--NQNILKWGN Rv0064|M.tuberculosis_H37Rv YGKLTVLELPTDTLTQGPQQIQNSMISDTRVASERTLLER--SNRIHYGN Mb0065|M.bovis_AF2122/97 YGKLTVLELPTDTLTQGPQQIQNSMISDTRVASERTLLER--SNRIHYGN **::*** :* .:**: *:: :* :: . : .* :::** Mflv_4654|M.gilvum_PYR-GCK LLTLPMGDGGLLYVAPIYAS-PGNTDAASTYPRLIRVAMMYND------- Mvan_1814|M.vanbaalenii_PYR-1 LLTLPMGQGGLLYVAPVYAS-PGASDAASSYPRLIRVAMMYND------- MSMEG_1959|M.smegmatis_MC2_155 LLTLPVADGGLLYVAPVYAS-PGSSDAASSYPRLIRVAMLYND------- MMAR_1371|M.marinum_M LLTLPVGQGGLLYVEPVYAS-PGASDAASSYPRLIRVAMMYND------- MUL_2505|M.ulcerans_Agy99 LLTLPVGQGGLLYVEPVYAS-PGASDAASSYPRLIRVAMMYND------- MAV_4137|M.avium_104 LLTLPVGQGGLLYVEPVYAS-PGASDAASSYPRLIRVAMMYND------- MLBr_00644|M.leprae_Br4923 LLTLPVAQGGLLYVEPVYAS-PGVSDAASSYPRLIRVAMMYND------- MAB_3498c|M.abscessus_ATCC_199 LLTLPVANGGLLFVEPLYAS-PGQGDQSS-YPRLIRVGMYYNG------- Rv0064|M.tuberculosis_H37Rv LLSLPIADGGVLYVEPLYTERISTSPSSSTFPQLSRVLVSVREPRTEGGV Mb0065|M.bovis_AF2122/97 LLSLPIADGGVLYVEPLYTERISTSPSSSTFPQLSRVLVSVREPRTEGGV **:**:.:**:*:* *:*:. . :* :*:* ** : . Mflv_4654|M.gilvum_PYR-GCK QIGYGPTVRDALTDLFGPGADATATGPAATEPPAGQAPQTQGNNTAPPAA Mvan_1814|M.vanbaalenii_PYR-1 QIGYGPTVRDALTDLFGPGADATATGPAATEPPAGQAPQPQGNN-QPPAA MSMEG_1959|M.smegmatis_MC2_155 RVGYGPTVSDALTELFGPGAGATATDVAPAE---GRPAQSTPNGQQPAAS MMAR_1371|M.marinum_M KIGYGPTVRDALNGLFGPGAGDAATGIQPTE---GGAPA------NVPPN MUL_2505|M.ulcerans_Agy99 KIGYGPTVRDALNGLFGPGAGDAATGIQPTE---GGAPA------NVPPN MAV_4137|M.avium_104 KIGYGPTVRDALTGLFGPGAGAAATNIQPTE---GGAPA------ASPPA MLBr_00644|M.leprae_Br4923 KIGYGPTVGDALTGLFGPGAASAATGIEPTE---AVPPK------SPAGS MAB_3498c|M.abscessus_ATCC_199 KVGYATTVRDALDMVFGPGAGATATAPAVEP---GAMPP------APPGG Rv0064|M.tuberculosis_H37Rv RVGYAPTLAESLDQVFGPGTGRVATARGGDA---ASAPP--------PGA Mb0065|M.bovis_AF2122/97 RVGYAPTLAESLDQVFGPGTGRVATAPGGDA---ASAPP--------PGA ::**..*: ::* :****: .** . . . Mflv_4654|M.gilvum_PYR-GCK QPPNRQGQAPAGR-PEVPVAVPPTGPTQLSAAKSAALQDVNAALDALRGA Mvan_1814|M.vanbaalenii_PYR-1 APPNRPGQAPTPQQPEVPVAVPPTGPTQLSAGKAAALQDVNAALDALQDA MSMEG_1959|M.smegmatis_MC2_155 PPPAANADGRPAQAPPPPSAATPTGPVQISQAKAEALQDLESALTAAQEA MMAR_1371|M.marinum_M NAPSPEALPGTPPSPPTAVPPAPEASVTLSPAKAAAMKEIQSAIGAARDA MUL_2505|M.ulcerans_Agy99 NAPSPEALPGTPPSPPTAVPPAPEASVTLSPARAAAMKEIQSAIGAARDA MAV_4137|M.avium_104 NAPAPAVTPGS--APPVAAPPVPDGSVTLSPAKAAVLQEIQAAIGAAKDA MLBr_00644|M.leprae_Br4923 STP-----------PIAVVPSAPDGSVALSAAKAAALQEIQAVIGAAREA MAB_3498c|M.abscessus_ATCC_199 QNVP----------VVPPVTPPPTGSAELSSAKAAALQEVQRAIGEVKEA Rv0064|M.tuberculosis_H37Rv GGP------------APPQAVPPPRTTQPPAAPPRGPDVPPATVAELRET Mb0065|M.bovis_AF2122/97 GGP------------APPQAVPPPRTTQPPAAPPRGPDVPPATVAELRET . * .. . . . . .: : : Mflv_4654|M.gilvum_PYR-GCK QESGDFAQYGEALQRLDDAVNKYQETD- Mvan_1814|M.vanbaalenii_PYR-1 QRSGDFAQYGEALQRLDDAVNKYQATN- MSMEG_1959|M.smegmatis_MC2_155 QRSGDFAEYGQALQRLNDAMKKYDSAK- MMAR_1371|M.marinum_M QKKGDFAAYGAALQRLDDAITKFNNTQ- MUL_2505|M.ulcerans_Agy99 QKKGDFAAYGAALQRLDDAITKFNNTQ- MAV_4137|M.avium_104 QKKGDFAGYGAALQRLDDAITKYNNTK- MLBr_00644|M.leprae_Br4923 QKKGDFVAYGSALQRLDDAITKFNSTK- MAB_3498c|M.abscessus_ATCC_199 QKSGDFARYGQALKGLDDAMTKFTQAR- Rv0064|M.tuberculosis_H37Rv -----LADLRAVLDRLEKAIDAAETPGG Mb0065|M.bovis_AF2122/97 -----LADLRAVLDRLEKAIDAAETPGG :. .*. *:.*: .