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MCGIVGLHLRTPELYPRLGELLTGMLCEMGDRGSDSAGVAVYGDPTWSPAGRGCVSVADLGTGRTEDADQ VAAAVAAALGGDVSGVGVDVSYVLSADVDSEVLLAALRSAYPDALVAGFGSDMAVLKGVGHPRALTERWG LAKAQGWQGVGHTRMATESAVTPAGCHPYAVGAGQCMVHNGSFANHATIRRELRAAGVPFDSENDTEVGA RFIARLLTEGRDVEGALKELCATFDGFYTLLVSNRDSFAVVRDAIACKPAVIAETDEWVAMASEYRALAG LPGVEEARIWEPEPEVVYAWSK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5510 | - | - | 100% (302) | glutamine amidotransferase, class-II |
| M. vanbaalenii PYR-1 | Mvan_1480 | - | 4e-14 | 33.09% (136) | D-fructose-6-phosphate amidotransferase |
| M. vanbaalenii PYR-1 | Mvan_5114 | - | 3e-08 | 26.52% (181) | amidophosphoribosyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3466c | glmS | 7e-17 | 36.03% (136) | glucosamine--fructose-6-phosphate aminotransferase |
| M. gilvum PYR-GCK | Mflv_1299 | - | 1e-149 | 84.44% (302) | glutamine amidotransferase, class-II |
| M. tuberculosis H37Rv | Rv3436c | glmS | 8e-17 | 36.03% (136) | glucosamine--fructose-6-phosphate aminotransferase |
| M. leprae Br4923 | MLBr_00371 | glmS | 2e-13 | 31.43% (140) | glucosamine--fructose-6-phosphate aminotransferase |
| M. abscessus ATCC 19977 | MAB_3743c | - | 3e-14 | 32.33% (133) | glucosamine--fructose-6-phosphate aminotransferase |
| M. marinum M | MMAR_1114 | glmS | 3e-15 | 33.82% (136) | glucosamine-fructose-6-phosphate aminotransferase, GlmS |
| M. avium 104 | MAV_4377 | glmS | 5e-15 | 34.56% (136) | D-fructose-6-phosphate amidotransferase |
| M. smegmatis MC2 155 | MSMEG_6261 | - | 1e-137 | 78.48% (302) | glutamine amidotransferase, class II |
| M. thermoresistible (build 8) | TH_1701 | glmS | 1e-15 | 34.56% (136) | PROBABLE GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE |
| M. ulcerans Agy99 | MUL_0872 | glmS | 2e-15 | 33.82% (136) | glucosamine--fructose-6-phosphate aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3466c|M.bovis_AF2122/97 MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDG----GTLTVRR
Rv3436c|M.tuberculosis_H37Rv MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDG----GTLTVRR
MMAR_1114|M.marinum_M MCGIVGYVGQRPACEVVLDALRRMEYRGYDSSGIALVDGS---GKLTVRR
MUL_0872|M.ulcerans_Agy99 MCGIVGYVGQRPACEVVLDALRRMEYRGYDSSGIALVDGS---GKLTVRR
MAV_4377|M.avium_104 MCGIVGYVGQQPACAVVMAALRRMEYRGYDSSGVALVNGD---GTLTVSR
MLBr_00371|M.leprae_Br4923 MCGLVGYVGQRPACGVVMDALRRMEYRGYDSSGIALINGSAKSGNLTVRR
MAB_3743c|M.abscessus_ATCC_199 MCGIVGYVGHRDALSVVLEALRRLEYRGYDSAGVALADGH---GGLLVQR
TH_1701|M.thermoresistible__bu MCGIVGYVGARNALDIVVDALRRMEYRGYDSAGVALLDGA---GGLTVRR
Mvan_5510|M.vanbaalenii_PYR-1 MCGIVGLHLR----------------------------------TPELYP
Mflv_1299|M.gilvum_PYR-GCK MCGIVGLHLR----------------------------------TPGLHP
MSMEG_6261|M.smegmatis_MC2_155 MCGIVGLHLR----------------------------------TAELYP
***:** :
Mb3466c|M.bovis_AF2122/97 RAGRLANLEEAVAEMPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAG
Rv3436c|M.tuberculosis_H37Rv RAGRLANLEEAVAEMPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAG
MMAR_1114|M.marinum_M RAGRLANLETAVAEMSAESLTGTTGLGHTRWATHGRPTDRNAHPHRDAAG
MUL_0872|M.ulcerans_Agy99 RAGRLANLETAVAEMPAESLTGTTGLGHTRWATHGRPTDRNAHPHRDAAG
MAV_4377|M.avium_104 RAGRLANLEEAVAQLPPSALTGTTGLGHTRWATHGRPTDRNAHPHRDAAG
MLBr_00371|M.leprae_Br4923 RAGRLSNLESVLAEMVPASLAGNVGLGHIRWATHGRPTDRNAHPHRDATG
MAB_3743c|M.abscessus_ATCC_199 KAGRLANLESAIAES-GESFAATTGMGHTRWATHGAPTDRNAHPHQDATG
TH_1701|M.thermoresistible__bu RAGRLANLEAELAATDPGLLAGTAGLGHTRWATHGRPTDRNAHPHRDASG
Mvan_5510|M.vanbaalenii_PYR-1 RLGELLTGMLCEMGDRGSDSAGVAVYGDPTWSPAGR-------------G
Mflv_1299|M.gilvum_PYR-GCK RLGELLTGMLCEMGDRGSDSAGVAVYGDPDWSPPGR-------------G
MSMEG_6261|M.smegmatis_MC2_155 RLGEMLTEMLCEMSDRGADSAGVAVYGDPVWSPPGR-------------G
: *.: . :. . *. *:. * *
Mb3466c|M.bovis_AF2122/97 KIAVVHNGIIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETA
Rv3436c|M.tuberculosis_H37Rv KIAVVHNGIIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETA
MMAR_1114|M.marinum_M KIAVVHNGIIENFAVLRQELEAAGVEFASDTDTEVAVHLVAQAFHHGETA
MUL_0872|M.ulcerans_Agy99 KIAVVHNGIIENFAVLRQELEAAGVEFASDTDTEVAVHLVAQAFHHGETA
MAV_4377|M.avium_104 KIAVVHNGIIENYAGLRHELEADGVEFASDTDTEVAVHLVAQAYRHGLTA
MLBr_00371|M.leprae_Br4923 KIAVVHNGIIENFPSLRHELEIAGVEFVSDTDTEVAVHLVAQAYCAGETA
MAB_3743c|M.abscessus_ATCC_199 KVAVVHNGIIENFAVLRAELESAGVEFASDTDSEVAVHLVSRQFESGDTA
TH_1701|M.thermoresistible__bu KFAVAHNGIIENNAVLRAELEAAGVEFASDTDTEVAVHLLARAYQHGETA
Mvan_5510|M.vanbaalenii_PYR-1 CVSVADLGTGR-----TEDADQVAAAVAAALGGDVSGVGVDVSY------
Mflv_1299|M.gilvum_PYR-GCK CVSVADLGIAA-----AEDATQVSAAVGTELGGDVDGVAVGAGY------
MSMEG_6261|M.smegmatis_MC2_155 CVSVTDL------------------AVAPDLGPDVEVVQVDSTY------
.:*.. . . . :* : :
Mb3466c|M.bovis_AF2122/97 DDFVGSVLAVLRRLEGHFTLVFANADDPGTLVAARRSTPLVLGIGDNEMF
Rv3436c|M.tuberculosis_H37Rv DDFVGSVLAVLRRLEGHFTLVFANADDPGTLVAARRSTPLVLGIGDNEMF
MMAR_1114|M.marinum_M GDFPASVLSVLRRLEGHFTLVFANADDPGTIVAARRSTPLVLGIGDGEMF
MUL_0872|M.ulcerans_Agy99 GDFPASVLSVLRRLEGHFTLVFANADDPGTIVAARRSTPLVLGIGDGEMF
MAV_4377|M.avium_104 GDFAASVLAVLRRLDGHFTLVFANADEPGTIVAARRSTPLVIGIGDGEMF
MLBr_00371|M.leprae_Br4923 GDFVGSVLAVLRRLQGHFTLVFANADEPGTIVAARRSTPLVLGIGDGEMF
MAB_3743c|M.abscessus_ATCC_199 GDFVASVQSVVRRLEGHFTLVFSHADDPGTIVAARRSTPLVVGIGDGEMF
TH_1701|M.thermoresistible__bu GDFVASVLSVLRRLDGHFTLVFANADEPGTIIAARRSTPLVVGVGDGEMF
Mvan_5510|M.vanbaalenii_PYR-1 -------------------VLSADVDSEVLLAALRSAYPDALVAG-----
Mflv_1299|M.gilvum_PYR-GCK -------------------TLSADVDSEALLSAVRAAYPHAIIAG-----
MSMEG_6261|M.smegmatis_MC2_155 -------------------LLSADTPSEDLLERVKAAYPSALIAG-----
: :.. . : : : * .: *
Mb3466c|M.bovis_AF2122/97 VGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQAGRDFRP
Rv3436c|M.tuberculosis_H37Rv VGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQAGRDFRP
MMAR_1114|M.marinum_M VGSDVAAFITHTRHAVELGQDQAVVITADGYRISDFDGNDDLLAGTDYRE
MUL_0872|M.ulcerans_Agy99 VGSDVAAFITHTRHAVDLGQDQAVVITADGYRISDFDGNDDLLAGTDYRE
MAV_4377|M.avium_104 VGSDVAAFIPHTRNAIELGQDQAVVLTADGYRITDFDGNDDLGPG-AYRE
MLBr_00371|M.leprae_Br4923 VGSDVAAFIEHTRQAVELGQDQAVVITADGYRISDFDGND---DAVNART
MAB_3743c|M.abscessus_ATCC_199 LGSDVAAFIEYTRDAVELGQDQVVVITADGYRITDFEGND---DTGNARV
TH_1701|M.thermoresistible__bu VGSDVAAFIEHTRDAVELGQDQAVVITADSYRVLDFLGAD---VTAQARH
Mvan_5510|M.vanbaalenii_PYR-1 FGSDMAVLKGVG----------------------------------HPRA
Mflv_1299|M.gilvum_PYR-GCK FGSDIAVLKGVG----------------------------------HPRA
MSMEG_6261|M.smegmatis_MC2_155 FGADLAVLKGVG----------------------------------HPRA
.*:*:*.: *
Mb3466c|M.bovis_AF2122/97 FHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRL
Rv3436c|M.tuberculosis_H37Rv FHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRL
MMAR_1114|M.marinum_M FHIDWDLAAAEKGGYEYFMLKEIAEQPTAVAETLLGHFVGNRIVLDEQRL
MUL_0872|M.ulcerans_Agy99 FHIDWDLAAAEKGGYEYFMLKEIAEQPTAVAETLLGHFVGNRIVLDEQRL
MAV_4377|M.avium_104 FHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVDGRIVLDEQRL
MLBr_00371|M.leprae_Br4923 FHIDWDLAAAEKGGYEYFMLKEIAEQPDAVVDTLLGHFTGGRIVLDEQRL
MAB_3743c|M.abscessus_ATCC_199 FTIDWDLSAAEKGGYEYFMLKEIAEQPAAVSDTLLGHFDLDRIVLDEQRL
TH_1701|M.thermoresistible__bu FHIDWDLSAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVDGRIVLDEQRL
Mvan_5510|M.vanbaalenii_PYR-1 LTERWGLAKAQG--------------------------------------
Mflv_1299|M.gilvum_PYR-GCK LTDGWGLAGARG--------------------------------------
MSMEG_6261|M.smegmatis_MC2_155 LTDAWGLVKAQG--------------------------------------
: *.* *.
Mb3466c|M.bovis_AF2122/97 SDQELREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRD
Rv3436c|M.tuberculosis_H37Rv SDQELREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRD
MMAR_1114|M.marinum_M SDQELREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRD
MUL_0872|M.ulcerans_Agy99 SDQELREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRD
MAV_4377|M.avium_104 SDQELREVDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRD
MLBr_00371|M.leprae_Br4923 SDQELREIDKVFVVACGTAYHSGLLAKYTIEHWTRLPVEVELASEFRYRD
MAB_3743c|M.abscessus_ATCC_199 SDQELRDIDKVFVVACGTAFHSGLLAKYAIEHWTRLPVEIELASEFRYRD
TH_1701|M.thermoresistible__bu SDQELREVDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRD
Mvan_5510|M.vanbaalenii_PYR-1 ---------------WQGVGHTRMATESAVTPAGCHPYAVGAGQCMVHNG
Mflv_1299|M.gilvum_PYR-GCK ---------------WQGVGHTRMATESAVTPAGCHPYAVGPEQCMVHNG
MSMEG_6261|M.smegmatis_MC2_155 ---------------WQGVGHTRMATESAVTPSGCHPYTVGPEQCLVHNG
. *: : :: :: * : . : :..
Mb3466c|M.bovis_AF2122/97 PVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPREC
Rv3436c|M.tuberculosis_H37Rv PVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPREC
MMAR_1114|M.marinum_M PVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPREC
MUL_0872|M.ulcerans_Agy99 PVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPREC
MAV_4377|M.avium_104 PVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPREC
MLBr_00371|M.leprae_Br4923 PVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPREC
MAB_3743c|M.abscessus_ATCC_199 PVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAVCNTNGSQIPREC
TH_1701|M.thermoresistible__bu PVLDRSTLVVAISQSGETADTLEAVRHAKAQKAKVLAICNTNGSQIPRES
Mvan_5510|M.vanbaalenii_PYR-1 SFANHATIRRELRAAGVPFDSENDTEVG----ARFIARLLTEGRDVEGAL
Mflv_1299|M.gilvum_PYR-GCK SFANHATIRRTLRADGVLFDSENDTEVG----ARFIAKLLAEGRDVESAL
MSMEG_6261|M.smegmatis_MC2_155 SFSNHATIRRELRRAGVQFDSENDTEVG----ARFVAQQLAAGRDVQTAL
.. :::*: : * *: : .. . *:.:* : * ::
Mb3466c|M.bovis_AF2122/97 DAVLYTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREY
Rv3436c|M.tuberculosis_H37Rv DAVLYTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREY
MMAR_1114|M.marinum_M DAVLYTRAGPEIGVASTKTFLAQVTANYLLGLALAQARGTKYPDEVEREY
MUL_0872|M.ulcerans_Agy99 DAVLYTRAGPEIGVASTKTFLAQVTANYLLGLALAQARGTKYPDEVEREY
MAV_4377|M.avium_104 DAVLYTRAGPEIGVASTKTFLAQITANYLVGLALAQARGTKYPDEVEREY
MLBr_00371|M.leprae_Br4923 DAVLYTRAGPEIGVASTKTFLAQVAANYLLGLALAQARGTKYPDEVQREY
MAB_3743c|M.abscessus_ATCC_199 DAVLYTRAGPEIGVAATKTFLAQVTANYIVGLALAQARGTKYPDEVAREY
TH_1701|M.thermoresistible__bu DAVLYTRAGPEIGVAATKTFLAQIVANYLVGLALAQARGTKYPDEVEREY
Mvan_5510|M.vanbaalenii_PYR-1 KELCATFDGFYTLLVSNRDSFAVVRD--AIACKPAVIAETDEWVAMASEY
Mflv_1299|M.gilvum_PYR-GCK KELCAVFDGFYTLLVSNRDSFAVVRD--AIACKPAVIAETGDWVAMASEY
MSMEG_6261|M.smegmatis_MC2_155 KALCATFDGFYTLLVSNRDSFAVVRD--AIACKPAVIAETDEWVAMASEY
. : . * :.:.: :* : :. * * : **
Mb3466c|M.bovis_AF2122/97 HELEAMPDLVARVIAATGPVAELAHRFAQSSTVLFLGRHVGYPVALEGAL
Rv3436c|M.tuberculosis_H37Rv HELEAMPDLVARVIAATGPVAELAHRFAQSSTVLFLGRHVGYPVALEGAL
MMAR_1114|M.marinum_M RELEAMPDLVARVISAIKPVADLAYRFAQSSTVLFLGRHVGYPVALEGAL
MUL_0872|M.ulcerans_Agy99 RELEAMPDLVARVISAIKPVAHLAYRFAQSSTVLFLGRHVGYPVALEGAL
MAV_4377|M.avium_104 HELEAMPDLVARVLATIKPVAALAQRFAQSPTVLFLGRHVGYPVALEGAL
MLBr_00371|M.leprae_Br4923 RELEAMPDLVARVIAGMGPVADLAYRFAQSTTVLFLGRHVGYPVALEGAL
MAB_3743c|M.abscessus_ATCC_199 HELEAMPELIERVISQMDPVADLARQYAQSSSILFLGRHVGYPVALEGAL
TH_1701|M.thermoresistible__bu RELEAMPALVQRVVSTVEPVSALARQFAGAPAVLFLGRHVGYPVALEGAL
Mvan_5510|M.vanbaalenii_PYR-1 RALAGLPGVEEARIWEPEPEVVYAWSK-----------------------
Mflv_1299|M.gilvum_PYR-GCK RALAALPGVDQARIWEPEPEVVYAWQR-----------------------
MSMEG_6261|M.smegmatis_MC2_155 RALSGLPGVEKARIWEPEPEVVYAWTR-----------------------
: * .:* : : * *
Mb3466c|M.bovis_AF2122/97 KLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSATLHAKLL
Rv3436c|M.tuberculosis_H37Rv KLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSATLHAKLL
MMAR_1114|M.marinum_M KLKELAYMHAEGFAAGELKHGPIALVEDELPVIVIMPSPKGSATLHAKLL
MUL_0872|M.ulcerans_Agy99 KLKELAYMHAEGFAAGELKHGPIALVEDELPVIVIMPSPKGSATLHAKLL
MAV_4377|M.avium_104 KLKELAYMHAEGFAAGELKHGPIALIEDDLPVIVIMPSPKGSAVLHAKLL
MLBr_00371|M.leprae_Br4923 KLKELAYMHAEGFAAGELKHGPIALIEENLPVIVVMPSPKGSAMLHAKLL
MAB_3743c|M.abscessus_ATCC_199 KLKELAYMHAEGFAAGELKHGPIALIEEGLPVIVVMPSPKGMGLLHSKLL
TH_1701|M.thermoresistible__bu KLKELAYMHAEGFAAGELKHGPIALIEEGLPVIVVMPSPKHALTLHGKLL
Mvan_5510|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1299|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6261|M.smegmatis_MC2_155 --------------------------------------------------
Mb3466c|M.bovis_AF2122/97 SNIREIQTRGAVTIVIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPL
Rv3436c|M.tuberculosis_H37Rv SNIREIQTRGAVTIVIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPL
MMAR_1114|M.marinum_M SNIREIQTRGAVTIVIAEEGDDTVRPFADHLIEIPAVSTLLQPLLSTIPL
MUL_0872|M.ulcerans_Agy99 SNIREIQTRGAVTIVIAEEGDDTVRPFADHLIEIPAVSTLLQPLLSTIPL
MAV_4377|M.avium_104 SNIREIQARGAITIVIAEEGDDTVRPYADHLIEIPSVSTLLQPLLSTIPL
MLBr_00371|M.leprae_Br4923 SNIREIQTRGAVTIVIAEEGDDTVRLYADHLIELPAVSTLLQPLLSTIPL
MAB_3743c|M.abscessus_ATCC_199 SNIREIQARGARTIVIAEEGDETIRPYADHLIEIPAVSTLYQPLLSTIPM
TH_1701|M.thermoresistible__bu SNIREIQARGAVTIVIAEEGDDTVRPYADHLIEIPVVSTLFQPLLSTVPL
Mvan_5510|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1299|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6261|M.smegmatis_MC2_155 --------------------------------------------------
Mb3466c|M.bovis_AF2122/97 QVFAASVARARGYDVDKPRNLAKSVTVE
Rv3436c|M.tuberculosis_H37Rv QVFAASVARARGYDVDKPRNLAKSVTVE
MMAR_1114|M.marinum_M QVFAAAVAQARGYDVDKPRNLAKSVTVE
MUL_0872|M.ulcerans_Agy99 QVFAAAVAQARGYDVDKPRNLAKSVTVE
MAV_4377|M.avium_104 QVFAASVAQARGYDVDKPRNLAKSVTVE
MLBr_00371|M.leprae_Br4923 QVFAASVAQARGYDVDKPRNLAKSVTVE
MAB_3743c|M.abscessus_ATCC_199 QVFAAAVAQARGYDVDKPRNLAKSVTVE
TH_1701|M.thermoresistible__bu QVFAASVAQARGYDVDKPRNLAKSVTVE
Mvan_5510|M.vanbaalenii_PYR-1 ----------------------------
Mflv_1299|M.gilvum_PYR-GCK ----------------------------
MSMEG_6261|M.smegmatis_MC2_155 ----------------------------