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RTPVVVVAGQSDTDGITGVLLDGAGTVLVEHRFDGHVVHRSTTVVQGGLLDTADEVLELTNCCLSCTVRE DLLSHLRRLHRRPDVKRIAVRLGPWMEPEQVCFAITRLPAARDVAIAAVVTAVDTSTWLRQALGDDELDD GRTVAQVVVGQVEFADVVVLTGPDPDVVAVTRRLAPRARVAVGAQRLGVALADLDPDARRGRSDDPHASL LSGQPPLEAAGPVRLVEFQSRRPFHPLRLHAAVDLLLDGVIRSRGRLWLANRPGHALWLETAGGGLRVTR TGKWLAAMTSREIAYVGPERRAMADLIWGYPHGDRHTSMTVLVCGAEPADIIDALQGALLTDAEMQRPQD WGRYEDPFHDTLEGDADEARLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5488 | - | - | 100% (373) | cobalamin synthesis CobW domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5332 | - | e-110 | 55.28% (369) | cobalamin synthesis CobW domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5321 | - | 6e-20 | 27.19% (342) | cobalamin synthesis protein, P47K |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0109 | - | 1e-132 | 62.10% (372) | hypothetical protein Mb0109 |
| M. gilvum PYR-GCK | Mflv_1313 | - | 1e-146 | 70.24% (373) | cobalamin synthesis CobW domain-containing protein |
| M. tuberculosis H37Rv | Rv0106 | - | 1e-132 | 62.10% (372) | hypothetical protein Rv0106 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0335 | - | 1e-125 | 59.14% (372) | cobalamin synthesis protein |
| M. marinum M | MMAR_0293 | - | 1e-131 | 61.84% (380) | hypothetical protein MMAR_0293 |
| M. avium 104 | MAV_4874 | - | 1e-125 | 62.99% (354) | CobW/P47K domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6069 | - | 1e-118 | 58.12% (382) | CobW/P47K domain-containing protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4830 | - | 1e-130 | 61.32% (380) | hypothetical protein MUL_4830 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0109|M.bovis_AF2122/97 MRTPVILVAGQDHTD----EVTGALLRRTGTVVVEHRFDGHVVRRMTATL
Rv0106|M.tuberculosis_H37Rv MRTPVILVAGQDHTD----EVTGALLRRTGTVVVEHRFDGHVVRRMTATL
MMAR_0293|M.marinum_M MRTPVVLVAGQGDTD----DVTGLLLRRPGTVVVEHRFDGHVVRRNIITF
MUL_4830|M.ulcerans_Agy99 MRTPVVLVAGQGDTD----DVTGLLLRRPGTVVVEHRFDGHVVRRNIITF
MAB_0335|M.abscessus_ATCC_1997 MRTPVLLVSGQTDTD----AVTQVLARDPGTVVVTHRFDGHIVMRSVAGI
MAV_4874|M.avium_104 ---------------------MGALLRTSGTLVVEHRFDGHVVRRTTAVL
MSMEG_6069|M.smegmatis_MC2_155 -----MLVAGQDDARGTGRAVVEELLKAPGTLLVSHTFDGHVVVRTVSSS
Mvan_5488|M.vanbaalenii_PYR-1 MRTPVVVVAGQSDTD----GITGVLLDGAGTVLVEHRFDGHVVHRSTTVV
Mflv_1313|M.gilvum_PYR-GCK MRTPVVVVTGQSDTG----DIGDLLLADGATALVEHHVEGHVVHRTTTVL
* .* :* * .:**:* *
Mb0109|M.bovis_AF2122/97 SRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAPW
Rv0106|M.tuberculosis_H37Rv SRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAPW
MMAR_0293|M.marinum_M RRGELSTAEEVLELAHGCVSCTIRNDLLILLRRLHRRDGVDRIVVHLAPW
MUL_4830|M.ulcerans_Agy99 RRGELSTAEEALELAHGCVSCTIRNDLLILLRRLHRRDGVDRIVVHLAPW
MAB_0335|M.abscessus_ATCC_1997 RG----VTETVLELAHGCVSCTIRDDLLVLLRKLHRRDDVGRIVLHLEPW
MAV_4874|M.avium_104 TDGVLTSTECGLELAHGCVSCTIRNDLLVLLRQLHRRDDVDRIVVHLAPW
MSMEG_6069|M.smegmatis_MC2_155 VD----SSQWVLELVHGCVSCTVRDDLLILLRRLHRRADVTRIVVQMMPW
Mvan_5488|M.vanbaalenii_PYR-1 QGGLLDTADEVLELTNCCLSCTVREDLLSHLRRLHRRPDVKRIAVRLGPW
Mflv_1313|M.gilvum_PYR-GCK RRGVVVKAVSVVEMTNGCPSCAVREDLVDHLCRLHLRPDVARIAVLLSPW
: :*:.: * **::*:**: * :** * .* **.: : **
Mb0109|M.bovis_AF2122/97 LEPQPICWAIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSLG
Rv0106|M.tuberculosis_H37Rv LEPQPICWAIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSLG
MMAR_0293|M.marinum_M LEPEPICWAINHVRVRVGPGYPDAPAGRDVRIGAVVTCVDSANWLAQSLG
MUL_4830|M.ulcerans_Agy99 LEPEPICWAINHVRVRVGPGYPDAPAGRDVRIGAVVTCVDSANWLAQSLG
MAB_0335|M.abscessus_ATCC_1997 LEADPICWAINTVPVRVGPGFVDGPAARDVQIAGVVSCVDSANWLEQALG
MAV_4874|M.avium_104 LEPEPICLAINHVRVRVAPGGVDGPAALDVSIAAVVTCVDSSTWLSQALG
MSMEG_6069|M.smegmatis_MC2_155 LEPEPVRWAIDNVHVRVGPGYIDGPAARDVEVAAVVTCVDTAAWLEQALG
Mvan_5488|M.vanbaalenii_PYR-1 MEPEQVCFAITRL-----------PAARDVAIAAVVTAVDTSTWLRQALG
Mflv_1313|M.gilvum_PYR-GCK MEPEPVCVALTRS-----------TAARHVAVSAVVATVDTSVWLHQALG
:*.: : *: .*. .* :..**: ** ** *:**
Mb0109|M.bovis_AF2122/97 EDELPDGRTVAQVTVGQAEFADLLVLTHPEPVAVAVLRRLAPRARITGGV
Rv0106|M.tuberculosis_H37Rv EDELPDGRTVAQVTVGQAEFADLLVLTHPEPVAVAVLRRLAPRARITGGV
MMAR_0293|M.marinum_M DEELADGRTFAQVTVGQAEFADVLVLNRPDPVTLAVLPRLAPRARITVGL
MUL_4830|M.ulcerans_Agy99 DEELADGRTFAQVTVGQAEFADVLVLNRPDPVTLAVLPRLAPRARITVGL
MAB_0335|M.abscessus_ATCC_1997 DDELADGRTVAQVVIGQAEFADVLLVRNPEPEVLSVLRRLAPRARITARV
MAV_4874|M.avium_104 EDELDDGRTHAQVVIGQAEFADVVVLDHPNPFLAAVLRRLAPRARVRVGA
MSMEG_6069|M.smegmatis_MC2_155 EDELADGRTAAQVVVGQAEVADVLVLGEPEATTLAVLRRLAPRARITVGP
Mvan_5488|M.vanbaalenii_PYR-1 DDELDDGRTVAQVVVGQVEFADVVVLTGPDPDVVAVTRRLAPRARVAVGA
Mflv_1313|M.gilvum_PYR-GCK DDELDDGRTVAQVVVGQVEFADVVVLTEAHRDTLAVVRRLAPAARITVGV
::** **** ***.:**.*.**:::: .. :* **** **:
Mb0109|M.bovis_AF2122/97 DRVELALAHLDDNSRRGRTDTPHTPLLAGLPPLAADGEVAIVEFSARRPF
Rv0106|M.tuberculosis_H37Rv DRVELALAHLDDNSRRGRTDTPHTPLLAGLPPLAADGEVAIVEFSARRPF
MMAR_0293|M.marinum_M DRVELALANLDDYSRRGRSDHPHASLLGGRPPLGTDGGVGIVEFNARRPF
MUL_4830|M.ulcerans_Agy99 DRVELALANLDDYSRRGRSDHPHASLLGGRPPLGTDGGVGIVEFNARRPF
MAB_0335|M.abscessus_ATCC_1997 GRVEQALDHLEEDARCGRADNPHGALLAGQPSLAADGRVELVEFNARRPF
MAV_4874|M.avium_104 DGIDDALNNLYRDARRGRVDDPHGPLLAGQPPLDARGPIRLVEFNSRRPF
MSMEG_6069|M.smegmatis_MC2_155 DRLELALAHLEPDTPRGRALSPRDSLLAGQPPLTADGEVRIVEFTARRPF
Mvan_5488|M.vanbaalenii_PYR-1 QRLGVALADLDPDARRGRSDDPHASLLSGQPPLEAAGPVRLVEFQSRRPF
Mflv_1313|M.gilvum_PYR-GCK SRFTLALANLDADARRGRGNDPHGSLLAGQPPLEPAGRVRLVEFAARRPF
. ** .* : ** *: .**.* *.* . * : :*** :****
Mb0109|M.bovis_AF2122/97 HPQRLHAAVDLLLDGVVRTRGRLWLANRPDQVMWLESAGGGLRVASAGKW
Rv0106|M.tuberculosis_H37Rv HPQRLHAAVDLLLDGVVRTRGRLWLANRPDQVMWLESAGGGLRVASAGKW
MMAR_0293|M.marinum_M RPERLHDAVDHLLDGVIRTRGRLWLANRPDQVMWLESAGGGLRVASAGKW
MUL_4830|M.ulcerans_Agy99 RPERLHDAVDHLLDGVIRTRGRLWLANRPDQVMWLESAGGGLRVAWAGKW
MAB_0335|M.abscessus_ATCC_1997 HPLRLHAAIDMLLDGVIRTRGRLWLATQGEQAMWLESAGGGLRVSAAGKW
MAV_4874|M.avium_104 HPGRLHACLDLLLDGVIRTRGRLWLASRADRAMWLESAGAGLRVSSAGKW
MSMEG_6069|M.smegmatis_MC2_155 HPVRLHAAIDLLLDGVVRTRGRAWLANRDAEVMWIESAGGGLRVSTAGKW
Mvan_5488|M.vanbaalenii_PYR-1 HPLRLHAAVDLLLDGVIRSRGRLWLANRPGHALWLETAGGGLRVTRTGKW
Mflv_1313|M.gilvum_PYR-GCK HPSRLHAAVDLLLEGVVRSRGRLWLAHLPDMAVGLDSAGGGLLVTRAGKW
:* *** .:* **:**:*:*** *** .: :::**.** *: :***
Mb0109|M.bovis_AF2122/97 LAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVLVCGADPTDIVNA
Rv0106|M.tuberculosis_H37Rv LAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVLVCGADPTDIVNA
MMAR_0293|M.marinum_M LAAMSPAEVDHADPERRLFAELMWEYRFGDRHTAMTVLACGADRAEITRV
MUL_4830|M.ulcerans_Agy99 LAAMSPAEVDHADPERRLFAEMMWEYRFGDRHTAMTVLACGADRAEITRV
MAB_0335|M.abscessus_ATCC_1997 LAAMDSVEVQRVDPERRAFADLMWDYQFGDRHNAMTVLVCGADSREVLDA
MAV_4874|M.avium_104 LAAMTGPERDGIDAQRRVLAALGWDDRHGDRHTAMAILVCGADPAEILDA
MSMEG_6069|M.smegmatis_MC2_155 LAAMNSSELAYTDPQWRALAAIDWDPSFGDRHVSLVMLVCGARTDDILDA
Mvan_5488|M.vanbaalenii_PYR-1 LAAMTSREIAYVGPERRAMADLIWGYPHGDRHTSMTVLVCGAEPADIIDA
Mflv_1313|M.gilvum_PYR-GCK LAAMTSRELAYVGAERRAMADMMWDDRYGDRHTSMTVLVCGADPAEIVSA
**** * . : * :* : * .**** ::.:*.*** :: .
Mb0109|M.bovis_AF2122/97 LNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAG--EFSAHRNS
Rv0106|M.tuberculosis_H37Rv LNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAG--EFSAHRNS
MMAR_0293|M.marinum_M LTGALLTDREMARPQDWPAYDDPFGDWHEDPCHETPDESG--QFSGHLNK
MUL_4830|M.ulcerans_Agy99 LTGALLTDREMARPQDWPAYDDPFGDWHEDPCHETPDESG--QFSGHLNK
MAB_0335|M.abscessus_ATCC_1997 LRGALLTDDEMASPADWDEFDDPFGDWHEDPCEHLSEAEAFLAYGDHNTE
MAV_4874|M.avium_104 LQAALLTDEELERPGEWQGYDDPFGDWHEEPCVGLEAADN--AAQGARQD
MSMEG_6069|M.smegmatis_MC2_155 LRGALLTDAEFARRQEWRHYPDPFGDWHQEPCDADQAAHA-AQFSDARHH
Mvan_5488|M.vanbaalenii_PYR-1 LQGALLTDAEMQRPQDWGRYEDPFHDTLEGDADEARLA------------
Mflv_1313|M.gilvum_PYR-GCK LRGALLTDAEMGRPQDWPRFDDPFGDWHP---QEARLA------------
* .***:* *: * : *** *
Mb0109|M.bovis_AF2122/97 GESR-----
Rv0106|M.tuberculosis_H37Rv GESR-----
MMAR_0293|M.marinum_M GELE-----
MUL_4830|M.ulcerans_Agy99 GELE-----
MAB_0335|M.abscessus_ATCC_1997 GNH------
MAV_4874|M.avium_104 PDPS-----
MSMEG_6069|M.smegmatis_MC2_155 PDPQTGEQS
Mvan_5488|M.vanbaalenii_PYR-1 ---------
Mflv_1313|M.gilvum_PYR-GCK ---------