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MQSQTGVVNCQFVQSEAVCHAAHAYADDVTSPDPAVGGSQTPPAPTPPDRPIRTAAFFDLDKTVLAKSST LAFSKPFYSQGLINRRAVLKSSYAQFLFLMSGADHDQMDRMRTYITNMCTGWDVEQIKAIVGETLHDIVD PLVFAEAAELIADHKLCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVEDGKYTGDIAFYCYGEGKA EAILALADREGYALEHCYAYSDSITDLPMLATVGHPTVVNPDRTLRKEAAARGWPVRTFSKPVSLRDRLP APSGAAVATTAAVGVSALAAGALTYSLLRRFAF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5423 | - | - | 100% (313) | HAD family hydrolase |
| M. vanbaalenii PYR-1 | Mvan_0843 | - | 2e-29 | 32.19% (292) | HAD family hydrolase |
| M. vanbaalenii PYR-1 | Mvan_4075 | - | 9e-19 | 26.14% (264) | HAD family hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3685 | - | 1e-127 | 80.36% (275) | hypothetical protein Mb3685 |
| M. gilvum PYR-GCK | Mflv_1382 | - | 1e-154 | 87.62% (307) | HAD family hydrolase |
| M. tuberculosis H37Rv | Rv3661 | - | 1e-128 | 80.73% (275) | hypothetical protein Rv3661 |
| M. leprae Br4923 | MLBr_02424 | - | 1e-32 | 35.43% (254) | hypothetical protein MLBr_02424 |
| M. abscessus ATCC 19977 | MAB_0431c | - | 1e-131 | 82.04% (284) | hypothetical protein MAB_0431c |
| M. marinum M | MMAR_5149 | serB | 1e-131 | 79.65% (285) | phosphoserine phosphatase SerB |
| M. avium 104 | MAV_0469 | - | 1e-130 | 80.07% (286) | HAD-superfamily protein subfamily protein IB hydrolase |
| M. smegmatis MC2 155 | MSMEG_6173 | - | 1e-136 | 84.72% (288) | morphological differentiation-associated protein |
| M. thermoresistible (build 8) | TH_0711 | - | 1e-137 | 87.87% (272) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4234 | serB | 1e-131 | 79.30% (285) | phosphoserine phosphatase SerB |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3685|M.bovis_AF2122/97 ----------------------------MTVSDSPAQRQTPPQTPGGT--
Rv3661|M.tuberculosis_H37Rv ----------------------------MTVSDSPAQRQTPPQTPGGT--
MMAR_5149|M.marinum_M ----------------------------MTVSDPAAQQQDSPQSPEKP--
MUL_4234|M.ulcerans_Agy99 ----------------------------MTVSDPAAQQQDSPQSPKKP--
MAV_0469|M.avium_104 ----------------------------MTVFDPAAEQSAPEQSAPSG--
Mvan_5423|M.vanbaalenii_PYR-1 MQSQTGVVNCQFVQSEAVCHAAHAYADDVTSPDPAVGGSQTPPAPTPP--
Mflv_1382|M.gilvum_PYR-GCK -------MNCQFVRSAANCHIRHLYADGVTSSDPVVGGGRAPDMPVEP--
TH_0711|M.thermoresistible__bu ----------------------------VTDSEQPETIDGAPRAEVAN--
MSMEG_6173|M.smegmatis_MC2_155 ------------------------MLALVTASDRAAEESIAATSDATPRG
MAB_0431c|M.abscessus_ATCC_199 ------------------------MTDHATAPGSSPSIEDRDAAASTQPA
MLBr_02424|M.leprae_Br4923 -------MASPDLSNAYNGRIDLGSLANNASINRALNDMPTAVDDAGVRP
:
Mb3685|M.bovis_AF2122/97 --APRARTAAFFDLDKTIIAKPSTLAFSKPFFAQGLLNRRAVLKSSYAQF
Rv3661|M.tuberculosis_H37Rv --APRARTAAFFDLDKTIIAKSSTLAFSKPFFAQGLLNRRAVLKSSYAQF
MMAR_5149|M.marinum_M --PARARTAAFFDLDKTIIAKSSTLAFSKPFFAQGLMNRRAVLKSSYAQF
MUL_4234|M.ulcerans_Agy99 --PAHARTAAFFDLDKTIIAKSSTLAFSKPFFAQGLMNRRAVLKSSYAQF
MAV_0469|M.avium_104 --VPHARTAAFFDLDKTIIAKSSTLAFSKPFFAQGLLNRRAVLKSSYAQF
Mvan_5423|M.vanbaalenii_PYR-1 --DRPIRTAAFFDLDKTVLAKSSTLAFSKPFYSQGLINRRAVLKSSYAQF
Mflv_1382|M.gilvum_PYR-GCK --ERPIRTAAFFDLDKTVIAKSSTLAFSKPFFSQGLINRRAVLKSTYAQF
TH_0711|M.thermoresistible__bu --DRPVRTAAFFDLDKTVIAKSSTLAFSKPFFEQGLINRRAVLKSTYAQF
MSMEG_6173|M.smegmatis_MC2_155 DDGRPVRTAAFFDLDKTVIAKSSTLAFSKPFFDQGLLNRRTVLKSSYAQF
MAB_0431c|M.abscessus_ATCC_199 SAGPAPKTAAFFDLDKTVIAKSSTLAFSKPFFDQGLINRRAVLKSSYAQF
MLBr_02424|M.leprae_Br4923 QPPIDLTAAAFFDVDNTLVQGSSAVHFGRGLAARDYFTYRDVLGFIYAQA
:*****:*:*:: .*:: *.: : :. :. * ** ***
Mb3685|M.bovis_AF2122/97 IFLLSG-ADHDQMDRMRTHLTNMCAGWDVAQVRSIVNETLHDIVTPLVFA
Rv3661|M.tuberculosis_H37Rv IFLLSG-ADHDQMDRMRTHLTNMCAGWDVAQVRSIVNETLHDIVTPLVFA
MMAR_5149|M.marinum_M IFLLSG-ADHDQMDRMRTHMTNMCTGWDAEQVKSIVNETLHDIVTPLVFA
MUL_4234|M.ulcerans_Agy99 IFLLSG-ADHDQMDRVRTHMTNMCTGWDAEQVKSIVNETLHDIVTPLVFA
MAV_0469|M.avium_104 IYLLSG-ADHDQMDRMRAHMTNMCTGWDVEQVKSIVNETLHDIVTPLVFA
Mvan_5423|M.vanbaalenii_PYR-1 LFLMSG-ADHDQMDRMRTYITNMCTGWDVEQIKAIVGETLHDIVDPLVFA
Mflv_1382|M.gilvum_PYR-GCK LFSMSG-ADHDQMDRMRNYLTTMCAGWDVEQVKAVVGETLHDIVDPLVFA
TH_0711|M.thermoresistible__bu LFMMSG-ADHDQMDRMRSYLTNMVAGWDVDQVKSIVAETLHDIVDPLVFA
MSMEG_6173|M.smegmatis_MC2_155 LFLMSG-ADHDQMDRMRDYITNMCAGWDVEQVKSIVGETLHGIVDPLVFA
MAB_0431c|M.abscessus_ATCC_199 FFLLSG-ADHDQMDRMRTHITNMCTGWDVEQVKAIVAETLHDIVDPLVFA
MLBr_02424|M.leprae_Br4923 KFQLLGKENSQDVAAGQRKALAFIEGRSVEQLVALGEEIYDEIIADKIWA
: : * : ::: : : * .. *: :: * . *: ::*
Mb3685|M.bovis_AF2122/97 EAADLIAAHKLCGRDVVVVSASGEEIVGPIARALGATHAMATRMIVEDGK
Rv3661|M.tuberculosis_H37Rv EAADLIAAHKLCGRDVVVVSASGEEIVGPIARALGATHAMATRMIVEDGK
MMAR_5149|M.marinum_M EAADLIAGHKLCGRDVVVVSASGEEIVGPIARALGATHAMATRMVVADGK
MUL_4234|M.ulcerans_Agy99 EAADLIAGHKLCGRDVVVVSASGEEIVGPIARALGATHAMATRMVVADGK
MAV_0469|M.avium_104 EAADLIAAHKLCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVEDGR
Mvan_5423|M.vanbaalenii_PYR-1 EAAELIADHKLCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVEDGK
Mflv_1382|M.gilvum_PYR-GCK EAAELIADHKRCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVEDGR
TH_0711|M.thermoresistible__bu EAAELIADHKLCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVEDGK
MSMEG_6173|M.smegmatis_MC2_155 EAAELIADHKLCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVEDGR
MAB_0431c|M.abscessus_ATCC_199 EAADLIADHKLCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVEDGK
MLBr_02424|M.leprae_Br4923 GTRQLTQIHLDAGQQVWLITATPYELAATIARRLGLTGALGTVAESVDGI
: :* * .*::* :::*: *:...*** ** * *:.* **
Mb3685|M.bovis_AF2122/97 YTG-EVAFYCYGEGKAQAIRELAASEGYPLEHCYAYSDSITDLPMLEAVG
Rv3661|M.tuberculosis_H37Rv YTG-EVAFYCYGEGKAQAIRELAASEGYPLEHCYAYSDSITDLPMLEAVG
MMAR_5149|M.marinum_M YTG-EVAFYCYGEGKVQAIRELAAREGYPLEHCYAYSDSITDLPMLEAVG
MUL_4234|M.ulcerans_Agy99 YTG-EVAFYCYGEGKVQAIRELAAREGYPLEHCYAYSDSITDLPMLEAVG
MAV_0469|M.avium_104 YTG-EIAFYCYGEGKVQAIRELAAREGYPLEHCYAYSDSITDLPMLEAVG
Mvan_5423|M.vanbaalenii_PYR-1 YTG-DIAFYCYGEGKAEAILALADREGYALEHCYAYSDSITDLPMLATVG
Mflv_1382|M.gilvum_PYR-GCK YTG-DIAFYCYGEGKAEAIRALADREGYALEHCYAYSDSITDIPMLESVG
TH_0711|M.thermoresistible__bu YTG-EIAFYCYGENKAEAIRQLAAREGYALEHCYAYSDSITDLPMLEAVG
MSMEG_6173|M.smegmatis_MC2_155 YTG-EIAFYCYGEGKAQAIKALAAREGYALEHCYAYSDSITDLPMLETVG
MAB_0431c|M.abscessus_ATCC_199 YTG-DVAFYCYGEGKVAAIQELAKREGYPLEHCYAYSDSITDLPMLESVG
MLBr_02424|M.leprae_Br4923 FTGRLVDELLHGVGKAHAVRSLAIREGLNLKRCTAYSDSYNDVPMLSLVG
:** : :* .*. *: ** ** *::* ***** .*:*** **
Mb3685|M.bovis_AF2122/97 HASVVNPDRGLRKEASVRGWPVLSFSRPVSLRDRIP-APSAAAIATTAAV
Rv3661|M.tuberculosis_H37Rv HASVVNPDRGLRKEASVRGWPVLSFSRPVSLRDRIP-APSAAAIATTAAV
MMAR_5149|M.marinum_M HPSVVNPDRGLRKEAMERGWPVLSFSRPVSLRDRIP-APSGAAIATSAAV
MUL_4234|M.ulcerans_Agy99 HPSVVNPDRGLRKEAMERGWPVLSFSRPVSLRDRIP-APSGAAIATSAAV
MAV_0469|M.avium_104 HPSVVNPDRGLRREALERGWPVMSFSRPVSLRDRIP-APSGAAIATTAAV
Mvan_5423|M.vanbaalenii_PYR-1 HPTVVNPDRTLRKEAAARGWPVRTFSKPVSLRDRLP-APSGAAVATTAAV
Mflv_1382|M.gilvum_PYR-GCK HPTVVNPDRGLRKEATARGWPVRAFSKPVSLRDRLPAAPSGAAVATTAAV
TH_0711|M.thermoresistible__bu HPTVVNPDRALRKEAAARNWPVLTFTRPVSLRDRIP-APSGAAVATTAAV
MSMEG_6173|M.smegmatis_MC2_155 HPTAVNPDRALRKEALARDWPVLTFTKPVSLRDRFP-APSGAAVATTAAV
MAB_0431c|M.abscessus_ATCC_199 HPTAVNPDRALRKESMARGWPVLTFSRPVSLGDRIP-VPSGAAAATTAAV
MLBr_02424|M.leprae_Br4923 TAVAINPDAQLRSLARERGWEIRDFRT----------ARKAARIGVPSAL
. .:*** ** : *.* : * . ..* ...:*:
Mb3685|M.bovis_AF2122/97 GISALAAGAVTYALLRRFAFQP
Rv3661|M.tuberculosis_H37Rv GISALAAGAVTYALLRRFAFQP
MMAR_5149|M.marinum_M GISALAAGAVSYLLLRRFAF--
MUL_4234|M.ulcerans_Agy99 GISALAAGAVSYLLLRRFAF--
MAV_0469|M.avium_104 GISALAAGAVTYSLLRRYSF--
Mvan_5423|M.vanbaalenii_PYR-1 GVSALAAGALTYSLLRRFAF--
Mflv_1382|M.gilvum_PYR-GCK GFSALAAGALTYSLLRRFAF--
TH_0711|M.thermoresistible__bu GMSALAAGALTYSLLRRFAF--
MSMEG_6173|M.smegmatis_MC2_155 GISALAAGALTYSLLRRFAL--
MAB_0431c|M.abscessus_ATCC_199 GLSAIAAGALTYSLIRKLRP--
MLBr_02424|M.leprae_Br4923 ALGGALAAAVSRRRDRE-----
.... *.*:: *.