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VYFVGLDLAWGEKNQSGLAVIDADGRLLQVGTAHDDDSIEAALAPFVADECLVAIDAPLIVKNPTGHRPA ESQFNKDFQRFEAGARPAFTDRPEFKHPRAARIAERLGLDTDPSSSSPRRAIEVYPHPATVVLFDLEKTL KYKRGVFEDRQRELLRLMTLIEGLDDATPRLRVNRSAAWVELRKRVEAATKPSHLDRDEDPVDAVLCAYV GLYWYHRPEDVTIYGDAASGYIVTPSLPEGRRPRAARTSRTSPSAAPSPAVAEYASRRPALVAATEHYLG LVKGLLDEAGINYLSVTARTKTVESFAAKADRRSGDGKPLYSEPLVEITDLIGLRVITYLREDVATVADL LAEEMRLLDDRDMGQETAREGRWGYASRHLLFGVEGVQQPASIQVRTVLQHAWAEFEHEIRYKGSIPAAH APDLDRRFTLAAGLLELADREFSAVRERLRDAVPDTSAPEATDDPRIPTPVLATYLGNRFPDAGWSRTDH YAWIAGLLLDLGIESIDAVDTVLDGVDTDAVNAAMDYRYPAGAVRRLDDALLAVYGRRYLELDGNSHRPT LLDNRLQRLVEKLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5146 | - | - | 100% (574) | RelA/SpoT domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0799c | - | 1e-73 | 56.92% (260) | hypothetical protein Mb0799c |
| M. gilvum PYR-GCK | Mflv_1612 | - | 0.0 | 83.74% (572) | RelA/SpoT domain-containing protein |
| M. tuberculosis H37Rv | Rv0776c | - | 1e-73 | 56.92% (260) | hypothetical protein Rv0776c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4917 | - | 2e-68 | 54.25% (247) | hypothetical protein MMAR_4917 |
| M. avium 104 | MAV_0720 | - | 8e-71 | 53.61% (263) | hypothetical protein MAV_0720 |
| M. smegmatis MC2 155 | MSMEG_5849 | - | 0.0 | 66.78% (572) | hypothetical protein MSMEG_5849 |
| M. thermoresistible (build 8) | TH_1266 | - | 5e-73 | 56.92% (260) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0489 | - | 6e-67 | 53.04% (247) | hypothetical protein MUL_0489 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0799c|M.bovis_AF2122/97 ----MYFVGVDLAWAGRNPTGVAAVDADGCLVGVGAARDDASVLAALRPY
Rv0776c|M.tuberculosis_H37Rv ----MYFVGVDLAWAGRNPTGVAAVDADGCLVGVGAARDDASVLAALRPY
MMAR_4917|M.marinum_M ----MYFAGVDLAWAGRNPTGVAVLDSDGHLVCAGAVREDAAVLAALGPY
MUL_0489|M.ulcerans_Agy99 ----MYFAGVDLAWAGRNPTGVAVLDSDRHLVCAGAVREDATVLAALGPY
MAV_0720|M.avium_104 ----MYFAGVDLAWAGRNPTGVAVIDSGGELVSVAAVRDDDEILAALDPY
TH_1266|M.thermoresistible__bu ----MRFVGLDLAWGTRNPSGVAVLAADGTLDHVGAARDHRTVLDTVRPF
Mvan_5146|M.vanbaalenii_PYR-1 ----MYFVGLDLAWGEKNQSGLAVIDADGRLLQVGTAHDDDSIEAALAPF
Mflv_1612|M.gilvum_PYR-GCK ----MNFVGLDLAWGEKNQTGVAVVDSDGRLLHVGAATDDDSIAAAIAPY
MSMEG_5849|M.smegmatis_MC2_155 MHHPPYFVGIDLAWGERKPTGVAVVDTDGRLVHLSAATDDDSIIAALAPF
*.*:****. :: :*:*.: :. * .:. :. : :: *:
Mb0799c|M.bovis_AF2122/97 VVGDCLVAFDAPLVVANRTGQRPAEAALNRDFRQFEAGAYPANTEKPEFA
Rv0776c|M.tuberculosis_H37Rv VVGDCLVAFDAPLVVANRTGQRPAEAALNRDFRQFEAGAYPANTEKPEFA
MMAR_4917|M.marinum_M LRGACRVAFDAPLVVANATGQRPAETALNRDFRKFEAGAHPANTGKPEFA
MUL_0489|M.ulcerans_Agy99 LRGACRVAFDAPLVVANATGQRPADTALNRDFRKFEAGAHPVNTGKPEFA
MAV_0720|M.avium_104 VRGECLVAFDAPLVVNNPTGQRPAETALNRDFRRFQAGTHPCNTGKPEFA
TH_1266|M.thermoresistible__bu TTGACLVGIDAPLIVRNATGRRPAEAALNADFARFDAGAHPANTSLPVFA
Mvan_5146|M.vanbaalenii_PYR-1 VADECLVAIDAPLIVKNPTGHRPAESQFNKDFQRFEAGARPAFTDRPEFK
Mflv_1612|M.gilvum_PYR-GCK TAEECLVAIDAPLIVKNATGHRPAETRFNRDFSRFEAGARPAFTDRPEFK
MSMEG_5849|M.smegmatis_MC2_155 TGAECVAGIDAPLIVTNPTGNRPAEAALNRDFRPFEAGAHPSNTGKPEFA
* ..:****:* * **.***:: :* ** *:**: * * * *
Mb0799c|M.bovis_AF2122/97 DVPRAARLARQLALDMDPLSSATRRAIEVYPHPATVALFRLPRALKYKAK
Rv0776c|M.tuberculosis_H37Rv DVPRAARLARQLALDMDPLSSATRRAIEVYPHPATVALFRLPRALKYKAK
MMAR_4917|M.marinum_M RGPRAARLADSLSLDIDPFSPASRRAIEVYPHAATVALFRLPRTLKYKAK
MUL_0489|M.ulcerans_Agy99 RGPRAARLADSLSLDIDPFSPASRRAIEVYPHAATVALFRLPRTLKYKAK
MAV_0720|M.avium_104 DGPRAARLAAALGLALDPRSPRPRRAIEVYPHAATVALFGLQQTLKYKAK
TH_1266|M.thermoresistible__bu AGLPGARIADALGLDVDPRSTAERRAIEVYPHPATVALFRLGRTLKYKRR
Mvan_5146|M.vanbaalenii_PYR-1 -HPRAARIAERLGLDTDPSSSSPRRAIEVYPHPATVVLFDLEKTLKYKRG
Mflv_1612|M.gilvum_PYR-GCK -HPRAARIAERLGLDTDPSSAAPRRAIEVYPHPATVVLFDLDRTLKYKRG
MSMEG_5849|M.smegmatis_MC2_155 GTPRGARLAEALDLDLDPRSERPRRALEVYPHAASVALFRLGRTLKYKAK
.**:* * * ** * ***:*****.*:*.** * ::****
Mb0799c|M.bovis_AF2122/97 PGRSVDLLKSELLRLMDGVEGLAQAGVRMQVAGQPDWVSLRRQVTVAQRK
Rv0776c|M.tuberculosis_H37Rv PGRSVDLLKSELLRLMDGVEGLAQAGVRMQVAGQPDWVSLRRQVTVAQRK
MMAR_4917|M.marinum_M PGRSVDRLRSELLRLMDEVEALRTAPVPLQVTGNQDWLSLRRQVVTAQRK
MUL_0489|M.ulcerans_Agy99 PGRSVDRLRSELLRLMDEVEALRTAPVPLQVTGNQDWLSLRRQVVTAQRK
MAV_0720|M.avium_104 PGRSLERLKSELLLLMAGVERLAHAPVPVRVGGHAGWRALRRAVECAQRK
TH_1266|M.thermoresistible__bu GRRTVEQRKSALLQLMWLLEGLDTADPSLYVD-HPHWRALRRQVATATGP
Mvan_5146|M.vanbaalenii_PYR-1 V---FEDRQRELLRLMTLIEGLDDATPRLRVNRSAAWVELRKRVEAATKP
Mflv_1612|M.gilvum_PYR-GCK P---FEDRHRELLRLMTFIEGLDDATPRLRVNRSVAWVELRKRVEAATKP
MSMEG_5849|M.smegmatis_MC2_155 PGRSFEQLRSELLRLMELIAGLRHADVPLDVSASEQWRQLYSAVEGASTK
.: : ** ** : * * : * * * * *
Mb0799c|M.bovis_AF2122/97 SDLRAAEDPIDAVVCAYVALYAQRRPADVTIYGDFTTGYIVTPSLPTD--
Rv0776c|M.tuberculosis_H37Rv SDLRAAEDPIDAVVCAYVALYAQRRPADVTIYGDFTTGYIVTPSLPTD--
MMAR_4917|M.marinum_M CELRRAEDPVDAVVCAYVALYAERCPADITVYGDLTSGYILTPTLPAG--
MUL_0489|M.ulcerans_Agy99 CELRRAEDPVDAVVCAYVALYAERCPADITVYGDLTSGYILTPTLPAG--
MAV_0720|M.avium_104 SELRRAEDPVDAVVCAYVALFAQRRPDAVTSYGDPGTGCIVTPSLPAARR
TH_1266|M.thermoresistible__bu VQLDRAEDPVDAVLCAYIAMFAHRRPGDVVVYGDGATGYIVTPRLPAD--
Mvan_5146|M.vanbaalenii_PYR-1 SHLDRDEDPVDAVLCAYVGLYWYHRPEDVTIYGDAASGYIVTPSLPEGRR
Mflv_1612|M.gilvum_PYR-GCK SHLDRDEDPVDAVICAYVGLYWYHRPDDVTIYGDHASGYILTPSLPKSRL
MSMEG_5849|M.smegmatis_MC2_155 SELRRAEDPVDAVLCAYIALYAARRPDDITIYGDTETGYILTPTLPQDLT
.* ***:***:***:.:: : * :. *** :* *:** **
Mb0799c|M.bovis_AF2122/97 ----------------------FRTAPDAGRRARARR-------------
Rv0776c|M.tuberculosis_H37Rv ----------------------FRTAPDAGRRARARR-------------
MMAR_4917|M.marinum_M ----------------------LTPAPTARR-------------------
MUL_0489|M.ulcerans_Agy99 ----------------------LTPAPTARR-------------------
MAV_0720|M.avium_104 Q--------------------SLRSAPAADRSGPAPR-------------
TH_1266|M.thermoresistible__bu ----------------------LTPAPRVRAVSPAAAPSWPDRRRRGWGC
Mvan_5146|M.vanbaalenii_PYR-1 PRAARTSRTSPS-----AAPSPAVAEYASRRPALVAATEHYLGLVKGLLD
Mflv_1612|M.gilvum_PYR-GCK PEAAPTKKPRPDRRADLTRPSAVVAEYAARRPALVEATDHYLALVTGLLD
MSMEG_5849|M.smegmatis_MC2_155 PHSALP---------------PAVAEYAARRPALVQATARYHDLVTGLLD
.
Mb0799c|M.bovis_AF2122/97 --------------------------------------------------
Rv0776c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4917|M.marinum_M --------------------------------------------------
MUL_0489|M.ulcerans_Agy99 --------------------------------------------------
MAV_0720|M.avium_104 --------------------------------------------------
TH_1266|M.thermoresistible__bu RADG----------------------------------------------
Mvan_5146|M.vanbaalenii_PYR-1 EAGINYLSVTARTKTVESFAAKADRRSGDGKPLYSEPLVEITDLIGLRVI
Mflv_1612|M.gilvum_PYR-GCK DAGINYLSVAARTKTVESFAAKTRRRGADGKPLYSEPLVEVTDLIGLRVI
MSMEG_5849|M.smegmatis_MC2_155 DAGINYLSITSRTKTVESFAEKAVRTAG-GEPLYTDPLVEITDQVGLRVI
Mb0799c|M.bovis_AF2122/97 --------------------------------------------------
Rv0776c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4917|M.marinum_M --------------------------------------------------
MUL_0489|M.ulcerans_Agy99 --------------------------------------------------
MAV_0720|M.avium_104 --------------------------------------------------
TH_1266|M.thermoresistible__bu --------------------------------------------------
Mvan_5146|M.vanbaalenii_PYR-1 TYLREDVATVADLLAEEMRLLDDRDMGQETAREGRWGYASRHLLFGVEGV
Mflv_1612|M.gilvum_PYR-GCK TYLREDVDTVANLLAEEMRLLDDRDMGQETAREGRWGYASRHLLVGVEGV
MSMEG_5849|M.smegmatis_MC2_155 TYLREDVDAVANLLADEMRLLDDRDMGAETAREGRWGYASRHLLVGMEGE
Mb0799c|M.bovis_AF2122/97 --------------------------------------------------
Rv0776c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4917|M.marinum_M --------------------------------------------------
MUL_0489|M.ulcerans_Agy99 --------------------------------------------------
MAV_0720|M.avium_104 --------------------------------------------------
TH_1266|M.thermoresistible__bu --------------------------------------------------
Mvan_5146|M.vanbaalenii_PYR-1 QQPASIQVRTVLQHAWAEFEHEIRYKGSIPAAHAPDLDRRFTLAAGLLEL
Mflv_1612|M.gilvum_PYR-GCK QQPASIQVRTVLQHAWAEFEHEIRYKGSIPEAYVPDLDRRFTLAAGLLEL
MSMEG_5849|M.smegmatis_MC2_155 QQPASIQVRTVLQHAWAEFEHDVRYKGSIPAAHVTELDRRFTLAAGLLEL
Mb0799c|M.bovis_AF2122/97 --------------------------------------------------
Rv0776c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4917|M.marinum_M --------------------------------------------------
MUL_0489|M.ulcerans_Agy99 --------------------------------------------------
MAV_0720|M.avium_104 --------------------------------------------------
TH_1266|M.thermoresistible__bu --------------------------------------------------
Mvan_5146|M.vanbaalenii_PYR-1 ADREFSAVRERLRDAVPDTSAPEATDDPRIPTPVLATYLGNRFPDAGWSR
Mflv_1612|M.gilvum_PYR-GCK ADREFSAVRERLRTALPETAEPEIGSDPRIPTPVLATYLGNRFPDAGWSR
MSMEG_5849|M.smegmatis_MC2_155 ADREFSEIRNRLRTTMTEEET-EFSPDSRIPSPVLATYLGNRFDDAGWSR
Mb0799c|M.bovis_AF2122/97 --------------------------------------------------
Rv0776c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4917|M.marinum_M --------------------------------------------------
MUL_0489|M.ulcerans_Agy99 --------------------------------------------------
MAV_0720|M.avium_104 --------------------------------------------------
TH_1266|M.thermoresistible__bu --------------------------------------------------
Mvan_5146|M.vanbaalenii_PYR-1 TDHYAWIAGLLLDLGIESIDAVDTVLDGVDTDAVNAAMDYRYPAGAVRRL
Mflv_1612|M.gilvum_PYR-GCK TDHYAWIAGLLLDLGIDSIDEVEAALAGIDTDAVNAAMDYRYPAGAVRRL
MSMEG_5849|M.smegmatis_MC2_155 TDHYGWISGLLLELGITSLDALTAVLDSVDTDEINRLMDYRYPPGAVRRL
Mb0799c|M.bovis_AF2122/97 -------------------------------------
Rv0776c|M.tuberculosis_H37Rv -------------------------------------
MMAR_4917|M.marinum_M -------------------------------------
MUL_0489|M.ulcerans_Agy99 -------------------------------------
MAV_0720|M.avium_104 -------------------------------------
TH_1266|M.thermoresistible__bu -------------------------------------
Mvan_5146|M.vanbaalenii_PYR-1 DDALLAVYGRRYLELDGNSHRPTLLDNRLQRLVEKLG
Mflv_1612|M.gilvum_PYR-GCK DDALLALYGTDYIRLQDNSHRVKLLEARLARLRPV--
MSMEG_5849|M.smegmatis_MC2_155 DDALLAVFGDRYLDLQGNAHRVALLRNRFEKLQA---