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RPALTDYQHLASGKVRELYRIDGGHLLFVATDRISAYDHILKSEIPDKGRVLTAMSVFFFDYLSRTAAVS NHLAGPPDDERIPEEVLGRALVVEQLEMLPVEAVARGYLTGSGLIDYQQTGTVCGIALPSGLVEASRFDE PLFTPATKAELGEHDVNISFDDVVGLIGAERAEELRDRTLRTYSQGAAHALTRGIIVADTKFEFGVDARG ELKLADEVFTPDSSRYWRADDYAEGQVQNSFDKQFVRNWLTGPDSGWDRHGDQPPPPLPPDIVDATRARY IEAYERISGLRFDDWIGVSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5138 | - | - | 100% (301) | phosphoribosylaminoimidazole-succinocarboxamide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0803 | hemH | 1e-131 | 75.42% (301) | phosphoribosylaminoimidazole-succinocarboxamide synthase |
| M. gilvum PYR-GCK | Mflv_1616 | - | 1e-149 | 86.05% (301) | phosphoribosylaminoimidazole-succinocarboxamide synthase |
| M. tuberculosis H37Rv | Rv0780 | hemH | 1e-131 | 75.42% (301) | phosphoribosylaminoimidazole-succinocarboxamide synthase |
| M. leprae Br4923 | MLBr_02227 | purC | 1e-122 | 70.43% (301) | phosphoribosylaminoimidazole-succinocarboxamide synthase |
| M. abscessus ATCC 19977 | MAB_0689 | - | 1e-128 | 73.09% (301) | phosphoribosylaminoimidazole-succinocarboxamide synthase |
| M. marinum M | MMAR_4909 | purC | 1e-128 | 74.42% (301) | phosphoribosylaminoimidazole- succinocarboxamide synthase, |
| M. avium 104 | MAV_0725 | purC | 1e-129 | 74.58% (299) | phosphoribosylaminoimidazole-succinocarboxamide synthase |
| M. smegmatis MC2 155 | MSMEG_5841 | purC | 1e-141 | 80.54% (298) | phosphoribosylaminoimidazole-succinocarboxamide synthase |
| M. thermoresistible (build 8) | TH_1816 | purC | 1e-142 | 80.07% (301) | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE |
| M. ulcerans Agy99 | MUL_0497 | purC | 1e-128 | 73.75% (301) | phosphoribosylaminoimidazole-succinocarboxamide synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4909|M.marinum_M MRPQLSDYQHLASGKVRELYRVDDEHLLLVASDRISAYDYVLDSMIPDKG
MUL_0497|M.ulcerans_Agy99 MRPQLSDYQHLASGKVRELYRVDDEHLLVVASDRISAYDYVLDSMIPDKG
MAV_0725|M.avium_104 -MPALSDYQHLVSGKVRELYRVDDEHLLLVATDRISAYDFVLDSTIPDKG
Mb0803|M.bovis_AF2122/97 MRPALSDYQHVASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKG
Rv0780|M.tuberculosis_H37Rv MRPALSDYQHVASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKG
MLBr_02227|M.leprae_Br4923 MRPALFDYRHLASGKVREIYRIDDEHLLMVASDRISAFDYVLDSTIPDKG
Mvan_5138|M.vanbaalenii_PYR-1 MRPALTDYQHLASGKVRELYRIDGGHLLFVATDRISAYDHILKSEIPDKG
Mflv_1616|M.gilvum_PYR-GCK MRPALSDYQHLASGKVRELYRVDDRHLLFVATDRISAYDFILDSEIPDKG
TH_1816|M.thermoresistible__bu MRPALSDYQHLASGKVRELYRVDADHLLFVATDRISAYDHVLDTQIPDKG
MSMEG_5841|M.smegmatis_MC2_155 MRPALSDYQHLASGKVREIYRIDDEHLLFVASDRISAYDYILDSQIPDKG
MAB_0689|M.abscessus_ATCC_1997 MRPSLSDYQHVASGKVRELYRVDDEHLLFVATDRISAFDFVLDTPIPDKG
* * **:*:.******:**:* ***.**:*****:*.:*.: *****
MMAR_4909|M.marinum_M RILTAMSVFFFGLVD----APNHLAGPPDDPRIPDEVLGRALVVCQLEML
MUL_0497|M.ulcerans_Agy99 RILTAMSVFFFGLVD----APNHLAGPPDDPRIPDEVLGRALVVRQLEML
MAV_0725|M.avium_104 RILTAMSVFFFGLVD----APNHLAGPPDDPRIPDEVLGRALVVRQLEML
Mb0803|M.bovis_AF2122/97 RVLTAMSAFFFGLVD----APNHLAGPPDDPRIPDEVLGRALVVRRLEML
Rv0780|M.tuberculosis_H37Rv RVLTAMSAFFFGLVD----APNHLAGPPDDPRIPDEVLGRALVVRRLEML
MLBr_02227|M.leprae_Br4923 RILTAMSVFFFSFVD----APNHLAGPPDDPRIPEEVLGRALVVRQLDML
Mvan_5138|M.vanbaalenii_PYR-1 RVLTAMSVFFFDYLSRTAAVSNHLAGPPDDERIPEEVLGRALVVEQLEML
Mflv_1616|M.gilvum_PYR-GCK RVLTAMSVFFFGLVD----SPNHLAGPPDDERIPEEVLGRALVVRQLDML
TH_1816|M.thermoresistible__bu RILTAMSVFFFDLLEREHGVANHLAGPADDPRIPGEVLGRALVVRELQML
MSMEG_5841|M.smegmatis_MC2_155 RILTAMSVFFFDHLLRTAGVPNHLAGPPDDERIPADVLGRALVVRRLDML
MAB_0689|M.abscessus_ATCC_1997 RILTAMSVFFFGLLT----VPNHLAGPPDDPRIPEEVLGRALLVRRLDML
*:*****.***. : .******.** *** :******:* .*:**
MMAR_4909|M.marinum_M PVECVARGYLTGSGLLDYQASGKVCGIALPPGLVEASKFAEPLFTPATKA
MUL_0497|M.ulcerans_Agy99 PVECVARGYLTGSGLLDYQASGKVCGIALPPGLVGASKFAEPLFTPATKA
MAV_0725|M.avium_104 PVECVARGYLTGSGLLDYQATGKVCGIALPPGLVEASKFAEPLFTPATKA
Mb0803|M.bovis_AF2122/97 PVECVARGYLTGSGLLDYQATGKVCGIALPPGLVEASRFATPLFTPATKA
Rv0780|M.tuberculosis_H37Rv PVECVARGYLTGSGLLDYQATGKVCGIALPPGLVEASRFATPLFTPATKA
MLBr_02227|M.leprae_Br4923 PMECVARGYLTGSGLLDYQATGKVCGIPLPPGLVEASRFAAPLFTPAMKA
Mvan_5138|M.vanbaalenii_PYR-1 PVEAVARGYLTGSGLIDYQQTGTVCGIALPSGLVEASRFDEPLFTPATKA
Mflv_1616|M.gilvum_PYR-GCK PVEAVARGYLTGSGLIDYQKTGSVCGIPLPSGLVEASKFDEPLFTPATKA
TH_1816|M.thermoresistible__bu PVECVARGYLTGSGLIDYQKTGAVCGIPLPPGLVEASKFDEPLFTPATKA
MSMEG_5841|M.smegmatis_MC2_155 PVECVARGYLTGSGLIDYEKTGTVCGIALPPGLGEASKFDEPLFTPATKA
MAB_0689|M.abscessus_ATCC_1997 PVECVARGYLTGSGLLDYQRTGAVCGHVLPQGLGEASRLDPPLFTPATKA
*:*.***********:**: :* *** ** ** **:: ****** **
MMAR_4909|M.marinum_M ELGDHDENISFAQVIETVGGVRANQLRDRTLQIYVKAADHALTRGIIIAD
MUL_0497|M.ulcerans_Agy99 ELGDHDENISFAQVIETVGGVRANQLRDRTLQIYVKAADHALTRGVIIAD
MAV_0725|M.avium_104 ALGDHDENISFARVIEMVGGVRANQLRDRTLQIYVQAADHALRKGIIIAD
Mb0803|M.bovis_AF2122/97 ALGDHDENISFDRVVEMVGALRANQLRDRTLQTYVQAADHALTRGIIIAD
Rv0780|M.tuberculosis_H37Rv ALGDHDENISFDRVVEMVGALRANQLRDRTLQTYVQAADHALTRGIIIAD
MLBr_02227|M.leprae_Br4923 VLGEHDENISFSRMIEMVGVVRANQLRDRTLQIYLQAADHALKTGIIIAD
Mvan_5138|M.vanbaalenii_PYR-1 ELGEHDVNISFDDVVGLIGAERAEELRDRTLRTYSQGAAHALTRGIIVAD
Mflv_1616|M.gilvum_PYR-GCK DLGEHDVNITYDDVVELIGAERAEQLRERTLAVYQQGADHALSNGIIVAD
TH_1816|M.thermoresistible__bu AQGDHDENITFDDVVALVGGERAEQLRTLTLRTYRAGAEHALRKGIIVAD
MSMEG_5841|M.smegmatis_MC2_155 EIGEHDENISFAKVIELVGAELANQLRDRTLQTYTAGADHALSKGIIIAD
MAB_0689|M.abscessus_ATCC_1997 DIGEHDMNVDFAAVVGLVGAVRANQLRDETIKIYTRAAAHALHKGIILAD
*:** *: : :: :* *::** *: * .* *** *:*:**
MMAR_4909|M.marinum_M TKFEFGADRDGNLLLADEIFTPDSSRYWPADEYRAGVVQNSFDKQFVRNW
MUL_0497|M.ulcerans_Agy99 TKFEFGADRDGNLLLADEIFTPDSSRYWPADEYRAGVVQNSFDKQFVRNW
MAV_0725|M.avium_104 TKFEFGTDPDGNLLLADEIFTPDSSRYWPADEYRVGVPQTSFDKQFVRNW
Mb0803|M.bovis_AF2122/97 TKFEFGIDRHGNLLLADEIFTPDSSRYWPADDYRAGVVQTSFDKQFVRSW
Rv0780|M.tuberculosis_H37Rv TKFEFGIDRHGNLLLADEIFTPDSSRYWPADDYRAGVVQTSFDKQFVRSW
MLBr_02227|M.leprae_Br4923 TKFEFGIDRDGNLLLADEIFTPDSSRYWSVDDYRVGVVQRSFDKQFVRNW
Mvan_5138|M.vanbaalenii_PYR-1 TKFEFGVDARGELKLADEVFTPDSSRYWRADDYAEGQVQNSFDKQFVRNW
Mflv_1616|M.gilvum_PYR-GCK TKFEFGIDADGELTLADEVFTPDSSRYWRADDYAEGQVQNSFDKQFVRNW
TH_1816|M.thermoresistible__bu TKFEFGVDDSGALRLADEVFTPDSSRYWPADSYTEGQVQPSFDKQFVRNW
MSMEG_5841|M.smegmatis_MC2_155 TKFEFGVDRDGTVVLADEVFTPDSSRYWRADSYQPGVVQNSFDKQFVRNW
MAB_0689|M.abscessus_ATCC_1997 TKFEFGVDIEGNLVLADEVFTPDSSRYWDAAHYQPGVVQDSFDKQFVRNW
****** * * : ****:********* . * * * ********.*
MMAR_4909|M.marinum_M LTSAESGWDRGGDQPPPPLPDHIIAATRERYIEAYERISGLSFGEWIGPG
MUL_0497|M.ulcerans_Agy99 LTSAESGWDRGGDQPPPPLPDHIIEATRERYIEAYERISGLGFGEWIGPG
MAV_0725|M.avium_104 LTSPESGWDRHGTEPPPPLPDHIIEATRNRYIEAYERISGLRFDDWIGPR
Mb0803|M.bovis_AF2122/97 LTGSESGWDRGSDRPPPPLPEHIVEATRARYINAYERISELKFDDWIGPG
Rv0780|M.tuberculosis_H37Rv LTGSESGWDRGSDRPPPPLPEHIVEATRARYINAYERISELKFDDWIGPG
MLBr_02227|M.leprae_Br4923 LVSPESGWVRAGALSPPSLPDDIIEATRLCYVEVYERISGMSFDDWIGPG
Mvan_5138|M.vanbaalenii_PYR-1 LTGPDSGWDRHGDQPPPPLPPDIVDATRARYIEAYERISGLRFDDWIGVS
Mflv_1616|M.gilvum_PYR-GCK LTGPDSGWDRNGDQAPPPLPPDIVAATRARYIEAYERISGLRFDDWIGGA
TH_1816|M.thermoresistible__bu LTSPESGWDRYGDQPPPPLPPHIVNATRERYIEAYERISGLNFDEWIGPS
MSMEG_5841|M.smegmatis_MC2_155 LTGPESGWDRHGNTPPPALPDDIVAATRERYIEAYERISGLSFDDWIGA-
MAB_0689|M.abscessus_ATCC_1997 LTGPESGWDRASDTPPPPLPDEVAVATRERYIEAYERISGLSFSDWIGPS
*...:*** * . .**.** .: *** *::.***** : *.:***
MMAR_4909|M.marinum_M A
MUL_0497|M.ulcerans_Agy99 A
MAV_0725|M.avium_104 A
Mb0803|M.bovis_AF2122/97 A
Rv0780|M.tuberculosis_H37Rv A
MLBr_02227|M.leprae_Br4923 A
Mvan_5138|M.vanbaalenii_PYR-1 A
Mflv_1616|M.gilvum_PYR-GCK A
TH_1816|M.thermoresistible__bu A
MSMEG_5841|M.smegmatis_MC2_155 -
MAB_0689|M.abscessus_ATCC_1997 A