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VEDVKEPRSLLDVAPVMPVISVRRAADAVPVARAITAAGLPLVQVALDGPTALEAIARIAEEAPDVIVGA GAVTEADQPERARAAGAEFLIATTGGAALCAAMRDSELPHLPGVTTAAEAAGLLDAGYTDLVLHPAAAAG GLRHLKALAAFAPAARFCASGGITAADLTGYLAAPNVGCVSADWLAPADAVRRRDWDRIRRLADVALKLS TPTVTTVRAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4889 | - | - | 100% (220) | 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1359 | - | 1e-05 | 28.66% (157) | ATP-dependent DNA helicase |
| M. avium 104 | MAV_4147 | - | 2e-06 | 29.81% (161) | superfamily protein I DNA and RNA helicases |
| M. smegmatis MC2 155 | MSMEG_0312 | eda | 3e-59 | 54.04% (198) | 2-dehydro-3-deoxyphosphogluconate |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2520 | - | 4e-06 | 28.66% (157) | ATP-dependent DNA helicase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1359|M.marinum_M MNPRYSPDEIASALGIFPPTDEQAAVIAAPPGPLVVIAGAGAGKTETMAA
MUL_2520|M.ulcerans_Agy99 MNPRYSPDEIASALGIFPPTDEQAAVIAAPPGPLVVIAGAGAGKTETMAA
MAV_4147|M.avium_104 MSDRYSPRELACALGLFPPTEEQAAVIAAPPGPLVVIAGAGAGKTETMAA
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M RVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRLARLAGTTVGVAVG
MUL_2520|M.ulcerans_Agy99 RVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRLARLAGTTVGVAVG
MAV_4147|M.avium_104 RVVWLIANGYAHPGQVLGLTFTRKAAGQLLRRVRSRLARLAGVGLGAASP
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M -----EAAGAPTVSTYHAFAGSLLRDHGLLLPIEPDTRLLSETELWQLAF
MUL_2520|M.ulcerans_Agy99 -----EAAGAPTVSTYHAFAGSLLRDHGLLLPIEPDTRLLSETELWQLAF
MAV_4147|M.avium_104 NHGAVDPEAAPVVSTYHAFAGSLLRDYGLLLPVEPDTRLLSETELWQLAF
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M EVVNGYRGELCTQKTPAAVTATVLRLWGQLAEHLVDTRQLRDTHIELERL
MUL_2520|M.ulcerans_Agy99 EVVNGYRGELCTQKTPAAVTATVLRLWGQLAEHLVDTRQLRDTHIELERL
MAV_4147|M.avium_104 DVVNRYRGPLRTDKTPAAVTSMVLRLWGQLAEHLVDTSQLRETHLELERL
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M VHALPAGPNQRDSGPNQWLLRMLATQTERAELVPLLDALHERMRAAKVMD
MUL_2520|M.ulcerans_Agy99 VHALPAGPNQRDSGPNQWLLRMLVTQTERAELVPLLDALHERMRAAKVMD
MAV_4147|M.avium_104 VHALPAGPYQRDRGPSQWLRRLSGTQSERAELVPLLEALDERMRAVKVMD
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M FGMQMAAAARLAATCPQVGEELRSRYRVVLLDEYQDTGHSQRVALSALFG
MUL_2520|M.ulcerans_Agy99 FGMQMAAAARLAATCPQVGGELRSRYRVVLLDEYQDTGHSQRIALSALFG
MAV_4147|M.avium_104 FGMQMASAARLAAAFPQVGADLRGRYRVVLLDEYQDTGHAQRIALSALFG
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M GGVDDGLALTAVGDPIQSIYGWRGASATNLPRFSTDFALSDGAPAPVLEL
MUL_2520|M.ulcerans_Agy99 GGVDDGLALTAVGDPIQSIYGWRGASATNLPRFSTDFALSDGAPAPVLEL
MAV_4147|M.avium_104 GGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPRSDGTPAPVLEL
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M RTSWRNPPRALHLANAISAEARRRSVAVHALRSRPDAPAGTVRCALLADV
MUL_2520|M.ulcerans_Agy99 RTSWRNPPRALHLANAISAEPRRRSVAVHALRSRPDAPAGTVRCALLADV
MAV_4147|M.avium_104 RTSWRNPPRTLRVANAISAEARRRSVAVHALCPRPDAPPGTVRCALLPDM
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M QAERDWIADQLQGHYQRAAADGVSPPTAAVLVRRNADAAPIADALVARGI
MUL_2520|M.ulcerans_Agy99 QAERDWIADQLQGHYQRAAADGVSPPTAAVLVRRNADAAPIADALVARGI
MAV_4147|M.avium_104 VAEREWIADHIDAHYRRARADGVSPPTAAVLVRRNADAAPIADALRARGI
Mvan_4889|M.vanbaalenii_PYR-1 ----------MEDVKEPRSLLDVAPVMPVISVRRAADAVPVARAITAAGL
MSMEG_0312|M.smegmatis_MC2_155 --------------MSLDSLLDLVPVIPVVVVHDAADAVPIAKALVEGGL
.: * ..: *: ***.*:* *: *:
MMAR_1359|M.marinum_M PVEVVGLAGLLSIPEVADLVAMLRLVGDPTAGAAAMRVLTGPRWRLGGSD
MUL_2520|M.ulcerans_Agy99 PVEVVGLAGLLSIPEVADLVAMLRLVGDPTAGAAAMRVLTGPRWRLGGSD
MAV_4147|M.avium_104 PVEVVGLAGLLSVPEVAELVAMLRLVADPTAGAAAMRVLTGPRWRLGARD
Mvan_4889|M.vanbaalenii_PYR-1 PLVQVALDGPTALEAIARIAEEA------------------PDVIVGAGA
MSMEG_0312|M.smegmatis_MC2_155 PVIELTLRTPAALDAIKRIADEV------------------PEILVGAGT
*: : * :: : :. * :*.
MMAR_1359|M.marinum_M VAALWRRAVALVGGPQVGASASPGAVAAAAGP---DTDTACLADAICDPG
MUL_2520|M.ulcerans_Agy99 VAALWRRAVALVGGPQVGASVSPGAVAAAAGP---DTDTACLADAICDPG
MAV_4147|M.avium_104 LAALWQRARALGGAGTAGGPATAEAIASAADPRNVEADAVCLADAIADPG
Mvan_4889|M.vanbaalenii_PYR-1 VTEADQPERARAAGAEFLIATTGGAALCAAMR---DSELPHLP-GVTTAA
MSMEG_0312|M.smegmatis_MC2_155 VVDSAQPEQAAANGAQFLVSPGSTPSLRAAMR---DSGLPHLP-GVSTVS
:. : * . . . ** :: *. .: .
MMAR_1359|M.marinum_M PADWYSSAGYERIGALAAELNALRGHLGHWLPDLVAEVRRVLGLDCDVRA
MUL_2520|M.ulcerans_Agy99 PADWYSSAGYERIGALAAELNALRGHLGHWLPDLVAEVRRVLGLDCDVRA
MAV_4147|M.avium_104 PAEGYSAAGYARIAALAAELSALRAHLDHPLGDLVAEVRRVMDLDCEVRA
Mvan_4889|M.vanbaalenii_PYR-1 EAAGLLDAGYTDLVLHPAAAAG----------------------------
MSMEG_0312|M.smegmatis_MC2_155 EVLTLLEEGYTELKFFPAEQAG----------------------------
. ** : .* .
MMAR_1359|M.marinum_M AATASGAWAGAEHLDAFADVVADYAERAAISAGSALSTKASVDGLLAYLD
MUL_2520|M.ulcerans_Agy99 AATASGAWAGAEHLDAFADVVADYAERTAISAGSALSTKASVDGLLAYLD
MAV_4147|M.avium_104 AAAAG--WAGTEHLDAFADVVAGYAER-ADTGGTDASASASVAGLLAFLD
Mvan_4889|M.vanbaalenii_PYR-1 ---------GLRHLKALAAFAP--AARFCASGG---ITAADLTGYLAAPN
MSMEG_0312|M.smegmatis_MC2_155 ---------GAKYLRAIHSPVP--AARFCPTGG---ITPANMGDYLASPN
* .:* *: .. * * . :.* : *.: . ** :
MMAR_1359|M.marinum_M VAAEVENGLPPAQLTVARDRVQVLTVHAAKGLEWQVVAVAHLSAGVFPST
MUL_2520|M.ulcerans_Agy99 VAAEVENGLPPAQLTVARDGVQVLTVHAAKGLEWQVVAVAHLSAGVFPST
MAV_4147|M.avium_104 VAESVENGLPAAPLAVARDRVQVLTVHSAKGLEWQLVAVAHLSGGVFPST
Mvan_4889|M.vanbaalenii_PYR-1 VGCVSADWLAPADAVRRRD--------------WDRIRRLADVALKLSTP
MSMEG_0312|M.smegmatis_MC2_155 VGCVGGSWLTPADVVGRKD--------------WAEVARLARTAKAAAEA
*. . *..* . :* * : . . .
MMAR_1359|M.marinum_M ASRSSWLTDPGELPPLLRGDRASVGALGIPVLDTSAVTNRKQLSDTISAH
MUL_2520|M.ulcerans_Agy99 ASRSSWLTDPGELPPLLRGDRASVGALGIPVLDTSAVTNRKQLSDTISAH
MAV_4147|M.avium_104 TAKTTWLTDAAELPPLLRGDRARPGALGIPVLDTSDVTNRKQLSDKISEH
Mvan_4889|M.vanbaalenii_PYR-1 TVTTVRAL------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 F-------------------------------------------------
MMAR_1359|M.marinum_M REQLDQRRVDEERRLLYVGVTRAEDTVLVSGHHWGATGLKPRGPSDFLCE
MUL_2520|M.ulcerans_Agy99 REQLDQRRVDEERRLLYVGVTRAEDTVLVSGHHWGATGLKPRGPSDFLCE
MAV_4147|M.avium_104 RRQLEQRRVDEERRLLYVAVTRAEDTLLVSGHHWAATGIKPRGPSDFLCE
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M LKDIIERSAAAGDPCGTVDQWDPAPVAGERNPLLDDVVEAVWPTDPLATR
MUL_2520|M.ulcerans_Agy99 LKDIIERSAAAGDPCGTVDQWDRAPVAGERNPLLDDVVEAVWPTDPLATR
MAV_4147|M.avium_104 IKDVIDASAAAGDPCGTVEQWAPAPADGERNPLRDNAVEAVWPADPLASR
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M RGDVERGARLVAEAISADAGVEAPAGGAAVADIEGWTADVDALLAERARA
MUL_2520|M.ulcerans_Agy99 RGDVERGARLVAEAISADAGVEAPAGGAAVADIEGWTADVDALLAERARA
MAV_4147|M.avium_104 RGEVERGAALVRQAMAAEP-------GDPGADVEGWAADVDALLVERARV
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M VGPPTRALPNQLSVSGLVELARDPVGARQRLVHRLPTRPDPHAQLGNAFH
MUL_2520|M.ulcerans_Agy99 VGPPTRALPNQLSVSGLVELARDPVGARQRLVHRLPTRPDPHAQLGNIFH
MAV_4147|M.avium_104 TGPPPQVLPGQLSVSSLVGLARDPARAAQRLRHRLPSRPEPHALLGNAFH
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M TWVQQFYGAELLFDLGDLPGAADSDVGQVEDLAPLQEAFAGSPWAARTPI
MUL_2520|M.ulcerans_Agy99 TWVQQFYGAELLFDLGDLPGAADSDVGQVEDLAPLQEAFAGSPWAARTPI
MAV_4147|M.avium_104 AWVQKFYGAECLFELGDLPGAADSDVGDTAELAELQAAFLESPWAARTPV
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M AVEVPFEMPVGDTVVRGRIDAVFEDPDGGATVVDWKTGEPPRGPEAMRQA
MUL_2520|M.ulcerans_Agy99 AVEVPFEMPVGDTVVRGRIDAVFEDPDGGATVVDWKTGEPPRGPEAMRQA
MAV_4147|M.avium_104 AVEVPFEMPIGDTLVRGRIDAVFAESDGGATVVDWKTGAPPDSPEAMRQA
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M AVQLAVYRMAWAALRGCPESSVRTAFHYVRTGVTVIPDELPDGMALAELL
MUL_2520|M.ulcerans_Agy99 AVQLAVYRMAWAALRGCPESSVRTAFHYVRTGVTVIPDELPDGMALAELL
MAV_4147|M.avium_104 AVQLAVYRLAWAALAKVPESSVRTAFHYVRARTTVVPEALPTSDQLAGLL
Mvan_4889|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0312|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1359|M.marinum_M ADSDPPCSC
MUL_2520|M.ulcerans_Agy99 ADSDPPCSC
MAV_4147|M.avium_104 APTAPV---
Mvan_4889|M.vanbaalenii_PYR-1 ---------
MSMEG_0312|M.smegmatis_MC2_155 ---------