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SDNDDLFRRPIRRALISVYDKTGLVPLAQGLHAAGVDIVSTGSTAKTIAGAGIPVTPVEDVTGFPEVLDG RVKTLHPHVHAGLLADQRKAEHVAALAELGVTAFELVVVNLYPFTQTVNSGADEDECVEQIDIGGPSMVR AAAKNHPSVAVVVDPLGYDGVLAAVRAGGFTYSERKKLAALAFRHTAEYDVAVASWMESVLAPEAEATSG DLPPWLGATFRRAAVLRYGENPHQQAALYRDDGGWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEDI CVAIIKHANPCGIAISPVSVADAHRKAHECDPLSAFGGVIAANTEVTVEMAETVAGIFTEVIIAPAYEPG AVEVLSGKKNIRVLVASEPQRGGTEFRQVSGGLLLQQRDALDAAGDNPNTWTLAAGPAADPDTLADLAFA WRTCRAVKSNAIVLARDGATVGVGMGQVNRVDAARLAVERAGGRSSGAVGASDAFFPFPDGLETLIRAGV KAVVHPGGSVRDDEVTAAAEADGITLYLTGARHFAH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4856 | purH | - | 100% (527) | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0982 | purH | 0.0 | 78.56% (527) | bifunctional phosphoribosylaminoimidazolecarboxamide |
| M. gilvum PYR-GCK | Mflv_1875 | purH | 0.0 | 90.06% (533) | bifunctional phosphoribosylaminoimidazolecarboxamide |
| M. tuberculosis H37Rv | Rv0957 | purH | 0.0 | 78.56% (527) | bifunctional phosphoribosylaminoimidazolecarboxamide |
| M. leprae Br4923 | MLBr_00161 | purH | 0.0 | 77.59% (522) | bifunctional phosphoribosylaminoimidazolecarboxamide |
| M. abscessus ATCC 19977 | MAB_1064 | - | 0.0 | 76.49% (519) | bifunctional phospho ribosylaminoimidazole carboxamide |
| M. marinum M | MMAR_4542 | purH | 0.0 | 80.65% (522) | bifunctional purine biosynthesis protein PurH |
| M. avium 104 | MAV_1081 | purH | 0.0 | 81.50% (519) | bifunctional phosphoribosylaminoimidazolecarboxamide |
| M. smegmatis MC2 155 | MSMEG_5515 | purH | 0.0 | 81.87% (524) | bifunctional phosphoribosylaminoimidazolecarboxamide |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4712 | purH | 0.0 | 80.46% (522) | bifunctional phosphoribosylaminoimidazolecarboxamide |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4856|M.vanbaalenii_PYR-1 ------MSDNDD----LFRRPIRRALISVYDKTGLVPLAQGLHAAGVDIV
Mflv_1875|M.gilvum_PYR-GCK ------MSDND------FRRPIRRALISVYDKSGLEALAQGLHAAGVDIV
Mb0982|M.bovis_AF2122/97 ------MSTDD------GRRPIRRALISVYDKTGLVDLAQGLSAAGVEII
Rv0957|M.tuberculosis_H37Rv ------MSTDD------GRRPIRRALISVYDKTGLVDLAQGLSAAGVEII
MLBr_00161|M.leprae_Br4923 ------MSSDGER--DMARKPIRRALISVYDKTGLIDLAQGLNAAGVDIV
MMAR_4542|M.marinum_M ------MSTDH------IRRPIRRALISVYDKTGLVDLAQGLTAAGVEIV
MUL_4712|M.ulcerans_Agy99 ------MSTDH------IRRPIRRALISVYDKTGLVDLAQGLTAAGVEIV
MAV_1081|M.avium_104 MKGDQPMSTDDWR--ENAKRPIRRALISVYDKTGLVELAQGLTEAGIEIV
MSMEG_5515|M.smegmatis_MC2_155 ------MSDKK---------PVRRALISVYDKTGLADLARGLHQAGVAIV
MAB_1064|M.abscessus_ATCC_1997 ------MERKKGLHQVSTQRPVRRALISVYDKTGLEELASGLHAAGVELV
*. . *:**********:** ** ** **: ::
Mvan_4856|M.vanbaalenii_PYR-1 STGSTAKTIAGAGIPVTPVEDVTGFPEVLDGRVKTLHPHVHAGLLADQRK
Mflv_1875|M.gilvum_PYR-GCK STGSTAKNIAAAGIPVTPVEDVTGFPEVLDGRVKTLHPHVHAGLLADQRK
Mb0982|M.bovis_AF2122/97 STGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLRK
Rv0957|M.tuberculosis_H37Rv STGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLRK
MLBr_00161|M.leprae_Br4923 STGSTAKAIADQGIAVTPVEELTGFPEVLDGRVKTLHPRVHAGLLADLRK
MMAR_4542|M.marinum_M STGSTAKTIASKGIPVTRVEELTGFPEVLDGRVKTLHPRVHAGLLADLRN
MUL_4712|M.ulcerans_Agy99 STGSTAKTIASKGIPVTRVEELTGFPEVLDGRVKTLHPRVHAGLLADLRN
MAV_1081|M.avium_104 STGSTAKVIAEKGIPVTRVEELTGFPEVLDGRVKTLHPRVHAGLLADLRK
MSMEG_5515|M.smegmatis_MC2_155 STGSTAKTIAAAGVPVTPVEQVTGFPEVLDGRVKTLHPRVHAGLLADTRK
MAB_1064|M.abscessus_ATCC_1997 STGSTAKTIAAASIPVTPVEDVTGFPEVLDGRVKTLHPHVHAGVLADTRR
******* ** .:.** **::****************:****:*** *.
Mvan_4856|M.vanbaalenii_PYR-1 AEHVAALAELGVTAFELVVVNLYPFTQTVNSGADEDECVEQIDIGGPSMV
Mflv_1875|M.gilvum_PYR-GCK AEHVTALEQLGVAAFELVVVNLYPFTQTVNSGAGVDECVEQIDIGGPSMV
Mb0982|M.bovis_AF2122/97 SEHAAALEQLGIEAFELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMV
Rv0957|M.tuberculosis_H37Rv SEHAAALEQLGIEAFELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMV
MLBr_00161|M.leprae_Br4923 PEHAAALEQLGIEAFELVVVNLYPFSQTVKSGATVDECVEQIDIGGSSMV
MMAR_4542|M.marinum_M PEHEAALAELGVEAFELVVVNLYPFSQTVESGASVDECVEQIDIGGPSMV
MUL_4712|M.ulcerans_Agy99 PEHEAALAELGVEAFELVVVNLYPFSQTVESGASVDECVEQIDIGGPSMV
MAV_1081|M.avium_104 PEHAAALEQLGIAAFELVVVNLYPFTETVDSGAGIDECVEQIDIGGPSMV
MSMEG_5515|M.smegmatis_MC2_155 PEHLAALKELDVEAFELVVVNLYPFSETVASGASVDECVEQIDIGGPSMV
MAB_1064|M.abscessus_ATCC_1997 EEHLTQLEELGVQGFELVVVNLYPFAATVASGASEDECVEQIDIGGPSMV
** : * :*.: .***********: ** *** *:*********.:**
Mvan_4856|M.vanbaalenii_PYR-1 RAAAKNHPSVAVVVDPLGYDGVLAAVRAGGFTYSERKKLAALAFRHTAEY
Mflv_1875|M.gilvum_PYR-GCK RAAAKNHPSVAVVVDPLGYDGVLAAVRAGGFTYTERKKLAALAFRHTAEY
Mb0982|M.bovis_AF2122/97 RAAAKNHPSAAVVTDPLGYHGVLAALRAGGFTLAERKRLASLAFQHIAEY
Rv0957|M.tuberculosis_H37Rv RAAAKNHPSAAVVTDPLGYHGVLAALRAGGFTLAERKRLASLAFQHIAEY
MLBr_00161|M.leprae_Br4923 RAAAKNHPSVAVVTDPLGYVGVLAAVQGGGFTLAERKMLASMAFQHIAEY
MMAR_4542|M.marinum_M RAAAKNHPSVAVVTDPQGYDGVLAAVSSGGFTLAERKKLASLAFQHTAEY
MUL_4712|M.ulcerans_Agy99 RAAAKNHPSVAVVTDPQGYDGVLAAVRSGGFTFAERKKLASLAFQHTAEY
MAV_1081|M.avium_104 RAAAKNHPSVAVVVDPLGYDGVLAAVRHGGFTLAERKRLAALAFQHTADY
MSMEG_5515|M.smegmatis_MC2_155 RAAAKNHPSVAVVVDPLGYDGVLAAVRAGGFTLAERKKLASVAFRHTAEY
MAB_1064|M.abscessus_ATCC_1997 RAAAKNHPSVAVVVDPAAYGEVLAAVTAGGFTLEARKVLAAKAFRHTAEY
*********.***.** .* ****: **** ** **: **:* *:*
Mvan_4856|M.vanbaalenii_PYR-1 DVAVASWMESVLAPEAEATSG------DLPPWLGATFRRAAVLRYGENPH
Mflv_1875|M.gilvum_PYR-GCK DVAVASWMGSVLAPEDDAPEGAADDVAQLPPWLGSTFRRSAVLRYGENPH
Mb0982|M.bovis_AF2122/97 DIAVASWMQQTLAPEH--------PVAAFPQWFGRSWRRVAMLRYGENPH
Rv0957|M.tuberculosis_H37Rv DIAVASWMQQTLAPEH--------PVAAFPQWFGRSWRRVAMLRYGENPH
MLBr_00161|M.leprae_Br4923 EIAVASWMQSTLAPEQ--------PPTAFPQWFGRSWRRSAILRYGENPH
MMAR_4542|M.marinum_M DIAVASWMQSTVAPEQ--------PETDFPRWFGRNWRRQAMLRYGENPH
MUL_4712|M.ulcerans_Agy99 DIAVASWMQSTVAPEQ--------PETDFPRWFGRNWRRQAMLRYGENPH
MAV_1081|M.avium_104 DIAVATWMESTLAPEH--------PPTTFPKWLGRSWRRSAMLRYGENPH
MSMEG_5515|M.smegmatis_MC2_155 DVAVASWMGSTLSPEEGSAEGGA-VEPSLPQWFAGTWHRAAVLRYGENPH
MAB_1064|M.abscessus_ATCC_1997 DVAVAGWLSGVAEPGD----------AELPSWIGGTWNRSAVLRYGENPH
::*** *: . * :* *:. .:.* *:********
Mvan_4856|M.vanbaalenii_PYR-1 QQAALYRDDGGWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEDICVA
Mflv_1875|M.gilvum_PYR-GCK QKAALYGDEGGWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDQEAICVA
Mb0982|M.bovis_AF2122/97 QQAALYGDPTAWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVA
Rv0957|M.tuberculosis_H37Rv QQAALYGDPTAWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVA
MLBr_00161|M.leprae_Br4923 QQAALYSDPSACPGLAQAEQLHGKNMSYNNFTDADAAWRAAFDHEQSCVA
MMAR_4542|M.marinum_M QQAALYADPGAWPGLAQAEQLHGKEMSYNNFTDADAAWRAAFDHEQKCVA
MUL_4712|M.ulcerans_Agy99 QQAALYADPGAWPGLAQAEQLHGKEMSYNNFTDADAAWRAAFDHEQKCVA
MAV_1081|M.avium_104 QQASLYSDPGAWPGLAQAEQLHGKEMSYNNFTDADAAWRAAFDHEQTCVA
MSMEG_5515|M.smegmatis_MC2_155 QKAAVYRDNAAWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEQTCVA
MAB_1064|M.abscessus_ATCC_1997 QQAALYIG-AAGQGLAQAEQLHGKEMSYNNYTDADAAWRAAWDQDKACAA
*:*::* . . ***********:*****:**********:*:: *.*
Mvan_4856|M.vanbaalenii_PYR-1 IIKHANPCGIAISPVSVADAHRKAHECDPLSAFGGVIAANTEVTVEMAET
Mflv_1875|M.gilvum_PYR-GCK IIKHANPCGIAISSVSVADAHRKAHECDPLSAFGGVIAANTEVTVEMAET
Mb0982|M.bovis_AF2122/97 IIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEY
Rv0957|M.tuberculosis_H37Rv IIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEY
MLBr_00161|M.leprae_Br4923 IIKHANPCGIAISSLSVADAHRKAHECDPLSAYGGVIAANTEVSLEMAEY
MMAR_4542|M.marinum_M IIKHANPCGIAISEVSVADAHRKAHACDPLSAYGGVIACNTEVSPEMAEY
MUL_4712|M.ulcerans_Agy99 IIKHANPCGIAISEVSVADAHRKAHACDPLSAYGGVIACNTEVSPEMAEY
MAV_1081|M.avium_104 IIKHANPCGIAISSTSVADAHRKAHECDPLSAFGGVIAANTEVSVEMAEY
MSMEG_5515|M.smegmatis_MC2_155 IIKHANPCGIAISSTSVADAHRKAHECDPLSAFGGVIAANTEVSVEMAET
MAB_1064|M.abscessus_ATCC_1997 IIKHANPCGIAVSDISIADAHLKAHECDPLSAFGGVIAVNREVSVEMAER
***********:* *:**** *** ******:***** * **: ****
Mvan_4856|M.vanbaalenii_PYR-1 VAGIFTEVIIAPAYEPGAVEVLSGKKNIRVLVASEPQRGGTEFRQVSGGL
Mflv_1875|M.gilvum_PYR-GCK VAGIFTEVIIAPAYEPGAVDVLKGKKNIRVLVASEPQPGGTEFRQISGGL
Mb0982|M.bovis_AF2122/97 VSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGL
Rv0957|M.tuberculosis_H37Rv VSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGL
MLBr_00161|M.leprae_Br4923 VSTIFTEVIVAPSYAPGAVDVLSCKKNVRVLVASAPLRGGSELRPVSGGL
MMAR_4542|M.marinum_M VSTIFTEVIVAPAYAPAALDQLTKKKNIRVLVASEPQDGGAELRPISGGL
MUL_4712|M.ulcerans_Agy99 VSTIFTEVIVAPAYAPAALDQLTKKKNIRVLVASEPQDGGAELRPISGGL
MAV_1081|M.avium_104 VSTIFTEVIIAPAYQPAALDILTRKKNIRVLVASEPLTGGTELRPISGGL
MSMEG_5515|M.smegmatis_MC2_155 ISEIFTEVIIAPAYEPGAVEVLARKKNIRILVASQPPIGGTEVRQISGGL
MAB_1064|M.abscessus_ATCC_1997 VADIFTEVIVAPGYADGAVEVLSRKKNVRLLRAAQPESGSTEWRQISGGL
:: ******:**.* .*:: * ***:*:* *: * *.:* * :****
Mvan_4856|M.vanbaalenii_PYR-1 LLQQRDALDAAGDNPNTWTLAAGPAADPDTLADLAFAWRTCRAVKSNAIV
Mflv_1875|M.gilvum_PYR-GCK LLQQRDALDASGDDPNNWTLATGAPADPDTLADLVFAWRTCRAVKSNAIV
Mb0982|M.bovis_AF2122/97 LIQQSDQLDAHGDNPANWTLATGSPADPATLTDLVFAWRACRAVKSNAIV
Rv0957|M.tuberculosis_H37Rv LIQQSDQLDAHGDNPANWTLATGSPADPATLTDLVFAWRACRAVKSNAIV
MLBr_00161|M.leprae_Br4923 LIQQPDQLDTAGDNPANWTLATGSPAGPATLTDLVFAWRACRAVKSNAIV
MMAR_4542|M.marinum_M LMQQRDQLDAAGDNPANWTLATGSPADPATLTDLVFAWRSCRAVKSNAIV
MUL_4712|M.ulcerans_Agy99 LMQQRDQLDAAGDNPANWILATGSPADPATLTDLVFAWRSCRAVKSNAIV
MAV_1081|M.avium_104 LVQQRDELDAHGDNPANWTLATGAPADPATLADLVFAWRVCRAVKSNAIV
MSMEG_5515|M.smegmatis_MC2_155 LLQQRDALDADGDDPNNWTLATGEPADPKTLEDLVFAWRACRAVKSNAIV
MAB_1064|M.abscessus_ATCC_1997 LVQERDALDAEGDDPANWTLVAGAAADADTLADLVFAWKVGRAVKSNAIV
*:*: * **: **:* .* *.:* .*.. ** **.***: *********
Mvan_4856|M.vanbaalenii_PYR-1 LARDGATVGVGMGQVNRVDAARLAVERAGGRSSGAVGASDAFFPFPDGLE
Mflv_1875|M.gilvum_PYR-GCK LAKDGATVGVGMGQVNRVDAARLAVERAGERTRDAVGASDAFFPFPDGLQ
Mb0982|M.bovis_AF2122/97 IAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLE
Rv0957|M.tuberculosis_H37Rv IAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLE
MLBr_00161|M.leprae_Br4923 IAADGATIGVGMGQVNRVDAARLAVERGGDRVRGAVVASDAFFPFADGLQ
MMAR_4542|M.marinum_M IVADGATIGVGMGQVNRVDAARLAVERGGERVNGAVAASDAFFPFPDGLE
MUL_4712|M.ulcerans_Agy99 IVADGATIGVGMGQVNRVDAARLAVERGGERVNGAVAASDAFFPFPDGLE
MAV_1081|M.avium_104 IAAGGATIGVGMGQVNRVDAARLAVERGGDRVRGAVAASDAFFPFPDGLE
MSMEG_5515|M.smegmatis_MC2_155 VARDGATVGVGMGQVNRVDAAKLAVQRGGDRVAGAVAASDAFFPFPDGLQ
MAB_1064|M.abscessus_ATCC_1997 IASGGATIGVGMGQVNRVDAARLAVSRGGDRVSGAVAASDAFFPFPDGLE
:. .***:*************:***.*.* * .** ********.***:
Mvan_4856|M.vanbaalenii_PYR-1 TLIRAGVKAVVHPGGSVRDDEVTAAAEADGITLYLTGARHFAH
Mflv_1875|M.gilvum_PYR-GCK TLIDAGVKAVVHPGGSVRDDEVTAAAEAAGITLYLTGARHFAH
Mb0982|M.bovis_AF2122/97 TLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH
Rv0957|M.tuberculosis_H37Rv TLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH
MLBr_00161|M.leprae_Br4923 TLAAAGVTAIVHPGGSVRDAEVTAAATKAGVTLYLTGVRHFVH
MMAR_4542|M.marinum_M TLTAAGVKAIVHPGGSVRDEEVTAAAAKAGITLYLTGSRHFAH
MUL_4712|M.ulcerans_Agy99 TLTAAGVKAIVHPGGSVRDEEVTAAAAKAGITLYLTGSRHFVH
MAV_1081|M.avium_104 TLTGAGVKAVVHPGGSVRDDEVTAAAANAGITLYLTGARHFAH
MSMEG_5515|M.smegmatis_MC2_155 VLTEADVKAIVHPGGSVRDAEVTAAAELAGITLYLTGARHFAH
MAB_1064|M.abscessus_ATCC_1997 VLSQAGVRAVVHPGGSMRDELVTDAAKAAGITLYTTGARHFAH
.* *.* *:******:** ** ** *:*** ** ***.*