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TAGRLLVGATPLGQPSDASARLVRALRSADVIAAEDTRRVRTLAQALEVKPVGRIVSLYDQNEASRVPAL LDDIKGGATVLLVSDAGMPLISDPGYRLVAACVEHDLPVQCLPGPSAVTTALAVAGLPAERFCFEGFAPR RQAARRTWLRSLSAEPRTCVFFESPRRLAELLGDAVEVLGPDRRAVVCRELTKTHEEIVRGRLGELAEWA ADGVLGEITVVLEGATPTADPDALVAEVNRLVDDGMRVKDACAQVVAATPGSPSKRELYDAVLRARG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4808 | - | - | 100% (278) | uroporphyrin-III C/tetrapyrrole methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2305 | - | 9e-05 | 30.53% (131) | uroporphyrin-III C-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1030 | - | 1e-102 | 67.87% (277) | hypothetical protein Mb1030 |
| M. gilvum PYR-GCK | Mflv_1925 | - | 1e-141 | 91.34% (277) | uroporphyrin-III C/tetrapyrrole methyltransferase |
| M. tuberculosis H37Rv | Rv1003 | - | 1e-102 | 67.87% (277) | hypothetical protein Rv1003 |
| M. leprae Br4923 | MLBr_00193 | - | 1e-102 | 70.04% (277) | hypothetical protein MLBr_00193 |
| M. abscessus ATCC 19977 | MAB_1123 | - | 6e-99 | 64.49% (276) | hypothetical protein MAB_1123 |
| M. marinum M | MMAR_4490 | - | 1e-103 | 69.42% (278) | hypothetical protein MMAR_4490 |
| M. avium 104 | MAV_1128 | - | 1e-107 | 71.12% (277) | hypothetical protein MAV_1128 |
| M. smegmatis MC2 155 | MSMEG_5445 | - | 1e-120 | 77.26% (277) | hypothetical protein MSMEG_5445 |
| M. thermoresistible (build 8) | TH_1146 | - | 1e-126 | 81.23% (277) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4662 | - | 1e-103 | 69.78% (278) | hypothetical protein MUL_4662 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4808|M.vanbaalenii_PYR-1 MTAGRLLVGATPLGQPSDASARLVRALRSADVIAAEDTRRVRTLAQALEV
Mflv_1925|M.gilvum_PYR-GCK MTAGRLLVGATPLGQPSDASARLVRALGSADVIAAEDTRRVRTLATALEV
TH_1146|M.thermoresistible__bu MAPGRLLIGATPLGQPKDASARLIEALATADVVAAEDTRRVRTLAQLLDV
MSMEG_5445|M.smegmatis_MC2_155 MTLGKLLIGATPLGQPSDASARLVRALRDADIVAAEDTRRIRSLAQALEV
Mb1030|M.bovis_AF2122/97 MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLAKALDI
Rv1003|M.tuberculosis_H37Rv MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLAKALDI
MMAR_4490|M.marinum_M MTVGRLLLGATPLGQPSDASARLIDALTSADVVAAEDTRRVRTLAKALDI
MUL_4662|M.ulcerans_Agy99 MTVGRLLLGATPLGQPSDASARLIDALTSADVVAAEDTRRVLTLAKALDI
MAV_1128|M.avium_104 MTTGRLLLGATPLGQPSDASPRLLDALARADVVAAEDTRRVRTLAKALDV
MLBr_00193|M.leprae_Br4923 MTYGRLLLGATPLGQPLDASRRLTDALCCADVVAAEDTRRARTLAKTLGV
MAB_1123|M.abscessus_ATCC_1997 --MGNLLLAATPLGEPADASPRLREALAKTSVVAAEDTRRVRALAKSLDV
*.**:.*****:* *** ** ** :.::******* ** * :
Mvan_4808|M.vanbaalenii_PYR-1 KPVGRIVSLYDQNEASRVPALLDDIKGGATVLLVSDAGMPLISDPGYRLV
Mflv_1925|M.gilvum_PYR-GCK KPRGRIVSLYDQNEASRVPALLDDIKGGATVLLVSDAGMPLISDPGYRLV
TH_1146|M.thermoresistible__bu TPAGRVVSLYDQNEASRVPGLIGQIADGATVLLVSDAGMPLINDPGYRLV
MSMEG_5445|M.smegmatis_MC2_155 TPTGRVLSFFDQNEASRVPGLVEEIRAGATVLVVSDAGMPLINDPGYRLV
Mb1030|M.bovis_AF2122/97 RIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLV
Rv1003|M.tuberculosis_H37Rv RIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLV
MMAR_4490|M.marinum_M SIGGRVVSLFDRVEALRVGSLVEAIEAGATVLVVSDAGMPVINDPGYRLV
MUL_4662|M.ulcerans_Agy99 SIGGRVVSLFDRVEALRVGALVEAIEAGATVLVVSDAGMPIINDPGYRLV
MAV_1128|M.avium_104 AITGRVISMFDRVEAARVDSLLEAIRSGATVLVVSDAGMPVISDPGFRLV
MLBr_00193|M.leprae_Br4923 VITGRVISLFDQIEAVRVSALVAEIEAGATVLVISDAGMSVISDPGYRLV
MAB_1123|M.abscessus_ATCC_1997 QISGQIISFYDQNEASRIEPLLADLEAGYDVLVVTDAGMPSISDPGYRLV
*:::*::*: ** *: *: : * **:::*** . *.***:***
Mvan_4808|M.vanbaalenii_PYR-1 AACVEHDLPVQCLPGPSAVTTALAVAGLPAERFCFEGFAPRRQAARRTWL
Mflv_1925|M.gilvum_PYR-GCK AACAEHDLPVQCLPGPSAVTTALAVAGLPSERFCFEGFAPRKQSARATWL
TH_1146|M.thermoresistible__bu TACIEADLPVTCLPGPSAVTTALAVSGLPADRFCFEGFAPRRQAARRSWL
MSMEG_5445|M.smegmatis_MC2_155 AACAEAGLPVSCLPGPSAVTTALAVSGLASDRFCFEGFAPRKHAARMTWL
Mb1030|M.bovis_AF2122/97 AACIDAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWL
Rv1003|M.tuberculosis_H37Rv AACIDAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWL
MMAR_4490|M.marinum_M AACIEAGISVTCLPGPSAVTTALVVSGLASDKFCFEGFAPRKSGARRAWL
MUL_4662|M.ulcerans_Agy99 AACIEAGISVTCLPGPSAVTTALVVSGLASDKFCFEGFAPRKSGARRAWL
MAV_1128|M.avium_104 TACVQAGLPVGCLPGPSAVMTALAVSGLPAEKFCFEGFAPRKKAARRGWL
MLBr_00193|M.leprae_Br4923 AACIAAGLPVRCLPGPSAVMTALAVSGLSSEKFCFEGFAPRKSSARRTWL
MAB_1123|M.abscessus_ATCC_1997 AACVRQGIPITCLPGPSAVTTALAVSGLPVDRFCFEGFAPRKQGARSRWL
:** .:.: ******** ***.::**. ::*********: .** **
Mvan_4808|M.vanbaalenii_PYR-1 RSLSAEPRTCVFFESPRRLAELLGDAVEVLGPDRRAVVCRELTKTHEEIV
Mflv_1925|M.gilvum_PYR-GCK RTLSAEPRTCVFFESPRRLAETLRDAVEVLGPDRRAVVCRELTKTHEEIV
TH_1146|M.thermoresistible__bu RTLADEPRTCVFFESPRRLAECLDDAVAVLGGDRRAVVCRELTKTHEEIV
MSMEG_5445|M.smegmatis_MC2_155 QTLAHEMRTCVFFESPRRLAETLRDAVDALGADRRAVVCRELTKTHEEIK
Mb1030|M.bovis_AF2122/97 AELAEERRTCVFFESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVV
Rv1003|M.tuberculosis_H37Rv AELAEERRTCVFFESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVV
MMAR_4490|M.marinum_M ASLAEEPRTCVFFESPRRLAACLRDAVEQLGGSRPAAVCRELTKVHEEVR
MUL_4662|M.ulcerans_Agy99 ASLAEEPRTCVFFESPRRLAACLRDAVEQLGGSRRAAVCRELTKVHEEVR
MAV_1128|M.avium_104 DSLADERRTCVFFESPRRLPACLQDAVERLGGERRAAICRELTKVHEEVV
MLBr_00193|M.leprae_Br4923 ASLADERRTCVFFESPRRLAACLRDAVDQLGSARPVVVCRELTKVHEEVV
MAB_1123|M.abscessus_ATCC_1997 SELVAEPRTCVFFESPRRLAETLADAVQVLGPERRVAVCRELTKTHEEVL
* * ************. * *** ** * ..:******.***:
Mvan_4808|M.vanbaalenii_PYR-1 RGRLGELAEWAADG-VLGEITVVLEGATP-TADPDALVAEVNRLVDDGMR
Mflv_1925|M.gilvum_PYR-GCK RGTLGELAEWAAEG-VLGEITVVLDGATP-SADPEALVAEALRLVDDGMR
TH_1146|M.thermoresistible__bu RGTLAELADWSAGG-VLGEITVVLAGGVA-RADLDALVAEVSALVDNGMR
MSMEG_5445|M.smegmatis_MC2_155 RGSLAELADWADDG-VLGEITVVLAGATP-TADLPTLVAEVEELVAAGTR
Mb1030|M.bovis_AF2122/97 RGSLDELAIWAAGG-VLGEITVVVAGAAP-HAELSSLIAQVEEFVAAGIR
Rv1003|M.tuberculosis_H37Rv RGSLDELAIWAAGG-VLGEITVVVAGAAP-HAELSSLIAQVEEFVAAGIR
MMAR_4490|M.marinum_M RGSLGELADWAADG-VLGEITVVLAGAAPLHVDLQSLVAEVENLVAAGIR
MUL_4662|M.ulcerans_Agy99 RGSLGELADWAADG-VLGEITVVLAGAAPLHVDLQPLVAEVENLVAGGIR
MAV_1128|M.avium_104 RGTLDELAAWAGDG-VLGEITVVLAGATP-RTDLPSLVAEVEQRVADGAR
MLBr_00193|M.leprae_Br4923 RGSLDELATWAANG-VLGEITVVLAGATP-RADLFLLVPEVENLVAGGAR
MAB_1123|M.abscessus_ATCC_1997 RGTLRELAAWAEGNEVLGEITVVLDGGRPAVPEIETLVARVEELMDDGMG
** * *** *: . ********: *. . : *:... : *
Mvan_4808|M.vanbaalenii_PYR-1 VKDACAQVVAATPGSPSKRELYDAVLRARG--------
Mflv_1925|M.gilvum_PYR-GCK VKDACAQVVAGNPGAPPRRALYDAVLRARE--------
TH_1146|M.thermoresistible__bu VKDACAQVVAAHPGAPSRRELYDAVLRARA--------
MSMEG_5445|M.smegmatis_MC2_155 VKDACARVVADNPGAPSKRELYDAVLRSRD--------
Mb1030|M.bovis_AF2122/97 VKDACSEVAAAHPGVRT-RQLYDAVLQSRRETGGPAQP
Rv1003|M.tuberculosis_H37Rv VKDACSEVAAAHPGVRT-RQLYDAVLQSRRETGGPAQP
MMAR_4490|M.marinum_M VKDACSEVATGHQGIRT-RELYDAVQLARRETDTAP--
MUL_4662|M.ulcerans_Agy99 VKDACSEVATGHQGIRT-RELYDAVQLARRETDAAP--
MAV_1128|M.avium_104 IKDACGEVAAAQPGVRS-RQLYDAVLKARRD-------
MLBr_00193|M.leprae_Br4923 VKDACGQVAAVHSSVRS-RQLYDAVLRARQVSSR----
MAB_1123|M.abscessus_ATCC_1997 LREACATAIGESGATLSRRDLYDAVVKARD--------
:::**. . . . * ***** :*