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TLGKLLIGATPLGQPSDASARLVRALRDADIVAAEDTRRIRSLAQALEVTPTGRVLSFFDQNEASRVPGL VEEIRAGATVLVVSDAGMPLINDPGYRLVAACAEAGLPVSCLPGPSAVTTALAVSGLASDRFCFEGFAPR KHAARMTWLQTLAHEMRTCVFFESPRRLAETLRDAVDALGADRRAVVCRELTKTHEEIKRGSLAELADWA DDGVLGEITVVLAGATPTADLPTLVAEVEELVAAGTRVKDACARVVADNPGAPSKRELYDAVLRSRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5445 | - | - | 100% (278) | hypothetical protein MSMEG_5445 |
| M. smegmatis MC2 155 | MSMEG_2618 | cobA | 1e-08 | 36.50% (137) | uroporphyrin-III C-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1030 | - | 1e-101 | 68.25% (274) | hypothetical protein Mb1030 |
| M. gilvum PYR-GCK | Mflv_1925 | - | 1e-120 | 76.62% (278) | uroporphyrin-III C/tetrapyrrole methyltransferase |
| M. tuberculosis H37Rv | Rv1003 | - | 1e-101 | 68.25% (274) | hypothetical protein Rv1003 |
| M. leprae Br4923 | MLBr_00193 | - | 1e-105 | 72.20% (277) | hypothetical protein MLBr_00193 |
| M. abscessus ATCC 19977 | MAB_1123 | - | 8e-96 | 62.23% (278) | hypothetical protein MAB_1123 |
| M. marinum M | MMAR_4490 | - | 1e-108 | 72.66% (278) | hypothetical protein MMAR_4490 |
| M. avium 104 | MAV_1128 | - | 1e-109 | 70.76% (277) | hypothetical protein MAV_1128 |
| M. thermoresistible (build 8) | TH_1146 | - | 1e-119 | 78.10% (274) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4662 | - | 1e-108 | 72.30% (278) | hypothetical protein MUL_4662 |
| M. vanbaalenii PYR-1 | Mvan_4808 | - | 1e-121 | 77.26% (277) | uroporphyrin-III C/tetrapyrrole methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1925|M.gilvum_PYR-GCK MTAGRLLVGATPLGQPSDASARLVRALGSADVIAAEDTRRVRTLATALEV
Mvan_4808|M.vanbaalenii_PYR-1 MTAGRLLVGATPLGQPSDASARLVRALRSADVIAAEDTRRVRTLAQALEV
TH_1146|M.thermoresistible__bu MAPGRLLIGATPLGQPKDASARLIEALATADVVAAEDTRRVRTLAQLLDV
MSMEG_5445|M.smegmatis_MC2_155 MTLGKLLIGATPLGQPSDASARLVRALRDADIVAAEDTRRIRSLAQALEV
Mb1030|M.bovis_AF2122/97 MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLAKALDI
Rv1003|M.tuberculosis_H37Rv MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLAKALDI
MMAR_4490|M.marinum_M MTVGRLLLGATPLGQPSDASARLIDALTSADVVAAEDTRRVRTLAKALDI
MUL_4662|M.ulcerans_Agy99 MTVGRLLLGATPLGQPSDASARLIDALTSADVVAAEDTRRVLTLAKALDI
MAV_1128|M.avium_104 MTTGRLLLGATPLGQPSDASPRLLDALARADVVAAEDTRRVRTLAKALDV
MLBr_00193|M.leprae_Br4923 MTYGRLLLGATPLGQPLDASRRLTDALCCADVVAAEDTRRARTLAKTLGV
MAB_1123|M.abscessus_ATCC_1997 --MGNLLLAATPLGEPADASPRLREALAKTSVVAAEDTRRVRALAKSLDV
*.**:.*****:* *** ** ** :.::******* ** * :
Mflv_1925|M.gilvum_PYR-GCK KPRGRIVSLYDQNEASRVPALLDDIKGGATVLLVSDAGMPLISDPGYRLV
Mvan_4808|M.vanbaalenii_PYR-1 KPVGRIVSLYDQNEASRVPALLDDIKGGATVLLVSDAGMPLISDPGYRLV
TH_1146|M.thermoresistible__bu TPAGRVVSLYDQNEASRVPGLIGQIADGATVLLVSDAGMPLINDPGYRLV
MSMEG_5445|M.smegmatis_MC2_155 TPTGRVLSFFDQNEASRVPGLVEEIRAGATVLVVSDAGMPLINDPGYRLV
Mb1030|M.bovis_AF2122/97 RIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLV
Rv1003|M.tuberculosis_H37Rv RIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLV
MMAR_4490|M.marinum_M SIGGRVVSLFDRVEALRVGSLVEAIEAGATVLVVSDAGMPVINDPGYRLV
MUL_4662|M.ulcerans_Agy99 SIGGRVVSLFDRVEALRVGALVEAIEAGATVLVVSDAGMPIINDPGYRLV
MAV_1128|M.avium_104 AITGRVISMFDRVEAARVDSLLEAIRSGATVLVVSDAGMPVISDPGFRLV
MLBr_00193|M.leprae_Br4923 VITGRVISLFDQIEAVRVSALVAEIEAGATVLVISDAGMSVISDPGYRLV
MAB_1123|M.abscessus_ATCC_1997 QISGQIISFYDQNEASRIEPLLADLEAGYDVLVVTDAGMPSISDPGYRLV
*:::*::*: ** *: *: : * **:::*** . *.***:***
Mflv_1925|M.gilvum_PYR-GCK AACAEHDLPVQCLPGPSAVTTALAVAGLPSERFCFEGFAPRKQSARATWL
Mvan_4808|M.vanbaalenii_PYR-1 AACVEHDLPVQCLPGPSAVTTALAVAGLPAERFCFEGFAPRRQAARRTWL
TH_1146|M.thermoresistible__bu TACIEADLPVTCLPGPSAVTTALAVSGLPADRFCFEGFAPRRQAARRSWL
MSMEG_5445|M.smegmatis_MC2_155 AACAEAGLPVSCLPGPSAVTTALAVSGLASDRFCFEGFAPRKHAARMTWL
Mb1030|M.bovis_AF2122/97 AACIDAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWL
Rv1003|M.tuberculosis_H37Rv AACIDAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWL
MMAR_4490|M.marinum_M AACIEAGISVTCLPGPSAVTTALVVSGLASDKFCFEGFAPRKSGARRAWL
MUL_4662|M.ulcerans_Agy99 AACIEAGISVTCLPGPSAVTTALVVSGLASDKFCFEGFAPRKSGARRAWL
MAV_1128|M.avium_104 TACVQAGLPVGCLPGPSAVMTALAVSGLPAEKFCFEGFAPRKKAARRGWL
MLBr_00193|M.leprae_Br4923 AACIAAGLPVRCLPGPSAVMTALAVSGLSSEKFCFEGFAPRKSSARRTWL
MAB_1123|M.abscessus_ATCC_1997 AACVRQGIPITCLPGPSAVTTALAVSGLPVDRFCFEGFAPRKQGARSRWL
:** .:.: ******** ***.::**. ::*********: .** **
Mflv_1925|M.gilvum_PYR-GCK RTLSAEPRTCVFFESPRRLAETLRDAVEVLGPDRRAVVCRELTKTHEEIV
Mvan_4808|M.vanbaalenii_PYR-1 RSLSAEPRTCVFFESPRRLAELLGDAVEVLGPDRRAVVCRELTKTHEEIV
TH_1146|M.thermoresistible__bu RTLADEPRTCVFFESPRRLAECLDDAVAVLGGDRRAVVCRELTKTHEEIV
MSMEG_5445|M.smegmatis_MC2_155 QTLAHEMRTCVFFESPRRLAETLRDAVDALGADRRAVVCRELTKTHEEIK
Mb1030|M.bovis_AF2122/97 AELAEERRTCVFFESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVV
Rv1003|M.tuberculosis_H37Rv AELAEERRTCVFFESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVV
MMAR_4490|M.marinum_M ASLAEEPRTCVFFESPRRLAACLRDAVEQLGGSRPAAVCRELTKVHEEVR
MUL_4662|M.ulcerans_Agy99 ASLAEEPRTCVFFESPRRLAACLRDAVEQLGGSRRAAVCRELTKVHEEVR
MAV_1128|M.avium_104 DSLADERRTCVFFESPRRLPACLQDAVERLGGERRAAICRELTKVHEEVV
MLBr_00193|M.leprae_Br4923 ASLADERRTCVFFESPRRLAACLRDAVDQLGSARPVVVCRELTKVHEEVV
MAB_1123|M.abscessus_ATCC_1997 SELVAEPRTCVFFESPRRLAETLADAVQVLGPERRVAVCRELTKTHEEVL
* * ************. * *** ** * ..:******.***:
Mflv_1925|M.gilvum_PYR-GCK RGTLGELAEWAAEG-VLGEITVVLDGATP-SADPEALVAEALRLVDDGMR
Mvan_4808|M.vanbaalenii_PYR-1 RGRLGELAEWAADG-VLGEITVVLEGATP-TADPDALVAEVNRLVDDGMR
TH_1146|M.thermoresistible__bu RGTLAELADWSAGG-VLGEITVVLAGGVA-RADLDALVAEVSALVDNGMR
MSMEG_5445|M.smegmatis_MC2_155 RGSLAELADWADDG-VLGEITVVLAGATP-TADLPTLVAEVEELVAAGTR
Mb1030|M.bovis_AF2122/97 RGSLDELAIWAAGG-VLGEITVVVAGAAP-HAELSSLIAQVEEFVAAGIR
Rv1003|M.tuberculosis_H37Rv RGSLDELAIWAAGG-VLGEITVVVAGAAP-HAELSSLIAQVEEFVAAGIR
MMAR_4490|M.marinum_M RGSLGELADWAADG-VLGEITVVLAGAAPLHVDLQSLVAEVENLVAAGIR
MUL_4662|M.ulcerans_Agy99 RGSLGELADWAADG-VLGEITVVLAGAAPLHVDLQPLVAEVENLVAGGIR
MAV_1128|M.avium_104 RGTLDELAAWAGDG-VLGEITVVLAGATP-RTDLPSLVAEVEQRVADGAR
MLBr_00193|M.leprae_Br4923 RGSLDELATWAANG-VLGEITVVLAGATP-RADLFLLVPEVENLVAGGAR
MAB_1123|M.abscessus_ATCC_1997 RGTLRELAAWAEGNEVLGEITVVLDGGRPAVPEIETLVARVEELMDDGMG
** * *** *: . ********: *. . : *:... : *
Mflv_1925|M.gilvum_PYR-GCK VKDACAQVVAGNPGAPPRRALYDAVLRARE--------
Mvan_4808|M.vanbaalenii_PYR-1 VKDACAQVVAATPGSPSKRELYDAVLRARG--------
TH_1146|M.thermoresistible__bu VKDACAQVVAAHPGAPSRRELYDAVLRARA--------
MSMEG_5445|M.smegmatis_MC2_155 VKDACARVVADNPGAPSKRELYDAVLRSRD--------
Mb1030|M.bovis_AF2122/97 VKDACSEVAAAHPGVRT-RQLYDAVLQSRRETGGPAQP
Rv1003|M.tuberculosis_H37Rv VKDACSEVAAAHPGVRT-RQLYDAVLQSRRETGGPAQP
MMAR_4490|M.marinum_M VKDACSEVATGHQGIRT-RELYDAVQLARRETDTAP--
MUL_4662|M.ulcerans_Agy99 VKDACSEVATGHQGIRT-RELYDAVQLARRETDAAP--
MAV_1128|M.avium_104 IKDACGEVAAAQPGVRS-RQLYDAVLKARRD-------
MLBr_00193|M.leprae_Br4923 VKDACGQVAAVHSSVRS-RQLYDAVLRARQVSSR----
MAB_1123|M.abscessus_ATCC_1997 LREACATAIGESGATLSRRDLYDAVVKARD--------
:::**. . . . * ***** :*