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SRADGSTNSLARATSPYLRQHADNPVHWQQWAPDALALAAERDVPILLSIGYAACHWCHVMAHECFEDDE VAAAMNAGFVCIKVDREERPDLDAVYMNATVALTGQGGWPMTCFLTPDGRPFFCGTYYPKASFLQLLAAV VDTWRTRRADVEETSDKIAAELRSMASGLPRGGPPVAAEVCDDASAAVLRDEDTVDGGFGAAPKFPPSAL LEALLRNHERTGSPAPLAAVSRACEAMARGGIYDQLGGGFARYSVDAAWVVPHFEKMLYDNAQLLRVYAH WARRTGNPLAHRVVDETVRFLIEDLRVGGMFVSSLDADTAGVEGLTYVWTPGQLCEVLGEGDGRWAAELF GVTAAGTFEGGASVLQMRADPDDADRFVRVRDALRAARLTRPQPTRDDKVVTAWNGLAITALVEASVLDR PEYLSAAIQCARTLLDAHLVDGRLRRSSLGGVVGDSMAVLEDHAALATGLLALHQATGERVWLQEATGLL DLALDHFSDSAEVGRWFDVADDAEQLMLRPSDPLDGATPSGASLIAEALQLAAHLAPEAAAQRYAAAAEA TMAGATVLLARVPRSAGHWLAVAEAAVRGPIQIAVAGGADSALLAAARRLAPGGAVVVGGEVNSSELLRD RPRVDGADAAYVCRGRVCDLPVTTVEDLATALGASV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4665 | - | - | 100% (667) | Fis family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1113 | - | 0.0 | 75.23% (662) | hypothetical protein Mb1113 |
| M. gilvum PYR-GCK | Mflv_2052 | - | 0.0 | 77.31% (670) | hypothetical protein Mflv_2052 |
| M. tuberculosis H37Rv | Rv1084 | - | 0.0 | 75.23% (662) | hypothetical protein Rv1084 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1205 | - | 0.0 | 69.39% (660) | hypothetical protein MAB_1205 |
| M. marinum M | MMAR_4383 | - | 0.0 | 75.08% (658) | transmembrane protein |
| M. avium 104 | MAV_1208 | - | 0.0 | 73.35% (668) | hypothetical protein MAV_1208 |
| M. smegmatis MC2 155 | MSMEG_5259 | - | 0.0 | 73.18% (660) | hypothetical protein MSMEG_5259 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0196 | - | 0.0 | 74.62% (658) | transmembrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4665|M.vanbaalenii_PYR-1 ----MSR-ADGSTNSLARATSPYLRQHADNPVHWQQWAPDALALAAERDV
Mflv_2052|M.gilvum_PYR-GCK ----MSPPADGPGNLLADATSPYLRQHADNPVHWRQWGADALAEAAARDV
MSMEG_5259|M.smegmatis_MC2_155 -----------MANLLNRSTSPYLRQHADNPVHWREWTPEALAEAAERDV
Mb1113|M.bovis_AF2122/97 MSPANP----SGTNTLALATSPYLRQHADNPVHWQQWTPQALAEAAARAV
Rv1084|M.tuberculosis_H37Rv MSPANP----SGTNTLALATSPYLRQHADNPVHWQQWTPQALAEAAARAV
MMAR_4383|M.marinum_M MTPADSSAGFSGTNTLAQATSPYLRQHADNPVHWQQWTPQALADASARDV
MUL_0196|M.ulcerans_Agy99 MTPADSSAGFSGTNTLAQATSPYLRQHADNPVHWQQWTPQALADAAARDV
MAV_1208|M.avium_104 MSPADP----SATNTLGRATSPYLRQHADNPVHWQQWTPQALADAAARDV
MAB_1205|M.abscessus_ATCC_1997 ----------MTVNRLGEATSPYLRQHVDNPVHWQQWTPEALAEAQSRDV
* * :********.******::* .:*** * * *
Mvan_4665|M.vanbaalenii_PYR-1 PILLSIGYAACHWCHVMAHECFEDDEVAAAMNAGFVCIKVDREERPDLDA
Mflv_2052|M.gilvum_PYR-GCK PILLSIGYAACHWCHVMAHESFSDDEVAAAANRDFVCIKVDREERPDLDA
MSMEG_5259|M.smegmatis_MC2_155 PILLSIGYAACHWCHVMAHESFEDAEVAALANANYVCIKVDREERPDLDA
Mb1113|M.bovis_AF2122/97 PILLSVGYAACHWCHVMAHESFDDDEVAAAMNAGFVCIKVDREERPDIDA
Rv1084|M.tuberculosis_H37Rv PILLSVGYAACHWCHVMAHESFDDDEVAAAMNAGFVCIKVDREERPDIDA
MMAR_4383|M.marinum_M PILLSIGYAACHWCHVMAHESFEDDEVAAVMNAGFVNIKVDREERPDIDA
MUL_0196|M.ulcerans_Agy99 PILLSIGYAACHWCHVMAHESFEDDEVAAVMNAGFVNIKVDREERPDIDA
MAV_1208|M.avium_104 PILLSVGYAACHWCHVMAHESFEDPDVAAAMNSGFVCVKVDREERPDIDA
MAB_1205|M.abscessus_ATCC_1997 PILLSIGYAACHWCHVMAHESFEDDEVAAVMNAGFVNIKVDREERPDLDA
*****:**************.*.* :*** * .:* :*********:**
Mvan_4665|M.vanbaalenii_PYR-1 VYMNATVALTGQGGWPMTCFLTPDGRPFFCGTYYPKASFLQLLAAVVDTW
Mflv_2052|M.gilvum_PYR-GCK VYMSVTVALTGQGGWPMTCFLTPDGRPFFCGTYYPKVSFLQLLAAVSETW
MSMEG_5259|M.smegmatis_MC2_155 VYMNATVALTGQGGWPMTCFLTPDGRPFFCGTYYPKANFLQLLTAVAETW
Mb1113|M.bovis_AF2122/97 VYMNATVALTGQGGWPMTCFLTPNGRPFFCGTYYPKAAFLQLLSAISETW
Rv1084|M.tuberculosis_H37Rv VYMNATVALTGQGGWPMTCFLTPNGRPFFCGTYYPKAAFLQLLSAISETW
MMAR_4383|M.marinum_M VYMNATVALTGQGGWPMTCFLTPDGRPFYCGTYYPKAGFLQLLSAVSETW
MUL_0196|M.ulcerans_Agy99 VYMNATVALTGQGGWPMTCFLTPDGRPFYCGTYYPKAGFLQLLSAVSETW
MAV_1208|M.avium_104 VYMNATVALTGHGGWPMTCFLTPDGRPFFCGTYYPKDAFLQLLSAVSATW
MAB_1205|M.abscessus_ATCC_1997 VYMNATVAMNGQGGWPMTCFLTPDGRPFYTGTYYPKQGFLQLLSAVREAW
***..***:.*:***********:****: ****** *****:*: :*
Mvan_4665|M.vanbaalenii_PYR-1 RTRRADVEETSDKIAAELRSMASGLPRGGPPVAAEVCDDASAAVLRDEDT
Mflv_2052|M.gilvum_PYR-GCK RTRRDEVEQTSDHIAAELRSMATGLPRGSRTVDSAGCDDAVAAVLRDEDV
MSMEG_5259|M.smegmatis_MC2_155 RDRRGEVERASDQITTELRKMAGGLPAGGPPVSAEMCDHAVASVLGDEDK
Mb1113|M.bovis_AF2122/97 RERRAEVEQASDHIAAELRSMASGLPGGGPEVAPELCDDAVAGVLREQDT
Rv1084|M.tuberculosis_H37Rv RERRAEVEQASDHIAAELRSMASGLPGGGPEVAPELCDDAVAGVLREQDT
MMAR_4383|M.marinum_M RERRGEVEEASDHIAGELRSMASGPPGGGPDVAPELCDHAVAVVLGEQDT
MUL_0196|M.ulcerans_Agy99 RERRGEVEEASDHIAGELRSMASGPPGGGPDVAPELCDHAVAVVLGEQDT
MAV_1208|M.avium_104 RERRGEVEEASDRIAGELRKMTSGLPAGGADLAAALCDEAVAAIIADRDT
MAB_1205|M.abscessus_ATCC_1997 ERRRDEVEEAASSITGQLQAMSGRLPAG-PGVDIALCDTAIAAILPAEDV
. ** :**.::. *: :*: *: * * : ** * * :: .*
Mvan_4665|M.vanbaalenii_PYR-1 VDGGFG----AAPKFPPSALLEALLRNHERTGSPAPLAAVSRACEAMARG
Mflv_2052|M.gilvum_PYR-GCK ARGGFSNSPSGAPKFPPSALLEALLRHHERTASPEALATVERTCTAMARG
MSMEG_5259|M.smegmatis_MC2_155 RHGGFG----GAPKFPPSALLEGLLRHYERTGSAAAVSAVQRTCKAMARG
Mb1113|M.bovis_AF2122/97 AHGGFG----GAPKFPPSALLEALMRHYERTRSPAALEAVARTGNAMARG
Rv1084|M.tuberculosis_H37Rv AHGGFG----GAPKFPPSALLEALMRHYERTRSPAALEAVARTGNAMARG
MMAR_4383|M.marinum_M VHGGWG----TAPKFPPSALLEALLRHYERTGSPAALAAVSRTGAAMARG
MUL_0196|M.ulcerans_Agy99 VHGGWG----TAPKFPPSALLEALLRHYERTGSLAALAAVSRTGAAMARG
MAV_1208|M.avium_104 VHGGFG----GAPKFPPSALLEALLRSYERTGSAAVLQAVAHTGAAMARG
MAB_1205|M.abscessus_ATCC_1997 RFGGFG----GAPKFPPSALLEALLRGYERTGDAPVLAVVARTAAAMARG
**:. ***********.*:* :*** . : .* :: *****
Mvan_4665|M.vanbaalenii_PYR-1 GIYDQLGGGFARYSVDAAWVVPHFEKMLYDNAQLLRVYAHWARRTGNPLA
Mflv_2052|M.gilvum_PYR-GCK GIYDQLAGGFARYSVDSSWVVPHFEKMLYDNAQLLRVYAHWARRTADPSA
MSMEG_5259|M.smegmatis_MC2_155 GIYDQLSGGFARYSVDPYWVVPHFEKMLYDNALLLRVYAHLARRTGSVLA
Mb1113|M.bovis_AF2122/97 GIYDQLGGGFARYSVDGAWVVPHFEKMLYDNALLLRAYAHWARRTGDPLA
Rv1084|M.tuberculosis_H37Rv GIYDQLGGGFARYSVDGAWVVPHFEKMLYDNALLLRAYAHWARRTGDPLA
MMAR_4383|M.marinum_M GIYDQLAGGFARYSVDKAWVVPHFEKMLYDNALLLRAYAHWARRTGDELA
MUL_0196|M.ulcerans_Agy99 GIYDQLAGGFARYSVDKAWVVPHFEKMLYDNALLLRAYAHWARRTGDELA
MAV_1208|M.avium_104 GIYDQLGGGFARYSVDNAWVVPHFEKMLYDNALLLRVYAHWARRTGDPLA
MAB_1205|M.abscessus_ATCC_1997 GIYDQLAGGFARYSVDAAWVVPHFEKMLYDNALLLRFYGHLARRTGDALA
******.********* ************** *** *.* ****.. *
Mvan_4665|M.vanbaalenii_PYR-1 HRVVDETVRFLIEDLRVGG---MFVSSLDADTAGVEGLTYVWTPGQLCEV
Mflv_2052|M.gilvum_PYR-GCK RRIADETARFLLDDLRRDA---LFVSSLDADTEGVEGLTYVWTPDQLRRV
MSMEG_5259|M.smegmatis_MC2_155 RRIASETADFMIAELGDRD---MFTSSLDADAAGSEGSTYVWTPAELRSV
Mb1113|M.bovis_AF2122/97 RRVAAQTARFLLDELGSKAPADMFTSSLDADADGREGSTYVWTPVQLTEV
Rv1084|M.tuberculosis_H37Rv RRVAAQTARFLLDELGSKAPADMFTSSLDADADGREGSTYVWTPVQLTEV
MMAR_4383|M.marinum_M RRVAAQTAGFLLDGLAAGG---MFTSSLDADTDGREGSTYVWTPEQLIEL
MUL_0196|M.ulcerans_Agy99 CRVAAQTAGFLLDGLAAGG---MFTSSLDADTDGREGSTYVWTPEQLIEL
MAV_1208|M.avium_104 ARVTAETARFLLDDLADGD---MFTSSLDADADGREGSTYVWTPAQLTEV
MAB_1205|M.abscessus_ATCC_1997 RRIASETADFLLNELRVGE---LFVSSLDADADGSEGSTYVWTPEQLAEV
*:. :*. *:: * :*.******: * ** ****** :* :
Mvan_4665|M.vanbaalenii_PYR-1 LGEGDGRWAAELFGVTAAGTFEGGASVLQMRADPDDADRFVRVRDALRAA
Mflv_2052|M.gilvum_PYR-GCK LGEDDGRWAAEVFEVTSDGTFEDGQSVLQLLRDPDDPERFERVRIALRAE
MSMEG_5259|M.smegmatis_MC2_155 LGDDDGIWAAAVFGVTDEGTFEHGASVLQLPATPDDPARFETIRTTLLAA
Mb1113|M.bovis_AF2122/97 LGGDDGRWAAEVFGVTEAGTFEHGTSVLQLPADPDDAARLDRVRAALLVA
Rv1084|M.tuberculosis_H37Rv LGGDDGRWAAEVFGVTEAGTFEHGTSVLQLPADPDDAARLDRVRAALLVA
MMAR_4383|M.marinum_M LGEDDGRWAAEVYAVTAAGTFEHGASVLQLPSDPHDAERLQRVSGALSAA
MUL_0196|M.ulcerans_Agy99 LGEDDGRWAAEVYAVTAAGTFEHGSSVLQLPSDPHDAERLQRVSGALSAA
MAV_1208|M.avium_104 LGPDDGRWAAAVFGVTETGTFEHGSSVLRLPADPPDTPRFDRVRAALLAA
MAB_1205|M.abscessus_ATCC_1997 LGPEDGAWAATLFEVTPTGTFERGSSVLQLLRDPEDAARWQRVRQALLAA
** ** *** :: ** **** * ***:: * *. * : :* .
Mvan_4665|M.vanbaalenii_PYR-1 RLTRPQPTRDDKVVTAWNGLAITALVEAS-VLDRPEYLSAAIQCARTLLD
Mflv_2052|M.gilvum_PYR-GCK RRARPQPARDDKVIAAWNGLAITALAEAAFALGRPEYFSAAVDCAQALLD
MSMEG_5259|M.smegmatis_MC2_155 RAARPQPARDDKVVTAWNGFAVTALAEASVALQRPELLDAASRCARRLID
Mb1113|M.bovis_AF2122/97 RLARAQPARDDKVVTSWNGLAITALAEASVALDDPALAHAARRCATRLLD
Rv1084|M.tuberculosis_H37Rv RLARAQPARDDKVVTSWNGLAITALAEASVALDDPALAHAARRCATRLLD
MMAR_4383|M.marinum_M RRGRAQPGRDDKVVTSWNGLAITALVEASIALQQPELAQAARRCARVLLD
MUL_0196|M.ulcerans_Agy99 RRGRAQPGRDDKVVTSWNGLAITALVEASIALQQPELAQAARRCASVLLD
MAV_1208|M.avium_104 RRSRIQPGRDDKVVTSWNGLAITAFTEASVALDDLGLADAARRCARSVLD
MAB_1205|M.abscessus_ATCC_1997 RLVRVQPGRDDKAVTAWNGLAITALVEASVALDRDDLLEAAGGCAAALLE
* * ** ****.:::***:*:**:.**: .* ** ** :::
Mvan_4665|M.vanbaalenii_PYR-1 AHLVDGRLRRSSLGGVVGDSMAVLEDHAALATGLLALHQATGERVWLQEA
Mflv_2052|M.gilvum_PYR-GCK LHIVDGRLRRSSLGGVVGDGAAILEDHAALATALLTLHQGTGERRWLDAA
MSMEG_5259|M.smegmatis_MC2_155 LHMVDGRLRRASLGGAVGASAGILEDHAALATALLTLYQQTG--QWLPEA
Mb1113|M.bovis_AF2122/97 LHVVDGRLRRASLGGVVGDSAAILEDHAMLATGLLALYQLTSEGAWLTAA
Rv1084|M.tuberculosis_H37Rv LHVVDGRLRRASLGGVVGDSAAILEDHAMLATGLLALYQLTSEGAWLTAA
MMAR_4383|M.marinum_M LHVVDGRLRRACLGGVVGDSAAILEDHAMLATGLLALYQLTSEPGWLTSA
MUL_0196|M.ulcerans_Agy99 LHVVDGRLRRASLGGVVGDSAAILEDHAMLATGLLALYQLTSEPGWLTSA
MAV_1208|M.avium_104 LHVVDGRLRRASLGGVVGDSAAILEDYAMLATGLLALYQLSAEDSWLTAA
MAB_1205|M.abscessus_ATCC_1997 LHLRDGRLRRASLGGQVSEGDGVLEDYGTLATGLLSLYQVTGQWRWREAA
*: ******:.*** *. . .:***:. ***.**:*:* :. * *
Mvan_4665|M.vanbaalenii_PYR-1 TGLLDLALDHFSDSAEVGRWFDVADDAEQLMLRPSDPLDGATPSGASLIA
Mflv_2052|M.gilvum_PYR-GCK TRLLNLALDHFADPDEPGRWYDVADDAERLVVRPSDPMDGATPSGASLVA
MSMEG_5259|M.smegmatis_MC2_155 RHLLDLALEHFADPEQPGRWYDTADDAETLMVRPADPIDGATPAGASLIA
Mb1113|M.bovis_AF2122/97 TGLLDTAVAHFGDPQRPGRWFDTADDAERLMLRPSDPLDGATPSGASSIA
Rv1084|M.tuberculosis_H37Rv TGLLDTAVAHFGDPQRPGRWFDTADDAERLMLRPSDPLDGATPSGASSIA
MMAR_4383|M.marinum_M CDLLDTALAHFGDPQRPGRWFDTADDAERLMLRPGDPLDGATPSGASSIA
MUL_0196|M.ulcerans_Agy99 CDLLDTALAHFGDPQRPGRWFDTADDAERLMLRPGDPLDGATASGASSIA
MAV_1208|M.avium_104 TDLLDTALAHFADPQRPGRWFDTADDAERLMLRPADPLDGATPSGASSVT
MAB_1205|M.abscessus_ATCC_1997 AQLLDAALDHFADPESPGAWFDVADDAEQLVLRPSDPLDGATPSGASSVT
**: *: **.*. * *:*.***** *::**.**:****.:*** ::
Mvan_4665|M.vanbaalenii_PYR-1 EALQLAAHLAPEAAAQRYAAAAEATMAGATVLLARVPRSAGHWLAVAEAA
Mflv_2052|M.gilvum_PYR-GCK EALQVAAHLADDG-ADRYAAAADAALSSAAVLLERAPRSAGHWLAVAEAA
MSMEG_5259|M.smegmatis_MC2_155 EALQLAAYLTGSS---RYAEAAQATLATAVPILTRAARSGGHWLAVAEAQ
Mb1113|M.bovis_AF2122/97 EALLTAGHVVDGARAERYWQLAADTLRAHAVLLARAPRSAGHWLAVAEAV
Rv1084|M.tuberculosis_H37Rv EALLTAGHVVDGARAERYWQLAADTLRAHAVLLARAPRSAGHWLAVAEAV
MMAR_4383|M.marinum_M EALLTAAHLVADDRAPRYLQAATETLREHSVLLARAPRSAGHWLSVAEAA
MUL_0196|M.ulcerans_Agy99 EALLTAAHLVADDRAPRYLQAATDTLREHSVLLAHAPRSAGHWLSVAEAA
MAV_1208|M.avium_104 EALLTAAHLVGGERAERYLRAATDALRAQAVLLERAPRTAGHWLAVAEAA
MAB_1205|M.abscessus_ATCC_1997 EALLTAGYLLEDP---RYREAAYASLAAASMALARAPRSAGHWLAVAEAA
*** *.:: ** * :: * :..*:.****:****
Mvan_4665|M.vanbaalenii_PYR-1 VRGPIQIAVAG-GADSALLAAARRLAPGGAVVVGGEVNSSELLRDRPRVD
Mflv_2052|M.gilvum_PYR-GCK VRGPIQIAVACEGPDSALLAAARALAPGGAVVIGGVTDSSALLRDRPRVR
MSMEG_5259|M.smegmatis_MC2_155 LRGPIQIAVAC-EPSSELLAAARTLAPGGAVVVGGAVDSSELLRGRDRVD
Mb1113|M.bovis_AF2122/97 VRGPLQIAVACDLPRSSLLADARRLAPGGAIVVGGAAGSSALLVGRDRVA
Rv1084|M.tuberculosis_H37Rv VRGPLQIAVACDLPRSSLLADARRLAPGGAIVVGGAAGSSALLVGRDRVA
MMAR_4383|M.marinum_M VRGPLQIAVACDDPQSELLAAARRLAPGGAIVVGGRLDSAPLLIGRDRVA
MUL_0196|M.ulcerans_Agy99 VRGPLQIAVACDDPQSELLAAARRLAPGGAIVVGGRLDSAPLLIGRDRVA
MAV_1208|M.avium_104 VRGPLQIAVACDPARSALLADARRLAPGGAIVVGGPRDSSELLSGRDRVA
MAB_1205|M.abscessus_ATCC_1997 VRGPIQVAVACDAETSALLRSARLLAPGGAIVVGGVKDSSELLRDRGQIG
:***:*:*** * ** ** ******:*:** .*: ** .* ::
Mvan_4665|M.vanbaalenii_PYR-1 GADAAYVCRGRVCDLPVTTVEDLATALGASV-
Mflv_2052|M.gilvum_PYR-GCK GADAAYVCRGRACDLPVTTAGELAAALGCSV-
MSMEG_5259|M.smegmatis_MC2_155 GADAAYVCRGTVCDLPVTTVGDLADALGVAV-
Mb1113|M.bovis_AF2122/97 GADAAYVCRGRVCDLPVTSAAELATALGVPG-
Rv1084|M.tuberculosis_H37Rv GADAAYVCRGRVCDLPVTSAAELATALGVPG-
MMAR_4383|M.marinum_M GADAAYVCRGRVCDLPVTGTDELAAALPVPG-
MUL_0196|M.ulcerans_Agy99 GADAAYVCRGRVCDLPVTGTDELAVALPVPG-
MAV_1208|M.avium_104 GADAAYVCRGRVCDLPVTRTPELAAALGAPAP
MAB_1205|M.abscessus_ATCC_1997 DADAAYVCRGTVCDLPVTGTQQLDAALGR---
.********* .****** . :* **