For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. vanbaalenii PYR-1 Mvan_4057 (-)

annotation: aminopeptidase N
coordinates: 4338932 - 4341541
length: 869

MRLVLTSVALPNLTRDQAAERAALVTVDSYRIHLDLTDGAGKPGERTFRSVTTVEFDAVAGADTYIDLAA
DSVRSATLNGTEIDVSGYDESTGIPLTGVAGHNVLVVDADCRYSNTGEGLHRFVDPVDNEVYLYSQFETA
DAKRMFACFDQPDLKAFFDVTVVAPGHWEVVSNGATVEVEELDSGAKRHTFKATPRMSTYLAALIAGPYA
RWDDVYSDDHGDIPLGIFCRKSLAEYMDAERLFTETKQGFAFYHNNFGVPYAFGKYDQLFVPEFNAGAME
NAGAVTFLEDYVFRSKVTRYSYERRAETVLHEMAHMWFGDLVTMQWWDDLWLNESFATFASVLCQAEATE
YTQAWTTFANVEKSWAYRQDQLPSTHPVAADIPDLHAVEVNFDGITYAKGASVLKQLVAYVGLDAFLAGL
RDYFRDHAYGNATFGDLLGALEKSSGRDLSGWGRQWLKTTGLNTLRPDFDVDADGRFTRFAIEQEGAKPG
DGETRVHRLAVGVYDDDSSGKLVRVHREELDVDGSVTEVPALQGVSRGKFILVNDDDLTYCSLRLDPESL
QTVLTRIADIADPLPRTLAWSAAWEMTRDAELRARDFVALVIGGLHAESEVGVAQRLLLQAQTALGSYAD
PAWAAENGWPAFGDALLDLARESAPGSDHQLAFVNALCTSVLSPNHVAVLSTLLDNEPAAVNLPGLVLDT
DLRWRIVTALARAGVIDADGTQTPFIDAEAANDPTAAGRRQAAAASAARPQAAVKAGAWEQVVEDDTLAN
ITARAIIGGFVQPGQGELLAPFRERYFGAISGVWERRSSEVAQTVVIGLYPSWDISGEALDAADRFLSDP
DVPPALRRLVLEGRAGVERSLKARQFDVT
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_4057--100% (869)aminopeptidase N
M. vanbaalenii PYR-1Mvan_5387-3e-1323.75% (320) peptidase M1, membrane alanine aminopeptidase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2494pepN0.078.56% (863) aminopeptidase N
M. gilvum PYR-GCKMflv_2577-0.091.02% (869) aminopeptidase N
M. tuberculosis H37RvRv2467pepN0.078.56% (863) aminopeptidase N
M. leprae Br4923MLBr_01486-0.075.12% (864) putative aminopeptidase
M. abscessus ATCC 19977MAB_1571c-0.076.29% (869) aminopeptidase
M. marinum MMMAR_3817pepN0.078.22% (863) aminopeptidase N PepN
M. avium 104MAV_1704pepN0.079.47% (862) aminopeptidase N
M. smegmatis MC2 155MSMEG_4690pepN0.081.79% (862) aminopeptidase N
M. thermoresistible (build 8)TH_0345pepD0.081.16% (860) PROBABLE AMINOPEPTIDASE N PEPN (LYSYL AMINOPEPTIDASE)
M. ulcerans Agy99MUL_3742pepN0.077.75% (863) aminopeptidase N PepN

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3817|M.marinum_M               ----------------------------MALPNLTRDQAVERAALITVDS
MUL_3742|M.ulcerans_Agy99           ----------------------------MALPNLTRDQAVERAALITVDS
Mb2494|M.bovis_AF2122/97            ----------------------------MALPNLTRDQAVERAALITVDS
Rv2467|M.tuberculosis_H37Rv         ----------------------------MALPNLTRDQAVERAALITVDS
MLBr_01486|M.leprae_Br4923          ----------------------------MALPNLTRDQAVERSALITVDS
MAV_1704|M.avium_104                ----------------------------MALPNLTREQAVERAALVTVAG
MAB_1571c|M.abscessus_ATCC_199      ----------------------------MALPNLTRDQAAARAAAIDVEH
Mvan_4057|M.vanbaalenii_PYR-1       ---------------------MRLVLTSVALPNLTRDQAAERAALVTVDS
Mflv_2577|M.gilvum_PYR-GCK          MSTSGTDDASEQRSAPVLSSRIRLVLASVALPNLTRDQAAERAALVTVDS
TH_0345|M.thermoresistible__bu      ----------------------------VALPNLTRDQAVERAALVTVDR
MSMEG_4690|M.smegmatis_MC2_155      ----------------------------MALPNLTRDQAIERAALVTVDT
                                                                :*******:**  *:* : *  

MMAR_3817|M.marinum_M               YQVNLDVT-------GERTFRSTTTVMFDALPGADTVIDIAAEGVRSASL
MUL_3742|M.ulcerans_Agy99           YQVNLDVT-------GERTFRSTTTVMFDALPGADTVIDIAAEGVRSASL
Mb2494|M.bovis_AF2122/97            YQIILDVTDG-NGAPGERTFRSTTTVVFDALPGADTVIDISAHTVRRASL
Rv2467|M.tuberculosis_H37Rv         YQIILDVTDG-NGAPGERTFRSTTTVVFDALPGADTVIDISAHTVRRASL
MLBr_01486|M.leprae_Br4923          YQINLDLTDGPDNAPSDRTFRSITTVVFDALAGADTVIDIAADAVRSATL
MAV_1704|M.avium_104                YRIDLDLTDG-NGAPGERTFRSITTVVFDALAGADTVIDIAADTVRSATL
MAB_1571c|M.abscessus_ATCC_199      YAITLDLTND-DGGPSEETFHSSSTVTFTAQPGTSTVIDIAARTVRRVEL
Mvan_4057|M.vanbaalenii_PYR-1       YRIHLDLTDG-AGKPGERTFRSVTTVEFDAVAGADTYIDLAADSVRSATL
Mflv_2577|M.gilvum_PYR-GCK          YHVSLDLTDG-AGKPGERTFRSVTTVKFDALAGSDTYIDLAADTVRSATL
TH_0345|M.thermoresistible__bu      YHIELDLTDG-RGNPGAETFRSITTVEFESLPGAETFIDLAARRIRSATL
MSMEG_4690|M.smegmatis_MC2_155      YRIVLDLTDG-QGKPSERTFRSTTTVEFDALAGGETVLDLAADKIHSATL
                                    * : **:*       . .**:* :** * : .* .* :*::*  :: . *

MMAR_3817|M.marinum_M               NGQELDVSGYDESTGIPLRGLSHRNVVIVDADCRYSNTGEGLHRFVDPVD
MUL_3742|M.ulcerans_Agy99           NGQELDVSGYDESTGIPLRGLSHRNVVIVDADCRYSNTGEGLHRFVDPVD
Mb2494|M.bovis_AF2122/97            NDQDLDVSGYDEAAGIPLRGLAQRNVVVVDADCHYSNTGEGLHRFVDPVD
Rv2467|M.tuberculosis_H37Rv         NDQDLDVSGYDEAAGIPLRGLAQRNVVVVDADCHYSNTGEGLHRFVDPVD
MLBr_01486|M.leprae_Br4923          NDHELDVSEYDESTGIPLPGLADRNVVVVDADCRYSNTGEGLHRFVDPVD
MAV_1704|M.avium_104                NGRDIDVSGYDESTGIPLQGLADRNVVVVDADCRYSNTGEGLHRFVDPVD
MAB_1571c|M.abscessus_ATCC_199      NGTELDVSGYDEEQGITLPGLAATNTVVVEADCEYSHTGEGLHRFVDPVD
Mvan_4057|M.vanbaalenii_PYR-1       NGTEIDVSGYDESTGIPLTGVAGHNVLVVDADCRYSNTGEGLHRFVDPVD
Mflv_2577|M.gilvum_PYR-GCK          NGVDIDVSGYDESTGIPLRGLQGHNTLVVDADCRYSNTGEGLHRFVDPVD
TH_0345|M.thermoresistible__bu      NGRPIDVSGYDESTGVPLTVLDKHNVLVVDADCHYSNTGEGLHRFVDPVD
MSMEG_4690|M.smegmatis_MC2_155      NGKPIDVSAYDESTGIPLVGLAEHNVVVVDADCLYSNTGEGLHRFVDPVD
                                    *.  :*** ***  *:.*  :   *.::*:*** **:*************

MMAR_3817|M.marinum_M               GEAYLYSQFETADAKRMFACFDQPDLKATFEIRVTAPQHWKVVSNAAAVE
MUL_3742|M.ulcerans_Agy99           GEAYLYSQFETADAKRMFACFDQPDLKATFEIRVTAPQHWKVISNAAAVE
Mb2494|M.bovis_AF2122/97            GETYLYSQFETADAKRMFACFDQPDLKATFDVRVTAPAHWKVISNGAPLA
Rv2467|M.tuberculosis_H37Rv         GETYLYSQFETADAKRMFACFDQPDLKATFDVRVTAPAHWKVISNGAPLA
MLBr_01486|M.leprae_Br4923          DEIYLYSQFETADAKRMFACFDQPDLKATFEVEVTACKNWKVISNSVCIN
MAV_1704|M.avium_104                DEVYLYSQFETADAKRMFACFDQPDLKATFDVRVTAPRHWKVISNSAAVS
MAB_1571c|M.abscessus_ATCC_199      DEVYLYSQFETADAKRMFACFDQPDLKAAFDVTVTAPAHWQVISNGAALS
Mvan_4057|M.vanbaalenii_PYR-1       NEVYLYSQFETADAKRMFACFDQPDLKAFFDVTVVAPGHWEVVSNGATVE
Mflv_2577|M.gilvum_PYR-GCK          DEVYLYSQFETADAKRMFACFDQPDLKAAFDVTVVAPAHWEVISNGATVD
TH_0345|M.thermoresistible__bu      GEVYLYSQFETADAKRMFACFDQPDLKAAFDVVVTAPAHWEVISNGAVES
MSMEG_4690|M.smegmatis_MC2_155      DEVYLYSQFETADAKRMFACFDQPDLKATFDVEVTAPTHWEVVSNGATTS
                                    .* ************************* *:: *.*  :*:*:**..   

MMAR_3817|M.marinum_M               VSQSQSAA-VHSFGVTPRMSTYLVALVAGPYAVWNDTYSDEHGDIPLGIY
MUL_3742|M.ulcerans_Agy99           VSQSQSAA-VHSFGVTPRMSTYLVALIAGPYAVWNDTYSDEHGDIPLGIY
Mb2494|M.bovis_AF2122/97            AAN----G-VHTFATTPRMSTYLVALIAGPYAAWTDTYIDDHGEIPLGIY
Rv2467|M.tuberculosis_H37Rv         AAN----G-VHTFATTPRMSTYLVALIAGPYAAWTDTYIDDHGEIPLGIY
MLBr_01486|M.leprae_Br4923          ITEG-----THTFATTPRMSTYLVALIAGPYAAWYASYRDEHGEIPLGIY
MAV_1704|M.avium_104                VNDAAQHR-VHTFATTPRMSTYLVALIAGPYAEWKDSYVDEHGEIPLGIY
MAB_1571c|M.abscessus_ATCC_199      VADG-----VHTFATTPKMSTYLVALIAGPYARWNDEYSDEHGTIDLGIY
Mvan_4057|M.vanbaalenii_PYR-1       VEELDSGAKRHTFKATPRMSTYLAALIAGPYARWDDVYSDDHGDIPLGIF
Mflv_2577|M.gilvum_PYR-GCK          ATD-EGGARRHTFKATPRMSTYLVALIAGPYARWDDVYSDDHGDIPLGLF
TH_0345|M.thermoresistible__bu      IRG-EGPARVHTFVRTPRISTYLVALIAGPYARWDDVYRDEHGEIPLGLF
MSMEG_4690|M.smegmatis_MC2_155      AEV-TGGATVHTFATTPRMSTYLVALIAGPYAVWRDEYTDEYGTIPLGLF
                                              *:*  **::****.**:***** *   * *::* * **::

MMAR_3817|M.marinum_M               CRASLAQYMDAERLFTQTKQGFGFYHKHFGIPYAFGKYDQLFVPEFNAGA
MUL_3742|M.ulcerans_Agy99           CRASLAQYMDAERLFTQTKQGFGFYHKHFGIPYAFGKYDQLFVPEFNAGA
Mb2494|M.bovis_AF2122/97            CRASLAEYMDAERLFTQTKQGFGFYHKHFGLPYAFGKYDQLFVPEFNAGA
Rv2467|M.tuberculosis_H37Rv         CRASLAEYMDAERLFTQTKQGFGFYHKHFGLPYAFGKYDQLFVPEFNAGA
MLBr_01486|M.leprae_Br4923          CRASLAQFMDAERLFTQTKKGFNFYHKHFGLPYAFGKYDQLFVPEFNAGA
MAV_1704|M.avium_104                CRASLAQYMDAERLFTQTKQGFGFYHKNFGMPYAFGKYDQLFVPEFNAGA
MAB_1571c|M.abscessus_ATCC_199      CRASLSEFMDADRLFTETKQGFGFYHKNFGTPYAFGKYDQLFVPEFNAGA
Mvan_4057|M.vanbaalenii_PYR-1       CRKSLAEYMDAERLFTETKQGFAFYHNNFGVPYAFGKYDQLFVPEFNAGA
Mflv_2577|M.gilvum_PYR-GCK          CRRSLADHMDAERLFTETKQGFGFYHNNFGVPYAFGKYDQLFVPEFNAGA
TH_0345|M.thermoresistible__bu      CRRSLAEHMDAERLFTETKQGFGFYHKHFGVPYVFGKYDQLFVPEFNAGA
MSMEG_4690|M.smegmatis_MC2_155      CRKSLAEHMDAERLFTETKQGFGFYHANFGVPYAFGKYDQLFVPEFNAGA
                                    ** **::.***:****:**:** *** :** **.****************

MMAR_3817|M.marinum_M               MENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMTWWD
MUL_3742|M.ulcerans_Agy99           MENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMTWWD
Mb2494|M.bovis_AF2122/97            MENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMTWWD
Rv2467|M.tuberculosis_H37Rv         MENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMTWWD
MLBr_01486|M.leprae_Br4923          MENAGAVTFLEDYVFRSKVTRASYERRTETVLHEMAHMWFGNLVTMTWWD
MAV_1704|M.avium_104                MENAGAVTLLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMAWWD
MAB_1571c|M.abscessus_ATCC_199      MENAGAVTFLEDYVFRSKVTKYSYERRAETVLHEMAHMWFGDLVTMRWWD
Mvan_4057|M.vanbaalenii_PYR-1       MENAGAVTFLEDYVFRSKVTRYSYERRAETVLHEMAHMWFGDLVTMQWWD
Mflv_2577|M.gilvum_PYR-GCK          MENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMQWWD
TH_0345|M.thermoresistible__bu      MENAGAVTFLEDYVFRSKVTRASYERRCETLLHEMAHMWFGDLVTMRWWD
MSMEG_4690|M.smegmatis_MC2_155      MENAGAVTFLEDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMRWWD
                                    ********:***********: ***** **:**********:**** ***

MMAR_3817|M.marinum_M               DLWLNESFATFASVLCQSEATEFTEAWTTFATVEKSWAYRQDQLPSTHPI
MUL_3742|M.ulcerans_Agy99           DLWLNESFATFASVLCQSEATEFTEAWTTFATVEKSWAYRQDQLPSTHPI
Mb2494|M.bovis_AF2122/97            DLWLNESFATFASVLCQSEATEFTEAWTTFATVEKSWAYRQDQLPSTHPI
Rv2467|M.tuberculosis_H37Rv         DLWLNESFATFASVLCQSEATEFTEAWTTFATVEKSWAYRQDQLPSTHPI
MLBr_01486|M.leprae_Br4923          DLWLNESFATFASVLCQSEATEFTEAWTTFATVEKSWAYCQDQLPSTHPI
MAV_1704|M.avium_104                DLWLNESFATFASVLCQSEATEFTEAWTTFATVEKSWAYRQDQLPSTHPI
MAB_1571c|M.abscessus_ATCC_199      DLWLNESFATFASVLCQAEATEYTEAWTTFANVEKSWAYRQDQLPSTHPV
Mvan_4057|M.vanbaalenii_PYR-1       DLWLNESFATFASVLCQAEATEYTQAWTTFANVEKSWAYRQDQLPSTHPV
Mflv_2577|M.gilvum_PYR-GCK          DLWLNESFATFASVLCQAESTEYTQAWTTFANAEKSWAYRQDQLPSTHPV
TH_0345|M.thermoresistible__bu      DLWLNESFATWASVLCQAEATEYTEAWTTFANVEKSWAYRQDQLPSTHPV
MSMEG_4690|M.smegmatis_MC2_155      DLWLNESFATFASVLCQAEATEYKQAWTTFANVEKSWAYRQDQLPSTHPV
                                    **********:******:*:**:.:******..****** *********:

MMAR_3817|M.marinum_M               AADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLEHFLAGLRDYFRAHA
MUL_3742|M.ulcerans_Agy99           AADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLEHFLAGLRDYFRAHA
Mb2494|M.bovis_AF2122/97            AADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLERFLAGLRDYFRTHA
Rv2467|M.tuberculosis_H37Rv         AADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLERFLAGLRDYFRTHA
MLBr_01486|M.leprae_Br4923          VADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLEQFLAGLRDYFRKHA
MAV_1704|M.avium_104                AADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLEHFLAGLRDYFRAHA
MAB_1571c|M.abscessus_ATCC_199      AADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLENFLAGLRSYFRDHA
Mvan_4057|M.vanbaalenii_PYR-1       AADIPDLHAVEVNFDGITYAKGASVLKQLVAYVGLDAFLAGLRDYFRDHA
Mflv_2577|M.gilvum_PYR-GCK          AADIPDLHAVEVNFDGITYAKGASVLKQLVAYVGLDAFLAGLRDYFRDHA
TH_0345|M.thermoresistible__bu      AADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGLDEFLAGLREYFRDHA
MSMEG_4690|M.smegmatis_MC2_155      AADIPDLHAVEVNFDGITYAKGASVLKQLVAYVGKEEFLSGLRDYFRDHA
                                    .****** ************************** : **:***.*** **

MMAR_3817|M.marinum_M               FGNATFSDLITALEKASGRDLSNWGQQWLKTTGLNTLRPDFDVDADGRFT
MUL_3742|M.ulcerans_Agy99           FGNATFSDLITALEKASGRDLSNWGQQWLKTTGLNTLRPDFDVDADGRFT
Mb2494|M.bovis_AF2122/97            FGNASFDDLLAALEKASGRDLSNWGEQWLKTTGLNTLRPDFEVDAEGRFT
Rv2467|M.tuberculosis_H37Rv         FGNASFDDLLAALEKASGRDLSNWGEQWLKTTGLNTLRPDFEVDAEGRFT
MLBr_01486|M.leprae_Br4923          FANATFDDLLVALENASGRDLSHWSQQWLKTTGINMLRPDFDVDADGKFT
MAV_1704|M.avium_104                FGNATFDDLVAALEKASGRDLSDWGRQWLKTTGLNTLRPDFDVDDRGRFT
MAB_1571c|M.abscessus_ATCC_199      FGNATFDDLLGALEKASGRDLSDWGSQWLKTTGLNTLSPDFEVDDEGKFT
Mvan_4057|M.vanbaalenii_PYR-1       YGNATFGDLLGALEKSSGRDLSGWGRQWLKTTGLNTLRPDFDVDADGRFT
Mflv_2577|M.gilvum_PYR-GCK          FGNATFGDLLGALEKSSGRDLSGWGRQWLKTTGLNTLRPDFDVDADGTFT
TH_0345|M.thermoresistible__bu      FGNATFADLLGALEKASGRDLSGWGQLWLKTTGLNTLRPEFDLGADGRFT
MSMEG_4690|M.smegmatis_MC2_155      FANATFGDLLGALEKASGRDLSGWGQQWLKTTGLNKLRADFDVDSSGAFT
                                    :.**:* **: ***::****** *.  ******:* * .:*::.  * **

MMAR_3817|M.marinum_M               RFVVQQSGAAPGAGETRVHRLAVGVYDDD------VAGGSGKLVRVHREE
MUL_3742|M.ulcerans_Agy99           RFVVQQSGAALGAGETRVHRLAVGVYDDD------VAGGSGKLVRVHREE
Mb2494|M.bovis_AF2122/97            RFAVTQSGAAPGAGETRVHRLAVGIYDDD------GSKSSGKLVRVHREE
Rv2467|M.tuberculosis_H37Rv         RFAVTQSGAAPGAGETRVHRLAVGIYDDD------GSKSSGKLVRVHREE
MLBr_01486|M.leprae_Br4923          RFSVMQSGAEPGAGETRVHRLAVGIYDN--------CGEADKLVRVHREE
MAV_1704|M.avium_104                RFAVTQSGAAPGAGETRVHRLVIGIYDDD---------GSGKLVRVHRAE
MAB_1571c|M.abscessus_ATCC_199      RFAVKQSGAAPGAGETRVHRLAVGIYDDAGAADSATSGASGKLVRIHREE
Mvan_4057|M.vanbaalenii_PYR-1       RFAIEQEGAKPGDGETRVHRLAVGVYDDD---------SSGKLVRVHREE
Mflv_2577|M.gilvum_PYR-GCK          RFAIEQGGAKPGEGETRVHRLAVGVYDDD---------ASGKLVRVHREE
TH_0345|M.thermoresistible__bu      RFTICQSGAQPGAGETRVHRLAVGIYDDD---------GTGKLARIHREE
MSMEG_4690|M.smegmatis_MC2_155      RFTVAQSGAAPGAGETRVHRLAVGIYDD----------VDGKLQRVRREE
                                    ** : * **  * ********.:*:**:            .** *::* *

MMAR_3817|M.marinum_M               LDVAGTESEVPALVGVPRGKLILVNDDDLTYCSLRLDGDSLQTALGRIAD
MUL_3742|M.ulcerans_Agy99           LDVAGTESEVPALVGVPRGKLILVNDDDLTYCSLRLDGDSLQTALGRIAD
Mb2494|M.bovis_AF2122/97            LDVSGPITNVPALVGVSRGKLILVNDDDLTYCSLRLDERSLQTALDRIAD
Rv2467|M.tuberculosis_H37Rv         LDVSGPITNVPALVGVSRGKLILVNDDDLTYCSLRLDERSLQTALDRIAD
MLBr_01486|M.leprae_Br4923          LDVEGTETEVPALVGISQGKLILVNDDDLTYCSLRLDAQSLQTALQSIAD
MAV_1704|M.avium_104                LDVEGPVTEVPALVGVSRGKLVLVNDDDLTYCSVRLDAESLGTALDRIAD
MAB_1571c|M.abscessus_ATCC_199      LDVEGPLTDVPALVGVSRGKLVLVNDDDLTYCSLRLDDESLETLLTRIAD
Mvan_4057|M.vanbaalenii_PYR-1       LDVDGSVTEVPALQGVSRGKFILVNDDDLTYCSLRLDPESLQTVLTRIAD
Mflv_2577|M.gilvum_PYR-GCK          LDVEGSTTDVPGLHGVSRGKLILVNDDDLTYCSLRLDPDSLQTVLSRIAD
TH_0345|M.thermoresistible__bu      LDVEGEYTDVPALQGVSRGKLMLLNDDDLTYCSLRLDPESLQTVLTRIAD
MSMEG_4690|M.smegmatis_MC2_155      LDVEGPRTEVPELVGVSRGQLILVNDDDLTYCSLRLDPDSLSTVVTRIAD
                                    *** *  ::** * *:.:*:::*:*********:***  ** * :  ***

MMAR_3817|M.marinum_M               IAEPLPRSLVWSAAWEMTREAELRARDFVSLVSGGIHAETEVGVAQRLLL
MUL_3742|M.ulcerans_Agy99           IAEPLPRSLVWSAAWEMTREAELRARDFVSLVSGGIHAETEVGVAQRLLL
Mb2494|M.bovis_AF2122/97            IAEPLPRTLVWSAAWEMTREAELRARDFVSLVSGGVHAETEVGVAQRLLL
Rv2467|M.tuberculosis_H37Rv         IAEPLPRTLVWSAAWEMTREAELRARDFVSLVSGGVHAETEVGVAQRLLL
MLBr_01486|M.leprae_Br4923          IAEPLPRTLVWSTAWEMTREAELRARDFVALVSGALHAETEVGVAQRLLL
MAV_1704|M.avium_104                IAEPLPRSLVWSAAWEMTREAELRARDFVALVAGGVQGETEVGVAQRLLL
MAB_1571c|M.abscessus_ATCC_199      IAEPLPRTLAWSAAWEMTREAELRARDFVALVSSGVHAESEVGVAQRLLL
Mvan_4057|M.vanbaalenii_PYR-1       IADPLPRTLAWSAAWEMTRDAELRARDFVALVIGGLHAESEVGVAQRLLL
Mflv_2577|M.gilvum_PYR-GCK          IAEPLPRTLAWSAAWEMTRDAELRARDFVALVISGLHAETEVGVAQRLVM
TH_0345|M.thermoresistible__bu      IAEPLPRTLSWSAAWEMTRDAELKARDFVALVCRGVHAESEVGVLQRLLL
MSMEG_4690|M.smegmatis_MC2_155      IADPLPRTLAWSAAWEMTRDAEMKARDFVALVSSGVHAETEVGVLQRLLM
                                    **:****:* **:******:**::*****:**  .::.*:**** ***::

MMAR_3817|M.marinum_M               QAQTALGSYAEPGWASETGWPQFADRLVELARAADAGSDHQLAFINALCT
MUL_3742|M.ulcerans_Agy99           QAQTALGSYAEPGWASETGWPQFADRLVELARAADAESDHQLAFINALCT
Mb2494|M.bovis_AF2122/97            QAQTALGCYAEPGWARERGWPQFADRLLELAREAEPGSDHQLAYINSLCS
Rv2467|M.tuberculosis_H37Rv         QAQTALGCYAEPGWARERGWPQFADRLLELAREAEPGSDHQLAYINSLCS
MLBr_01486|M.leprae_Br4923          QAQTALGSYADPDWARDYGWPQFADRILELARAAVSGSDHQLAFINTLCS
MAV_1704|M.avium_104                QAQTALSSYAEPEWARDHGWPQFADRLLELARAAETGSDHQLAFVNALCS
MAB_1571c|M.abscessus_ATCC_199      QAQTALSSYAEPAWAREHGWPAFADRLLELARAAEPGSDHQLAFVNALTG
Mvan_4057|M.vanbaalenii_PYR-1       QAQTALGSYADPAWAAENGWPAFGDALLDLARESAPGSDHQLAFVNALCT
Mflv_2577|M.gilvum_PYR-GCK          QAQTALGSYADPAWAAENGWPAFGDALLDLAAQSAPGSDHQLAFVNALCS
TH_0345|M.thermoresistible__bu      QAQTALTSYAEPGWAAEQGWPEFADRLLGLARAAAPGSDHQLAYVNALCA
MSMEG_4690|M.smegmatis_MC2_155      QAQTALGSYADPEWATTEGWPGFADRLLELARAAEAGSDHQLAYVNALTT
                                    ****** .**:* **   *** *.* :: **  : . ******::*:*  

MMAR_3817|M.marinum_M               SVLSPRHVETLAALLDNDPAELGLAGLEVDTDLRWRIVTALATAGVIDSD
MUL_3742|M.ulcerans_Agy99           SVLSPRHVETLAALLDNDPAELGLAGLEVDTDLRWRIVTALATAGVIDSD
Mb2494|M.bovis_AF2122/97            SVLSPRHVQTLGALLEGEPAACGLAGLAVDTDLRWRIVTALATAGAIDAD
Rv2467|M.tuberculosis_H37Rv         SVLSPRHVQTLGALLEGEPAACGLAGLAVDTDLRWRIVTALATAGAIDAD
MLBr_01486|M.leprae_Br4923          SVLSPRHVQTLAALLNDDPTELGLPGVQVDTDLRWRIVTALATAGTLDAN
MAV_1704|M.avium_104                SLLSTRHVVTLADLLDHDPAELGLAGLEIDTDLRWRIVTALAAAGEIDAD
MAB_1571c|M.abscessus_ATCC_199      SVLSAGHTVVLQALLDSDPASLDLPGLTVDTDLRWRIVNALAASGALEPD
Mvan_4057|M.vanbaalenii_PYR-1       SVLSPNHVAVLSTLLDNEPAAVNLPGLVLDTDLRWRIVTALARAGVIDAD
Mflv_2577|M.gilvum_PYR-GCK          SVLSPNHVAVLSTLLDNEPAAVNLEGLVVDTDLRWRVVTALARAGVIDAD
TH_0345|M.thermoresistible__bu      SVLSARHIEVLEALLDRDPAVEGLDGLVVDAELRWRIVTALAAAGQIDNT
MSMEG_4690|M.smegmatis_MC2_155      SVLSARHTTLLADLLDKDPGSLGLEGLVVDTDLRWRIVIALARSGEIDAD
                                    *:**. *   *  **: :*   .* *: :*::****:* *** :* ::  

MMAR_3817|M.marinum_M               GPESPRIDAEEKRDPTATGKRSSAHARAARPQFPVKDRAFTTVVEDDTLA
MUL_3742|M.ulcerans_Agy99           GPESPRIDAEEKRDPTATGKRSSAHARAARPQFPVKDRAFTTVVEDDTLA
Mb2494|M.bovis_AF2122/97            GPETPRIDAEVQRDPTAAGKRHAAQARAARPQFVVKDEAFTTVVEDDTLA
Rv2467|M.tuberculosis_H37Rv         GPETPRIDAEVQRDPTAAGKRHAAQARAARPQFVVKDEAFTTVVEDDTLA
MLBr_01486|M.leprae_Br4923          GPQTPWIDAEMQRDPTAAGKRHGAQAAAARPQSDIKDKAFTTVVEDDTLT
MAV_1704|M.avium_104                GPATPFIDAEVQRDPTAAGKRHAAQAAAARPQLPVKEQAWTTVVEDDTLA
MAB_1571c|M.abscessus_ATCC_199      --ASVFIDTELERDPTAAGKRQAAQARAARPVAEVKETAWKQVIEDDSLP
Mvan_4057|M.vanbaalenii_PYR-1       GTQTPFIDAEAANDPTAAGRRQAAAASAARPQAAVKAGAWEQVVEDDTLA
Mflv_2577|M.gilvum_PYR-GCK          GTATPFIDAEADNDRTAAGRRHAAAAAAARPQAAVKDAAWEQVVEDDTLA
TH_0345|M.thermoresistible__bu      GVATPFIDAEAQRDPTAAGQRHARAAAAARPQPAVKEQAWQQVIEDDTLS
MSMEG_4690|M.smegmatis_MC2_155      GPETPFIDAEAQRDPTAAGKRQAAAASAARPQDVVKANAWQQVVEDDTLA
                                       :  **:*  .* **:*:* .  * ****   :*  *:  *:***:*.

MMAR_3817|M.marinum_M               NATGRAIIAGIGAPGQGELLKPFTARYFEVILGVWERRSSEVAQSVVIGL
MUL_3742|M.ulcerans_Agy99           NATGRAIIAGIGAPGQGELLKPFTARYFEVILGVWERRSSEVAQSVVIGL
Mb2494|M.bovis_AF2122/97            NATGRAMIAGIAAPGQGELLKPFARRYFQAIPGVWARRSSEVAQSVVIGL
Rv2467|M.tuberculosis_H37Rv         NATGRAMIAGIAAPGQGELLKPFARRYFQAIPGVWARRSSEVAQSVVIGL
MLBr_01486|M.leprae_Br4923          NAAGRAIIAGIVAPGQGELLKPFTARYFAAIPGVWTRRSSEVAQTVVIGL
MAV_1704|M.avium_104                NITARSMIAGIAQPGQHELLKPFTPRYFEAIPGVWARRSSEVAQTVVVGL
MAB_1571c|M.abscessus_ATCC_199      NITARSVIAGIVQPGQAELLAPFSGRYFDVIEDVWARRSSEVAQTVVIGL
Mvan_4057|M.vanbaalenii_PYR-1       NITARAIIGGFVQPGQGELLAPFRERYFGAISGVWERRSSEVAQTVVIGL
Mflv_2577|M.gilvum_PYR-GCK          NITARAIIGGFAQPGQGEVLAPFRDRYFGAISGVWQRRSSEVAQTVVVGL
TH_0345|M.thermoresistible__bu      NVTTRAIVGGFVRPGQAEVLAPFTERYFAAIRGVWQRRSSEVAQTVVIGL
MSMEG_4690|M.smegmatis_MC2_155      NIMTRAIVGGIVQPGQAELLTPFTTQYFAAISGVWARRSSEVAQTVVIGL
                                    *   *:::.*:  *** *:* **  :** .* .** ********:**:**

MMAR_3817|M.marinum_M               YPYWDITEEGVAAADRFLSDPE--LAPALRRLVSEGQAAVKRSLRARRFD
MUL_3742|M.ulcerans_Agy99           YPYWDITEEGVAAANRFLADPE--LAPALRRLVSEGQAAVKRSLRARRFD
Mb2494|M.bovis_AF2122/97            YPHWDISEQGITAAEEFLSDPE--VPPALRRLVLEGQAAVQRSLRARNFD
Rv2467|M.tuberculosis_H37Rv         YPHWDISEQGITAAEEFLSDPE--VPPALRRLVLEGQAAVQRSLRARNFD
MLBr_01486|M.leprae_Br4923          YPHWDISDVGIAAAEEFLTAPESKVPPALRRLVLEGQAAVKRALRARMFD
MAV_1704|M.avium_104                YPAWDISDEGIAAADRFLSDPQ--VPAALRRLVLEGQAGVKRALRARRFD
MAB_1571c|M.abscessus_ATCC_199      YPSWDISPEALGLADAFLAKEV---PSALRRLVSEGRAGIVRSLRAREFD
Mvan_4057|M.vanbaalenii_PYR-1       YPSWDISGEALDAADRFLSDPD--VPPALRRLVLEGRAGVERSLKARQFD
Mflv_2577|M.gilvum_PYR-GCK          YPSWEISQDALDAADRFLSDPE--VPPALRRLVLEGRAGVERSLRAREFD
TH_0345|M.thermoresistible__bu      YPSWDISQAGLDTADRFLADPD--LPPPLRRLVLEGRAGVERALRAREFD
MSMEG_4690|M.smegmatis_MC2_155      YPSWDISQNGLDAADAFLSDPE--VPPALRRLVLEGRAGVERALRARAFD
                                    ** *:*:  .:  *: **:      ...***** **:*.: *:*:** **

MMAR_3817|M.marinum_M               AAL-
MUL_3742|M.ulcerans_Agy99           AAL-
Mb2494|M.bovis_AF2122/97            ADG-
Rv2467|M.tuberculosis_H37Rv         ADG-
MLBr_01486|M.leprae_Br4923          SAD-
MAV_1704|M.avium_104                ATAD
MAB_1571c|M.abscessus_ATCC_199      AGS-
Mvan_4057|M.vanbaalenii_PYR-1       VT--
Mflv_2577|M.gilvum_PYR-GCK          VT--
TH_0345|M.thermoresistible__bu      AR--
MSMEG_4690|M.smegmatis_MC2_155      VS--