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GIEYESVVEHPRDDVWQWHARPGAMRRLVPPWQPMSVVSEAESLADGVAVLGLPGGLRWVARHDPAEYVA GRRFVDELSSDGPASWPPRVIGGWRHTHTFADADGGTRVHDQVDTAVPAAALRSTFVYRHRQLADDLAAH RRAAEAGAAPMVVAITGASGLVGSALSAFLSTGGHRVIRLVRGPARGAHERQWDPRDPAPDLLTGVDAVV HLAGASIAGRFTEAHRAAIRDSRIEPTRLLASAAASAPDGPRTFVSASAIGFYGFDRGDTQLTEDSTRGD GFLADVVADWEAATTPAADAGLRVVKVRTGIVQAAAGGTLHLLRPLFAAGLGGRLGSGRQWLSWIGLDDL VEVYHRALYDDGLSGPVNAVGPDPVRNSDYTRELARVLHRPALLPVPALGPRILLGEQGARELAMASQRV VPSKLLAAGQPFRHPDLRGALAHQLGRE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3512 | - | - | 100% (449) | hypothetical protein Mvan_3512 |
| M. vanbaalenii PYR-1 | Mvan_3580 | - | 7e-61 | 47.28% (294) | hypothetical protein Mvan_3580 |
| M. vanbaalenii PYR-1 | Mvan_1926 | - | 8e-06 | 33.53% (167) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2239 | - | 6e-64 | 45.36% (302) | hypothetical protein Mb2239 |
| M. gilvum PYR-GCK | Mflv_2999 | - | 0.0 | 82.63% (449) | hypothetical protein Mflv_2999 |
| M. tuberculosis H37Rv | Rv2216 | - | 6e-64 | 45.36% (302) | hypothetical protein Rv2216 |
| M. leprae Br4923 | MLBr_00860 | - | 3e-60 | 43.14% (299) | hypothetical protein MLBr_00860 |
| M. abscessus ATCC 19977 | MAB_1944c | - | 3e-62 | 45.58% (294) | hypothetical protein MAB_1944c |
| M. marinum M | MMAR_1679 | - | 0.0 | 69.04% (449) | hypothetical protein MMAR_1679 |
| M. avium 104 | MAV_3880 | - | 1e-170 | 67.82% (435) | nucleoside-diphosphate sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_3083 | - | 1e-162 | 64.86% (444) | nucleoside-diphosphate sugar epimerase |
| M. thermoresistible (build 8) | TH_2675 | - | 1e-177 | 70.60% (449) | PUTATIVE domain of unknown function DUF1731 |
| M. ulcerans Agy99 | MUL_3576 | - | 2e-65 | 47.16% (299) | hypothetical protein MUL_3576 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3512|M.vanbaalenii_PYR-1 ---MGIEYESVVEHPRDDVWQWHARPGAMRRLVPPWQPMSVVSEAESLAD
Mflv_2999|M.gilvum_PYR-GCK ---MGIEYESIVDHPRGEVWAWFSRPGAMPRLVPPWQPMTALVEAASLAD
TH_2675|M.thermoresistible__bu ---MGIEYESVVPHPIADVFAWYGRPGALTRLIPPWQPMTAVAEAASLAD
MMAR_1679|M.marinum_M ---MGVVYSSVVDAPRDEVFEWHSRPGAFSRLSPPWQPMRLVTEARSLED
MAV_3880|M.avium_104 -----------MDAAITEVFDWHARPGAFERLSPPWSPIRLLTEAASLKD
MSMEG_3083|M.smegmatis_MC2_155 MMCSERVFSTVVDAPRDEVFAWHARPGAIHRLFPPWQPLRIEAEAASLAD
Mb2239|M.bovis_AF2122/97 --------------------------------------------------
Rv2216|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00860|M.leprae_Br4923 --------------------------------------------------
MUL_3576|M.ulcerans_Agy99 --------------------------------------------------
MAB_1944c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3512|M.vanbaalenii_PYR-1 GVAVLGLPGGLRWVARHDPAEYVAGRRFVDELSSDGPASWPPRVIGGWRH
Mflv_2999|M.gilvum_PYR-GCK GVAVLGLPGGLRWVARHDPSAYVPESRFADELSSRGPTSWPPRVIGRWRH
TH_2675|M.thermoresistible__bu GRAVLALPGGLRWVAQHDPAGYVPPRRFVDTLASGGPRSWPTRLIGHWQH
MMAR_1679|M.marinum_M GRATLALPGGLRWLAQHQPDSYDPPRRFVDTIASHGLASLPARIAVRWRH
MAV_3880|M.avium_104 GRATLALPGGLRWVAVHRPDGYDPPRRFVDSIGGDGLAALPARIAVRWRH
MSMEG_3083|M.smegmatis_MC2_155 GTARLALPGGLTWVARHVAESYDPPRCFVDTIATDGVTSLPARAVVRWRH
Mb2239|M.bovis_AF2122/97 --------------------------------------------------
Rv2216|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00860|M.leprae_Br4923 --------------------------------------------------
MUL_3576|M.ulcerans_Agy99 --------------------------------------------------
MAB_1944c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3512|M.vanbaalenii_PYR-1 THTFADADGG-TRVHDQVDTAVPAAALRSTFVYRHRQLADDLAAHRRAAE
Mflv_2999|M.gilvum_PYR-GCK THSFFDAGAG-TRIHDQVEAPVPAAALRPTFVYRHRQIADDLAAHRRASD
TH_2675|M.thermoresistible__bu IHEFDPVDDGHTRVRDRVRAPVPRALLEPMLRYRHRQLADDLAAHREAAA
MMAR_1679|M.marinum_M THDFEDAGAGRTRVIDRVDTPIPASALRPMFVYRHQQLADDLAAHKLAAA
MAV_3880|M.avium_104 IHEFEDVGGDRTRVIDRVETPVPASLLRPMFDYRHRQLAGDLAAHRLAAQ
MSMEG_3083|M.smegmatis_MC2_155 IHEFDDTGDGRTRMTDRVQTYVPERALRPMFAYRHRQLADDLAAHRQARA
Mb2239|M.bovis_AF2122/97 ------------------------------------------------MA
Rv2216|M.tuberculosis_H37Rv ------------------------------------------------MA
MLBr_00860|M.leprae_Br4923 ------------------------------------------------MA
MUL_3576|M.ulcerans_Agy99 ------------------------------------------------MG
MAB_1944c|M.abscessus_ATCC_199 ------------------------------------------------MG
Mvan_3512|M.vanbaalenii_PYR-1 AGAAPMVVAITGASGLVGSALSAFLSTGGHRVIRLVRGPARGAHERQWDP
Mflv_2999|M.gilvum_PYR-GCK AGMAPKVIAMTGASGLVGTALAAFLTSGGHRVIRLVRGDAQGANERHWDP
TH_2675|M.thermoresistible__bu ARAGPWTLAVTGASGLVGSALTALLSTGGHRVIRLVRRPARGPGERRWEP
MMAR_1679|M.marinum_M AGLGPTTIAVTGSSGLVGSALTAFLSTGGHRVVRLVRGTPRGADERHWDP
MAV_3880|M.avium_104 HGLRPLTVAVTGSSGLVGSALTAFLRTGGHRVIRLVRRAARGDDERRWDP
MSMEG_3083|M.smegmatis_MC2_155 HGLKPMTIAVTGSSGLVGTALSALLSTGGHRVIRLVRRAPAGPGERRWNP
Mb2239|M.bovis_AF2122/97 N----AVVAIAGSSGLIGSALTAALRAADHTVLRIVRRAPANSEELHWNP
Rv2216|M.tuberculosis_H37Rv N----AVVAIAGSSGLIGSALTAALRAADHTVLRIVRRAPANSEELHWNP
MLBr_00860|M.leprae_Br4923 QASRKAVVAIAGSSGMIGSALAAALRANDHLVLRIVRRTPANAEELHWNP
MUL_3576|M.ulcerans_Agy99 K----AVVAIAGSSGLIGSALAAALRAADHRVLRIVRRTPANSEELHWNP
MAB_1944c|M.abscessus_ATCC_199 AESQHKRIVIAGSSGVIGSALVASLRSANHTVVRLVRRDPMGPDERRWDP
:.::*:**::*:** * * : .* *:*:** . . * :*:*
Mvan_3512|M.vanbaalenii_PYR-1 RDP--APDLLTGVDAVVHLAGASIAG-RFTEAHRAAIRDSRIEPTRLLAS
Mflv_2999|M.gilvum_PYR-GCK FSP--APDLLSGVDAVVHLAGASIAG-RFTEAHRAAIRDSRIEPTRLLAS
TH_2675|M.thermoresistible__bu EYP--APDLLDGVDTVIHLAGASIAG-RFTAQHRAAIRDSRIGPTRRLAE
MMAR_1679|M.marinum_M HDP--DPELLTGIDAVIHLAGASIAG-RFTTAHRNAIRESRIGPTRRLAE
MAV_3880|M.avium_104 EDP--DPGLCDGVDAVIHLAGASIAG-RFTDRHREAVRDSRIGPTRRLAE
MSMEG_3083|M.smegmatis_MC2_155 DDP--HPELLTGVDAVIHLAGASIAG-RFTDEHRRAIRDSRVGPTRRLAE
Mb2239|M.bovis_AF2122/97 ESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSLRDSRITPTEVLSA
Rv2216|M.tuberculosis_H37Rv ESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSLRDSRITPTEVLSA
MLBr_00860|M.leprae_Br4923 ESGEFDTDAITDVDAVVNLCGVNLGQRRWSGSFKQNLRDSRITPTEVLSA
MUL_3576|M.ulcerans_Agy99 ESGEFDPDALTDVDVVINLCGVGIGRRRWSGAFKQSLRDSRITPTEVLSS
MAB_1944c|M.abscessus_ATCC_199 ASGQIEPGGLDGADAVVNMCGVGVGDKRWSGAYKQEIYDSRVIPTEVLAR
. . *.*:::.*..:. *:: .: : :**: **. *:
Mvan_3512|M.vanbaalenii_PYR-1 AAASAPDGPRTFVSASAIGFYGFDRGDTQLTEDSTRGDGFLADVVADWEA
Mflv_2999|M.gilvum_PYR-GCK AAASAGDGPGTFVSASAIGFYGADRGDTQLTEDSTRGDGFLADVVAEWEA
TH_2675|M.thermoresistible__bu LAGRAA-GVRTFVSASAIGYYGPDRGDDLLTEADARGDGFLADVVADWEA
MMAR_1679|M.marinum_M LLGRGADGPRVLISASAVGYYGYDRADEMLTEESGRGEGFLADVVAEWEA
MAV_3880|M.avium_104 LLGRGRPRPAALISASAIGYYGYDRGDETLTEDSDRGDGFLADVVADWEQ
MSMEG_3083|M.smegmatis_MC2_155 LAA--ATGLETFVSASAIGFYGACPGG-PVTEESGRGDGFLADVVAQWED
Mb2239|M.bovis_AF2122/97 AVADAG--VATLINASAVGYYG-NTKDRVVDENDSAGTGFLAQLCVDWET
Rv2216|M.tuberculosis_H37Rv AVADAG--VATLINASAVGYYG-NTKDRVVDENDSAGTGFLAQLCVDWET
MLBr_00860|M.leprae_Br4923 AVAEAG--VKTFINASAVGYYG-NTRDRVVDENDRAGTGFLAQLCQDWEG
MUL_3576|M.ulcerans_Agy99 AVADAG--VPTLINASAVGYYG-DTRDRVVDENDPAGMGFLAQLCVDWEA
MAB_1944c|M.abscessus_ATCC_199 AVAEAG--VPVLINASAVGYYG-DSGDRIIDETASSGTSFLARVCLDWEA
. .::.***:*:** . : * * .*** : :**
Mvan_3512|M.vanbaalenii_PYR-1 ATTPAADAGLRVVKVRTGIVQAAAGGTLHLLRPLFAAGLGGRLGSGRQWL
Mflv_2999|M.gilvum_PYR-GCK ATTPASDAGLRVVKVRTGIVQAAAGGTLRLLRPLFAAGVGGRLGSGKQWL
TH_2675|M.thermoresistible__bu ATEPALAAGVRVVCVRTGIVQAARGGTLRVLRPLFSAGLGGPIGGGTQWL
MMAR_1679|M.marinum_M ATGPARQDGVRVVLVRTGIVQSPRGGTLQLLRPLFSAGLGGRLGDGRQWL
MAV_3880|M.avium_104 ATTPALDAGVRVMQVRTGIVQSPRGGTLKLMRPLFSAGLGGRLGDGRQWL
MSMEG_3083|M.smegmatis_MC2_155 AAAAAEQAGVRVVRVRTGVVQSPRGGILRVLAPLFRLGLGGRVGDGAQWL
Mb2239|M.bovis_AF2122/97 ATRPAQQSGARVVLARTGVVLSPAGGMLRRMRPLFSVGLGARLGSGRQYM
Rv2216|M.tuberculosis_H37Rv ATRPAQQSGARVVLARTGVVLSPAGGMLRRMRPLFSVGLGARLGSGRQYM
MLBr_00860|M.leprae_Br4923 ATLPAQYAGTRVILARTGMVLAQEAGVLSRMRPLFSFALGARIGNGRQYM
MUL_3576|M.ulcerans_Agy99 ATLPAQYAGTRVVLARTGLVLAPAGGTLRPLRPAFSVGLGARLGSGRQYM
MAB_1944c|M.abscessus_ATCC_199 ATAEAAQAGARVVIVRTGLVLSPAGGLFGRSRPLFSLGLGARLGNGRWYM
*: * * **: .***:* : .* : * * .:*. :*.* ::
Mvan_3512|M.vanbaalenii_PYR-1 SWIGLDDLVEVYHRALYDDGLSGPVNAVGPDPVRNSDYTRELARVLHRPA
Mflv_2999|M.gilvum_PYR-GCK SWIGLDDLIDIYHRALYDDALAGPVNAVGPAPVRNTEYTAELARTLHRPA
TH_2675|M.thermoresistible__bu SWIGLDDLLDVYHRAAYDIRLTGPVNAVAPHPVRNSDYTAALAGVLRRPA
MMAR_1679|M.marinum_M SWIGIDDLVDIYHRALWDTALSGPVNAVAPQPVRNAEYTRTLAQVLHRPA
MAV_3880|M.avium_104 SWIGIDDLIDVYHRALWDSRLNGPVNAVAPQPVRNREYTTALAAVLHRPA
MSMEG_3083|M.smegmatis_MC2_155 SWIGIDDLVDIYLRALWDTDLTGPVNAVAPEPVRNSQYTRTLARVLHRPA
Mb2239|M.bovis_AF2122/97 SWISLEDEVRALQFAIAQPNLSGPVNLTGPAPVTNAEFTTAFGRAVNRPT
Rv2216|M.tuberculosis_H37Rv SWISLEDEVRALQFAIAQPNLSGPVNLTGPAPVTNAEFTTAFGRAVNRPT
MLBr_00860|M.leprae_Br4923 SWISLEDEVRALLFAISHQSLSGPLNLTGPAPVTNAEFTTAFGRAINRPT
MUL_3576|M.ulcerans_Agy99 AWISLEDEVRALLFAISNPTLSGPVNMAGPAPVTNAEFTTAFGRALNRPT
MAB_1944c|M.abscessus_ATCC_199 PWISLEDHIRALEFALAEPAVSGPVNLTGPAPVTNAEFTAALGRVLHRPT
.**.::* : * . : **:* ..* ** * ::* :. .:.**:
Mvan_3512|M.vanbaalenii_PYR-1 LLPVPALGPRILLGEQGARELAMASQRVVPSKLLAAGQPFRHPDLRGALA
Mflv_2999|M.gilvum_PYR-GCK LVPVPSLGPRILLGEQGARELAEASQRVVPAKLLALGHPFRHPTVGDALA
TH_2675|M.thermoresistible__bu RIPVPPAVPRLLLGAQGATELALADQRVVPAELQRLGHRFRHRTITEALA
MMAR_1679|M.marinum_M VLPVPALGPRLLLGDQGARELACASQRVLPARLALAEHRFRQPDLDTALR
MAV_3880|M.avium_104 VLPVPSLGPRLLLGGQGARELAGASQRVAPAKLAAAGHRFRHPDIERALR
MSMEG_3083|M.smegmatis_MC2_155 VLPVPAAGPRLLLGEQGAREVALASQHVTSAELRRAGHRFRHPDLESALR
Mb2239|M.bovis_AF2122/97 PLMLPSVAVRAAFGEFADEGLLIG-QRAIPSALERAGFQFHHNTIGEALG
Rv2216|M.tuberculosis_H37Rv PLMLPSVAVRAAFGEFADEGLLIG-QRAIPSALERAGFQFHHNTIGEALG
MLBr_00860|M.leprae_Br4923 PLMLPSFAVRAALGEFADEGLLIG-QRAIPAALERAGFQFHHNTIGEALS
MUL_3576|M.ulcerans_Agy99 PLMLPGFAARAVLGEFADEGLLIG-QRAIPTALEQAGFQFHHNTIGEALS
MAB_1944c|M.abscessus_ATCC_199 LLVAPQFALSLIFGEFADAELTSS-MRVIPAVLEQHGFEFEHHTIGEALA
: * :* . : . :. .: * *.: : **
Mvan_3512|M.vanbaalenii_PYR-1 HQLGRE----
Mflv_2999|M.gilvum_PYR-GCK HQLGKERPAT
TH_2675|M.thermoresistible__bu HQLGRG----
MMAR_1679|M.marinum_M HLLGRHR---
MAV_3880|M.avium_104 HLLGRGG---
MSMEG_3083|M.smegmatis_MC2_155 HVLG------
Mb2239|M.bovis_AF2122/97 YATTRPG---
Rv2216|M.tuberculosis_H37Rv YATTRPG---
MLBr_00860|M.leprae_Br4923 YATTRPSQN-
MUL_3576|M.ulcerans_Agy99 YATERRDQI-
MAB_1944c|M.abscessus_ATCC_199 YANNSRPMK-
: