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MTTTASATTTVDAAAQASIGAAARELHLPTVRTEATRLAEIAGRERHTHLGYLAEVLAAEVDDRTERRRA RRINDAKFPRLKRLAEFNIDAVPGIAPATIGHLAAGHYMDAGEPVVLLGDSGTGKSHLLIGLGLAACEQG RRVRYVTTAQLVNELVEAADERVLSRVVARYGRLDLLCLDELGYVQIDPRGAELLFQIITEREERASVAI ATNLPFSEWGTVFPDPRLVAAIVDRVTFNAHIIETGTKSYRLRTSKTTTRTKRAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3265 | - | - | 100% (265) | IstB ATP binding domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0481 | - | 3e-13 | 39.84% (123) | DNA replication protein-like |
| M. vanbaalenii PYR-1 | Mvan_5932 | - | 9e-07 | 31.45% (124) | hypothetical protein Mvan_5932 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3662 | - | 1e-33 | 33.47% (248) | transposase |
| M. gilvum PYR-GCK | Mflv_0579 | - | 1e-38 | 40.99% (222) | IstB ATP binding domain-containing protein |
| M. tuberculosis H37Rv | Rv3638 | - | 1e-33 | 33.47% (248) | transposase |
| M. leprae Br4923 | MLBr_00001 | dnaA | 1e-05 | 29.49% (78) | chromosomal replication initiation protein |
| M. abscessus ATCC 19977 | MAB_0001 | dnaA | 4e-06 | 26.90% (171) | chromosomal replication initiation protein |
| M. marinum M | MMAR_0001 | dnaA | 5e-05 | 29.49% (78) | chromosomal replication initiator protein DnaA |
| M. avium 104 | MAV_3532 | - | 6e-40 | 36.22% (254) | helper protein |
| M. smegmatis MC2 155 | MSMEG_2150 | - | 1e-31 | 32.22% (270) | putative transposition helper protein |
| M. thermoresistible (build 8) | TH_1648 | - | 2e-33 | 32.58% (267) | putative transposition helper protein |
| M. ulcerans Agy99 | MUL_0001 | dnaA | 3e-05 | 29.49% (78) | chromosomal replication initiation protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2150|M.smegmatis_MC2_155 ---------------------------------MTPTPRTAKN-TATVTE
TH_1648|M.thermoresistible__bu ---------------------------------MTPTPRTPKTATTTTVE
MAV_3532|M.avium_104 -------------------------------------------MTTAAKP
Mb3662|M.bovis_AF2122/97 ---------------------------------------MAAKTATN---
Rv3638|M.tuberculosis_H37Rv ---------------------------------------MAAKTATN---
Mflv_0579|M.gilvum_PYR-GCK ---------------------------------------MTTKTATTKTA
Mvan_3265|M.vanbaalenii_PYR-1 --------------------------------------------MTTTAS
MMAR_0001|M.marinum_M -------------------MTNDPGSGFAAVWNAVVAELNGEPNTDGDAG
MUL_0001|M.ulcerans_Agy99 -------------------MTNDPGSGFAAVWNAVVAELNGEPNTDGDAG
MLBr_00001|M.leprae_Br4923 MFVPHAKKPEIYENQRDTSLADDLGLGFTTVWNAVVSELNGESNTDDEAT
MAB_0001|M.abscessus_ATCC_1997 -------------------MTDELNSQFTAVWNTVVAELNGDDNQYLSS-
MSMEG_2150|M.smegmatis_MC2_155 EPPSTAASRYQKLRSHLAELKLHAAAAALPAVLDQASAENLSLTVALERL
TH_1648|M.thermoresistible__bu ESPSAAASRYQQLRSHLAELKLAAAAEALPAVLDEATAEGLSLTVALERL
MAV_3532|M.avium_104 VAPSSAAPLAADLDAALRRLKLATVRRNAAEVLQVAKTQRWTPEEILRTL
Mb3662|M.bovis_AF2122/97 -----SRDVAAELAYLTRALKAPTLRGAIEQLADRARTKTWSYEEFLAAC
Rv3638|M.tuberculosis_H37Rv -----SRDVAAELAYLTRALKAPTLRGAIEQLADRARTKTWSYEEFLAAC
Mflv_0579|M.gilvum_PYR-GCK AASVASRDLTAEIGFLTRALKAPTMREAVARLAERARAESWTHEEFLVAC
Mvan_3265|M.vanbaalenii_PYR-1 ATTTVDAAAQASIGAAARELHLPTVRTEATRLAEIAGRERHTHLGYLAEV
MMAR_0001|M.marinum_M TGTTLTSPLTPQQRAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRTP
MUL_0001|M.ulcerans_Agy99 TGTTLTSPLTPQQRAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRTP
MLBr_00001|M.leprae_Br4923 NDSTLVTPLTPQQRAWLNLVQPLTIIEGFALLSVPSSFVQNEIERHLRTP
MAB_0001|M.abscessus_ATCC_1997 -----FPPLTPQQRAWLTLVKPLTMAEGFALLSVPSSFVQNEIERHLRGP
. :: : : : *
MSMEG_2150|M.smegmatis_MC2_155 LAVEVEASTARRLAGRLRFACLPT--------------------------
TH_1648|M.thermoresistible__bu LAVEVEASTARRLAGRLRFACLPT--------------------------
MAV_3532|M.avium_104 VEAEIAARDASNTANRLKAAAFPV--------------------------
Mb3662|M.bovis_AF2122/97 LQREVSARESHGGEGRIRAARFPS--------------------------
Rv3638|M.tuberculosis_H37Rv LQREVSARESHGGEGRIRAARFPS--------------------------
Mflv_0579|M.gilvum_PYR-GCK LQREVSARESHGGEGRIRAARFPS--------------------------
Mvan_3265|M.vanbaalenii_PYR-1 LAAEVDDRTERRRARRINDAKFPR--------------------------
MMAR_0001|M.marinum_M ITAALSRRLGQQIQLGVRIAPPPADDDDDSVAAAVEDPGLEASPETSQEV
MUL_0001|M.ulcerans_Agy99 ITAALSRRLGQQIQLGVRIAPPPADDDDDSVAAAVEDPGLEASPETSQEV
MLBr_00001|M.leprae_Br4923 ITDALSRRLGQQIQLGVRIAPPSTDHIDDNSSSAD-------VLLTDDCG
MAB_0001|M.abscessus_ATCC_1997 IVEALSRRLGENVELGVRIAAPAPGEDSEVAGAAP------------EVE
: : :. * .
MSMEG_2150|M.smegmatis_MC2_155 -------------------------------------PATLDDFDVDAAA
TH_1648|M.thermoresistible__bu -------------------------------------PATLADFDVDAAA
MAV_3532|M.avium_104 -------------------------------------TKTLDGFDVTGSS
Mb3662|M.bovis_AF2122/97 -------------------------------------RKSLEEFDFDHAR
Rv3638|M.tuberculosis_H37Rv -------------------------------------RKSLEEFDFDHAR
Mflv_0579|M.gilvum_PYR-GCK -------------------------------------RKSLEEFDFDHAR
Mvan_3265|M.vanbaalenii_PYR-1 -------------------------------------LKRLAEFNIDAVP
MMAR_0001|M.marinum_M SDEIDDFGENAPNSRQSWPTHFKKRSTDADTSASAGGTSLNRRYTFDTFV
MUL_0001|M.ulcerans_Agy99 SDEIDDFGENAPKSRQSWPTHFKKRSTDADTSASADGTSLNRRYTFDTFV
MLBr_00001|M.leprae_Br4923 TDTDENYGEPLTGEYQGLPTYFTERPHHTESTVTG-GTSLNRRYTFETFV
MAB_0001|M.abscessus_ATCC_1997 LDEVDETTEALASAHESWPSYFINRPGGADKAETP-DTSLNARYTFESFV
: .
MSMEG_2150|M.smegmatis_MC2_155 GIDRKLIDELGTCRYLESAT----NILLVGPPGTGKTHLSVGLA--RAAA
TH_1648|M.thermoresistible__bu GIDRKLIDELGTCRYLESAT----NILLIGPPGTGKTHLSVGLA--RAAA
MAV_3532|M.avium_104 -ITAATFDYLSSLEWIRAQQ----NLAVIGPPGTGKSHLLIGCG--HAAV
Mb3662|M.bovis_AF2122/97 GLKRDTIAHLGTLDFVT---------------------LAIGIA--IRAC
Rv3638|M.tuberculosis_H37Rv GLKRDTIAHLGTLDFVT---------------------LAIGIA--IRAC
Mflv_0579|M.gilvum_PYR-GCK GLKRDTIAHLGTLDFVVAKD----NVVFLGPPGTGKTHLAIGIA--IRAC
Mvan_3265|M.vanbaalenii_PYR-1 GIAPATIGHLAAGHYMDAGE----PVVLLGDSGTGKSHLLIGLG--LAAC
MMAR_0001|M.marinum_M IGASNRFAHAATLAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRL
MUL_0001|M.ulcerans_Agy99 IGASNRFAHAATLAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRL
MLBr_00001|M.leprae_Br4923 IGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRL
MAB_0001|M.abscessus_ATCC_1997 IGASNRFSHAAAVAVSEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRL
: .: * . .
MSMEG_2150|M.smegmatis_MC2_155 HAGYRTYFTTAADLAARCHRAAIEGRWATTMRFYAGPTLLVIDELGYLPL
TH_1648|M.thermoresistible__bu HAGYRTYFTTAADLAARCHRAAIEGRWATTMRFYAGPTLLVIDELGYLPL
MAV_3532|M.avium_104 HAGFKVRYFTAADLIEVLYRGLADNTVGKIIDTLLRADLVILDEIGFAPL
Mb3662|M.bovis_AF2122/97 QAGHRVLFATASQWVDRLAAAHHSGTLQSELIRLARYPLLVVDEVGYIPF
Rv3638|M.tuberculosis_H37Rv QAGHRVLFATASQWVDRLAAAHHSGTLQSELIRLARYPLLVVDEVGYIPF
Mflv_0579|M.gilvum_PYR-GCK QAGHRVLFATASQWVARLAEAHQGGRLQQELIRLGRYPLLVVDEVGYIPF
Mvan_3265|M.vanbaalenii_PYR-1 EQGRRVRYVTTAQLVNELVEAADERVLSRVVARYGRLDLLCLDELGYVQI
MMAR_0001|M.marinum_M FPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEG
MUL_0001|M.ulcerans_Agy99 FPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEG
MLBr_00001|M.leprae_Br4923 FPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEG
MAB_0001|M.abscessus_ATCC_1997 FPGMRVKYVSTEEFTNDFINSLRDDRRVAFKRSYRDIDVLLVDDIQFIEG
* :. : :: : . :: :*:: :
MSMEG_2150|M.smegmatis_MC2_155 PAEAASALFQVVSQRY-LKTSIVITTNRG----------VGS---WGEIL
TH_1648|M.thermoresistible__bu PAEAASALFQVVSQRY-LKTSIVITTNRG----------VGA---WGEIL
MAV_3532|M.avium_104 DDTGTQLLFRLVAAGY-ERRSLAIASHWP----------FEQ---WGRFL
Mb3662|M.bovis_AF2122/97 EPEAANLFFQLVSSRY-ERASLIVTSNKP----------FGR---WGEVF
Rv3638|M.tuberculosis_H37Rv EPEAANLFFQLVSSRY-ERASLIVTSNKP----------FGR---WGEVF
Mflv_0579|M.gilvum_PYR-GCK EPEAANLFFQLVSSRY-ERASLIVTSNKP----------FGKAHLFARTC
Mvan_3265|M.vanbaalenii_PYR-1 DPRGAELLFQIITERE-ERASVAIATNLP----------FSE---WGTVF
MMAR_0001|M.marinum_M KEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLIT
MUL_0001|M.ulcerans_Agy99 KEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLIT
MLBr_00001|M.leprae_Br4923 KEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLIT
MAB_0001|M.abscessus_ATCC_1997 KEGIQEEFFHTFNTLHNANKQIVISSDRPPKGLATLEDRLRTRFEWGLIT
. :*: . . .: :::. . :.
MSMEG_2150|M.smegmatis_MC2_155 GDT--------TVAAAMLD--RLLHRSVVINLDGESYRLRDHQAAAETLR
TH_1648|M.thermoresistible__bu GDT--------TVAAAMLD--RLLHRSVVINLDGESYRLRDHQAAAETLR
MAV_3532|M.avium_104 PEH--------TTAASILD--RLLHHASIVVTSGESYRMRHADHKKGAAK
Mb3662|M.bovis_AF2122/97 GDD--------VVAAAMID--RLVHHAEVIALKGDSYRIKDRDLG----R
Rv3638|M.tuberculosis_H37Rv GDD--------VVAAAMID--RLVHHAEVIALKGDSYRIKDRDLG----R
Mflv_0579|M.gilvum_PYR-GCK AEV--------ALKRDMFAGIRVGRGGRAVGPRRGDRRDRSSLLRVSSRR
Mvan_3265|M.vanbaalenii_PYR-1 PDP--------RLVAAIVD--RVTFNAHIIETGTKSYRLRTSKTTTRTKR
MMAR_0001|M.marinum_M DVQPPELETRIAILRKKAQMERLAVPDDVLELIASSIERNIRELEGALIR
MUL_0001|M.ulcerans_Agy99 DVQPPELETRIAILRKKAQMERLAVPDDVLELIASSIERNIRELEGALIR
MLBr_00001|M.leprae_Br4923 DVQPPELETRIAILRKKAQMERLAVPGDVLELIASSIERNIRELEGALIR
MAB_0001|M.abscessus_ATCC_1997 DVQPPELETRIAILRKKAQMDRLDVPDDVLELIASRIERNIRELEGALIR
*: : . . :
MSMEG_2150|M.smegmatis_MC2_155 RATTGTRQALH---------------------------------------
TH_1648|M.thermoresistible__bu RTTTGTRQPLH---------------------------------------
MAV_3532|M.avium_104 N-------------------------------------------------
Mb3662|M.bovis_AF2122/97 VPTVTADDQ-----------------------------------------
Rv3638|M.tuberculosis_H37Rv VPTVTADDQ-----------------------------------------
Mflv_0579|M.gilvum_PYR-GCK LPRRVSGRSY----------------------------------------
Mvan_3265|M.vanbaalenii_PYR-1 AT------------------------------------------------
MMAR_0001|M.marinum_M VTAFASLNKTPIDKALAEIVLRDLIADAGTMQISAATIMAATAEYFDTTV
MUL_0001|M.ulcerans_Agy99 VTAFASLNKTPIDKALAEIVLRDLIADADTMQISAATIMAATVEYFDTTV
MLBr_00001|M.leprae_Br4923 VTAFASLNKTAIDKALAEIVLRDLIADASTMQISAATIMTATAEYFDTTI
MAB_0001|M.abscessus_ATCC_1997 VTAFASLNKSPIELSLAEIVLRDLIPDANAIQISAATIMAVTAEYFDTTV
MSMEG_2150|M.smegmatis_MC2_155 --------------------------------------------------
TH_1648|M.thermoresistible__bu --------------------------------------------------
MAV_3532|M.avium_104 --------------------------------------------------
Mb3662|M.bovis_AF2122/97 --------------------------------------------------
Rv3638|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0579|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3265|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0001|M.marinum_M EELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQR
MUL_0001|M.ulcerans_Agy99 EELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQR
MLBr_00001|M.leprae_Br4923 EELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQR
MAB_0001|M.abscessus_ATCC_1997 EELRGPGKTRALAQARQIAMYLCRELTDLSLPKIGQTFGRDHTTVMYADK
MSMEG_2150|M.smegmatis_MC2_155 -----------------------------
TH_1648|M.thermoresistible__bu -----------------------------
MAV_3532|M.avium_104 -----------------------------
Mb3662|M.bovis_AF2122/97 -----------------------------
Rv3638|M.tuberculosis_H37Rv -----------------------------
Mflv_0579|M.gilvum_PYR-GCK -----------------------------
Mvan_3265|M.vanbaalenii_PYR-1 -----------------------------
MMAR_0001|M.marinum_M KILSEMAERREVFDHVKELTTRIRQRSKR
MUL_0001|M.ulcerans_Agy99 KILSEMAERREVFDHVKELTTRIRQRSKR
MLBr_00001|M.leprae_Br4923 KILSEMAERREVFDHVKELTTRIRQRSKR
MAB_0001|M.abscessus_ATCC_1997 KVRGEMAQRREVFDHVKELTARIRQRSRH