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MTEQTGQWQPTACILCECNCGIVVQVEGRALARIRGDKLHPASRGYTCNKALRLDHYQNNRNRLTSPMRR KPDGSYEEIDWDTAISEIAAGFRGIADTHGGDKILYYGGGGQGNHLGGAYSGAFLKALGSHYRSNALAQE KTGEYWIDAHFYGGHTRGEFEHAEVSVFVGKNPWMSQSFPRARVVLNEIAKDPARSMIVIDPVLTDTAKM ADYHLRVRPGTDAWCLAALAGVLVQEKLCDETFLADHVTGVQAVRTVLAEVPVADYAQRCGVDEELLRAA ARRIGAAGSVAVFEDLGVQQSPNSTLCSYLNKMLWILTGNFAKRGAQHLHSSFAPLFRPGGVGRTPVTGA PIIGGLMPSSVIPEEIHTDHPDRFRAMIVESSNPAHSLADSAAVRRAFADLELLVVIDVAMTETARLAHY VLPAATQFEKAEATFFNLEFPHNTFHLRHRLMEPLPGTLPEPEIWARLMRELDVVDGAELAPLRRAAAQG LPEFTEAFLAAVGANPGLGKVLPFVLHETLGPTLPEGLSGAAALWGLAQKTAMTYPDAVRRAGHADGNAL FSAILDGRSGVTFTVHDYEDDFTLITHPDRKIALDIPEMLAEVAALSAAPAARTTADFPIVLSAGERRAY TANDIMRDPAWRKRDSDGALRVSVEDAAALGLSDGGRARITTAAGSAEATVEISASMLPGHASLPNGYGV DFADGAGGAAVPGVAPNALTSSAWRDAYAGTPWHKHVPARIEKVLADDGLRAVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3010 | - | - | 100% (754) | formate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5376 | - | 1e-57 | 29.42% (758) | molydopterin dinucleotide-binding region |
| M. vanbaalenii PYR-1 | Mvan_2003 | - | 1e-56 | 27.30% (773) | molybdopterin oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0203 | - | 0.0 | 78.06% (743) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3288 | - | 0.0 | 85.27% (747) | formate dehydrogenase |
| M. tuberculosis H37Rv | Rv0197 | - | 0.0 | 77.93% (743) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1495 | - | 0.0 | 78.57% (742) | oxidoreductase |
| M. marinum M | MMAR_0437 | - | 0.0 | 79.81% (743) | oxidoreductase |
| M. avium 104 | MAV_4983 | - | 0.0 | 80.22% (743) | molybdopterin oxidoreductase Fe4S4 subunit |
| M. smegmatis MC2 155 | MSMEG_3521 | - | 0.0 | 78.76% (744) | molybdopterin oxidoreductase |
| M. thermoresistible (build 8) | TH_4041 | - | 1e-66 | 28.59% (759) | PUTATIVE Formate dehydrogenase |
| M. ulcerans Agy99 | MUL_1474 | fdhF | 3e-31 | 23.22% (771) | formate dehydrogenase H FdhF |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3010|M.vanbaalenii_PYR-1 ------MTEQTGQWQPTACILCECNCGIVVQVE------GRALARIRGDK
Mflv_3288|M.gilvum_PYR-GCK ------MSEHPSEWQASACILCECNCGIVVQVR------DRTLARIRGDK
Mb0203|M.bovis_AF2122/97 --------MTSSDWLPTACILCECNCGIVVQVD------DRRLARIRGDK
Rv0197|M.tuberculosis_H37Rv --------MTSSDWLPTACILCECNCGIVVQVD------DRRLARIRGDK
MMAR_0437|M.marinum_M --------MTTTDWQPTACILCECNCGIVVQVE------DRTLAHIRGDK
MAV_4983|M.avium_104 ---------MTGEWQPSACILCECNCGIVVQVE------DRRLARIRGDK
MAB_1495|M.abscessus_ATCC_1997 ---------MTAEWLPTACILCECNCGIVVQTE------GRTLAKIRGDK
MSMEG_3521|M.smegmatis_MC2_155 MTSGTATNATGTEWHHTACILCECNCGIVVQVE------NRTLAKVRGDK
TH_4041|M.thermoresistible__bu ---------MATEQRVTYCRICEPLCGLIATVE------DGRLQSLRPDP
MUL_1474|M.ulcerans_Agy99 -------MAPNKDAVKTVCAYCGVGCGIVLQTTTDPQTGKRRVAKSTGDK
: : * * **:: . : *
Mvan_3010|M.vanbaalenii_PYR-1 LHPASRGYTCNKALRLDHYQNNRNRLTSP-MRRKPDGSYEEIDWDTAISE
Mflv_3288|M.gilvum_PYR-GCK EHPASRGYTCNKALRLDHYQNNPNRLTSP-MRRRPDGTYEEIDWETAISE
Mb0203|M.bovis_AF2122/97 AHPGSAGYTCNKALRLDHYQNNRARLSSP-MRRRADGTYEEIDWDTAIVE
Rv0197|M.tuberculosis_H37Rv AHPGSAGYTCNKALRLDHYQNNRARLSSP-MRRRADGTYEEIDWDTAIVE
MMAR_0437|M.marinum_M AHPASRGYTCNKALRLDHYQNSRGRLTAP-LRRRPDGTYEEIDWDTAIVE
MAV_4983|M.avium_104 AHPASQGYTCNKVLRLDHYQNSRARLTSP-LRRRPDGSYEEIDWDTAIVE
MAB_1495|M.abscessus_ATCC_1997 DHPGTKGYTCNKALRLNHYQNNANRLTSP-MRRRPDGTYEEIDWDTAIVE
MSMEG_3521|M.smegmatis_MC2_155 DHPASRGYTCNKALRLDHYQNSAGRLTTP-MRRRPDGEFEPVDWDTAIAE
TH_4041|M.thermoresistible__bu DHPLSRGRACPKGIAFTEVQNDPDRVLYP-LRRRADGEFERVGWDEALDD
MUL_1474|M.ulcerans_Agy99 SHPANLGRLCTKGTTTADLLAAPGRMESAHLRAHRAGHLESIPIDDAITQ
** . * * * . *: . :* : * * : : *: :
Mvan_3010|M.vanbaalenii_PYR-1 IAAGFRGIADTHGGDKILYYGGGGQGN---HLGGAYSGAFLKALGSHYRS
Mflv_3288|M.gilvum_PYR-GCK IADGFRAIAANHGGDTILYYGGGGQGN---HLGGAYSGAFLKALGSHYRS
Mb0203|M.bovis_AF2122/97 IAEGFKQIRDTHGGDKIFYYGGGGQGN---HLGGAYSGAFLKALGSRYRS
Rv0197|M.tuberculosis_H37Rv IAEGFKQIRDTHGGDKIFYYGGGGQGN---HLGGAYSGAFLKALGSRYRS
MMAR_0437|M.marinum_M IAEGFKRIRDVHGGDKIFYYGGGGQGN---HLGGVYSGAFLKALGSRYRS
MAV_4983|M.avium_104 IAEGFKRIRDSYGGDKIFYYGGGGQGN---HLGGAYSGAFLKALGSRYRS
MAB_1495|M.abscessus_ATCC_1997 IAEGFKHIRDSYGGDKIFYYGGGGQGN---HLGGAYSGAFLKAIGSKYRS
MSMEG_3521|M.smegmatis_MC2_155 VAEGFQRIAKTYGGERIFYYGGGGQGN---HLGGAYSGAFLRALGSRYRS
TH_4041|M.thermoresistible__bu IAARLTAIRDRHGGGAIGQYFGNPVAFG--YATALWSGMFVARLGSRHQY
MUL_1474|M.ulcerans_Agy99 CAMRLRAIIDEHGPDAVGVYVSGQMSIEAQYLANKLTKGFIGTKQIESNS
* : * :* : * .. . : : *: . .
Mvan_3010|M.vanbaalenii_PYR-1 NALAQEKTGEYWIDAHFYGGHTRG---EFEHAEVSVFVGKNPWMSQS---
Mflv_3288|M.gilvum_PYR-GCK NALAQEKTGEHWIDTHLYGNHTRG---EFEHAEVAVFVGKNPWMSQS---
Mb0203|M.bovis_AF2122/97 NALAQEKTGEAWVDFQLYGGHTRG---EFENAEVSVFVGKNPWMSQS---
Rv0197|M.tuberculosis_H37Rv NALAQEKTGEAWVDFQLYGGHTRG---EFENAEVSVFVGKNPWMSQS---
MMAR_0437|M.marinum_M NALAQEKTGEAWIDGKLYGGHTRG---EFEHAEVSVFIGKNPWMSQS---
MAV_4983|M.avium_104 NALAQEKTGESWIDGQLYGGHTRG---EFEHAEVAVFVGKNPWMSQS---
MAB_1495|M.abscessus_ATCC_1997 NALAQEKTGEAWIDKNLYGGHTRG---EFEYAEVSVFVGKNPWMSQS---
MSMEG_3521|M.smegmatis_MC2_155 NALAQEKTGEAWVDAHLYGGHTRG---EFEHAEVSVFVGKNPWMSQS---
TH_4041|M.thermoresistible__bu SSGSQDINSRFVASKLLYGAASQIPFPDLPRTDFLFMLGANPFVSHGSAL
MUL_1474|M.ulcerans_Agy99 RLCMAGASSGYKLSLGADGPPGSY--QDFDHADVFLVIGANMADCHP---
.. . * :: ::. ..:* * .:
Mvan_3010|M.vanbaalenii_PYR-1 -FPRARVVLNEIAKDPARSMIVIDPVLTDTAKMADYHLRVRPGTDAWCLA
Mflv_3288|M.gilvum_PYR-GCK -FPRARVVLNEIARDPGRSMIVIDPVITDTARMADIHLRVRPGSDAWCLA
Mb0203|M.bovis_AF2122/97 -FPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQPGCDAWCLA
Rv0197|M.tuberculosis_H37Rv -FPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQPGCDAWCLA
MMAR_0437|M.marinum_M -FPRARVVLNEIAKDPARSMIVIDPVVTDTAKMADFHLRVRPGADAWCVA
MAV_4983|M.avium_104 -FPRARVVLNEIAKDPARSMIVIDPVVTDTAKMADFHLRVRPGTDAWCLA
MAB_1495|M.abscessus_ATCC_1997 -FPRARVVLNEIAKDPQRSMIVIDPVNTDTAKMADFHLRVRPGTDAWCLA
MSMEG_3521|M.smegmatis_MC2_155 -FPRARVVLNEIARDPARSMIVIDPVLTETAALADHHLRVRPGTDAWCLA
TH_4041|M.thermoresistible__bu RAPRIKDDLTDITRRGGR-VVVVDPRRTETAR-AFEHIAVRPDSDAWLLL
MUL_1474|M.ulcerans_Agy99 ----ILFLRMMERVKSGAKLIVVDPRRTATADKADLFLQIAPGTDLALLN
::*:** * ** * .: : *. * :
Mvan_3010|M.vanbaalenii_PYR-1 ALAGVLVQEKLCDETFLADHVTGVQAVRTVLAEVPVADYAQRCGVDEELL
Mflv_3288|M.gilvum_PYR-GCK ALAGVLVQEDLCDDAFLAAHVNGVDAVREVLREVPVAEYARRCGVDEALI
Mb0203|M.bovis_AF2122/97 ALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQRCGVDEELL
Rv0197|M.tuberculosis_H37Rv ALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQRCGVDEELL
MMAR_0437|M.marinum_M ALAAVLVQENLCDEAFLAEHVRGVEEVREVLAEVPVAEFAQRCGVDEELL
MAV_4983|M.avium_104 ALAAVLVQENLCDEAFLAEHVRCADAVRHALRDVAVSEYAAHCGVDEELL
MAB_1495|M.abscessus_ATCC_1997 ALAAVLVQENLCDEAFLAEHVTGTEEVRDVLRTVPIADYARRCGVDEDLI
MSMEG_3521|M.smegmatis_MC2_155 ALAAVLVQENLCDEEFLTQHVHGADAVREVLRDVDIAENARRCGVAEEQI
TH_4041|M.thermoresistible__bu SMLQVIFAEGLEDTAAIARQTTGCSTLRGLVAGFPPEATAARTGVPADVV
MUL_1474|M.ulcerans_Agy99 GLLHLIVENEQTDPQFISEFTEGWEVMPSFLEQFTPDRVSEITGIPSEDI
.: ::. : : :: . . : : . : *: :
Mvan_3010|M.vanbaalenii_PYR-1 RAAARRIGAAGSVAVFEDLGVQQSPNSTLCSYLNKMLWILTGNFAKRGAQ
Mflv_3288|M.gilvum_PYR-GCK RSAARRIAAAGSVAVFEDLGVQQSLNSTLCSYLNKMLWILTGNFAKRGAQ
Mb0203|M.bovis_AF2122/97 RAAARRIGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILTGNFAKKGGQ
Rv0197|M.tuberculosis_H37Rv RAAARRIGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILTGNFAKKGGQ
MMAR_0437|M.marinum_M RAAARRIGGAASVAVFEDLGVQQAPNSTLVSYLNKMLWILTGNFAKKGGQ
MAV_4983|M.avium_104 RTAARRIGTADSVAVFEDLGVQQAPNSTLCSYLNKLLWILTGNFAKRGGQ
MAB_1495|M.abscessus_ATCC_1997 RRAARRVAAAESVAVFEDLGIQQAPNSTLSSYLNKMLWILTGNFAKRGGQ
MSMEG_3521|M.smegmatis_MC2_155 RAAARRIGRATSVSVFEDLGVQQAPNSTLCSYLDKLLWILTGNFAKPGGQ
TH_4041|M.thermoresistible__bu RSLARDFAAAPTAAAYGRTGACLGRHGTLVSFLLDALSIVTGNLDREGGL
MUL_1474|M.ulcerans_Agy99 RTAARWIGTAANWMSCWTMGLNQSTHGTWNTNALCNLHLATGAICRPGSG
* ** .. * . * . :.* : * : ** : : *.
Mvan_3010|M.vanbaalenii_PYR-1 HLHSSFAPLFRP--------GGVGRTPVTGAPIIGGLMPSSVIPEEIHTD
Mflv_3288|M.gilvum_PYR-GCK HLHSSFAPLFRP--------GGVGRTPVTGAPIIGGLMPSNVIPEEILTD
Mb0203|M.bovis_AF2122/97 HLHSSFAPLFS---------QVSGRTPVTGAPIIAGLIPGNVVPEEILTE
Rv0197|M.tuberculosis_H37Rv HLHSSFAPLFS---------QVSGRTPVTGAPIIAGLIPGNVVPEEILTE
MMAR_0437|M.marinum_M HLHSSFAPLFS---------MTSGRTPVTGARIIAGLVPGNVVPEEILTD
MAV_4983|M.avium_104 HLHSSFAPLFG---------QFSGRTPVTGAPIISGLVPSNVVPEEILTD
MAB_1495|M.abscessus_ATCC_1997 HLHSWMAPLMG---------GFFGYTPVTGARIIGGLVPSNVIPEEILTD
MSMEG_3521|M.smegmatis_MC2_155 HLHSTFAPLFGK--------SGVGRTPVTGAPVIAGLVPSNVVPEEILTD
TH_4041|M.thermoresistible__bu LMAHAVIPFEELGERTGRLTYGTERSRIGGLPEVISTFPAALMADEINTP
MUL_1474|M.ulcerans_Agy99 PFSLTGQPNAMGGRE-----MGYMGPGLPGQRSVLSAPDREFVEEQWGLP
: * . : * : . .: ::
Mvan_3010|M.vanbaalenii_PYR-1 H-------------------PDRFRAMIVESSNPAHSLADSAAVRRAFAD
Mflv_3288|M.gilvum_PYR-GCK H-------------------PDRFRALIVESSNPAHSVADSAAVRRAFSE
Mb0203|M.bovis_AF2122/97 H-------------------PDRFRAMIVESGNPAHSLADSAACRAAFQA
Rv0197|M.tuberculosis_H37Rv H-------------------PDRFRAMIVERGNPAHSLADSAACRAAFQA
MMAR_0437|M.marinum_M H-------------------PDRFRAMIVESANPAHSLADSAACRQAFEA
MAV_4983|M.avium_104 H-------------------PDRFRAMIVESSNPAHSLANSAACREAFAS
MAB_1495|M.abscessus_ATCC_1997 H-------------------PDRFRAMIVESSNPAHSLADSARCKEAFAA
MSMEG_3521|M.smegmatis_MC2_155 H-------------------PDRFRAMIVESSNPAHSVAASARVRAALQE
TH_4041|M.thermoresistible__bu G-------------------DGQLRALFVTAGNPVLTVPNGPALEKVLGK
MUL_1474|M.ulcerans_Agy99 GGALRTDVSGGVIDMFSRMADGEIKACWIICSNPVATVANRKTVLAGLEK
..::* : .**. ::. :
Mvan_3010|M.vanbaalenii_PYR-1 LELLVVIDVAMTETARLAHYVLPAATQFEKAEATF---------------
Mflv_3288|M.gilvum_PYR-GCK LELLVVIDVAMTETARLAHYVLPAASQFEKVEATF---------------
Mb0203|M.bovis_AF2122/97 LELMVVVDVAMTETARLAHYVLPAASQFEKPEATF---------------
Rv0197|M.tuberculosis_H37Rv LELMVVVDVAMTETARLAHYVLPAASQFEKPEATF---------------
MMAR_0437|M.marinum_M LELMVVIDVAMTETARLAHYVLPAASQFEKPEATF---------------
MAV_4983|M.avium_104 LELMVVIDVAMTETARLAHYVLPAASQFEKPEATF---------------
MAB_1495|M.abscessus_ATCC_1997 LELLVVVDVAMTETARLAHYVLPAATQFEKVEATF---------------
MSMEG_3521|M.smegmatis_MC2_155 LELLVVIDVAMTETARLADYVLPAATQFEKAEATF---------------
TH_4041|M.thermoresistible__bu LDLIVSLDFYVTETNRHAHYVLPATTFLERDDYPYG--------------
MUL_1474|M.ulcerans_Agy99 AELVISQDAFFETETNEYANVLLPAALWTESDGVMVNCERNMSLFPKAVD
:*:: * . . ** .:: . :
Mvan_3010|M.vanbaalenii_PYR-1 ------------------------FNLEFPHNTFHLRHRLMEPLP-----
Mflv_3288|M.gilvum_PYR-GCK ------------------------FNLEFPHNTFHLRHPLMEPLP-----
Mb0203|M.bovis_AF2122/97 ------------------------FNFEFPRNGFQLRRPLFPPLP-----
Rv0197|M.tuberculosis_H37Rv ------------------------FNFEFPRNGFQLRRPLFPPLP-----
MMAR_0437|M.marinum_M ------------------------FNLEFPHNAVHLRHPLLDPLP-----
MAV_4983|M.avium_104 ------------------------FNLEFPRNTFQLRRPLLTPLP-----
MAB_1495|M.abscessus_ATCC_1997 ------------------------FNLEFPHNTFQLRHPLFEPES-----
MSMEG_3521|M.smegmatis_MC2_155 ------------------------FNLEFPHNTFHLRHRLFEPLQ-----
TH_4041|M.thermoresistible__bu ------------------------FAANCPTVFIQSAEPVVGAYG-----
MUL_1474|M.ulcerans_Agy99 PVGDALPDWQIIARIACEMGFSESFSYSSAAEVFEEIKRFSNPATGYDLR
* . . .. . . .
Mvan_3010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3288|M.gilvum_PYR-GCK --------------------------------------------------
Mb0203|M.bovis_AF2122/97 --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0437|M.marinum_M --------------------------------------------------
MAV_4983|M.avium_104 --------------------------------------------------
MAB_1495|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
MUL_1474|M.ulcerans_Agy99 GISHDRLRETPLQWPCPPDGASNRSPIRYLNDGVSQLQFVRADGTVPRLA
Mvan_3010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3288|M.gilvum_PYR-GCK --------------------------------------------------
Mb0203|M.bovis_AF2122/97 --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0437|M.marinum_M --------------------------------------------------
MAV_4983|M.avium_104 --------------------------------------------------
MAB_1495|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
MUL_1474|M.ulcerans_Agy99 FPTATGRAVFFARPHLVPDEMPDGDYPFLLNTGRLAHQWHTLTKTGKIAK
Mvan_3010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3288|M.gilvum_PYR-GCK --------------------------------------------------
Mb0203|M.bovis_AF2122/97 --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0437|M.marinum_M --------------------------------------------------
MAV_4983|M.avium_104 --------------------------------------------------
MAB_1495|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
MUL_1474|M.ulcerans_Agy99 LNKLNPGPFVEVHPDDAADMQICEGDHIEIASRRGRAVLPVVITDRVRPG
Mvan_3010|M.vanbaalenii_PYR-1 --------------------------GTLPEPEIWARLMRELDVVDGAEL
Mflv_3288|M.gilvum_PYR-GCK --------------------------GTLPEPEIWARLMRALGVVDDAEL
Mb0203|M.bovis_AF2122/97 --------------------------GTLPEPEIWARLVRALGVVDEADL
Rv0197|M.tuberculosis_H37Rv --------------------------GTLPEPEIWARLVRALGVVDEADL
MMAR_0437|M.marinum_M --------------------------GTLPEPEIWARLVRALGFVTDDDL
MAV_4983|M.avium_104 --------------------------GTLPEPEIWARLVRALGVVTEADL
MAB_1495|M.abscessus_ATCC_1997 --------------------------GTLPEPEIWARLVRALGVVDDADL
MSMEG_3521|M.smegmatis_MC2_155 --------------------------GTLPEPEIWARLVRALGVVDEAEL
TH_4041|M.thermoresistible__bu --------------------------EARNEWEVFDELARRMGLSLFATG
MUL_1474|M.ulcerans_Agy99 NCFAPFHWNDAFGEYLSINAVTNDAVDPISRQPEYKACAVTLTKVARPQL
. . : :
Mvan_3010|M.vanbaalenii_PYR-1 APLRRAAAQGLPEFTEAFLAAVGANPGLGKVLPFVLHETLG--PTLPEGL
Mflv_3288|M.gilvum_PYR-GCK APLRRAAAQGLPAYTEAFLTAVSANPGLGKVLPFVLYETLG--PTLPEGL
Mb0203|M.bovis_AF2122/97 RPLREAAAQGRQAYTEAFLAAAATNPTVAKLTAYVLYETLG--PTLPDGL
Rv0197|M.tuberculosis_H37Rv RPLREAAAQGRQAYTEAFLAAAATNPTVAKLTAYVLYETLG--PTLPDGL
MMAR_0437|M.marinum_M RPLREAAQRGRQAYTEAFLVAVASNPSVAKLLPYVLYETLG--PTLPDGM
MAV_4983|M.avium_104 RPLHDAARRGRHAYTEAFLTAVSTNPTVAQLLPFVLYETLG--PTLPDGL
MAB_1495|M.abscessus_ATCC_1997 QPLREAAAQGREAYLQAFFAVLA-NPVLGALAPYVLYETLG--PTLPRGL
MSMEG_3521|M.smegmatis_MC2_155 QPLRRAAEAGLAEFTAAFFTAVASNPTLSKVLPFVLYETLG--PALPDGM
TH_4041|M.thermoresistible__bu PLERLNP-----------VLAWLDRRGVGRLTPRRLMELLL--RLGPYGD
MUL_1474|M.ulcerans_Agy99 QPEPGEPADACADATAPKLLADTAQFSVTQVDALAELLGVGNEPTPQFGP
. . . . : : . : *
Mvan_3010|M.vanbaalenii_PYR-1 SGAAALWGLAQ---------------------------------------
Mflv_3288|M.gilvum_PYR-GCK SGAAALWGLAQ---------------------------------------
Mb0203|M.bovis_AF2122/97 AGAAALWGLAQ---------------------------------------
Rv0197|M.tuberculosis_H37Rv AGAAALWGLAQ---------------------------------------
MMAR_0437|M.marinum_M AGAAALWGLAQ---------------------------------------
MAV_4983|M.avium_104 RGAAALWGLAQ---------------------------------------
MAB_1495|M.abscessus_ATCC_1997 EGAAALWGLAQ---------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 AGAAALWGLAQ---------------------------------------
TH_4041|M.thermoresistible__bu RFGLRRGGLNP---------------------------------------
MUL_1474|M.ulcerans_Agy99 SARSYLAGLIAGLRSETGRRMAGVSTLPISSPFDTGTRLWLDGLLAGMFA
**
Mvan_3010|M.vanbaalenii_PYR-1 ----KTAMTYPDAVRRAGHADGNALFSAILDGRSGVTFTVHDYEDDFTLI
Mflv_3288|M.gilvum_PYR-GCK ----KAALTYPKAVHRAGHADGNALFTAILDGRSGVTFTEHEYQDDFALI
Mb0203|M.bovis_AF2122/97 ----KTAMAYPDAVRRAGHADGNALFDAILERPSGVTFTVHNYEDDFALI
Rv0197|M.tuberculosis_H37Rv ----KTAMAYPDAVRRAGHADGNALFDAILERPSGVTFTVHNYEDDFALI
MMAR_0437|M.marinum_M ----KTAMTYPDAVRRAGHTDGNALFDAILNGRSGVTFTAHNYEDDFELI
MAV_4983|M.avium_104 ----KTALTYPEAVRRAGHADGNALFDAILDNPSGVTFTVHDYADDFTLI
MAB_1495|M.abscessus_ATCC_1997 ----KAMMTYPQAVARAGHPDGNALFDAILNSPSGVTFTVHDYEDDFALI
MSMEG_3521|M.smegmatis_MC2_155 ----KTAMTYPDAVRRAGHADGNALFEAILANPAGVTFTVHEYAEDFTLI
TH_4041|M.thermoresistible__bu ----RRLRENPHGIVVADRVPTGVLGKVVR--------------------
MUL_1474|M.ulcerans_Agy99 RAETPPALPFPQTPGAAAQSD-NAAEAAVEQPPIVVLWASQTGTAEELAA
*. * : .. .:
Mvan_3010|M.vanbaalenii_PYR-1 THPDRKIALDIPEMLAEVAALSAAPAARTTADFPIVLSAGE---------
Mflv_3288|M.gilvum_PYR-GCK SHPDRRIALEIPEMLADIRALADAADALTDDEFPIVLSAGE---------
Mb0203|M.bovis_AF2122/97 SHPDHKIALEIPEMLAEIRSLTQTPSRLTTPQLPIVLSVGE---------
Rv0197|M.tuberculosis_H37Rv SHPDHKIALEIPEMLAEIRSLTQTPSRLTTPQLPIVLSVGE---------
MMAR_0437|M.marinum_M NNDDHKIALGIPEMLDEIRSLADLKMSLTTTELPIVLSVGE---------
MAV_4983|M.avium_104 GHPDHKIALEIPAMLQELAKLSSGPPRLTTEEFPIVLSVGE---------
MAB_1495|M.abscessus_ATCC_1997 THADRKIALAIPEMLDEIKGLVSRPAQLTTPEFPIVLSAGE---------
MSMEG_3521|M.smegmatis_MC2_155 DHPDHKIALEIPEMLDEIRALRNQQAPLTSSEFPIVLSAGE---------
TH_4041|M.thermoresistible__bu -HRGGRVCLAPDEVVAEVHRLGQRHP--DDPAYPLLAIGMR---------
MUL_1474|M.ulcerans_Agy99 SVAAQLSAAELPVVLHGMDEFAVADLVSTQRLLLVTSTTGDGEPPDNGAA
. :: : : :
Mvan_3010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3288|M.gilvum_PYR-GCK --------------------------------------------------
Mb0203|M.bovis_AF2122/97 --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0437|M.marinum_M --------------------------------------------------
MAV_4983|M.avium_104 --------------------------------------------------
MAB_1495|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
MUL_1474|M.ulcerans_Agy99 FWRELCAPTAPSLAGTRYSVLALGDSNYADFCGHGRALDHRLAELGASRI
Mvan_3010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3288|M.gilvum_PYR-GCK --------------------------------------------------
Mb0203|M.bovis_AF2122/97 --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0437|M.marinum_M --------------------------------------------------
MAV_4983|M.avium_104 --------------------------------------------------
MAB_1495|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
MUL_1474|M.ulcerans_Agy99 TDRVDCEPDYEESAARWLQEVLDGLRRTAPPVITAEPVRAASIASRPQGY
Mvan_3010|M.vanbaalenii_PYR-1 -RRAYTANDIMRDPAWRKRDSDGALR----------VSVEDAAALGLSDG
Mflv_3288|M.gilvum_PYR-GCK -RRAYTANDIIRDPAWRTRDPDGALR----------VSVHDAAVLGLVDG
Mb0203|M.bovis_AF2122/97 -RRAYTANDIFRDPSWRKRDANGALR----------VSVEDAQALGLADG
Rv0197|M.tuberculosis_H37Rv -RRAYTANDIFRDPSWRKRDANGALR----------VSVEDAQALGLADG
MMAR_0437|M.marinum_M -RRAYTANDIFRDPSWRKRDADGALR----------VSVEDAQALGLTDG
MAV_4983|M.avium_104 -RRAYTANDIFRDPSWRKRDAEGALR----------VSVEDAQALGLADG
MAB_1495|M.abscessus_ATCC_1997 -RRAYTANDILRDPSWRKRDQQGALR----------ISPQDAQQLGVADG
MSMEG_3521|M.smegmatis_MC2_155 -RRAYTANDIIRDPAWRRRDPEGALR----------VSPHDAEELGLADG
TH_4041|M.thermoresistible__bu -EMRSQNTWMHNSPTLMKGDRRHRAR----------IHPADAAAAGVTHG
MUL_1474|M.ulcerans_Agy99 TKKRPLLTSVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYEAGDALGVWPR
. . : ...: * : . *:
Mvan_3010|M.vanbaalenii_PYR-1 GRARITTAAGSAEATVEISASMLPGH------ASLPNGYGVDFADGAGGA
Mflv_3288|M.gilvum_PYR-GCK GRARITTAAGTAEATVEISEAMLPGH------ASLPNGFGVDHLRPDGES
Mb0203|M.bovis_AF2122/97 CLARITTAAGSAEATVEVTETMLAGH------AALPNGFGLDYTGDDGRT
Rv0197|M.tuberculosis_H37Rv CLARITTAAGSAEATVEVTETMLAGH------AALPNGFGLDYTGDDGRT
MMAR_0437|M.marinum_M CRARITTAAGAAEATVEVTEVMLPGH------ASLPNGFGLDYVDGDGRT
MAV_4983|M.avium_104 CRARISTAAGSAEATVEISETMLAGH------AALPNGFGLDYVGDDGRT
MAB_1495|M.abscessus_ATCC_1997 ERVRIATAAGAAEATVEISDMMQPGH------ASLPNGFGLDYTDESGET
MSMEG_3521|M.smegmatis_MC2_155 GRARITTAAGTAVARVEISDAMLPGH------ASLPNGLGLDYRDGD-RV
TH_4041|M.thermoresistible__bu GPVRIESPYGAIETEALCTDEMTPGT------VAIPHGWGHNG-GWRLAN
MUL_1474|M.ulcerans_Agy99 NAHQLVDEWLGVTRLDGHTEVEVAGHGTMSLRAALTDRFEIAHLSPDLLR
:: : .* .::..
Mvan_3010|M.vanbaalenii_PYR-1 AVPGVAPNALTS---------------------SAWRDAYAGTPWHKHVP
Mflv_3288|M.gilvum_PYR-GCK LSPGVAPNTLTS---------------------SGRRDAYAGTPWHKHVP
Mb0203|M.bovis_AF2122/97 VVAGVAPNALTS---------------------TRWRDPYAGTPWHKHVP
Rv0197|M.tuberculosis_H37Rv VVAGVAPNALTS---------------------TRWRDPYAGTPWHKHVP
MMAR_0437|M.marinum_M VVPGVAPNALTS---------------------TKWRDPYAGTPWHKHVP
MAV_4983|M.avium_104 VVPGVAPNALTS---------------------TQWRDPYAGTPWHKHVP
MAB_1495|M.abscessus_ATCC_1997 HIPGVAPNALTS---------------------SAWRDEYAGTPWHKHVP
MSMEG_3521|M.smegmatis_MC2_155 VVPGVAPNALTS---------------------TEWRDPYAGTPWHKHVP
TH_4041|M.thermoresistible__bu RLAGANVNELTSN-------------------DSADLERLAGMSVLNGVP
MUL_1474|M.ulcerans_Agy99 FVAQRTLDSNTANQLAELMRPENKAALADWTWGRQSVDLLAQSPVRASVD
. : *: : * . *
Mvan_3010|M.vanbaalenii_PYR-1 ARIEKVLADDGLRAVG----------------------------------
Mflv_3288|M.gilvum_PYR-GCK ARIERVCADG-LVGVN----------------------------------
Mb0203|M.bovis_AF2122/97 AAIRRADAESPIW-------------------------------------
Rv0197|M.tuberculosis_H37Rv AAIRRADAESPIWYPKWAILPARGVLA-----------------------
MMAR_0437|M.marinum_M ARIEACRADA----------------------------------------
MAV_4983|M.avium_104 ARIEALADARR---------------------------------------
MAB_1495|M.abscessus_ATCC_1997 ARLETLTAAI----------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 ARLEAV--------------------------------------------
TH_4041|M.thermoresistible__bu VRLVPVG-------------------------------------------
MUL_1474|M.ulcerans_Agy99 EWMSVLKPIQPRLYSISSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTY
:
Mvan_3010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3288|M.gilvum_PYR-GCK --------------------------------------------------
Mb0203|M.bovis_AF2122/97 --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0437|M.marinum_M --------------------------------------------------
MAV_4983|M.avium_104 --------------------------------------------------
MAB_1495|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
MUL_1474|M.ulcerans_Agy99 LADRSPSDQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGIAPFRGFLQERR
Mvan_3010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3288|M.gilvum_PYR-GCK --------------------------------------------------
Mb0203|M.bovis_AF2122/97 --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0437|M.marinum_M --------------------------------------------------
MAV_4983|M.avium_104 --------------------------------------------------
MAB_1495|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
MUL_1474|M.ulcerans_Agy99 ALGHTGPNWLFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDK
Mvan_3010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3288|M.gilvum_PYR-GCK --------------------------------------------------
Mb0203|M.bovis_AF2122/97 --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0437|M.marinum_M --------------------------------------------------
MAV_4983|M.avium_104 --------------------------------------------------
MAB_1495|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3521|M.smegmatis_MC2_155 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
MUL_1474|M.ulcerans_Agy99 VYVQHLMQQRGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGG
Mvan_3010|M.vanbaalenii_PYR-1 ------------------------
Mflv_3288|M.gilvum_PYR-GCK ------------------------
Mb0203|M.bovis_AF2122/97 ------------------------
Rv0197|M.tuberculosis_H37Rv ------------------------
MMAR_0437|M.marinum_M ------------------------
MAV_4983|M.avium_104 ------------------------
MAB_1495|M.abscessus_ATCC_1997 ------------------------
MSMEG_3521|M.smegmatis_MC2_155 ------------------------
TH_4041|M.thermoresistible__bu ------------------------
MUL_1474|M.ulcerans_Agy99 LDPESATAFVHALSADKRYHRDVY