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PTVARTYVTAGVALVGAGLISAAPITTPHPLQRTASFEMGLVAATQSCLPGDASALCGTPSGVPTATPFT TTADSTNVFNIPANLFIALANTPYNFFTALGTGNVALGSEPDGGPSFQPGYEGVTLTQPDGNVVGLGANL HYGGSWWVYSPTNILGTDAADVTRYQALVNVLVPFPALSVPLGNMLAAVAASQLPMDEGCTGTGSGACEN PSGILSKMFDVRHIAALFSPDGYTFPESREGITCSEDGQCYVKDPDGREVPWSGQNVKLDPTSPFASFYD SLTATPDFSSIKPVTLELVLASLGSLAQGLNTAYNPFVLGTQCNICAPFVPNPDNEPIPGPVFEDPDTAE TLTTSVVSAQTETADVTETTETPDTAAAPVTPETAAAPVTTETPDAAEAAEALSAPVTAEEVEEVEEAPA GPKHRKPSATSETLKNVRDSINSTFSKLTDGLKKPSSTTDGTKAESTASEADSSNSDSGSDSGGSED*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2962 | - | - | 100% (488) | hypothetical protein Mvan_2962 |
| M. vanbaalenii PYR-1 | Mvan_3114 | - | 2e-39 | 29.73% (518) | hypothetical protein Mvan_3114 |
| M. vanbaalenii PYR-1 | Mvan_3110 | - | 2e-37 | 30.83% (399) | hypothetical protein Mvan_3110 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3909c | - | 3e-05 | 29.58% (142) | hypothetical protein Mb3909c |
| M. gilvum PYR-GCK | Mflv_3378 | - | 4e-32 | 28.25% (446) | hypothetical protein Mflv_3378 |
| M. tuberculosis H37Rv | Rv3879c | - | 9e-05 | 29.71% (138) | hypothetical protein Rv3879c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0974 | - | 4e-05 | 26.28% (137) | hypothetical protein MAB_0974 |
| M. marinum M | MMAR_0884 | - | 1e-06 | 26.29% (194) | hypothetical protein MMAR_0884 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_5322 | - | 5e-09 | 27.06% (170) | hypothetical protein MSMEG_5322 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0637 | - | 4e-06 | 24.15% (207) | hypothetical protein MUL_0637 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0884|M.marinum_M --------------------------MDVVLGVAIAGPIARLALVGAAAE
MUL_0637|M.ulcerans_Agy99 -------------MLVAGWPAEGEPQMDVVLGVAIAGPIARLALVGAAAE
Mb3909c|M.bovis_AF2122/97 MSITRPTGSYARQMLDPGGWVEADEDTFYDRAQEYSQVLQRVTDVLDTCR
Rv3879c|M.tuberculosis_H37Rv MSITRPTGSYARQMLDPGGWVEADEDTFYDRAQEYSQVLQRVTDVLDTCR
MSMEG_5322|M.smegmatis_MC2_155 --------------------MQQAVRSYLTAGVAFAGAGVIAVSPVAPLP
MAB_0974|M.abscessus_ATCC_1997 ----------------MHVGIRTVAVAAVCGLCVGAGVDARAVRPNLSIA
Mvan_2962|M.vanbaalenii_PYR-1 --------------------MPTVARTYVTAGVALVGAGLISAAPITTPH
Mflv_3378|M.gilvum_PYR-GCK --------------------MHSALRPYVTTGLALVGTSVIALAPIAPPA
.
MMAR_0884|M.marinum_M G--------SAVIDQSSVDLAEGPVAVLTETIVGTNQLL------ADEG-
MUL_0637|M.ulcerans_Agy99 G--------SAVIDQSSVDLAEGPVAVLTETIVGTNQLL------ADEG-
Mb3909c|M.bovis_AF2122/97 QQKG-HVFEGGLWSGGAANAANGALGANINQLMTLQDYL------ATVIT
Rv3879c|M.tuberculosis_H37Rv QQKG-HVFEGGLWSGGAANAANGALGANINQLMTLQDYL------ATVIT
MSMEG_5322|M.smegmatis_MC2_155 P----------DITERAQSSAGVALSALANPIDGYAAAF------TAALK
MAB_0974|M.abscessus_ATCC_1997 G----------TPTTRSVSSQAVSLASFSDLLAAAAPQN------DAAAQ
Mvan_2962|M.vanbaalenii_PYR-1 P------------LQRTASFEMGLVAATQSCLPGDASAL------CGTPS
Mflv_3378|M.gilvum_PYR-GCK PAFGGATVAKQVTQDVTLSARVVTLNPTPDALEMGEQLQGSICGGNGTPC
: . : . :
MMAR_0884|M.marinum_M -HHLVATRLCWSDQD-RAEDLRR--ALDDSGVLDVAVLSESEAVTA----
MUL_0637|M.ulcerans_Agy99 -HHLVATRLCWSDQD-RAEDLRR--ALDDSGVLDVAVLSESEAVTA----
Mb3909c|M.bovis_AF2122/97 WHRHIAGLIEQAKSD-IGNNVDG--AQREIDILENDPSLDADERHT----
Rv3879c|M.tuberculosis_H37Rv WHRHIAGLIEQAKSD-IGNNVDG--AQREIDILENDPSLDADERHT----
MSMEG_5322|M.smegmatis_MC2_155 NAEALTARIAAAPAP-ILSNIVRNQVNSAAGVATFAEVFTSSVITA----
MAB_0974|M.abscessus_ATCC_1997 MNSVGGGAVSSTDLIGTVAKLLATPNITQSGVTPGINTAAVGTVDP----
Mvan_2962|M.vanbaalenii_PYR-1 GVPTATPFTTTADSTNVFNIPANLFIALANTPYNFFTALGTGNVAL----
Mflv_3378|M.gilvum_PYR-GCK YEVEYAPIWTGPGYFGLGVEALREALTGNPGEETTIFAFSEGAVVASQWL
.
MMAR_0884|M.marinum_M -------------------LLG---PAHAGSAVLLVGEETASLSVLGGGD
MUL_0637|M.ulcerans_Agy99 -------------------LLG---PAHAGSAVLLVGEETASLSVLGGGD
Mb3909c|M.bovis_AF2122/97 -------------------AINSLVTATHGANVSLVAETAERVLESKNWK
Rv3879c|M.tuberculosis_H37Rv -------------------AINSLVTATHGANVSLVAETAERVLESKNWK
MSMEG_5322|M.smegmatis_MC2_155 -------------------LADTP--------------------------
MAB_0974|M.abscessus_ATCC_1997 -------------------PSSEPVDPPTGQPTDPPAADEPAPPTNFPGE
Mvan_2962|M.vanbaalenii_PYR-1 -------------------GSE----------------------------
Mflv_3378|M.gilvum_PYR-GCK EKHLEDPEAYPAPENLTFVVIGNPARKYGGSGTIWGRQWPTSPYQVIDVA
MMAR_0884|M.marinum_M AP------------------PTMLAAAPVEG-------------------
MUL_0637|M.ulcerans_Agy99 AP------------------PTMLAAAPVEG-------------------
Mb3909c|M.bovis_AF2122/97 PPKNALEDLLQQKSPPPPDVPTLVVPSPGTPGTPGTPGTPITPGTPITPG
Rv3879c|M.tuberculosis_H37Rv PPKNALEDLLQQKSPPPPDVPTLVVPSPGTPGTPGTP-------------
MSMEG_5322|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0974|M.abscessus_ATCC_1997 RPAFG---------------------------------------------
Mvan_2962|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3378|M.gilvum_PYR-GCK QQYDPTVDMPVNNLNVLATLNATMGFFTNHLGRGYSDVDIDDPANSRWEE
MMAR_0884|M.marinum_M -------------DATSTFDTLMAHLDDQGGAPGEVLLVGS--SEHTTVI
MUL_0637|M.ulcerans_Agy99 -------------DATSTFDTLMTHLDDEGGAPGEVLLVGS--SEHTTVI
Mb3909c|M.bovis_AF2122/97 TPITPGTPITPGTPITPIPGAPVTPITPTPGTPVTPVTPGKPVTPVTPVK
Rv3879c|M.tuberculosis_H37Rv --ITPGTPITPGTPITPIPGAPVTPITPTPGTPVTPVTPGKPVTPVTPVK
MSMEG_5322|M.smegmatis_MC2_155 ---------------------------EQLQSAVEKFSAGDVTGALETVL
MAB_0974|M.abscessus_ATCC_1997 -----------TPSYFAQLAFAVFHVVALPITVPVQFFLGS-AEGVPTVI
Mvan_2962|M.vanbaalenii_PYR-1 ------------------------------PDGGPSFQPGYEGVTLTQPD
Mflv_3378|M.gilvum_PYR-GCK DGIEYVFVPAKTLPLVEPLRWVGLGQLADELTPGLQYLIEQGYNRDDRIT
MMAR_0884|M.marinum_M ADQFRDA-------------------------STMR-VEVPEDPTFALAR
MUL_0637|M.ulcerans_Agy99 ADQFRDA-------------------------STMR-VEVPEDPTFALAR
Mb3909c|M.bovis_AF2122/97 PGTPGEP-------------------------TPITPVTPPVAPATPATP
Rv3879c|M.tuberculosis_H37Rv PGTPGEP-------------------------TPITPVTPPVAPATPATP
MSMEG_5322|M.smegmatis_MC2_155 QTVLGPV-------------------------VNGVVDTLLFNPDVWAGL
MAB_0974|M.abscessus_ATCC_1997 AAAINDL-------------------------SGLLGQIPGLSPQQPTEP
Mvan_2962|M.vanbaalenii_PYR-1 GNVVG------------------------------LGANLHYGGSWWVYS
Mflv_3378|M.gilvum_PYR-GCK GTTIDAPEKSWSYAPINFLEAIANIPYYSVAGTNRFANAMRASGSWWVYT
MMAR_0884|M.marinum_M GAAMAAAGAGSTMAQQVLGGDAG-EATTYLPPELAATAS---------GQ
MUL_0637|M.ulcerans_Agy99 GAAMAAAGAGSTMAQQVLGGDAG-EATTYLPPELAATAS---------GQ
Mb3909c|M.bovis_AF2122/97 ATPVTPAPAPHPQPAPAPAPSPGPQPVTPATPGPSGPATPGT-----PGG
Rv3879c|M.tuberculosis_H37Rv ATPVTPAPAPHPQPAPAPAPSPGPQPVTPATPGPSGPATPGT-----PGG
MSMEG_5322|M.smegmatis_MC2_155 QNAIRQPVANTLSVIDLLA-----EPEVYNVLG-----------------
MAB_0974|M.abscessus_ATCC_1997 QPQQIAQSSLPLQKLAAAETDPTTDPEPPAEPLPTNFPGPRP-----AFG
Mvan_2962|M.vanbaalenii_PYR-1 PTNILGTDAADVTRYQALVNVLVPFPALSVPLG-----------------
Mflv_3378|M.gilvum_PYR-GCK PTNVLGWDPANPEMTRAFVDFLVAIPSISTPMGMTADWWARANLPMNEGC
. .
MMAR_0884|M.marinum_M DEDEQLAYSQAGENELLPVTGADEYGDYGPDDDEFADDYEDEAPAGTRLS
MUL_0637|M.ulcerans_Agy99 DEDEQLAYSQAGENELLPVTGADEYGDYGPDDDEFADDYEDEAPAGTRLS
Mb3909c|M.bovis_AF2122/97 EPAPHVKPAALAEQPGVPGQHAGGGTQSGPAHADESAASVTPAAASGVPG
Rv3879c|M.tuberculosis_H37Rv EPAPHVKPAALAEQPGVPGQHAGGGTQSGPAHADESAASVTPAAASGVPG
MSMEG_5322|M.smegmatis_MC2_155 ---PLLAPVQLLTDLTDAVGAAGDDVFAGIKTGDLEKVANAVINLGPNFT
MAB_0974|M.abscessus_ATCC_1997 TPSYFAQLAFAVLHVLALPITVPVQAIIGKTEGVPSVIVAALNDLSSLLG
Mvan_2962|M.vanbaalenii_PYR-1 ----NMLAAVAASQLPMDEGCTGTGSGACENPSGILSKMFDVRHIAALFS
Mflv_3378|M.gilvum_PYR-GCK TGFPPCDNPAGITDQMFKVQLWDFFAPGGFTFTDPITPEYNPISDTEAFW
.
MMAR_0884|M.marinum_M SRSLLISNAVVAFAVIGFASLAVAVAVAIRPTASSEPVEGHQNAQPGKFM
MUL_0637|M.ulcerans_Agy99 SRSLLISNAVVAFAVIGFASLAVAVAVAIRPTAASEPVEGHQNAQPGKFM
Mb3909c|M.bovis_AF2122/97 ARAAAAAPSGTAVGAGARSSVGTAAASGAGSHAATGRAPVATSDKAAAPS
Rv3879c|M.tuberculosis_H37Rv ARAAAAAPSGTAVGAGARSSVGTAAASGAGSHAATGRAPVATSDKAAAPS
MSMEG_5322|M.smegmatis_MC2_155 YALLNGAPGMPGFSAGLLGPQGVVAG------------------------
MAB_0974|M.abscessus_ATCC_1997 QVPKPSAPVTDTKTTPQDSTSQQADKAAPTVDSASEKPGGATSGADAKAS
Mvan_2962|M.vanbaalenii_PYR-1 PDGYTFPESREGITCSEDGQCYVKDPDGREVPWSGQNVKLDPTSPFASFY
Mflv_3378|M.gilvum_PYR-GCK GQELGLTGDKVEWYGETVHPEPFGETKGFLDFLISTPEGIKTPTLQDQLN
.
MMAR_0884|M.marinum_M PLLPTQQQAPVPPPP---------PDAPTAGFQGGTIPTVQGVVPRQATP
MUL_0637|M.ulcerans_Agy99 PLLPTQQQAPVPPPP---------PDAPTAGFQGGTIPTVQGVVPRQATP
Mb3909c|M.bovis_AF2122/97 TRAASARTAPPARPPSTD--HIDKPDRSESADDGTPVSMIPVSAARAARD
Rv3879c|M.tuberculosis_H37Rv TRAASARTAPPARPPSTD--HIDKPDRSESADDGTPVSMIPVSAARAARD
MSMEG_5322|M.smegmatis_MC2_155 ------------------------------------LLTLRDMVADAIAP
MAB_0974|M.abscessus_ATCC_1997 KIERNEHEGKTADKAAEVPKAEHETKPGAASEETPKTDPAKEVVEPKVDP
Mvan_2962|M.vanbaalenii_PYR-1 DSLTATPDFSSIKPVT----------------LELVLASLGSLAQGLNTA
Mflv_3378|M.gilvum_PYR-GCK AFRNLADGLTTTWNPFVPKSYVWNPDMTPFAYLARPLAKILCPTCNAVDP
.
MMAR_0884|M.marinum_M TVPAPVAPAPAPAP-----------------GVVPAPIPLPIPIIIPPWP
MUL_0637|M.ulcerans_Agy99 TVPGPVAPAPAAAP-----------------GVVPAPIPLPIPIIIPPWP
Mb3909c|M.bovis_AF2122/97 AATAAASARQRGRG-----------------DALRLARRIAAALNASDNN
Rv3879c|M.tuberculosis_H37Rv AATAAASARQRGRG-----------------DALRLARRIAAALNASDNN
MSMEG_5322|M.smegmatis_MC2_155 ATTAAKTAAGTAAV-----------------AEPAALTRASVTLDVPKAL
MAB_0974|M.abscessus_ATCC_1997 AKVVESKTDPTKAV-----------------EPKADPTKVVEPQVVEPKV
Mvan_2962|M.vanbaalenii_PYR-1 YNPFVLGTQCNICA-----------------PFVPNPDNEPIPGPVFEDP
Mflv_3378|M.gilvum_PYR-GCK FMPEDWKVGLDVYPGAYIPPSVKDQYDPETGKYIGDPVDGLTDAEIAEWN
MMAR_0884|M.marinum_M N------WSPGMPTPSTVTVTPTT-----------PTTTAPSTVTPTTPT
MUL_0637|M.ulcerans_Agy99 N------WSPGMPTPSTVTVTPTT-----------PTTTAPSTLTPTTPT
Mb3909c|M.bovis_AF2122/97 AGDYGFFWITAVTTDGSIVVANSYGLAYIPDGMELPNKVYLASADHAIPV
Rv3879c|M.tuberculosis_H37Rv AGDYGFFWITAVTTDGSIVVANSYGLAYIPDGMELPNKVYLASADHAIPV
MSMEG_5322|M.smegmatis_MC2_155 VG---------------------------------PETPAAGAVTTPAEA
MAB_0974|M.abscessus_ATCC_1997 DP----------------------------AKAVEPKTDPAKAVEPKADA
Mvan_2962|M.vanbaalenii_PYR-1 D-----------------------------------TAETLTTSVVSAQT
Mflv_3378|M.gilvum_PYR-GCK EKAGLNDIVDETTDGTEETEESGDVSEDPADADTSLLSARSMATVDESSE
:
MMAR_0884|M.marinum_M TTAPSTVTPTTPTTTAPSTLTPTTPTTTVPSTVITPTTTAPITPTTVAPT
MUL_0637|M.ulcerans_Agy99 TTAPSTLTPSTPTTTAPSTLTPTTPTTTVPSTVITPTTTAPITPITVAPT
Mb3909c|M.bovis_AF2122/97 DEIARCATYPVLAVQAWAAFHDMTLRAVIGTAEQLASSDPGVAKIVLEPD
Rv3879c|M.tuberculosis_H37Rv DEIARCATYPVLAVQAWAAFHDMTLRAVIGTAEQLASSDPGVAKIVLEPD
MSMEG_5322|M.smegmatis_MC2_155 TTDAPAAATDTSTKQAPSATDAASASAASEAKPVADDSEEAITTPAKP--
MAB_0974|M.abscessus_ATCC_1997 AAEPAKPESSKPESSKAEVAKPVTAKPETKAQPAKPESAGPVKVTRDSLK
Mvan_2962|M.vanbaalenii_PYR-1 ETADVTETTETPDTAAAPVTPETAAAPVTTETPDAAEAAEALSAPVTAEE
Mflv_3378|M.gilvum_PYR-GCK DTGASDKKTDVISAAVQDLVDTFDKTPAAEDTEQGAETPAGSEEPTQPQD
. :
MMAR_0884|M.marinum_M TVNPTTVAP-----TTVAPTTQQTVVPQPTQETVAPLPTQQTVAPQPTIA
MUL_0637|M.ulcerans_Agy99 TVNPTTVAP-----TTVAPTTQQTVVPQPTQETVAPPPTQQTVAPQPTIA
Mb3909c|M.bovis_AF2122/97 DIPESGKMTGRSRLEVVDPSAAAQLADTTDQRLLDLLPPAPVDVNPPGDE
Rv3879c|M.tuberculosis_H37Rv DIPESGKMTGRSRLEVVDPSAAAQLADTTDQRLLDLLPPAPVDVNPPGDE
MSMEG_5322|M.smegmatis_MC2_155 --------------STVAKPKKVNAVKDIRNGIRGAIKNVRNGVKDAVAG
MAB_0974|M.abscessus_ATCC_1997 STPGETGTTG----GTKTTEGSKGSVTDSKTPAASTDTKVHDGLKPAVGA
Mvan_2962|M.vanbaalenii_PYR-1 VEEVEEAPAG---PKHRKPSATSETLKNVRDSINSTFSKLTDGLKKPSST
Mflv_3378|M.gilvum_PYR-GCK ETPAADADDDAGVDAEPVTTPRKPSSTTKSDVDASESADADATTSGTAGT
.
MMAR_0884|M.marinum_M PQPTQQAPEPPSGGSSGGSSGGGSSSGGGSSSGGGSSSGGGSSSGGGSSS
MUL_0637|M.ulcerans_Agy99 PQPTQQALEPPSGGSSGGSSGGGSSSGGGSSSGGGSSSG-----------
Mb3909c|M.bovis_AF2122/97 RHMLWFELMKPMTSTATGREAAHLRAFRAYAAHSQEIALHQAHTATDAAV
Rv3879c|M.tuberculosis_H37Rv RHMLWFELMKPMTSTATGREAAHLRAFRAYAAHSQEIALHQAHTATDAAV
MSMEG_5322|M.smegmatis_MC2_155 LSGKKAKPAKPVKQESSTKSGGSESDGGGSGGGAE---------------
MAB_0974|M.abscessus_ATCC_1997 KPDKPAD--KPSTEKSSSEKSGSSSEGSSHSSESKSHSSEGKSHSGSKD-
Mvan_2962|M.vanbaalenii_PYR-1 TDG-------TKAESTASEADSSNSDSGSDSGGSED--------------
Mflv_3378|M.gilvum_PYR-GCK SESSESEKSDTSSDSSASDSSASDSASSSDSSGSGAGSSGSGGSAGSGGG
. : . . .. .
MMAR_0884|M.marinum_M GGGSSSGGGSSSGGGSSSGGGSSSGGGSSSGRGSSSGGSSSGGHSSGGGS
MUL_0637|M.ulcerans_Agy99 -------------------------------RGSSSGGSSSGGHSSGGGS
Mb3909c|M.bovis_AF2122/97 QR----------------------VAVADWLYWQYVTGLLDRALAAAS--
Rv3879c|M.tuberculosis_H37Rv QR----------------------VAVADWLYWQYVTGLLDRALAAAC--
MSMEG_5322|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0974|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2962|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3378|M.gilvum_PYR-GCK SDD-----------------------------------------------