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VLSIPPRGKLGDMTVPHDVFSPAKLGPLTLRNRIIKAATFEASTPNALVTEDLITYHRLPAAGGVGMTTV AYCAVAPGGRTDGWQLWMRPEAVPGLRRLTDAVHAEGAAISAQIGHAGPVANARTNKATALAPVRFFNPL SMRFARKATADDIREVTEAHANAARLAIDSGFDAVEIHLGHNYLASSFLSPLINRRTDEFGGSLANRAKV ARGAVLAVKEAVGDRIAVTAKLNMSDGVRGGISIEESLQTAKWLEEDGGLDAIELTAGSSLLNPMFLFRG GAPIKEFARNFKPPLSWGMRMTGKKFMREYPYEEAYLMRDAKKFRDELTMPIILLGGITNRETMDRAMAE GFDFVAMGRALLAEPDLLNRIRADSSVKSICDHCNLCMPTIYNHTYCVRTGSPSPVSSGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4880 | - | - | 100% (410) | NADH:flavin oxidoreductase/NADH oxidase |
| M. gilvum PYR-GCK | Mflv_4553 | - | e-118 | 54.16% (397) | NADH:flavin oxidoreductase/NADH oxidase |
| M. gilvum PYR-GCK | Mflv_1689 | - | 4e-16 | 27.78% (234) | NADH:flavin oxidoreductase/NADH oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3394 | - | 1e-177 | 76.74% (387) | oxidoreductase |
| M. tuberculosis H37Rv | Rv3359 | - | 1e-177 | 76.74% (387) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3694 | - | 1e-162 | 70.76% (383) | oxidoreductase |
| M. marinum M | MMAR_1175 | - | 1e-178 | 77.27% (396) | oxidoreductase |
| M. avium 104 | MAV_4324 | - | 0.0 | 80.60% (397) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. smegmatis MC2 155 | MSMEG_1645 | - | 0.0 | 84.44% (392) | NADH:flavin oxidoreductase/NADH oxidase |
| M. thermoresistible (build 8) | TH_1966 | - | 0.0 | 88.31% (385) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1023 | fadH | 1e-22 | 33.07% (254) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. vanbaalenii PYR-1 | Mvan_1549 | - | 0.0 | 92.52% (401) | NADH:flavin oxidoreductase/NADH oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4880|M.gilvum_PYR-GCK MLSIPPRGKLGDMTVPHDVFSPAKLGPLTLRNRIIKAATFEASTPNALVT
Mvan_1549|M.vanbaalenii_PYR-1 --------MLCDMTVAPDVFSPAKLGPLTLRNRIIKAATFEASTPDALVT
TH_1966|M.thermoresistible__bu ------------------VFAPAKLGPLTLRNRIIKAATFEARTPDALVT
MSMEG_1645|M.smegmatis_MC2_155 --------MNTQPNVFTDVFSEAKLGPITLRNRIIKAATFEASTPDALVT
MMAR_1175|M.marinum_M --------MSP----TPDVLSPAQLGPLTLRNRVIKAATFEARTPNALVT
MAV_4324|M.avium_104 --------MPT----PPDVFSPAKLGPITLRNRIIKSATFEARTPDALVT
Mb3394|M.bovis_AF2122/97 --------MAPGSCEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVT
Rv3359|M.tuberculosis_H37Rv --------MAPGSCEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVT
MAB_3694|M.abscessus_ATCC_1997 --------MGSDAAGIPDVLAPARLGPITLRNRTIKAATFEAASPDAFVT
MUL_1023|M.ulcerans_Agy99 -----------MTSPYPNLLFPLDLGFTTLRNRVVMGSMHTGLEDRPKDT
:: ** ***** : .: . . . *
Mflv_4880|M.gilvum_PYR-GCK EDLITYHRLPAAGGVGMTTVA-YCAVAPGGRTDGWQLWMRPEAVPGLRRL
Mvan_1549|M.vanbaalenii_PYR-1 EDLITYHRLPAAGGVGMTTVA-YCAVAPGGRTDGWQLWMRPEAVPGLRRL
TH_1966|M.thermoresistible__bu DDLIEYHRLPAAGGVGMTTVA-YCAVSPGGRTDGWQLWMRPEAVPGLRRL
MSMEG_1645|M.smegmatis_MC2_155 EDLINYHRLPAAGGVGMTTVA-YCAVAPGGRTDGWQIWMRPEAVPGLQKL
MMAR_1175|M.marinum_M DDLIEYHRQPAAGGIAMTTVA-YCAVSPGGRTSGEQIWMRREAVPGLRRL
MAV_4324|M.avium_104 DDLIEYHRLPAAGGVGMTTVA-YCAVSPGGRTEGNGIWMRPEAVPGFRRL
Mb3394|M.bovis_AF2122/97 DDLIEYHRLPAAGGVAMTTVA-YCAVSPGGRTGGNQIWMRPHAVPGLRRL
Rv3359|M.tuberculosis_H37Rv DDLIEYHRLPAAGGVAMTTVA-YCAVSPGGRTGGNQIWMRPHAVPGLRRL
MAB_3694|M.abscessus_ATCC_1997 DDLIEYHRRPALGGVGMTTVA-YCAVAPEGRTEYGQVWMREEAIPGLRRL
MUL_1023|M.ulcerans_Agy99 DRLAEYFAERARGGVGMLITGGYAPNRTGWLYPFASELVTPAEARRHRRI
: * *. * **:.* .. *.. . : :::
Mflv_4880|M.gilvum_PYR-GCK TDAVHAEGAAISAQIGHAGPVANARTNKATALAPVRFFNPLSMRFARKAT
Mvan_1549|M.vanbaalenii_PYR-1 TDAIHAEGAAISAQIGHAGPVANARTNKAQALAPVRFFNPLSMRFAKKAT
TH_1966|M.thermoresistible__bu TDAVHAEGAAVSAQIGHAGPVANARTNKAQALAPIRFFNPLSMRFARKAT
MSMEG_1645|M.smegmatis_MC2_155 TEAVHAEGAAISAQIGHAGPVANARTNKAKALAPVRFFNPLSMRFAKKAT
MMAR_1175|M.marinum_M TEAIHAEGAAVSAQIGHAGPVADARSNKATALAPVRFFNPIAMRFAKRAT
MAV_4324|M.avium_104 TDAIHAEGAAVSAQIGHAGPVANARSNKAHALAPVRFFNPIGMRFAKKAT
Mb3394|M.bovis_AF2122/97 TEAIHAEGAAISAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKAT
Rv3359|M.tuberculosis_H37Rv TEAIHAEGAAISAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKAT
MAB_3694|M.abscessus_ATCC_1997 TDAIHDTGAAVSAQIGHAGPVANARSNGSPALSPIRFFNPLGMKFARRAS
MUL_1023|M.ulcerans_Agy99 TGAVHDADAKILLQVLHAG----RYAYHPLSVSASSIKAPINPFRSRKLT
* *:* .* : *: *** : . :::. : *: ::: :
Mflv_4880|M.gilvum_PYR-GCK ADDIREVTEAHANAARLAIDSGFDAVEIHLGHNYLASSFLSPLINRRTDE
Mvan_1549|M.vanbaalenii_PYR-1 REDIAEVTEAHANAARLAIDSGFDAVEIHLGHNYLASAFLSPLINRRTDE
TH_1966|M.thermoresistible__bu REDIREVTEAHATAAKLAVDAGFDAVEIHLGHNYLASSFLSPLLNRRTDE
MSMEG_1645|M.smegmatis_MC2_155 IDDIREVTAAHANAARLAIDSGFDAVEIHLGHNYLASSFLSPLINRRIDE
MMAR_1175|M.marinum_M RDDIDDVLAAHANAARLAVEAGFDAVEIHLGHNYLASSFLSPLINRRADE
MAV_4324|M.avium_104 REDIDEVIAAHANAARLAIEAGFDAVEIHLGHNYLASSFLSPLINRRNDE
Mb3394|M.bovis_AF2122/97 REDIDDVLAAHAHAARLAVDAGFDAVEIHLGHNYLASAFLSPLLNRRDDE
Rv3359|M.tuberculosis_H37Rv REDIDDVLAAHAHAARLAVDAGFDAVEIHLGHNYLASAFLSPLLNRRDDE
MAB_3694|M.abscessus_ATCC_1997 ASDIDGVIAAHANAARLAIEAGFDAVEIHLGHGYFVSSFLSPLFNRRGDE
MUL_1023|M.ulcerans_Agy99 SRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFLAPRTNQRTDS
.: . .* .*:** ::*:*.*** ...*: . **:* *:* *.
Mflv_4880|M.gilvum_PYR-GCK FGGSLANRAKVARGAVLAVKEAV----GDRIAVTAKLNMSDGVRGGISIE
Mvan_1549|M.vanbaalenii_PYR-1 FGGSLENRAKVARGVVLAVRRAV----GDQIAVTAKLNMSDGVRGGIPLE
TH_1966|M.thermoresistible__bu FGGSLENRAKVARGLVQAVKRAV----GDQIAVTAKLNMSDGVRGGITIE
MSMEG_1645|M.smegmatis_MC2_155 FGGSLENRAKVARGVVRAVRDAVDK-AGGTIAVTAKLNMSDGIRGGISLE
MMAR_1175|M.marinum_M FGGSLENRAKVARGLVRAVRGALDKDGISHVAVTAKLNMADGVRGGISTE
MAV_4324|M.avium_104 FGGSLQNRAKVARGMVMAVRRAVEKEGTP-IAVTAKLNMADGVRGGISTE
Mb3394|M.bovis_AF2122/97 FGGSLQNRAKVARGLVMAVRRAVR----QQVAVTAKLNMTDGIRGGITVD
Rv3359|M.tuberculosis_H37Rv FGGSLQNRAKVARGLVMAVRRAVR----QQVAVTAKLNMTDGIRGGITVD
MAB_3694|M.abscessus_ATCC_1997 YGGSLANRAKVARAVVQAVRKVAG----SRLAVTAKLTMTDGIRGGIPIE
MUL_1023|M.ulcerans_Agy99 WGGTPAKRRRFPVEIVRRTRAAVG----PDFIICYRMSMADYVEGGQSWD
:**: :* :.. * .: . . : ::.*:* :.** . :
Mflv_4880|M.gilvum_PYR-GCK ESLQTAKWLEEDGG---------------------------------LDA
Mvan_1549|M.vanbaalenii_PYR-1 ESLQTAKWLEEDGG---------------------------------LDA
TH_1966|M.thermoresistible__bu ESLQTAKWLEEDGG---------------------------------LDA
MSMEG_1645|M.smegmatis_MC2_155 ESLQTAKWLEEDGG---------------------------------LDA
MMAR_1175|M.marinum_M ESLRTAKWLEEDGG---------------------------------LDA
MAV_4324|M.avium_104 ESLTTAKWLESDGG---------------------------------LDA
Mb3394|M.bovis_AF2122/97 EALTTARWLQDDGG---------------------------------LDA
Rv3359|M.tuberculosis_H37Rv EALTTARWLQDDGG---------------------------------LDA
MAB_3694|M.abscessus_ATCC_1997 ESLQTATWLQEDGG---------------------------------LDA
MUL_1023|M.ulcerans_Agy99 EIVALATELESAGATIINSGFGWHEARIPTIVTSVPSGAFVEISNAVAEQ
* : * *:. *. :
Mflv_4880|M.gilvum_PYR-GCK IELTAGSS------LLNPMFLFRGGAPIKEFARNFKPPLSWGMRMTG---
Mvan_1549|M.vanbaalenii_PYR-1 LELTAGSS------LLNPMFLFRGGAPVKEFAGAFKPPLSWGIRMTG---
TH_1966|M.thermoresistible__bu IQLTAGSS------LVNPMYLFRGGAPVKEFAGAFKPPLSWGIRMTG---
MSMEG_1645|M.smegmatis_MC2_155 IELTAGSS------LVNPMYLFRGDAPVKEFAGAFKPPISWGMRTVG---
MMAR_1175|M.marinum_M IELTAGSS------LVNPMYLFRGDAPVKEFAAAFKPPMRWGVRMMG---
MAV_4324|M.avium_104 IELTAGSS------LVNPMYLFRGDAPLKEFAGAFKPPLRWGMRMTG---
Mb3394|M.bovis_AF2122/97 IELTAGSS------LVNPMYLFRGDAPVKEFAAAFKPPLRWGIRMTG---
Rv3359|M.tuberculosis_H37Rv IELTAGSS------LVNPMYLFRGDAPVKEFAAAFKPPLRWGIRMTG---
MAB_3694|M.abscessus_ATCC_1997 LELTAGSS------LVNPMYLFRGDVPIRELAKGFPKPMGWGVRLTG---
MUL_1023|M.ulcerans_Agy99 VSIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVLKAQSGRV
:.:.. :* * ...: .:* : * :: .
Mflv_4880|M.gilvum_PYR-GCK ---------------------------------KKFMREYPYE-------
Mvan_1549|M.vanbaalenii_PYR-1 ---------------------------------KKFMREYPYQ-------
TH_1966|M.thermoresistible__bu ---------------------------------TKFFREYPYH-------
MSMEG_1645|M.smegmatis_MC2_155 ---------------------------------KGFLREYPYR-------
MMAR_1175|M.marinum_M ---------------------------------KKFLREYPYR-------
MAV_4324|M.avium_104 ---------------------------------KKFLREYPYR-------
Mb3394|M.bovis_AF2122/97 ---------------------------------HRFFREYPYR-------
Rv3359|M.tuberculosis_H37Rv ---------------------------------HRFFREYPYR-------
MAB_3694|M.abscessus_ATCC_1997 ---------------------------------KKFFRSYPYH-------
MUL_1023|M.ulcerans_Agy99 DEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTMSPTQRARTVAV
:: * .
Mflv_4880|M.gilvum_PYR-GCK --------EAYLMRDAKKFRDELTMPIILLGGITNRETMDRAMAEGFDFV
Mvan_1549|M.vanbaalenii_PYR-1 --------EAYLMRDAKKFRDELKLPLILLGGITNRDTMDRAMAEGFDFV
TH_1966|M.thermoresistible__bu --------DAYLLRDARQFRAELTMPLILLGGITNRETMDRAMAEGFDFV
MSMEG_1645|M.smegmatis_MC2_155 --------EAYLLREAKQFRAELKLPLILLGGITNRDTMDQAMAEGFEFV
MMAR_1175|M.marinum_M --------DAYLLRDARLFRSELSMPLILLGGITNRETMDLAMAEGFEFV
MAV_4324|M.avium_104 --------EAYLLRDAKLFRAELKMPLILLGGITNRETMDLAMAEGFEFV
Mb3394|M.bovis_AF2122/97 --------DAYLLREARLFRAELTIPLILLGGITNRTTMDLAMAEGFEFV
Rv3359|M.tuberculosis_H37Rv --------DAYLLREARLFRAELTIPLILLGGITNRTTMDLAMAEGFEFV
MAB_3694|M.abscessus_ATCC_1997 --------DAFLLEDARRFRAELDIPLILLGGITGGESMDLAMAEGFEFV
MUL_1023|M.ulcerans_Agy99 VGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGKEEFNETI
* : : .* * . ::** . . * : :
Mflv_4880|M.gilvum_PYR-GCK AMGRALLAEP----DLLNRIRAD----SSVKSICDHCNLCMPTIYNHTYC
Mvan_1549|M.vanbaalenii_PYR-1 AMGRALLAEP----DLLNRIQAD----SSVKSICDHCNLCMPTIYSHTYC
TH_1966|M.thermoresistible__bu AMGRALLAEP----DLLNRIKAD----PGVQSICDHCNLCMPTIYSHTLC
MSMEG_1645|M.smegmatis_MC2_155 AMGRALLAEP----DLINRIKADGDA-HSVRSLCTHCNKCMPTIYTHTHC
MMAR_1175|M.marinum_M AMARALLAEP----DLINRIAAEG---NRVHSACTHCNQCMPTIYSRTRC
MAV_4324|M.avium_104 AMARALLAEP----DLINRIAADGAA-HRVHSACTHCNQCMPTIYSRTHC
Mb3394|M.bovis_AF2122/97 AMARALLAEP----DLVNRIAAEG---SQVRSACTHCNQCMATIYRRTHC
Rv3359|M.tuberculosis_H37Rv AMARALLAEP----DLVNRIAAEG---SQVRSACTHCNQCMATIYRRTHC
MAB_3694|M.abscessus_ATCC_1997 AMGRALLADP----DLVNRVAADR----ASHSRCTHCNQCMATIFSKTHC
MUL_1023|M.ulcerans_Agy99 RYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAPRIPAIPGIAHA
::**. * .* *: . :.:* : .
Mflv_4880|M.gilvum_PYR-GCK VRTGSP-SPVSSGR------------------------------------
Mvan_1549|M.vanbaalenii_PYR-1 VRTGSP-SPVSSGR------------------------------------
TH_1966|M.thermoresistible__bu VRTGMPDAAVKAGG------------------------------------
MSMEG_1645|M.smegmatis_MC2_155 VLTGAPDALVR---------------------------------------
MMAR_1175|M.marinum_M VVTGAPD-------------------------------------------
MAV_4324|M.avium_104 VVTGAPDRHTSAAT------------------------------------
Mb3394|M.bovis_AF2122/97 VVTGAP--------------------------------------------
Rv3359|M.tuberculosis_H37Rv VVTGAP--------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 VLT-----------------------------------------------
MUL_1023|M.ulcerans_Agy99 KVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLITESSPTLNLKEWKA
Mflv_4880|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1549|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1966|M.thermoresistible__bu --------------------------------------------------
MSMEG_1645|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1175|M.marinum_M --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mb3394|M.bovis_AF2122/97 --------------------------------------------------
Rv3359|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1023|M.ulcerans_Agy99 EWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKRLGKTSGWVHRA
Mflv_4880|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1549|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1966|M.thermoresistible__bu --------------------------------------------------
MSMEG_1645|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1175|M.marinum_M --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mb3394|M.bovis_AF2122/97 --------------------------------------------------
Rv3359|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1023|M.ulcerans_Agy99 SVKAKGVHQLSGVNYERISDDGLHISFGPDRQRPQLLAVDSVVICAGQEP
Mflv_4880|M.gilvum_PYR-GCK -------------------------------------------
Mvan_1549|M.vanbaalenii_PYR-1 -------------------------------------------
TH_1966|M.thermoresistible__bu -------------------------------------------
MSMEG_1645|M.smegmatis_MC2_155 -------------------------------------------
MMAR_1175|M.marinum_M -------------------------------------------
MAV_4324|M.avium_104 -------------------------------------------
Mb3394|M.bovis_AF2122/97 -------------------------------------------
Rv3359|M.tuberculosis_H37Rv -------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 -------------------------------------------
MUL_1023|M.ulcerans_Agy99 VRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTELAARL