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VKPAGDVATRVIPCLDVDGGRVVKGVNFANLRDAGDPVELAAAYDAEGADELTFLDVTASSSGRATMLDV VRRTAEQVFIPLTVGGGVRSVADVDALLRAGADKVSVNTAAIARPELLSELSRQFGSQCIVLSVDARTVP EGSQPTPSGWEVTTHGGRRGTGIDAVEWAVQGAELGVGEILLNSMDADGTKAGFDLEMLRAVRGAVTVPV IASGGAGAVEHFAPAVAAGADAVLAASVFHFGELTIGQVKAAMKAEGITVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2810 | - | - | 100% (261) | imidazole glycerol phosphate synthase subunit HisF |
| M. vanbaalenii PYR-1 | Mvan_2808 | - | 8e-16 | 25.00% (252) | 1-(5-phosphoribosyl)-5- |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1631 | hisF | 1e-126 | 88.37% (258) | imidazole glycerol phosphate synthase subunit HisF |
| M. gilvum PYR-GCK | Mflv_3607 | - | 1e-136 | 94.25% (261) | imidazole glycerol phosphate synthase subunit HisF |
| M. tuberculosis H37Rv | Rv1605 | hisF | 1e-127 | 88.76% (258) | imidazole glycerol phosphate synthase subunit HisF |
| M. leprae Br4923 | MLBr_01263 | hisF | 1e-119 | 85.88% (255) | imidazole glycerol phosphate synthase subunit HisF |
| M. abscessus ATCC 19977 | MAB_2664c | - | 1e-121 | 87.06% (255) | imidazole glycerol phosphate synthase, cyclase subunit HisF |
| M. marinum M | MMAR_2401 | hisF | 1e-126 | 89.41% (255) | cyclase HisF |
| M. avium 104 | MAV_3181 | hisF | 1e-126 | 89.80% (255) | imidazole glycerol phosphate synthase subunit HisF |
| M. smegmatis MC2 155 | MSMEG_3211 | hisF | 1e-128 | 88.51% (261) | imidazole glycerol phosphate synthase subunit HisF |
| M. thermoresistible (build 8) | TH_1157 | hisF | 1e-124 | 89.02% (255) | Probable cyclase hisF |
| M. ulcerans Agy99 | MUL_1578 | hisF | 1e-126 | 89.02% (255) | imidazole glycerol phosphate synthase subunit HisF |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2810|M.vanbaalenii_PYR-1 ---MKPA------GDVATRVIPCLDVDGGRVVKGVNFANLRDAGDPVELA
Mflv_3607|M.gilvum_PYR-GCK ---MKPA------SDVATRVIPCLDVDDGRVVKGVNFANLRDAGDPVELA
MAB_2664c|M.abscessus_ATCC_199 ---MS----------VATRVIACLDVDDGRVVKGVNFENLRDAGDPVELA
MSMEG_3211|M.smegmatis_MC2_155 ---MSAN------SDVATRVIPCLDVDNGRVVKGVNFENLRDAGDPVELA
TH_1157|M.thermoresistible__bu MTDNTAD------RKLAVRVIPCLDVDAGRVVKGVRFENLRDAGDPVELA
Mb1631|M.bovis_AF2122/97 ---MYADRDLPGAGGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELA
Rv1605|M.tuberculosis_H37Rv ---MYADRDLPGAGGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELA
MMAR_2401|M.marinum_M ---MYTD------TGLAVRVIPCLDVDAGRVVKGVNFENLRDAGDPVELA
MUL_1578|M.ulcerans_Agy99 ---MYTD------TGLAVRVIPCLDIDAGRVVKGVNFENLRDAGDPVELA
MLBr_01263|M.leprae_Br4923 ---MYSG------NGLAVRVIPCLDVYCGRVVKGVNFKNLRDAGDLVELA
MAV_3181|M.avium_104 ---MSPN-----SSGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELA
:*.***.***: *******.* ******* ****
Mvan_2810|M.vanbaalenii_PYR-1 AAYDAEGADELTFLDVTASSSGRATMLDVVRRTAEQVFIPLTVGGGVRSV
Mflv_3607|M.gilvum_PYR-GCK AAYDAEGADELTFLDVTASSSGRSTMLEVVRRTAEQVFIPLTVGGGVRSI
MAB_2664c|M.abscessus_ATCC_199 AAYDAEGVDELTFLDVTASSSGRATMLDVVRRTAEQVFIPLTVGGGVRSV
MSMEG_3211|M.smegmatis_MC2_155 AAYDAEGADELTFLDVTASSSGRSTMLEVVRRTAEQVFIPLTVGGGVRSV
TH_1157|M.thermoresistible__bu AVYDAEGADELCFLDVTASSSGRSTMLDVVRRTAEQVFIPLTVGGGVRSV
Mb1631|M.bovis_AF2122/97 AVYDAEGADELTFLDVTASSSGRATMLEVVRRTAEQVFIPLTVGGGVRTV
Rv1605|M.tuberculosis_H37Rv AVYDAEGADELTFLDVTASSSGRATMLEVVRRTAEQVFIPLTVGGGVRTV
MMAR_2401|M.marinum_M AAYDAEGADELTFLDVTASSSGRATMLEVVRHTAEQVFIPLTVGGGVRTV
MUL_1578|M.ulcerans_Agy99 AAYDAEGADELTFLDVTASSSGRATMLEVVRHTAEQVFIPLTVGGGVRTV
MLBr_01263|M.leprae_Br4923 AAYDAEGADELAFLDVTASSSGRATMLEVVRCTAEQVFIPLMVGGGVRTV
MAV_3181|M.avium_104 AVYDAEGADELTFLDVTASSSGRATMLDVVRRTAEQVFIPLTVGGGVRTV
*.*****.*** ***********:***:*** ********* ******::
Mvan_2810|M.vanbaalenii_PYR-1 ADVDALLRAGADKVSVNTAAIARPELLSELSRQFGSQCIVLSVDARTVPE
Mflv_3607|M.gilvum_PYR-GCK ADVDVLLRAGADKVSVNTAAIARPELLAELSRQFGSQCIVLSVDARTVPE
MAB_2664c|M.abscessus_ATCC_199 DDVNVLLRAGADKVGVNTAAIARPELLAELAQRFGSQCIVLSVDARRVRD
MSMEG_3211|M.smegmatis_MC2_155 DDVDVLLRAGADKVSVNTAAIARPELLAEMARQFGSQCIVLSVDARTVPK
TH_1157|M.thermoresistible__bu ADVDTLLRAGADKVSVNTAAIERPELLSELARQFGSQCIVLSVDARTVPE
Mb1631|M.bovis_AF2122/97 ADVDSLLRAGADKVAVNTAAIACLDLLADMARQFGSQCIVLSVDARTVPV
Rv1605|M.tuberculosis_H37Rv ADVDSLLRAGADKVAVNTAAIACPDLLADMARQFGSQCIVLSVDARTVPV
MMAR_2401|M.marinum_M ADVDLLLRAGADKVSVNTAAIARPDLLADMATQFGSQCIVLSVDARKVPV
MUL_1578|M.ulcerans_Agy99 ADVDLLLRAGADKVSVNTAAIARPDLLADMATQFGSQCIVLSVDARKVPV
MLBr_01263|M.leprae_Br4923 ADVDVLLRAGADKVAVNTAAIARPELLADMAGQFGSQCIVLSVDARTVPT
MAV_3181|M.avium_104 ADVDVLLRAGADKVSVNTAAIARPELLEEMARQFGSQCIVLSVDARTVPP
**: *********.****** :** ::: :************* *
Mvan_2810|M.vanbaalenii_PYR-1 GSQPTPSGWEVTTHGGRRGTGIDAVEWAVQGAELGVGEILLNSMDADGTK
Mflv_3607|M.gilvum_PYR-GCK GSTPTTSGWEVTTHGGRRGTGIDAVEWASQGAELGVGEILLNSMDADGTK
MAB_2664c|M.abscessus_ATCC_199 GDVPTSSGWEVTTHGGRRGTGIDAIEWTSRGAELGVGEILLNSMDADGTK
MSMEG_3211|M.smegmatis_MC2_155 GEQPTPSGWEVTTHGGRRGTGIDAIEWATRGAELGVGEILLNSMDRDGTK
TH_1157|M.thermoresistible__bu GSPPTSSGWEVTTHGGRRGTGIDAVEWAVRGAELGVGEILLNSMDRDGTK
Mb1631|M.bovis_AF2122/97 GSAPTPSGWEVTTHGGRRGTGMDAVQWAARGADLGVGEILLNSMDADGTK
Rv1605|M.tuberculosis_H37Rv GSAPTPSGWEVTTHGGRRGTGMDAVQWAARGADLGVGEILLNSMDADGTK
MMAR_2401|M.marinum_M GPAPTPSGWEVTTHGGRRGTGIDAVEWAARGADLGVGEILLNSMDADGTK
MUL_1578|M.ulcerans_Agy99 GSSPTPSGWEVTTHGGRRGTGIDAVEWAARGADLGVGEILLNSMDADGTK
MLBr_01263|M.leprae_Br4923 GSARTPSGWEATTHGGYRGTGIDAVEWAARGADLGVGEILLNSMDADGTK
MAV_3181|M.avium_104 GAVPTPSGWEVTTHGGRRGTGIDAVEWASRGADLGVGEILLNSMDADGTK
* *.****.***** ****:**::*: :**:************ ****
Mvan_2810|M.vanbaalenii_PYR-1 AGFDLEMLRAVRGAVTVPVIASGGAGAVEHFAPAVAAGADAVLAASVFHF
Mflv_3607|M.gilvum_PYR-GCK AGFDLKMLRAVRGAVTVPVIASGGAGAVEHFAPAVFAGADAVLAASVFHF
MAB_2664c|M.abscessus_ATCC_199 AGFDLEMIAAARAAVDVPVIASGGAGAIGHFAPAVQAGADAVLAASVFHF
MSMEG_3211|M.smegmatis_MC2_155 AGFDLKMLSAVRAAVSVPVIASGGAGAVEHFAPAVQAGADAVLAASVFHF
TH_1157|M.thermoresistible__bu DGFDLPMLRAVRGAVSIPIIASGGAGALEHFPAAVHAGADAVLAASVFHF
Mb1631|M.bovis_AF2122/97 AGFDLALLRAVRAAVTVPVIASGGAGAVEHFAPAVAAGADAVLAASVFHF
Rv1605|M.tuberculosis_H37Rv AGFDLALLRAVRAAVTVPVIASGGAGAVEHFAPAVAAGADAVLAASVFHF
MMAR_2401|M.marinum_M AGFDLAMLRAVRAAVTVPVIASGGAGNVDHFAPAVAAGADAVLAASVFHF
MUL_1578|M.ulcerans_Agy99 AGFDLAMLRAVRAAVTVPVIASGGAGNVDHFAPAVAAGADAVLAASVFHF
MLBr_01263|M.leprae_Br4923 AGFDLAMLRAVRAAVTVPVIASGGAGAIEHFVPAVTAGADAVLAASVFHF
MAV_3181|M.avium_104 AGFDLEMLQAVRSAVTVPVIASGGAGAAEHFAPAIEAGADAVLAASVFHF
**** :: *.*.** :*:******* ** .*: **************
Mvan_2810|M.vanbaalenii_PYR-1 GELTIGQVKAAMKAEGITVR---
Mflv_3607|M.gilvum_PYR-GCK GDLTIGEVKAAMKAEGIVVR---
MAB_2664c|M.abscessus_ATCC_199 RELTIGEVKAAMAAEGITVR---
MSMEG_3211|M.smegmatis_MC2_155 RELTVAEVKASMKAAGITVR---
TH_1157|M.thermoresistible__bu RELTIKQVKEAMAAEGITVR---
Mb1631|M.bovis_AF2122/97 RELTIGQVKAALAAEGITVR---
Rv1605|M.tuberculosis_H37Rv RELTIGQVKAALAAEGITVR---
MMAR_2401|M.marinum_M RELTIGQVKAAMAAEGITVR---
MUL_1578|M.ulcerans_Agy99 RELTIGQVKAAMAAEGNTVR---
MLBr_01263|M.leprae_Br4923 RELTIGQVKDAMAAAGIAVR---
MAV_3181|M.avium_104 RELTIGQVKAAMAEAGIPVRMVR
:**: :** :: * **