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VWRQRADVVIVGTGVAGLAAALAAHRRGRRVVLLSKASETATFYAQGGIAVVLPDALREGGDSVDAHVAD TLAAGAGLCDPQSVRSIVADGYRAVAELVSAGARFDETVPGRWALTREGGHTRRRIIHSGGDATGAEVQR ALDHAAATLDIRRNHVALDLLVDDGAVTGVTVLSGDGLGVVYAPSVILATGGSGHLYSATTNPDGSTGDG VALAMWAGLPVSDLEFIQFHPTMLYAGHGGGRRPLITEALRGEGAKLIDRQGESVTDGVHPMGDLAPRDV VAAAIEARLSEAGDPCVYLDATGVADFERRFPTVNASCLQAGIDATRQPIPVVPGAHYSCGGVVTDVHGR TGVAGLFAAGEVARTGMHGANRLASNSLLEGLVVGGRAGVAAAEHAEQTGPARVVEAAVPTRPALPRAEL QRAMTRHASVVRSGEGLRELTEQLESATPRALRSRSDFEDAALTAVAGAVTAAASARTESRGCHHRSDFP EPDPAQAVSTVFGADHAPVAVGCR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2799 | - | - | 100% (514) | L-aspartate oxidase |
| M. vanbaalenii PYR-1 | Mvan_1587 | sdhA | 3e-61 | 33.94% (548) | succinate dehydrogenase flavoprotein subunit |
| M. vanbaalenii PYR-1 | Mvan_0284 | sdhA | 1e-49 | 31.28% (569) | succinate dehydrogenase flavoprotein subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1621 | nadB | 0.0 | 70.82% (514) | L-aspartate oxidase |
| M. gilvum PYR-GCK | Mflv_3618 | - | 0.0 | 81.64% (512) | L-aspartate oxidase |
| M. tuberculosis H37Rv | Rv1595 | nadB | 0.0 | 70.82% (514) | L-aspartate oxidase |
| M. leprae Br4923 | MLBr_01226 | nadB | 0.0 | 67.79% (506) | L-aspartate oxidase |
| M. abscessus ATCC 19977 | MAB_2673c | - | 0.0 | 66.60% (503) | L-aspartate oxidase |
| M. marinum M | MMAR_2392 | nadB | 0.0 | 69.14% (499) | l-aspartate oxidase NadB |
| M. avium 104 | MAV_3190 | nadB | 0.0 | 69.94% (509) | L-aspartate oxidase |
| M. smegmatis MC2 155 | MSMEG_3200 | nadB | 0.0 | 70.59% (510) | L-aspartate oxidase |
| M. thermoresistible (build 8) | TH_0808 | nadB | 1e-159 | 72.41% (395) | L-aspartate oxidase |
| M. ulcerans Agy99 | MUL_1569 | nadB | 0.0 | 69.34% (499) | L-aspartate oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1621|M.bovis_AF2122/97 -----------MAGPAWRDAADVVVIGTGVAGLAAALAADRAGRSVVVLS
Rv1595|M.tuberculosis_H37Rv -----------MAGPAWRDAADVVVIGTGVAGLAAALAADRAGRSVVVLS
MMAR_2392|M.marinum_M ----------MRTSPTWRDAADVVVIGTGVAGLAAALSAHRAGRSVVLLN
MUL_1569|M.ulcerans_Agy99 ----------MRTSPTWRDAADVVVIGTGVAGLAAALSAHRAGRSVVLLN
MLBr_01226|M.leprae_Br4923 ----------MMAVPDWKHAADVVVIGTGVAGLAAALAAHRAGRNVVVLT
MAV_3190|M.avium_104 ----------MIARPQWTHSADVVVIGTGVAGLAAALAAHRADRSVVVLS
Mvan_2799|M.vanbaalenii_PYR-1 ---------------MWRQRADVVIVGTGVAGLAAALAAHRRGRRVVLLS
Mflv_3618|M.gilvum_PYR-GCK -----MTGCG--GAGGWRRRADVVIVGTGVAGLAAALAAHRRGLRVVLLS
MSMEG_3200|M.smegmatis_MC2_155 MTGAGTFACG--TSAYWQQRTDVVVIGTGVAGLVAALAAHRAGRRVTVLS
TH_0808|M.thermoresistible__bu MIHR--FGCGGSGSVAWQQRADVVVIGTGVAGLVAARAAGRAGRRVVVLS
MAB_2673c|M.abscessus_ATCC_199 --------MTMPAGTTWRTDADVVVVGAGVAGLAAALAVHRRGRKVVVLS
* :***::*:*****.** :. * . *.:*.
Mb1621|M.bovis_AF2122/97 KAAQTH-VTATHYAQGGIAVVLPD----NDDSVDAHVADTLAAGAGLCDP
Rv1595|M.tuberculosis_H37Rv KAAQTH-VTATHYAQGGIAVVLPD----NDDSVDAHVADTLAAGAGLCDP
MMAR_2392|M.marinum_M KAADTVGATATHYAQGGIAVVLPG----SDDSVDAHVADTVTAGAGLCDL
MUL_1569|M.ulcerans_Agy99 KATDTVGATATHYAQGGIAVVLPG----GDDSVDAHVADTVTAGAGLCDL
MLBr_01226|M.leprae_Br4923 KADQRRGETATHYAQGGIAVVLPG----SDDSVDAHASDTLAAGAGMCNL
MAV_3190|M.avium_104 KADQARGATATHYAQGGIAVVLPH----NDDSVEAHVADTVVAGAGLCDP
Mvan_2799|M.vanbaalenii_PYR-1 K----ASETATFYAQGGIAVVLPDALREGGDSVDAHVADTLAAGAGLCDP
Mflv_3618|M.gilvum_PYR-GCK K----AAETATFYAQGGIAVVLPDVLRDGGDSVDAHVADTLAAGAGLCDP
MSMEG_3200|M.smegmatis_MC2_155 K----VSETATFYAQGGIAVVLPAGVGSADDTIEAHVADTLAAGGGLCDA
TH_0808|M.thermoresistible__bu KT-DDIGQTATRYAQGGIAVVLPD----TDDSVDVHVADTLAAGGGLCDP
MAB_2673c|M.abscessus_ATCC_199 K----VGATATHFAQGGIAVVLPD----SQDSIEAHVLDTLSAGAGLCDA
* *** :********** *:::.*. **: **.*:*:
Mb1621|M.bovis_AF2122/97 DAVYSIVADGYRAVTDLVGAGARLDESVPGRWALTREGGHSRRRIVHAGG
Rv1595|M.tuberculosis_H37Rv DAVYSIVADGYRAVTDLVGAGARLDESVPGRWALTREGGHSRRRIVHAGG
MMAR_2392|M.marinum_M EAVYSIVADGFRAVTDLVGDGAKFDETSTGRWALTREGGHSRRRIVHAGG
MUL_1569|M.ulcerans_Agy99 EAVYSIVADGFRAVTDLVGDGAKFDETSTGRWALTREGGHSRRRIVHAGG
MLBr_01226|M.leprae_Br4923 DTVYSIVAEGYHAVTELVGYGARFDESIPGRWAVTCEGGHSRRRIVHAGG
MAV_3190|M.avium_104 QAVYSIVADGYAAVSELVGDGARFDESAPGQWALTREGGHSRRRIVHAGG
Mvan_2799|M.vanbaalenii_PYR-1 QSVRSIVADGYRAVAELVSAGARFDETVPGRWALTREGGHTRRRIIHSGG
Mflv_3618|M.gilvum_PYR-GCK AAVRSIVADGFDAVTELVAAGARFDESEPGRWALTREGGHSRRRIIHAGG
MSMEG_3200|M.smegmatis_MC2_155 EAVRSIVADGAKAITDLVADGALFDESAPGRWALTREGGHTRRRIIHAGG
TH_0808|M.thermoresistible__bu RIVRSIVADGYAAVCDLIGAGARFDRAASGGWARTREGGHTRRRVIHAGG
MAB_2673c|M.abscessus_ATCC_199 EAVRSIVSDGYRAVRDLVADGARFDESRSGQWALTREGGHSARRIIHAGG
* ***::* *: :*:. ** :*.: .* ** * ****: **::*:**
Mb1621|M.bovis_AF2122/97 DATGAEVQRALQDAAGMLDIRTGHVALRVLHDG----TAVTGLLVVRPDG
Rv1595|M.tuberculosis_H37Rv DATGAEVQRALQDAAGMLDIRTGHVALRVLHDG----TAVTGLLVVRPDG
MMAR_2392|M.marinum_M DATGAEVQRALDQAAGLLDIRASHVALRILHDD----TAVTGVLVLNPNG
MUL_1569|M.ulcerans_Agy99 DATGAEVQRALDQAAGLLDIRASHVALRILHDD----TAVTGVLVLNPNG
MLBr_01226|M.leprae_Br4923 DATGAEVQRALDHAADVLDIRTSHLALRVLHDG----TVVNGVSVLNPNG
MAV_3190|M.avium_104 DATGAEVQRALDHAARMLDIRTAHVALRVLHDGSMGDEAVTGVLVGNPHG
Mvan_2799|M.vanbaalenii_PYR-1 DATGAEVQRALDHAAATLDIRRNHVALDLLVDD----GAVTGVTVLSGDG
Mflv_3618|M.gilvum_PYR-GCK DATGAEVQKALDLAAASLDIRRNHVALDLILDG----GAIAGVTVLSDDG
MSMEG_3200|M.smegmatis_MC2_155 DATGAEVQRTLNHAAAHLDIRHNHVALRILQDE----AGVTGVLVHNDDG
TH_0808|M.thermoresistible__bu DATGVEVQRALEAAAAGLDIRCRHQAVQVLVRD----GAVAGVLVRNDDG
MAB_2673c|M.abscessus_ATCC_199 DATGAEVQRALDHAAAMLDVRRSHVVHDILVGP----EGVGGVLVGNSDG
****.***::*: ** **:* * . :: : *: * .*
Mb1621|M.bovis_AF2122/97 CGIISAPSVILATGGLGHLYSATTNPAGSTGDGIALGLWAGVAVSDLEFI
Rv1595|M.tuberculosis_H37Rv CGIISAPSVILATGGLGHLYSATTNPAGSTGDGIALGLWAGVAVSDLEFI
MMAR_2392|M.marinum_M VGIISAPSVILATGGLGQLYSATTNPDGATGDGIALALWAGVTVSDLEFI
MUL_1569|M.ulcerans_Agy99 VGIISAPSVILATGGLGQLYSATTNPDGATGDGIALALWAGVTVSDLEFI
MLBr_01226|M.leprae_Br4923 WGIVSAPSVILASGGLGHLYGATTNPEGSTGDGIALALWAGVAVSDLEFI
MAV_3190|M.avium_104 YGIISAPSVILASGGLGHLYGATTNPEGSTGDGIALGLWAGVAVSDLEFI
Mvan_2799|M.vanbaalenii_PYR-1 LGVVYAPSVILATGGSGHLYSATTNPDGSTGDGVALAMWAGLPVSDLEFI
Mflv_3618|M.gilvum_PYR-GCK VGAVYAPSVILATGGLGHLYSATTNPDGSTGDGVALAIWAGLPVGDLEFI
MSMEG_3200|M.smegmatis_MC2_155 PGILHAPSVVLATGGLGHLYAATTNPVGSTGDGIALALWAGVAVSDIEFV
TH_0808|M.thermoresistible__bu LGVLHTPAVVIATGGLGQLYTATTNPDGSTGDGVALALTAGAAVSDLEFI
MAB_2673c|M.abscessus_ATCC_199 IGVIHAGAVVLATGGLGHLYSATTNPEGSTGDGIALALRAGVSVADIEFI
* : : :*::*:** *:** ***** *:****:**.: ** .*.*:**:
Mb1621|M.bovis_AF2122/97 QFHPTMLFAGRAG--GRRPLITEAIRGEGAILVDRQGNSITAGVHPMGDL
Rv1595|M.tuberculosis_H37Rv QFHPTMLFAGRAG--GRRPLITEAIRGEGAILVDRQGNSITAGVHPMGDL
MMAR_2392|M.marinum_M QFHPTMLFDGSSG--GRRPLITEAIRGEGAILLDRQGRSITAGVHPLGDL
MUL_1569|M.ulcerans_Agy99 QFHPTMLFYGSSG--GRRPLITEAIRGEGAILLDRQGRSITAGVHPLGDL
MLBr_01226|M.leprae_Br4923 QFHPTMLFAAGTGTGGRRPLVTEAIRGEGAILLDSKGNSVTSGVHPLGDL
MAV_3190|M.avium_104 QFHPTMLFAPGAG-GGRRPLVTEAIRGEGAKLIDSQGDSVTAGVHPMGDL
Mvan_2799|M.vanbaalenii_PYR-1 QFHPTMLYAGHGG--GRRPLITEALRGEGAKLIDRQGESVTDGVHPMGDL
Mflv_3618|M.gilvum_PYR-GCK QFHPTMLYAGAGI--GRRPLITEALRGEGAKLVDRQGRSVTDGVHPMGDL
MSMEG_3200|M.smegmatis_MC2_155 QFHPTMLFGAAAG--GRRPLITEALRGEGAVLIDAQGHPVTAGVHPMGDL
TH_0808|M.thermoresistible__bu QFHPTMLFDGASG--GRRPLITEAVRGEGATLVDARGEPVMAGIHPMGDL
MAB_2673c|M.abscessus_ATCC_199 QFHPTMLHTPDAA--GCRPLISEAVRGEGAVLVDARGDSVTAGVHPQGDL
*******. * ***::**:***** *:* :* .: *:** ***
Mb1621|M.bovis_AF2122/97 APRDVVAAAIDARLKATGDPCVYLDARGIEGFASRFPTVTASCRAAGIDP
Rv1595|M.tuberculosis_H37Rv APRDVVAAAIDARLKATGDPCVYLDARGIEGFASRFPTVTASCRAAGIDP
MMAR_2392|M.marinum_M APRDVVAAAIDARMKANGDPCAYLDARSIKGFESRFPTVTASCRAAGIDP
MUL_1569|M.ulcerans_Agy99 APRDVVAAAIDARMKANGDPCAYLDARSIKGFESRFPTVTASCRAAGIDP
MLBr_01226|M.leprae_Br4923 APRDVVAAAIDARLKATGDSCVYLDARGIDGFASRFPTVTAACRTVGIDP
MAV_3190|M.avium_104 APRDVVAAAIDARLKATGDACVYLDARHIFDFADRFPTVTAACRAAGIDP
Mvan_2799|M.vanbaalenii_PYR-1 APRDVVAAAIEARLSEAGDPCVYLDATGVADFERRFPTVNASCLQAGIDA
Mflv_3618|M.gilvum_PYR-GCK APRDVVAAAIEARLSETGDECVYLDARGIADFPTRFPTVTASCLEAGIDP
MSMEG_3200|M.smegmatis_MC2_155 APRDVVAAAINARLAATGDPCVYLDARGVAGVADRFPTVTAACLAAGIDP
TH_0808|M.thermoresistible__bu APRDVVAAAIEARLAATGDPCVFLDARRVADFPRRFPTVTAVCHAAGCDP
MAB_2673c|M.abscessus_ATCC_199 APRDVVAGAIARRLRESGDQCVYLDARAIGNFAIRFPTITAACAAAGIDP
*******.** *: ** *.:*** : .. ****:.* * .* *.
Mb1621|M.bovis_AF2122/97 VRQPIPVVPGAHYSCGGIVTDVYGQTELLGLYAAGEVARTGLHGANRLAS
Rv1595|M.tuberculosis_H37Rv VRQPIPVVPGAHYSCGGIVTDVYGQTELLGLYAAGEVARTGLHGANRLAS
MMAR_2392|M.marinum_M VRQPIPVVPGAHYSCGGVITDVYGNTELPGLFAAGEVARTGMHGANRLAS
MUL_1569|M.ulcerans_Agy99 VRQPIPVVPGAHYSCGGVITDVYGNTELPGLFAAGEVARTGMHGANRLAS
MLBr_01226|M.leprae_Br4923 AREPIPVVPGAHYSCGGIVTDAYGQTELAGLFAAGEVARTGMHGANRLAS
MAV_3190|M.avium_104 VRQPIPVVPGAHYSCGGVVTDVYGRTELPGLFAAGEVARTGLHGANRLAS
Mvan_2799|M.vanbaalenii_PYR-1 TRQPIPVVPGAHYSCGGVVTDVHGRTGVAGLFAAGEVARTGMHGANRLAS
Mflv_3618|M.gilvum_PYR-GCK VRQPIPVVPGAHYSCGGVVTDVDGRTGISGLFAAGEVARTGMHGANRLAS
MSMEG_3200|M.smegmatis_MC2_155 AREPIPVVPGAHYSCGGVVTDVYGRTALPGLFAAGEVARTGMHGANRLAS
TH_0808|M.thermoresistible__bu VRQPIPVVPGAHYSCGGIDTDDQGRSTVPGLFAAGECARTGMHGANRLAS
MAB_2673c|M.abscessus_ATCC_199 SVQLIPVVPGAHYSCGGVVTDPYGHTEVAGLFAAGEVARTGMHGANRLAS
: *************: ** *.: : **:**** ****:********
Mb1621|M.bovis_AF2122/97 NSLLEGLVVGGRAGKAAAAHAAAAGRSRATSSATWPEPISYTALDRGDLQ
Rv1595|M.tuberculosis_H37Rv NSLLEGLVVGGRAGKAAAAHAAAAGRSRATSSATWPEPISYTALDRGDLQ
MMAR_2392|M.marinum_M NSLLEGLVVGGRAGKGAAAHAAAAG----LAHATMPEPIAHTAPRRDDLQ
MUL_1569|M.ulcerans_Agy99 NSLLEGLVVGGRAGKGAAAHAAAAG----LAHATMPEPIAHTAPRRDDLQ
MLBr_01226|M.leprae_Br4923 NSLLEGLVVGGRAGRAAAAHAAAAG----RAYVSKLEPVTHHALKRRELQ
MAV_3190|M.avium_104 NSLLEGLVVGGRAGRAAAAHAAEAG----RPRALAPEPVAHTAPPRAELQ
Mvan_2799|M.vanbaalenii_PYR-1 NSLLEGLVVGGRAGVAAAEHAEQTG----PARVVEAAVPTRPALPRAELQ
Mflv_3618|M.gilvum_PYR-GCK NSLLEGLVVGRRAGTAAAEHATVAG----PTRIVDPGPQVRPALPRAELQ
MSMEG_3200|M.smegmatis_MC2_155 NSLLEGLVVGSRAGRAAAAHAEQAG----SVRAVVPQQVRRDAVDRQVLQ
TH_0808|M.thermoresistible__bu NSLLEGLVMGX---------------------XAAPRSAR----------
MAB_2673c|M.abscessus_ATCC_199 NSLLEGLVVGRRAGEAAARIADRAG-------VVDERDPAPPRLDRRRLQ
********:*
Mb1621|M.bovis_AF2122/97 RAMSRDASMYRAAAGLHRLCDSLSGAQVRDVA----CRRDFEDVALTLVA
Rv1595|M.tuberculosis_H37Rv RAMSRDASMYRAAAGLHRLCDSLSGAQVRDVA----CRRDFEDVALTLVA
MMAR_2392|M.marinum_M RAMSRDASVVRDAAGLHRLAEMLDG-PTRGIA----DRNDFEDVALALAA
MUL_1569|M.ulcerans_Agy99 RAMSRDASVVRDAAGLHRLAEMLDG-PTRGIA----DRNDFEDVALALAA
MLBr_01226|M.leprae_Br4923 RVMSRDAAVMRNAAGLQRLSDTLAEAPIRHVT----GRRDFEDVALTLTA
MAV_3190|M.avium_104 AAMSRDASVVRDAAGLTRLSATLSQAPARSIG----GRRDFEDVALAVAA
Mvan_2799|M.vanbaalenii_PYR-1 RAMTRHASVVRSGEGLRELTEQLESATPRALR----SRSDFEDAALTAVA
Mflv_3618|M.gilvum_PYR-GCK AAMTRYASVVRTADGLHRIRDLVGTAPVRNLR----NRNDFEDAALTAVA
MSMEG_3200|M.smegmatis_MC2_155 AAMSTHASVVRDAQGLHRLAETLDAARAVVPS----DRASFEDAALTSVA
TH_0808|M.thermoresistible__bu --------------------------------------------------
MAB_2673c|M.abscessus_ATCC_199 SAMTRWASVLRDADGLGLLEAELRCGTVSPVDPARMTPRDVEDAALTLTA
Mb1621|M.bovis_AF2122/97 QSVTAAALARTESRGCHHRAEYPCTVPEQARSIVVRGADDANAVCVQALV
Rv1595|M.tuberculosis_H37Rv QSVTAAALARTESRGCHHRAEYPCTVPEQARSIVVRGADDANAVCVQALV
MMAR_2392|M.marinum_M RVVGAGALARNESRGCHHRAEYPDVVPEQGRGIVVRLAGDQDTVCVEALA
MUL_1569|M.ulcerans_Agy99 RVVGAGALARNESRGCHHRAEYPDVVPEQGRGIVVRLAGDQDTVCVEALA
MLBr_01226|M.leprae_Br4923 RAVAAAALARNESRGCHHCTEYPDTAPEHARSTVIRLADDQNLVRAEALA
MAV_3190|M.avium_104 RAVAAAALARTESRGCHHREEHPQAAPEQARSNLLRLADDQNSVLVQALA
Mvan_2799|M.vanbaalenii_PYR-1 GAVTAAASARTESRGCHHRSDFPEPDPAQAVSTVFGADHAPVAVGCR---
Mflv_3618|M.gilvum_PYR-GCK SAVADAALARTETRGCHHRSDHPLTDPAQAVSIASG--LAPATVGC----
MSMEG_3200|M.smegmatis_MC2_155 RAVVRAATARTESRGSHHRGDFPDTDPTQEVSMTVRIHDGDVAVDIPTAV
TH_0808|M.thermoresistible__bu --------------------------------------------------
MAB_2673c|M.abscessus_ATCC_199 QAVATAAAARTESRGCHARSDWPRTDSHFAVSLPVRRDADGCEVALPSGV
Mb1621|M.bovis_AF2122/97 AVC
Rv1595|M.tuberculosis_H37Rv AVC
MMAR_2392|M.marinum_M AVG
MUL_1569|M.ulcerans_Agy99 AVG
MLBr_01226|M.leprae_Br4923 TVG
MAV_3190|M.avium_104 AVV
Mvan_2799|M.vanbaalenii_PYR-1 ---
Mflv_3618|M.gilvum_PYR-GCK ---
MSMEG_3200|M.smegmatis_MC2_155 C--
TH_0808|M.thermoresistible__bu ---
MAB_2673c|M.abscessus_ATCC_199 PC-