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RRLVPAVVLSMAVVLPLAACSPGLAANPRFATDSGAGPQGSPQTSDQPPGPPGVEAPKNDLSWRDCTSRV FASAAVQPLGGVKLDCASYDADLDPINGATGTVSIGVVRATSVETPADAGPLVMTTGSDLPSSVQLPVWL SRAGSDVLKSHPIVSVDRRGIGMSGALDCRDLFDRQEMFEQAQFQSGDDPVANLGAITMTATTSCTDTIA PGDSAYDNSHAAEDIERLRTTWDVPTLALLGIGNGAQVALAYAGSHPNKVARLVLDSPLPLGISAEAATE QRVKGEQAALDAWAAQCVATNCPLGPDPKAAVDALLTAARQGNGPGGASVAAVADAISTALGYPRGGRVD AGTELALAIADARSGDTNRLNNLINQAETLRQTDGQFVNTCSDALNRPTPDRVRELVVAWGKMYPQFGTV GALDMVKCLNWPSGSAPKEPSELEIPTLLLGVANNPIVGNEGVAAVAATAINAGSSNRRVMWQGIGHGAT IYSSCALPPVLEYLKSGELPSTDTYCPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2489 | - | - | 100% (519) | TAP domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3599 | - | 1e-14 | 24.16% (505) | TAP domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3600 | - | 3e-14 | 23.50% (549) | TAP domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2691 | - | 0.0 | 70.52% (502) | secreted protease |
| M. gilvum PYR-GCK | Mflv_3914 | - | 0.0 | 90.75% (519) | TAP domain-containing protein |
| M. tuberculosis H37Rv | Rv2672 | - | 0.0 | 70.32% (502) | secreted protease |
| M. leprae Br4923 | MLBr_01339 | - | 0.0 | 65.70% (519) | putative secreted protease |
| M. abscessus ATCC 19977 | MAB_2977 | - | 1e-176 | 58.99% (517) | hypothetical protein MAB_2977 |
| M. marinum M | MMAR_2044 | - | 0.0 | 66.54% (523) | hypothetical protein MMAR_2044 |
| M. avium 104 | MAV_3564 | - | 0.0 | 70.33% (519) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_2786 | - | 0.0 | 74.42% (516) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_1513 | - | 1e-145 | 70.87% (357) | POSSIBLE SECRETED PROTEASE |
| M. ulcerans Agy99 | MUL_1332 | - | 2e-11 | 22.78% (439) | exported protease |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2489|M.vanbaalenii_PYR-1 ------MR-RLVPAVVLSMAVV-----LPLAACSPGLAANPRFATDSGAG
Mflv_3914|M.gilvum_PYR-GCK ------MR-RVVRAVVLSLAVV-----LPLSACSPGLAANPRYATDSGAG
MSMEG_2786|M.smegmatis_MC2_155 ---MVPMRDQLVRALRVSGVVVPVMSLAVLTACTPMFAADPRYATDSGAH
Mb2691|M.bovis_AF2122/97 MATVVGMSRPMTSTAMLVALTCSA--T-VLAACVPAFGADPRFATYSGAG
Rv2672|M.tuberculosis_H37Rv MATVVGMSRPMTSTAMLVALTCSA--T-VLAACVPAFGADPRFATYSGAG
MMAR_2044|M.marinum_M ------MSRRLPSTPILVAVAFSV--TTVLAACVPVLGADPRFATNTGAR
MLBr_01339|M.leprae_Br4923 MATVVGMRWHTRSATILVAV------TALLVGCVPGLAANPRFATNSGAR
MAV_3564|M.avium_104 ---MVGMSRPHPCATILVAV------TALLAGCVPGLAADPRFATNSGAR
MAB_2977|M.abscessus_ATCC_1997 ------MRARLMGVMAVAQLLTG-----VLAGCAPGPSAGPHFAMDEGHG
TH_1513|M.thermoresistible__bu -----------VSAVALSTV---------VAGCAPGLAANPRYATDSGAA
MUL_1332|M.ulcerans_Agy99 ----MFLSRRDKLARMLLIWTAIASVALVLTGCIRVVGGHARMAEPKLGQ
. : : .* .. .: *
Mvan_2489|M.vanbaalenii_PYR-1 PQGSPQ-TSDQPPGPPGVEAPKNDLSWRDCTSRVFASAAVQPLGGVKLDC
Mflv_3914|M.gilvum_PYR-GCK PQGAPE-TSDQPAGPPAVEAPKNELSWRDCTSRVFASASVPPLPGVKLDC
MSMEG_2786|M.smegmatis_MC2_155 PQGQPETTSAEPSGPPSIETPKSDLSWRDCTSRVFGDAGVPAIPGVTLDC
Mb2691|M.bovis_AF2122/97 PQGAAT-TTPPPAGPPPLAAPKNDLSWHDCTSRVYSNAGIPAAPGVKLEC
Rv2672|M.tuberculosis_H37Rv PQGAAT-TTPPPAGPPPLAAPKNDLSWHDCTSRVYSNAGIPAAPGVKLEC
MMAR_2044|M.marinum_M PQGAAT-TTPPPSGPPPIAAPKNDLSWTDCTSQVYSDAGVQGAPGTRLEC
MLBr_01339|M.leprae_Br4923 PQGAAA-TTTPAAGPLLIAAPKKDLSWHDCTSRLFRDAGVAAAPGIQLEC
MAV_3564|M.avium_104 PQGAAT-SKPAPGGPPPLAAPKNDLAWHDCTSRVFADAAVPPAPGIQLDC
MAB_2977|M.abscessus_ATCC_1997 NVGPST--APPQSGPPAIDKPKVDLSWQDCTREVLANANITTSPAFTLEC
TH_1513|M.thermoresistible__bu PQGEPP-PPQNESGPPPIEAPKNDLSWRECTTRVFGDAAVPPVPGVRLEC
MUL_1332|M.ulcerans_Agy99 P-----------------------IQWSPCRS---SNPNVKIPGGALCGK
: * * .. : .
Mvan_2489|M.vanbaalenii_PYR-1 ASYDADLDPINGATGTVSIGVVRATSVETPADAGPLVMTTGSDLPSSVQL
Mflv_3914|M.gilvum_PYR-GCK ASYDADLDSINGASGTVSIGVVRATSQQTPADAGPLVMTTGSDVPSSVQL
MSMEG_2786|M.smegmatis_MC2_155 ANYDADLDPLEGASGTLQIGVVRAKAADTPDDAGPIVMTTGSDIASSIQL
Mb2691|M.bovis_AF2122/97 ASYDTDLDPLVGGSTAVSIGVVRARSNQTPSDAGPLVFTTGSDLPSSTQL
Rv2672|M.tuberculosis_H37Rv ASYDTDLDPLVGGSTAVSIGVVRARSNQTPSDAGPLVFTTGSDLPSSTQL
MMAR_2044|M.marinum_M ATFDNDLDPVNGGSGSVSIGVVRARSGQTPRDAGPLVFTTGSDLPSSTQL
MLBr_01339|M.leprae_Br4923 ADYDSDLDPVNGGSGTVTIGAVRARSSQTPRDAGPLVFTTGSDLPSSAQL
MAV_3564|M.avium_104 ANYDADLDPVNGGGGALSIGVVRARSNQTPRDAGPLVFTTGSDLPSSAQL
MAB_2977|M.abscessus_ATCC_1997 AEYKAPLDPINGAPGSVTLGAVRAKTSQTPADAGPLVFTTGSDLPSSVQL
TH_1513|M.thermoresistible__bu ATYDADLDPIKGATGMVTIGAVKASTDQTPPDAGPLVLTTGSDLPSSTQL
MUL_1332|M.ulcerans_Agy99 LAVPVDYRQPRGDVAALALIRFPATG----DKIGSLVINPGGPGESGIEA
* : : . * . *.:*:..*. *. :
Mvan_2489|M.vanbaalenii_PYR-1 PVWLSRAG-SDVLKSHPIVSVDRRGIGMSG-ALDCRDLFDRQEMFEQAQF
Mflv_3914|M.gilvum_PYR-GCK PAWLSRAG-ADVLKTNPIVSVDRRGIGMSG-ALDCRDLFDRQEMFEQAQF
MSMEG_2786|M.smegmatis_MC2_155 PAWLSRTG-ADVLKAHPIVAVDRRGTGMSG-AIDCRDLYDRQEMLDQAQF
Mb2691|M.bovis_AF2122/97 PVWLAHAG-IDVLRSHPIVAVDRRGMGMSS-PIDCRDHFDRDEMRDQAQF
Rv2672|M.tuberculosis_H37Rv PVWLAHAG-IDVLRSHPIVAVDRRGMGMSS-PIDCRDHFDRDEMRDQAQF
MMAR_2044|M.marinum_M PVWLSHAG-ADVLRTHPIVAIDRRGMGMSS-PIDCRDHYERTEMRDQSQF
MLBr_01339|M.leprae_Br4923 PVWLSRSG-ADVVRTHPIVAVDRRGIGMSN-PIDCRDHYDRQKMRDQAQF
MAV_3564|M.avium_104 PVWLSRAG-ADVLAAHPIVAVDRRGIGMSS-PIDCRDKFDRQQMRDQSQF
MAB_2977|M.abscessus_ATCC_1997 ATWLNGPG-AEVLKQRPVVAVDRRGIGRSD-AITCRDTWDTRDMRDQAQN
TH_1513|M.thermoresistible__bu PVWLARSG-TDVLDKHPIVAVDRRGMGMSG-ALDCRDVFDRQEMIDQAQF
MUL_1332|M.ulcerans_Agy99 ALGVFQTLPKRVHERFDLVGFDPRGVASSRPALWCNSDADNDRLRAEPQV
. : . * :*..* ** . * .: *.. : : :.*
Mvan_2489|M.vanbaalenii_PYR-1 QSGDDPVANLGAITMTATTSCTDTIAP-GDSAYDNSHAAEDIERLRTTWD
Mflv_3914|M.gilvum_PYR-GCK QSGDDPVANLGAVTMTATTSCTDTIAP-GDSAYDNAHAAEDIERLRTTWD
MSMEG_2786|M.smegmatis_MC2_155 QSGNDPVANLGSITMTATTSCTDTIAP-GDSAYDNAHAAEDLERLRSTWD
Mb2691|M.bovis_AF2122/97 QAGDDPVANLSDISNTATTDCTDAIAP-GESAYDNTHAASDIERLRKLWD
Rv2672|M.tuberculosis_H37Rv QAGDDPVANLSDISNTATTDCTDAIAP-GESAYDNTHAASDIERLRKLWD
MMAR_2044|M.marinum_M QTGDDPVANLSTISNEATTDCTDAIAP-GASAYDNGHAASDIERLRNLWD
MLBr_01339|M.leprae_Br4923 ESGDDPVANLSDISNTATTNCTDAITP-GTSAYDNSHAASDIERLRNLWD
MAV_3564|M.avium_104 QAGDDPVANLSEVANTATTNCTDAIAP-GASAYDDAHAASDIERLRSTWD
MAB_2977|M.abscessus_ATCC_1997 RAGDDPVASLGKIVETATTNCTDTISP-GDSAYNDAHAAEDLEALRAQWD
TH_1513|M.thermoresistible__bu QAGDDTVANLNAVTVRATTDCTDIIAP-GDSAYDNARAAEDLERLRSTWD
MUL_1332|M.ulcerans_Agy99 DYSEAGVARMEEETKQFVARCVGKMGKNFLENVGTVNVARDLDAIRAALG
.: ** : .: *.. : . . ..* *:: :* .
Mvan_2489|M.vanbaalenii_PYR-1 VPTLALLGIGNGAQVALAYAGSHPNKVARLVLDSPLPLGISAEAATEQRV
Mflv_3914|M.gilvum_PYR-GCK VPALALFGVGNGAQVALAYAGAHPTKVARLVLDSPLPLGVSAEAATEQRV
MSMEG_2786|M.smegmatis_MC2_155 VPTLALLGVGNGAQVALAYAGAHPTKVSRLVLDSPLPLAIGAEAAAEQRV
Mb2691|M.bovis_AF2122/97 VPALAFVGIGNGTQVALAYAASRPDNVARLILDSPIALGVSAEAAAEQQV
Rv2672|M.tuberculosis_H37Rv VPALAFVGIGNGTQVALAYAASRPDNVARLILDSPIALGVSAEAAAEQQV
MMAR_2044|M.marinum_M VPALALVGIGNGAQVALTYAGSRPDKVARLILDSPVALGVSAEAAAEQQV
MLBr_01339|M.leprae_Br4923 VPALALIGIGNGAEVALAYAASRPDRVARLILDSPIALGIKTEAAAEQQV
MAV_3564|M.avium_104 VPALALIGIGNGAQVALAYAGSRPDKVARLILDSPVALGVNAEAAAEQQV
MAB_2977|M.abscessus_ATCC_1997 VPALALLGVGSGARVALAYAGSHPNKVARLLLDSPVAADIAAEAAAEQRL
TH_1513|M.thermoresistible__bu VPGLALLGVGNGAQVALAYAGSHPNKVARLVLDSPLPLAIGAEAAAQQRI
MUL_1332|M.ulcerans_Agy99 DDKLTYLGYSYGTRIGSAYAEAYPQRVRAMILDGAVDPNADPIEADLRQA
*: .* . *:.:. :** : * .* ::**..: . * ::
Mvan_2489|M.vanbaalenii_PYR-1 KGEQAALDAWAAQCVATN-CPLGPDPKAAVDALLTAARQGNGPGGASVAA
Mflv_3914|M.gilvum_PYR-GCK KGEQAALDAWATQCVATN-CPLGPDPKAAVDALMTDARAGRGPGGASVAA
MSMEG_2786|M.smegmatis_MC2_155 KGQQAALDAFAAQCVATG-CPLGPDPKAAVDSLLADARAGRGPGGASVAT
Mb2691|M.bovis_AF2122/97 QGQQAALDAFAAQCVAVN-CALGSDPKGAVSALLSAARSGDGPGGASVAA
Rv2672|M.tuberculosis_H37Rv QGQQAALDAFAAQCVAVN-CALGSHPKGAVSALLSAARSGDGPGGASVAA
MMAR_2044|M.marinum_M KGQQAALDAFAAQCVAVH-CALGSDPKGAVAALLNDARSDNGPGGESVAS
MLBr_01339|M.leprae_Br4923 RGQQAALDTFAAQCVALK-CALGPDPKSAVTALLAAAHAGKGPGGASVAA
MAV_3564|M.avium_104 KGQQAALDAFAAQCIAVN-CALGPDPKGAVSALLADARAGKGPGGVSVAQ
MAB_2977|M.abscessus_ATCC_1997 KGQQSAFDAFAAQCVANN-CPLGPDPAGAVGDLLNRAQNGGLP--WSRAT
TH_1513|M.thermoresistible__bu AGQQAALDAFAAQCVATD-CPLGPDPKAVVDSLLNDARAGRGPGGASVAA
MUL_1332|M.ulcerans_Agy99 KGFQEAFNDYAADCAENDSCPLGTDPAKAVAVYHSLVDKLVDPNNLQVSR
* * *:: :*::* *.**..* .* . * . :
Mvan_2489|M.vanbaalenii_PYR-1 VAD------------AISTALGYPRGGRVDAGTELALAIADARSGDTNRL
Mflv_3914|M.gilvum_PYR-GCK LAD------------AISTALGYPRGGRVDAGNELAQAIADARGGNTNRL
MSMEG_2786|M.smegmatis_MC2_155 VVD------------AITTALGFPRGDRVTATAELARTLAAARDGDPNPL
Mb2691|M.bovis_AF2122/97 VAN------------AVATALGFPDSGRVDSTTKLADALAAARSGDMNLL
Rv2672|M.tuberculosis_H37Rv VAN------------AVATALGFPDSGRVDSTTKLADALAAARSGDMNLL
MMAR_2044|M.marinum_M IAT------------AITTALGFPTGDRIRTTTNLADALVAARAGDMNQL
MLBr_01339|M.leprae_Br4923 VTN------------AITVSLGFPSGDRVGTTMSLANALAAARSGDANPL
MAV_3564|M.avium_104 VAN------------AITVALGFPSGGRVNATTDLANALASARSGDTNAL
MAB_2977|M.abscessus_ATCC_1997 VVR------------AITTALAYPVGDSTAVVQNLANTLNAARGPDSGAL
TH_1513|M.thermoresistible__bu LTT------------AITXXX-XAIPDRRQAT-KTSKAVAAASG------
MUL_1332|M.ulcerans_Agy99 PARTKDPRGLSYSDAIVGTIMALYSPNLWQHLTDGLTELTEDRGDTLLAL
. : . . :
Mvan_2489|M.vanbaalenii_PYR-1 NNLINQAETL----RQTDGQFVNTCSDALNRPTPDRVRELVVAWGKMYPQ
Mflv_3914|M.gilvum_PYR-GCK NNLINQAETL----RQTDGQFVNTCSDALNRPTPDRVRELVVAWGKMYPQ
MSMEG_2786|M.smegmatis_MC2_155 TDLIAETETT----RLTDGHFVNSCSDALNRPTPDRVRELVVAWGKLYPQ
Mb2691|M.bovis_AF2122/97 SALINRADTT----RDTDGQFISSCSDAVNRPTPDRVRELVVAWGKLYPQ
Rv2672|M.tuberculosis_H37Rv SALINRADTT----RDTDGQFISSCSDAVNRPTPDRVRELVVAWGKLYPQ
MMAR_2044|M.marinum_M SNLINRADAL----QHTDGQFVSSCSDAVNRPTPDRVRELVVAWGKLYPQ
MLBr_01339|M.leprae_Br4923 TNLIHRSDAT----QDSDGQFVNDCSDALNRPTPDRVRELVVAWGKLYPE
MAV_3564|M.avium_104 NNLINHANAM----QDSDGQFVNVCSDAVNRPTPDRVRELVVAWGKLYPQ
MAB_2977|M.abscessus_ATCC_1997 APLVDRANAL----RDTDGQFVNSCSDALARPTPDRVRELVVAWGKQYPL
TH_1513|M.thermoresistible__bu -----------------------SASPRLRSRGPRRD-------------
MUL_1332|M.ulcerans_Agy99 ADMYMRRDSHGHYTNATDARVAINCVDQPPITDRAKIVDEDRRSREIAPF
. :
Mvan_2489|M.vanbaalenii_PYR-1 FGT---VGALDMVKCLNWPSGSAPKEPSELEIPTLLLGVANNPIVGNEGV
Mflv_3914|M.gilvum_PYR-GCK FGT---TGALDMVKCLNWPSGSAPAEPSELEIPTLLLGVANDPIVGNEGV
MSMEG_2786|M.smegmatis_MC2_155 FGA---VGALSLVQCLNWPSGSAPQDPKELPVPVLLLGVQNDPIVGNEGV
Mb2691|M.bovis_AF2122/97 FGA---VAALNLVKCVHWPSSSPPQPPKDLKVDVLLLGVQNDPIVGNEGV
Rv2672|M.tuberculosis_H37Rv FGA---VAALNLVKCVHWPSSSPPQPPKDLKVDVLLLGVQNDPIVGNEGV
MMAR_2044|M.marinum_M FGT---VAALNLVKCVHWPSGSTTDAPKSLKVNVLLLGVQNDPIVGNEGV
MLBr_01339|M.leprae_Br4923 FGT---VGALNLVKCVHWPTGTTPQPPKNLKIDVMVLDVQNDPIVGFEGV
MAV_3564|M.avium_104 FGT---VAALNMVKCVHWPTGSPPPSPKSLKVDVLLLGVQNDPIVGTDGV
MAB_2977|M.abscessus_ATCC_1997 FGR---TSALELVNCLQWPSGSKPNPPQDLKINVLILGGQHDPISGSEGV
TH_1513|M.thermoresistible__bu ------------------PSGRPPRSR---------MRRRSVPIS-TAAA
MUL_1332|M.ulcerans_Agy99 MSYGKFTGHAPLGTCAFWPVPP-TSKPHAVSVPGLVPTVIVSTTHDPATP
* . .
Mvan_2489|M.vanbaalenii_PYR-1 AAVAATAINAGSSNRRVMWQGIGHGATIYSSCALPPVLEYLKSGELPSTD
Mflv_3914|M.gilvum_PYR-GCK AAVAATAINAGSSNRRVIWQGIGHGAAIYSPCALPPVLDYLTSGELPSTD
MSMEG_2786|M.smegmatis_MC2_155 AAVAATIINAGANNRRVIWQGIGHGASIYDTCAIAPVTSYLDNGKLPETD
Mb2691|M.bovis_AF2122/97 AATAATAINANAASKRVMWQGIGHGASIYSSCAVPPLVAYLDTGKLPDTD
Rv2672|M.tuberculosis_H37Rv AATAATAINANAASKRVMWQGIGHGASIYSSCAVPPLVAYLDTGKLPDTD
MMAR_2044|M.marinum_M AQTAATIINANAASKRVMWQGIGHGASIYSSCAVPPLIGYLNDGKLPGTD
MLBr_01339|M.leprae_Br4923 AATTAAIINANAASKRVMWQGIGHGASIYSACAVPPIIGYLTSGKLPATD
MAV_3564|M.avium_104 AATAAGIINANAASKRVMWQGIGHGASIYSGCAVPPLIGYLGSGKLPNTD
MAB_2977|M.abscessus_ATCC_1997 SATAAVIINAKAASKRVMWQGIGHGAIVYTPCAQPPALAYLGDGKLPDTD
TH_1513|M.thermoresistible__bu SSTAAQLISR-----------------------------------LPR--
MUL_1332|M.ulcerans_Agy99 YKAGVDLANQLHGSLLTFAGTQHTVVFQGDSCIDDYVTAYLIGGTTPPRG
. . . *
Mvan_2489|M.vanbaalenii_PYR-1 TYCPA
Mflv_3914|M.gilvum_PYR-GCK TYCPA
MSMEG_2786|M.smegmatis_MC2_155 TYCPA
Mb2691|M.bovis_AF2122/97 TYCPA
Rv2672|M.tuberculosis_H37Rv TYCPA
MMAR_2044|M.marinum_M TYCPA
MLBr_01339|M.leprae_Br4923 TYCPA
MAV_3564|M.avium_104 TYCPA
MAB_2977|M.abscessus_ATCC_1997 TFCPA
TH_1513|M.thermoresistible__bu -----
MUL_1332|M.ulcerans_Agy99 AKC--