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ATVVGMRWHTRSATILVAVTALLVGCVPGLAANPRFATNSGARPQGAAATTTPAAGPLLIAAPKKDLSWH DCTSRLFRDAGVAAAPGIQLECADYDSDLDPVNGGSGTVTIGAVRARSSQTPRDAGPLVFTTGSDLPSSA QLPVWLSRSGADVVRTHPIVAVDRRGIGMSNPIDCRDHYDRQKMRDQAQFESGDDPVANLSDISNTATTN CTDAITPGTSAYDNSHAASDIERLRNLWDVPALALIGIGNGAEVALAYAASRPDRVARLILDSPIALGIK TEAAAEQQVRGQQAALDTFAAQCVALKCALGPDPKSAVTALLAAAHAGKGPGGASVAAVTNAITVSLGFP SGDRVGTTMSLANALAAARSGDANPLTNLIHRSDATQDSDGQFVNDCSDALNRPTPDRVRELVVAWGKLY PEFGTVGALNLVKCVHWPTGTTPQPPKNLKIDVMVLDVQNDPIVGFEGVAATTAAIINANAASKRVMWQG IGHGASIYSACAVPPIIGYLTSGKLPATDTYCPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01339 | - | - | 100% (525) | putative secreted protease |
| M. leprae Br4923 | MLBr_01632 | - | 2e-15 | 23.21% (474) | putative hydrolase |
| M. leprae Br4923 | MLBr_01633 | - | 6e-15 | 23.43% (508) | putative secreted hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2691 | - | 0.0 | 74.62% (528) | secreted protease |
| M. gilvum PYR-GCK | Mflv_3914 | - | 0.0 | 64.35% (519) | TAP domain-containing protein |
| M. tuberculosis H37Rv | Rv2672 | - | 0.0 | 74.43% (528) | secreted protease |
| M. abscessus ATCC 19977 | MAB_2977 | - | 1e-175 | 59.68% (506) | hypothetical protein MAB_2977 |
| M. marinum M | MMAR_2044 | - | 0.0 | 75.63% (517) | hypothetical protein MMAR_2044 |
| M. avium 104 | MAV_3564 | - | 0.0 | 78.93% (522) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_2786 | - | 0.0 | 67.52% (505) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_1513 | - | 1e-128 | 62.95% (359) | POSSIBLE SECRETED PROTEASE |
| M. ulcerans Agy99 | MUL_1334 | - | 8e-13 | 24.66% (442) | exported protease |
| M. vanbaalenii PYR-1 | Mvan_2489 | - | 0.0 | 65.70% (519) | TAP domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01339|M.leprae_Br4923 MATVVGMRWHTRSATILVAV------TALLVGCVPGLAANPRFATNSGAR
MAV_3564|M.avium_104 ---MVGMSRPHPCATILVAV------TALLAGCVPGLAADPRFATNSGAR
Mb2691|M.bovis_AF2122/97 MATVVGMSRPMTSTAMLVALTCSA--T-VLAACVPAFGADPRFATYSGAG
Rv2672|M.tuberculosis_H37Rv MATVVGMSRPMTSTAMLVALTCSA--T-VLAACVPAFGADPRFATYSGAG
MMAR_2044|M.marinum_M ------MSRRLPSTPILVAVAFSV--TTVLAACVPVLGADPRFATNTGAR
Mflv_3914|M.gilvum_PYR-GCK ------MR-RVVRAVVLSLAVV-----LPLSACSPGLAANPRYATDSGAG
Mvan_2489|M.vanbaalenii_PYR-1 ------MR-RLVPAVVLSMAVV-----LPLAACSPGLAANPRFATDSGAG
MSMEG_2786|M.smegmatis_MC2_155 ---MVPMRDQLVRALRVSGVVVPVMSLAVLTACTPMFAADPRYATDSGAH
TH_1513|M.thermoresistible__bu -----------VSAVALSTVVA---------GCAPGLAANPRYATDSGAA
MAB_2977|M.abscessus_ATCC_1997 ------MRARLMGVMAVAQLLTG-----VLAGCAPGPSAGPHFAMDEGHG
MUL_1334|M.ulcerans_Agy99 ------MSAMLRLRTLSSALLSFG---LVLCGALPTTLAVAGAISEPDVG
.. * * . .
MLBr_01339|M.leprae_Br4923 PQGAAA-TTTPAAGPLLIAAPKKDLSWHDCTSRLFRDAGVAAAPGIQLEC
MAV_3564|M.avium_104 PQGAAT-SKPAPGGPPPLAAPKNDLAWHDCTSRVFADAAVPPAPGIQLDC
Mb2691|M.bovis_AF2122/97 PQGAAT-TTPPPAGPPPLAAPKNDLSWHDCTSRVYSNAGIPAAPGVKLEC
Rv2672|M.tuberculosis_H37Rv PQGAAT-TTPPPAGPPPLAAPKNDLSWHDCTSRVYSNAGIPAAPGVKLEC
MMAR_2044|M.marinum_M PQGAAT-TTPPPSGPPPIAAPKNDLSWTDCTSQVYSDAGVQGAPGTRLEC
Mflv_3914|M.gilvum_PYR-GCK PQGAPE-TSDQPAGPPAVEAPKNELSWRDCTSRVFASASVPPLPGVKLDC
Mvan_2489|M.vanbaalenii_PYR-1 PQGSPQ-TSDQPPGPPGVEAPKNDLSWRDCTSRVFASAAVQPLGGVKLDC
MSMEG_2786|M.smegmatis_MC2_155 PQGQPETTSAEPSGPPSIETPKSDLSWRDCTSRVFGDAGVPAIPGVTLDC
TH_1513|M.thermoresistible__bu PQGEPP-PPQNESGPPPIEAPKNDLSWRECTTRVFGDAAVPPVPGVRLEC
MAB_2977|M.abscessus_ATCC_1997 NVGPST--APPQSGPPAIDKPKVDLSWQDCTREVLANANITTSPAFTLEC
MUL_1334|M.ulcerans_Agy99 QTQSPG---------IPIAAPQQ--NWGSCGPFIDNVSEIPTAR-----C
. : *: * .* : : : *
MLBr_01339|M.leprae_Br4923 ADYDSDLDPVNGGSGTVTIGAVRARSSQTPRDAGPLVFTTGSDLPSSAQL
MAV_3564|M.avium_104 ANYDADLDPVNGGGGALSIGVVRARSNQTPRDAGPLVFTTGSDLPSSAQL
Mb2691|M.bovis_AF2122/97 ASYDTDLDPLVGGSTAVSIGVVRARSNQTPSDAGPLVFTTGSDLPSSTQL
Rv2672|M.tuberculosis_H37Rv ASYDTDLDPLVGGSTAVSIGVVRARSNQTPSDAGPLVFTTGSDLPSSTQL
MMAR_2044|M.marinum_M ATFDNDLDPVNGGSGSVSIGVVRARSGQTPRDAGPLVFTTGSDLPSSTQL
Mflv_3914|M.gilvum_PYR-GCK ASYDADLDSINGASGTVSIGVVRATSQQTPADAGPLVMTTGSDVPSSVQL
Mvan_2489|M.vanbaalenii_PYR-1 ASYDADLDPINGATGTVSIGVVRATSVETPADAGPLVMTTGSDLPSSVQL
MSMEG_2786|M.smegmatis_MC2_155 ANYDADLDPLEGASGTLQIGVVRAKAADTPDDAGPIVMTTGSDIASSIQL
TH_1513|M.thermoresistible__bu ATYDADLDPIKGATGMVTIGAVKASTDQTPPDAGPLVLTTGSDLPSSTQL
MAB_2977|M.abscessus_ATCC_1997 AEYKAPLDPINGAPGSVTLGAVRAKTSQTPADAGPLVFTTGSDLPSSVQL
MUL_1334|M.ulcerans_Agy99 TTVGVPIDYDKPGGAQAKLAVIRVP--ATGQRIGALLINPGGPGASAVDM
: :* . :..::. * *.:::..*. .*: ::
MLBr_01339|M.leprae_Br4923 PVWLS--RSGADVVRTHPIVAVDRRGIGMSN-PIDCRDHYDRQKMRDQAQ
MAV_3564|M.avium_104 PVWLS--RAGADVLAAHPIVAVDRRGIGMSS-PIDCRDKFDRQQMRDQSQ
Mb2691|M.bovis_AF2122/97 PVWLA--HAGIDVLRSHPIVAVDRRGMGMSS-PIDCRDHFDRDEMRDQAQ
Rv2672|M.tuberculosis_H37Rv PVWLA--HAGIDVLRSHPIVAVDRRGMGMSS-PIDCRDHFDRDEMRDQAQ
MMAR_2044|M.marinum_M PVWLS--HAGADVLRTHPIVAIDRRGMGMSS-PIDCRDHYERTEMRDQSQ
Mflv_3914|M.gilvum_PYR-GCK PAWLS--RAGADVLKTNPIVSVDRRGIGMSG-ALDCRDLFDRQEMFEQAQ
Mvan_2489|M.vanbaalenii_PYR-1 PVWLS--RAGSDVLKSHPIVSVDRRGIGMSG-ALDCRDLFDRQEMFEQAQ
MSMEG_2786|M.smegmatis_MC2_155 PAWLS--RTGADVLKAHPIVAVDRRGTGMSG-AIDCRDLYDRQEMLDQAQ
TH_1513|M.thermoresistible__bu PVWLA--RSGTDVLDKHPIVAVDRRGMGMSG-ALDCRDVFDRQEMIDQAQ
MAB_2977|M.abscessus_ATCC_1997 ATWLN--GPGAEVLKQRPVVAVDRRGIGRSD-AITCRDTWDTRDMRDQAQ
MUL_1334|M.ulcerans_Agy99 VAGMAPELRGTEIARHFDLVGFDPRGVGHSTPALRCRTDAEFDVFRRDPM
. : * :: :*..* ** * * .: ** : : :.
MLBr_01339|M.leprae_Br4923 FESGDDPVANLSDISNTATTNCTDAITPGTSA-YDNSHAASDIERLRNLW
MAV_3564|M.avium_104 FQAGDDPVANLSEVANTATTNCTDAIAPGASA-YDDAHAASDIERLRSTW
Mb2691|M.bovis_AF2122/97 FQAGDDPVANLSDISNTATTDCTDAIAPGESA-YDNTHAASDIERLRKLW
Rv2672|M.tuberculosis_H37Rv FQAGDDPVANLSDISNTATTDCTDAIAPGESA-YDNTHAASDIERLRKLW
MMAR_2044|M.marinum_M FQTGDDPVANLSTISNEATTDCTDAIAPGASA-YDNGHAASDIERLRNLW
Mflv_3914|M.gilvum_PYR-GCK FQSGDDPVANLGAVTMTATTSCTDTIAPGDSA-YDNAHAAEDIERLRTTW
Mvan_2489|M.vanbaalenii_PYR-1 FQSGDDPVANLGAITMTATTSCTDTIAPGDSA-YDNSHAAEDIERLRTTW
MSMEG_2786|M.smegmatis_MC2_155 FQSGNDPVANLGSITMTATTSCTDTIAPGDSA-YDNAHAAEDLERLRSTW
TH_1513|M.thermoresistible__bu FQAGDDTVANLNAVTVRATTDCTDIIAPGDSA-YDNARAAEDLERLRSTW
MAB_2977|M.abscessus_ATCC_1997 NRAGDDPVASLGKIVETATTNCTDTISPGDSA-YNDAHAAEDLEALRAQW
MUL_1334|M.ulcerans_Agy99 VDYSQAGVAHIEQVYRELAQHCADRMGLGFLANVGTAATARDMDMIRRAL
.: ** : : : *:* : * * . :* *:: :*
MLBr_01339|M.leprae_Br4923 DVPALALIGIGNGAEVALAYAASRPDRVARLILDSPIALGIKTEAAAEQQ
MAV_3564|M.avium_104 DVPALALIGIGNGAQVALAYAGSRPDKVARLILDSPVALGVNAEAAAEQQ
Mb2691|M.bovis_AF2122/97 DVPALAFVGIGNGTQVALAYAASRPDNVARLILDSPIALGVSAEAAAEQQ
Rv2672|M.tuberculosis_H37Rv DVPALAFVGIGNGTQVALAYAASRPDNVARLILDSPIALGVSAEAAAEQQ
MMAR_2044|M.marinum_M DVPALALVGIGNGAQVALTYAGSRPDKVARLILDSPVALGVSAEAAAEQQ
Mflv_3914|M.gilvum_PYR-GCK DVPALALFGVGNGAQVALAYAGAHPTKVARLVLDSPLPLGVSAEAATEQR
Mvan_2489|M.vanbaalenii_PYR-1 DVPTLALLGIGNGAQVALAYAGSHPNKVARLVLDSPLPLGISAEAATEQR
MSMEG_2786|M.smegmatis_MC2_155 DVPTLALLGVGNGAQVALAYAGAHPTKVSRLVLDSPLPLAIGAEAAAEQR
TH_1513|M.thermoresistible__bu DVPGLALLGVGNGAQVALAYAGSHPNKVARLVLDSPLPLAIGAEAAAQQR
MAB_2977|M.abscessus_ATCC_1997 DVPALALLGVGSGARVALAYAGSHPNKVARLLLDSPVAADIAAEAAAEQR
MUL_1334|M.ulcerans_Agy99 GDDQLNYLGYSYGTELGTAYLERFGSHVRAMVLDGAIDPMAGPIDENAKQ
. * .* . *:.:. :* .* ::**..: . ::
MLBr_01339|M.leprae_Br4923 VRGQQAALDTFAAQCVAL-KCALGPDPKSAVT-------ALLAAAHAGKG
MAV_3564|M.avium_104 VKGQQAALDAFAAQCIAV-NCALGPDPKGAVS-------ALLADARAGKG
Mb2691|M.bovis_AF2122/97 VQGQQAALDAFAAQCVAV-NCALGSDPKGAVS-------ALLSAARSGDG
Rv2672|M.tuberculosis_H37Rv VQGQQAALDAFAAQCVAV-NCALGSHPKGAVS-------ALLSAARSGDG
MMAR_2044|M.marinum_M VKGQQAALDAFAAQCVAV-HCALGSDPKGAVA-------ALLNDARSDNG
Mflv_3914|M.gilvum_PYR-GCK VKGEQAALDAWATQCVAT-NCPLGPDPKAAVD-------ALMTDARAGRG
Mvan_2489|M.vanbaalenii_PYR-1 VKGEQAALDAWAAQCVAT-NCPLGPDPKAAVD-------ALLTAARQGNG
MSMEG_2786|M.smegmatis_MC2_155 VKGQQAALDAFAAQCVAT-GCPLGPDPKAAVD-------SLLADARAGRG
TH_1513|M.thermoresistible__bu IAGQQAALDAFAAQCVAT-DCPLGPDPKAVVD-------SLLNDARAGRG
MAB_2977|M.abscessus_ATCC_1997 LKGQQSAFDAFAAQCVAN-NCPLGPDPAGAVG-------DLLNRAQNGGL
MUL_1334|M.ulcerans_Agy99 LAGFQTAFNDYAADCARSPVCPLGTDPAQWVNRYHALVYPLVSQPAKTSD
: * *:*:: :*::* *.**..* * *: .
MLBr_01339|M.leprae_Br4923 PGGASVAAVTNAITVSLGFPSGDRVGTTMSLANALAAARSGDANPLTNLI
MAV_3564|M.avium_104 PGGVSVAQVANAITVALGFPSGGRVNATTDLANALASARSGDTNALNNLI
Mb2691|M.bovis_AF2122/97 PGGASVAAVANAVATALGFPDSGRVDSTTKLADALAAARSGDMNLLSALI
Rv2672|M.tuberculosis_H37Rv PGGASVAAVANAVATALGFPDSGRVDSTTKLADALAAARSGDMNLLSALI
MMAR_2044|M.marinum_M PGGESVASIATAITTALGFPTGDRIRTTTNLADALVAARAGDMNQLSNLI
Mflv_3914|M.gilvum_PYR-GCK PGGASVAALADAISTALGYPRGGRVDAGNELAQAIADARGGNTNRLNNLI
Mvan_2489|M.vanbaalenii_PYR-1 PGGASVAAVADAISTALGYPRGGRVDAGTELALAIADARSGDTNRLNNLI
MSMEG_2786|M.smegmatis_MC2_155 PGGASVATVVDAITTALGFPRGDRVTATAELARTLAAARDGDPNPLTDLI
TH_1513|M.thermoresistible__bu PGGASVAALTTAITXXX---------------XAIPDRR-----------
MAB_2977|M.abscessus_ATCC_1997 P--WSRATVVRAITTALAYPVGDSTAVVQNLANTLNAARGPDSGALAPLV
MUL_1334|M.ulcerans_Agy99 PRGLSYADATTGTINALYAPQRWKYLTSGLLGLQRGTDAGDLLLLADDYD
* * * . .
MLBr_01339|M.leprae_Br4923 HRSDATQDSDGQFVNDCSDALNRPTPDRVRELVVAWGKL--------YPE
MAV_3564|M.avium_104 NHANAMQDSDGQFVNVCSDAVNRPTPDRVRELVVAWGKL--------YPQ
Mb2691|M.bovis_AF2122/97 NRADTTRDTDGQFISSCSDAVNRPTPDRVRELVVAWGKL--------YPQ
Rv2672|M.tuberculosis_H37Rv NRADTTRDTDGQFISSCSDAVNRPTPDRVRELVVAWGKL--------YPQ
MMAR_2044|M.marinum_M NRADALQHTDGQFVSSCSDAVNRPTPDRVRELVVAWGKL--------YPQ
Mflv_3914|M.gilvum_PYR-GCK NQAETLRQTDGQFVNTCSDALNRPTPDRVRELVVAWGKM--------YPQ
Mvan_2489|M.vanbaalenii_PYR-1 NQAETLRQTDGQFVNTCSDALNRPTPDRVRELVVAWGKM--------YPQ
MSMEG_2786|M.smegmatis_MC2_155 AETETTRLTDGHFVNSCSDALNRPTPDRVRELVVAWGKL--------YPQ
TH_1513|M.thermoresistible__bu -QATKTSKAVAAASGSASPRLRSRGPRRD---------------------
MAB_2977|M.abscessus_ATCC_1997 DRANALRDTDGQFVNSCSDALARPTPDRVRELVVAWGKQ--------YPL
MUL_1334|M.ulcerans_Agy99 GRDRAGRYNNGQDAFNAIRCVDAPTPTDAASWVSADQQFRQAAPFLSYGQ
. . . : *
MLBr_01339|M.leprae_Br4923 FGTVGALNLVKCVHWPTGTTPQPPKNLKI-DVMVLDVQNDPIVGFEGVAA
MAV_3564|M.avium_104 FGTVAALNMVKCVHWPTGSPPPSPKSLKV-DVLLLGVQNDPIVGTDGVAA
Mb2691|M.bovis_AF2122/97 FGAVAALNLVKCVHWPSSSPPQPPKDLKV-DVLLLGVQNDPIVGNEGVAA
Rv2672|M.tuberculosis_H37Rv FGAVAALNLVKCVHWPSSSPPQPPKDLKV-DVLLLGVQNDPIVGNEGVAA
MMAR_2044|M.marinum_M FGTVAALNLVKCVHWPSGSTTDAPKSLKV-NVLLLGVQNDPIVGNEGVAQ
Mflv_3914|M.gilvum_PYR-GCK FGTTGALDMVKCLNWPSGSAPAEPSELEI-PTLLLGVANDPIVGNEGVAA
Mvan_2489|M.vanbaalenii_PYR-1 FGTVGALDMVKCLNWPSGSAPKEPSELEI-PTLLLGVANNPIVGNEGVAA
MSMEG_2786|M.smegmatis_MC2_155 FGAVGALSLVQCLNWPSGSAPQDPKELPV-PVLLLGVQNDPIVGNEGVAA
TH_1513|M.thermoresistible__bu ---------------PSGRPPRSR----------MRRRSVPIS-TAAASS
MAB_2977|M.abscessus_ATCC_1997 FGRTSALELVNCLQWPSGSKPNPPQDLKI-NVLILGGQHDPISGSEGVSA
MUL_1334|M.ulcerans_Agy99 FTGLAPRDLCALWPVPATSVPHAASPAAPGKAVVVSTTHDPATPYQAGVD
*: . : * .
MLBr_01339|M.leprae_Br4923 TTAAIINANAASKRVMWQGIGHGASIYSACAVPPIIGYLTSGKLPATDTY
MAV_3564|M.avium_104 TAAGIINANAASKRVMWQGIGHGASIYSGCAVPPLIGYLGSGKLPNTDTY
Mb2691|M.bovis_AF2122/97 TAATAINANAASKRVMWQGIGHGASIYSSCAVPPLVAYLDTGKLPDTDTY
Rv2672|M.tuberculosis_H37Rv TAATAINANAASKRVMWQGIGHGASIYSSCAVPPLVAYLDTGKLPDTDTY
MMAR_2044|M.marinum_M TAATIINANAASKRVMWQGIGHGASIYSSCAVPPLIGYLNDGKLPGTDTY
Mflv_3914|M.gilvum_PYR-GCK VAATAINAGSSNRRVIWQGIGHGAAIYSPCALPPVLDYLTSGELPSTDTY
Mvan_2489|M.vanbaalenii_PYR-1 VAATAINAGSSNRRVMWQGIGHGATIYSSCALPPVLEYLKSGELPSTDTY
MSMEG_2786|M.smegmatis_MC2_155 VAATIINAGANNRRVIWQGIGHGASIYDTCAIAPVTSYLDNGKLPETDTY
TH_1513|M.thermoresistible__bu TAAQLISR-----------------------------------LPR----
MAB_2977|M.abscessus_ATCC_1997 TAAVIINAKAASKRVMWQGIGHGAIVYTPCAQPPALAYLGDGKLPDTDTF
MUL_1334|M.ulcerans_Agy99 LARQLGAPLITYDGTQHTAVFDG----NDCVDGAVVRYLLNLTPPPANLR
: *
MLBr_01339|M.leprae_Br4923 CPA
MAV_3564|M.avium_104 CPA
Mb2691|M.bovis_AF2122/97 CPA
Rv2672|M.tuberculosis_H37Rv CPA
MMAR_2044|M.marinum_M CPA
Mflv_3914|M.gilvum_PYR-GCK CPA
Mvan_2489|M.vanbaalenii_PYR-1 CPA
MSMEG_2786|M.smegmatis_MC2_155 CPA
TH_1513|M.thermoresistible__bu ---
MAB_2977|M.abscessus_ATCC_1997 CPA
MUL_1334|M.ulcerans_Agy99 CGS