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SEPETEGVSVDAEAPDDQAPQAEPLLRPRDGVPDVSVSRYEIAKAADLLASGHGPFAVDAERASGFRYSN RAYLVQIRRAGAGSVLIDPVSHGGDPLEVLAPVAEVLSDAEWVLHAADQDLPCLAEIGMRPPSLYDTELA GRLANYERVNLAAMVQRLLGLQLTKGHGAADWSKRPLPQDWLNYAALDVEVLVDLRHAISEVLQEQGKEG WAAEEFEYLRTVEATPTRRDRWRRTSGIHKVRDPRALAAVRELWTTRDQIARRRDIAPGRILPDSAIVNA ATANPDTIEKLTALPIFGGSKQRRSAAVWLDALARARTSEPPDVQEPSNGPPPASRWARRKPEAAVRLEA ARTELAALADRVSVPVENLLSPEIVRRLCWDWKPVEGVDATAAAVDAFLRDSAARRWQRELVVPALAKAL AGAGQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2479 | - | - | 100% (426) | 3'-5' exonuclease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2700 | - | 1e-163 | 68.10% (420) | hypothetical protein Mb2700 |
| M. gilvum PYR-GCK | Mflv_3921 | - | 0.0 | 83.65% (422) | 3'-5' exonuclease |
| M. tuberculosis H37Rv | Rv2681 | - | 1e-163 | 68.33% (420) | hypothetical protein Rv2681 |
| M. leprae Br4923 | MLBr_01040 | - | 1e-159 | 67.06% (419) | hypothetical protein MLBr_01040 |
| M. abscessus ATCC 19977 | MAB_2988 | - | 1e-149 | 64.62% (407) | hypothetical protein MAB_2988 |
| M. marinum M | MMAR_2035 | - | 1e-165 | 68.90% (418) | hypothetical protein MMAR_2035 |
| M. avium 104 | MAV_3576 | - | 1e-160 | 67.84% (426) | ribonuclease D |
| M. smegmatis MC2 155 | MSMEG_2778 | - | 1e-175 | 73.79% (412) | ribonuclease D |
| M. thermoresistible (build 8) | TH_2208 | - | 1e-179 | 76.62% (402) | CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN |
| M. ulcerans Agy99 | MUL_3315 | - | 1e-166 | 68.90% (418) | hypothetical protein MUL_3315 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2479|M.vanbaalenii_PYR-1 -MSEPETEGVSVDAEAPDDQ-----------APQAEPLLRPRDGVPDVSV
Mflv_3921|M.gilvum_PYR-GCK -MPEPETAGSAPETPEPTD-------------IEAEPLLTPRDGVPDVSS
MSMEG_2778|M.smegmatis_MC2_155 -MTQG-DTEPAD-----------------VEEAEATPLLTPAEGVPELCV
TH_2208|M.thermoresistible__bu -MTEATPHQPNDAVVGGSGDTGSTPHVQGTPEPEATPLLQPADGVPELAV
MAB_2988|M.abscessus_ATCC_1997 --MDTDSELPEP-----------------------TPLLRPAEGVPPITA
Mb2700|M.bovis_AF2122/97 MCPEPSHAGAAESEGTE---------------SEPTPLLRPAGGIPDLCV
Rv2681|M.tuberculosis_H37Rv MCPEPSHAGAAESEGTE---------------SEPTPLLRPAGGIPDLCV
MLBr_01040|M.leprae_Br4923 -MREPADD---QPGGTE---------------PDPTPLHYPAGGIPNLSV
MMAR_2035|M.marinum_M MCSALSPEGNEPPEGTA---------------PEATPLLSPASGVPELSV
MUL_3315|M.ulcerans_Agy99 MCSALSPEGNEPPEGTA---------------PEATPLLSPASGVPELSV
MAV_3576|M.avium_104 -MGEPSAEG---PGSGV---------------PAPIPLPHPSEGVPPISA
** * *:* :
Mvan_2479|M.vanbaalenii_PYR-1 SRYEIAKAADLLASGHGPFAVDAERASGFRYSNRAYLVQIRRAGAGSVLI
Mflv_3921|M.gilvum_PYR-GCK SRMEIARAADLLASGTGPFAVDAERASGFRYSNRAYLVQIRRVGAGTVLI
MSMEG_2778|M.smegmatis_MC2_155 SADEIAGAARQLAGGSGPFAIDAERASGFRYSNRAYLVQIRRAGAGTALI
TH_2208|M.thermoresistible__bu SAADIARAAEQLDRGHGAFAVDAERASGFRYSNRAYLVQIRRAGAGTVLI
MAB_2988|M.abscessus_ATCC_1997 STDEIRAAAQRLISGTGPFAVDAERASGFRYSNRAYLIQIRRRGAGTVLL
Mb2700|M.bovis_AF2122/97 TVGEIAAAAELLDRGRGPFAVDAERASGFRYSGRAYLIQIRRAEAGTVLI
Rv2681|M.tuberculosis_H37Rv TVGEIAAAAELLDRGRGPFAVDAERASGFRYSGRAYLIQIRRAEAGTVLI
MLBr_01040|M.leprae_Br4923 TPSEIAAAAERLDQGYGPFAVDTERASGFRYSNRAYLIQIRRANAGTVLI
MMAR_2035|M.marinum_M TAGQIEAAATLLDRGSGPFAVDAERASGFRYSNRAYLIQIRRAGAGTVLI
MUL_3315|M.ulcerans_Agy99 TAGQIEAAATLLDRGSGPFAVDAERASGFRYSNRAYLIQIRRAGAGTVLI
MAV_3576|M.avium_104 SVPDIEDAARRLDRGRGPFAVDAERASGFRYSNRAYLIQIRRAGAGTVLI
: :* ** * * *.**:*:*********.****:**** **:.*:
Mvan_2479|M.vanbaalenii_PYR-1 DPVSHGGDPLEVLAPVAEVLSDAEWVLHAADQDLPCLAEIGMRPPSLYDT
Mflv_3921|M.gilvum_PYR-GCK DPVSHGGDPMEVLAPVAAVLSTDEWVLHAADQDLPCLAEIGMRPTALYDT
MSMEG_2778|M.smegmatis_MC2_155 DPVNHGGSPIDTLEPVAQTLADDEWVLHAADQDLPCLAEIGLRPGKLYDT
TH_2208|M.thermoresistible__bu DPVSHGGDPVRTMAPIAEVLGSDEWVLHAADQDLPCLAELGMRPPRLYDT
MAB_2988|M.abscessus_ATCC_1997 DPTNVPG----SLGPIVDALGADEWILHAADQDLPCLAELAMKPPSLYDT
Mb2700|M.bovis_AF2122/97 DPVSHGGDPLTVLAPVAEVLSTNEWILHSADQDLPCLAEVGMRPPALYDT
Rv2681|M.tuberculosis_H37Rv DPVSHGGDPLTVLAPVAEVLSTNEWILHSADQDLPCLAEVGMRPPALYDT
MLBr_01040|M.leprae_Br4923 DPVSHGNDPLTALRPVAEVISKDEWILHSADQDLPCLAEVGMRPPALYDT
MMAR_2035|M.marinum_M DPVSHGGDPLTVLQPLAEVLAKDEWILHSADQDLPCLAEVGMRPSALYDT
MUL_3315|M.ulcerans_Agy99 DPVSHGGDPLTVLQPLAEVLAKDEWILHSADQDLPCLAEVGMRPSALYDT
MAV_3576|M.avium_104 DPVSHGADPVRALRPVAEVLGSDEWILHSADQDLPCLAEVGMRPPALYDT
**.. : *:. .:. **:**:**********:.::* ****
Mvan_2479|M.vanbaalenii_PYR-1 ELAGRLANYERVNLAAMVQRLLGLQLTKGHGAADWSKRPLPQDWLNYAAL
Mflv_3921|M.gilvum_PYR-GCK ELAGRLANFDRVNLAAMVQRLLGLQLTKGHGAADWSKRPLPDEWLNYAAL
MSMEG_2778|M.smegmatis_MC2_155 ELAGRLAGFERVNLAAMVQRLLGLQLMKGHGAADWSKRPLPDEWLNYAAL
TH_2208|M.thermoresistible__bu ELAGRLAGFARVNLATMVQQLLGLQLMKGHGAADWSKRPLPAEWLNYAAL
MAB_2988|M.abscessus_ATCC_1997 ELAGRLAGFEKVNLASMVHRLLGLGLAKGHGAADWSKRPLPDDWLNYAAL
Mb2700|M.bovis_AF2122/97 ELAGRLAGFDRVNLAAMVERLLGLGLTKGHGAADWSKRPLPSAWLNYAAL
Rv2681|M.tuberculosis_H37Rv ELAGRLAGFDRVNLAAMVERLLGLGLTKGHGAADWSKRPLPSAWLNYAAL
MLBr_01040|M.leprae_Br4923 ELAGRLAGFDRVNLATMVQRLLGFELAKGHGAADWSKRPLPSDWLNYAAL
MMAR_2035|M.marinum_M ELAGRLAGYDRVNLATMVERLLGMGLVKGHGAADWSKRPLPSDWLNYAAL
MUL_3315|M.ulcerans_Agy99 ELAGRLAGYDRVNLATMVERLLGMGLVKGHGAADWSKRPLPSDWLNYAAL
MAV_3576|M.avium_104 ELAGRLAGFERVNLATMVERLLGFGLAKGHGAADWSKRPLPAEWLNYAAL
*******.: :****:**.:***: * ************** *******
Mvan_2479|M.vanbaalenii_PYR-1 DVEVLVDLRHAISEVLQEQGKEGWAAEEFEYLRTVEAT--------PTRR
Mflv_3921|M.gilvum_PYR-GCK DVEVLTDLREAIAAVLDEQGKAEWARQEFEYLRTFEGS--------PTRR
MSMEG_2778|M.smegmatis_MC2_155 DVEVLLELRHAIAAVLEEQGKTEWAAQEFEHLRTYVAQ--------PTRR
TH_2208|M.thermoresistible__bu DVEVLLELRAAIAEVLDDQGKAEWAAEEFEYLRTYEAP--------PTRR
MAB_2988|M.abscessus_ATCC_1997 DVEVLVELRDKIAEVLAEQGKTEWARQEFEHLAHTPVP--------ATRR
Mb2700|M.bovis_AF2122/97 DVELLIELRAVISRVLAEQGKTDWAAQEFEHLRSFESR----PPPAAARQ
Rv2681|M.tuberculosis_H37Rv DVELLIELRAAISRVLAEQGKTDWAAQEFEHLRSFESR----PPPAAARQ
MLBr_01040|M.leprae_Br4923 DVELLIELRTAISKVLAEQDKTDWATQEFNYLRTYATRGATTETIPPTRR
MMAR_2035|M.marinum_M DVELLIELRSAISGVLAEQGKSDWAAQEFEYLRTFESR----WVPATAKP
MUL_3315|M.ulcerans_Agy99 DVELLIELRSAISGVLAEQGKSDWAAQEFEYLRTFESR----WVPATAKP
MAV_3576|M.avium_104 DVELLIELRAAIADVLAEQGKTDWAAQEFDYLREAGSK----EPGPAARR
***:* :** *: ** :*.* ** :**::* .::
Mvan_2479|M.vanbaalenii_PYR-1 DRWRRTSGIHKVRDPRALAAVRELWTTRDQIARRRDIAPGRILPDSAIVN
Mflv_3921|M.gilvum_PYR-GCK DRWRRTSGIHKVRDPRALAAVRELWTTRDQIARRRDIAPGRILPDSAIIS
MSMEG_2778|M.smegmatis_MC2_155 DRWRRTSGIHKVRNPRALAAVRELWTTRDNIARSRDIAPGRILPDAAIIN
TH_2208|M.thermoresistible__bu DRWRRTSGIHKVRNGRALAAVRELWVTRDQIARRRDIAPGRILPDSAIID
MAB_2988|M.abscessus_ATCC_1997 DNWRRTSGIHKVRKPGQLAAVRELWLSRDELARARDVAPGRTLPDSAIVE
Mb2700|M.bovis_AF2122/97 DRWRRTSGIHKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPDSAIID
Rv2681|M.tuberculosis_H37Rv DRWRRTSGIHKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPDSAIID
MLBr_01040|M.leprae_Br4923 DRWRRTSGIRRVRDRRALAAVRELWATRDHIAQRRDIAPRRILPDTAIID
MMAR_2035|M.marinum_M DRWRRTSGIHKVRDRRGLAAVRELWITRDRIAERRDIAPRRILPDSAIID
MUL_3315|M.ulcerans_Agy99 DRWRRTSGIHKVRDRRGLAAVRELWITRDRIAERRDIAPRRILPDSAIID
MAV_3576|M.avium_104 DRWRRTSGIHRVRDQRGLAAVRELWLTRDRIAQRRDIAPRRILPDSAIIE
*.*******::*:. ******** :**.:*. **:** * ***:**:.
Mvan_2479|M.vanbaalenii_PYR-1 AATANPDTIEKLTALPIFGGSKQRRSAAVWLDALARARTS-EPPDVQEPS
Mflv_3921|M.gilvum_PYR-GCK AATANPDTIEKLTALPVFGGSKQRRSAQVWLDALARARTN-DPPDAQEPS
MSMEG_2778|M.smegmatis_MC2_155 AATVDPKTTAELTALPVFGGAKQRRSAQVWLDALNRARQNPDPPSASEAS
TH_2208|M.thermoresistible__bu AATTDPKTISELTALPVFGGAKQRRSAHIWLEALDRARKSTDVPDSKEPT
MAB_2988|M.abscessus_ATCC_1997 AALADPKTRAELIALPVFGGPRQKQQADRWLAALAKARSGTAPPPVNEPT
Mb2700|M.bovis_AF2122/97 AAIADPKSVDDLVALPVFGGRNQRRSAAVWWAALAAARESPDPPEIAEPA
Rv2681|M.tuberculosis_H37Rv AAIADPKSVDDLVALPVFGGRNQRRSAAVWWAALAAARESPDPPEIAEPA
MLBr_01040|M.leprae_Br4923 AAIADPKTIDELIAMPVFGGANQRRSAAMWLAALETARQSQDLPDEAEPS
MMAR_2035|M.marinum_M AALSDPKSVEDLVSLPVFGGRNQRRNATMWLGALDVARKSQHPPEVAEPS
MUL_3315|M.ulcerans_Agy99 AALSDPKSVEDLVSLPVFGGRNQRRNATMWLGALDVARKSQHPPEVAEPS
MAV_3576|M.avium_104 AALANPTTIEELVALPVFGGRNQRRSAATWLAALDAARQSENPPVDSEPP
** :* : .* ::*:*** .*::.* * ** ** . * *..
Mvan_2479|M.vanbaalenii_PYR-1 NGPPPASRWARRKPEAAVRLEAARTELAALADRVSVPVENLLSPEIVRRL
Mflv_3921|M.gilvum_PYR-GCK NGPPPASRWSRRKPEAAVRLEAARAELTALAQQVSVPVENLLSPETVRRL
MSMEG_2778|M.smegmatis_MC2_155 NGPPPAARWARRKPEAAARLEAARAGLAELSERVSVPAENLITPEVVRRL
TH_2208|M.thermoresistible__bu NGPPPASRWARRKPEAAERLDAVRDALAKLSERVSVPAENLLSPDTVRRL
MAB_2988|M.abscessus_ATCC_1997 TGPPPVSRWSRRKPEAYARLEAARTALAALSEQISVPVENIVTPEIVRRI
Mb2700|M.bovis_AF2122/97 NGPPPPGRWVRRKPAAAARLDAARAALTEVSQRVRVPTENLVSPDLVRRL
Rv2681|M.tuberculosis_H37Rv NGPPPPGRWVRRKPAAAARLDAARAALTEVSQRVRVPTENLVSPDLVRRL
MLBr_01040|M.leprae_Br4923 NVPPPPGRWARRKPDAAARLEAARAALATVSQRVGVPTENLVSPELVRRL
MMAR_2035|M.marinum_M NGPPVPARWSRRKPEAAARLEAARAALSEVSDSVGVPTENLVTPELVRRL
MUL_3315|M.ulcerans_Agy99 NGPPVPARWSRRKPEAAARLEAARAALSEVSDSVGVPTENLVTPELVRRL
MAV_3576|M.avium_104 NGPPPPARWSRRKPEAAARLEAARAALAEVSERVHVPTENLVAPDLVRRL
. ** .** **** * **:*.* *: ::: : **.**:::*: ***:
Mvan_2479|M.vanbaalenii_PYR-1 CWDWKPVEGVDATA-AAVDAFLRDSAARRWQRELVVPALAKALAGAGQ--
Mflv_3921|M.gilvum_PYR-GCK CWDWQPPADGDAT--AAVEAFLRDSTARQWQRELTVPALGRALSEPPVS-
MSMEG_2778|M.smegmatis_MC2_155 CWDWQPVADVAST----VEEFLVDNQVRPWQRELTVPVLTVALAEN----
TH_2208|M.thermoresistible__bu CWDWKPADDPVAA----IDEFLRAAGTRRWQRELVVPVLADALGSPTEQA
MAB_2988|M.abscessus_ATCC_1997 CWDWDGHGD--------VDEQLAGHGARPWQRQLTVPLLTEALAD-----
Mb2700|M.bovis_AF2122/97 CWEWEDISQSSPDPIAAVEAYLRTGQARAWQLELVVPILTAALTGAPDAG
Rv2681|M.tuberculosis_H37Rv CWEWEDISQSSPDPIAAVEAYLRTGQARAWQLELVVPILTAALTGAPDAG
MLBr_01040|M.leprae_Br4923 CWDWEVLPESSVDPVNAVEEYLRVGQARAWQRELVVTILASAVKSS--AG
MMAR_2035|M.marinum_M CWDWAPVAAAEIT--STIDEFLATGQARVWQRELVVPALAAALANAAEPE
MUL_3315|M.ulcerans_Agy99 CWDWAPVAAAEIT--STIDEFLATGQARVWQRELVVPALAAALANAAEPE
MAV_3576|M.avium_104 CWDWEPTP----DPFAAVEAFLCAGHARPWQRELVDPVLARALQQPPPAV
**:* :: * .* ** :*. . * *:
Mvan_2479|M.vanbaalenii_PYR-1 -------
Mflv_3921|M.gilvum_PYR-GCK -------
MSMEG_2778|M.smegmatis_MC2_155 -------
TH_2208|M.thermoresistible__bu -------
MAB_2988|M.abscessus_ATCC_1997 -------
Mb2700|M.bovis_AF2122/97 AQGDDGS
Rv2681|M.tuberculosis_H37Rv AQGDDGS
MLBr_01040|M.leprae_Br4923 -------
MMAR_2035|M.marinum_M TEPGAR-
MUL_3315|M.ulcerans_Agy99 TEPGAR-
MAV_3576|M.avium_104 ADDDG--