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TQGDTEPADVEEAEATPLLTPAEGVPELCVSADEIAGAARQLAGGSGPFAIDAERASGFRYSNRAYLVQI RRAGAGTALIDPVNHGGSPIDTLEPVAQTLADDEWVLHAADQDLPCLAEIGLRPGKLYDTELAGRLAGFE RVNLAAMVQRLLGLQLMKGHGAADWSKRPLPDEWLNYAALDVEVLLELRHAIAAVLEEQGKTEWAAQEFE HLRTYVAQPTRRDRWRRTSGIHKVRNPRALAAVRELWTTRDNIARSRDIAPGRILPDAAIINAATVDPKT TAELTALPVFGGAKQRRSAQVWLDALNRARQNPDPPSASEASNGPPPAARWARRKPEAAARLEAARAGLA ELSERVSVPAENLITPEVVRRLCWDWQPVADVASTVEEFLVDNQVRPWQRELTVPVLTVALAEN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2778 | - | - | 100% (415) | ribonuclease D |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2700 | - | 1e-161 | 67.40% (408) | hypothetical protein Mb2700 |
| M. gilvum PYR-GCK | Mflv_3921 | - | 1e-179 | 76.34% (410) | 3'-5' exonuclease |
| M. tuberculosis H37Rv | Rv2681 | - | 1e-162 | 67.65% (408) | hypothetical protein Rv2681 |
| M. leprae Br4923 | MLBr_01040 | - | 1e-159 | 66.11% (422) | hypothetical protein MLBr_01040 |
| M. abscessus ATCC 19977 | MAB_2988 | - | 1e-157 | 67.16% (405) | hypothetical protein MAB_2988 |
| M. marinum M | MMAR_2035 | - | 1e-166 | 68.77% (413) | hypothetical protein MMAR_2035 |
| M. avium 104 | MAV_3576 | - | 1e-160 | 69.58% (401) | ribonuclease D |
| M. thermoresistible (build 8) | TH_2208 | - | 1e-180 | 76.75% (400) | CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN |
| M. ulcerans Agy99 | MUL_3315 | - | 1e-166 | 68.77% (413) | hypothetical protein MUL_3315 |
| M. vanbaalenii PYR-1 | Mvan_2479 | - | 1e-175 | 73.79% (412) | 3'-5' exonuclease |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2778|M.smegmatis_MC2_155 -MTQGDTEPAD------------------VEEAEATPLLTPAEGVPELCV
TH_2208|M.thermoresistible__bu -MTEATPHQPNDAVVGGSGDTGSTPHVQGTPEPEATPLLQPADGVPELAV
Mflv_3921|M.gilvum_PYR-GCK -MPEPETAGSA-----------PETPEPTD--IEAEPLLTPRDGVPDVSS
Mvan_2479|M.vanbaalenii_PYR-1 -MSEPETEGVS-----------VDAEAPDDQAPQAEPLLRPRDGVPDVSV
MAB_2988|M.abscessus_ATCC_1997 --MDTDSEL-----------------------PEPTPLLRPAEGVPPITA
Mb2700|M.bovis_AF2122/97 MCPEPSHAGAA---------------ESEGTESEPTPLLRPAGGIPDLCV
Rv2681|M.tuberculosis_H37Rv MCPEPSHAGAA---------------ESEGTESEPTPLLRPAGGIPDLCV
MLBr_01040|M.leprae_Br4923 -MREPADD------------------QPGGTEPDPTPLHYPAGGIPNLSV
MMAR_2035|M.marinum_M MCSALSPEGNE---------------PPEGTAPEATPLLSPASGVPELSV
MUL_3315|M.ulcerans_Agy99 MCSALSPEGNE---------------PPEGTAPEATPLLSPASGVPELSV
MAV_3576|M.avium_104 -MGEPSAEG------------------PGSGVPAPIPLPHPSEGVPPISA
. ** * *:* :
MSMEG_2778|M.smegmatis_MC2_155 SADEIAGAARQLAGGSGPFAIDAERASGFRYSNRAYLVQIRRAGAGTALI
TH_2208|M.thermoresistible__bu SAADIARAAEQLDRGHGAFAVDAERASGFRYSNRAYLVQIRRAGAGTVLI
Mflv_3921|M.gilvum_PYR-GCK SRMEIARAADLLASGTGPFAVDAERASGFRYSNRAYLVQIRRVGAGTVLI
Mvan_2479|M.vanbaalenii_PYR-1 SRYEIAKAADLLASGHGPFAVDAERASGFRYSNRAYLVQIRRAGAGSVLI
MAB_2988|M.abscessus_ATCC_1997 STDEIRAAAQRLISGTGPFAVDAERASGFRYSNRAYLIQIRRRGAGTVLL
Mb2700|M.bovis_AF2122/97 TVGEIAAAAELLDRGRGPFAVDAERASGFRYSGRAYLIQIRRAEAGTVLI
Rv2681|M.tuberculosis_H37Rv TVGEIAAAAELLDRGRGPFAVDAERASGFRYSGRAYLIQIRRAEAGTVLI
MLBr_01040|M.leprae_Br4923 TPSEIAAAAERLDQGYGPFAVDTERASGFRYSNRAYLIQIRRANAGTVLI
MMAR_2035|M.marinum_M TAGQIEAAATLLDRGSGPFAVDAERASGFRYSNRAYLIQIRRAGAGTVLI
MUL_3315|M.ulcerans_Agy99 TAGQIEAAATLLDRGSGPFAVDAERASGFRYSNRAYLIQIRRAGAGTVLI
MAV_3576|M.avium_104 SVPDIEDAARRLDRGRGPFAVDAERASGFRYSNRAYLIQIRRAGAGTVLI
: :* ** * * *.**:*:*********.****:**** **:.*:
MSMEG_2778|M.smegmatis_MC2_155 DPVNHGGSPIDTLEPVAQTLADDEWVLHAADQDLPCLAEIGLRPGKLYDT
TH_2208|M.thermoresistible__bu DPVSHGGDPVRTMAPIAEVLGSDEWVLHAADQDLPCLAELGMRPPRLYDT
Mflv_3921|M.gilvum_PYR-GCK DPVSHGGDPMEVLAPVAAVLSTDEWVLHAADQDLPCLAEIGMRPTALYDT
Mvan_2479|M.vanbaalenii_PYR-1 DPVSHGGDPLEVLAPVAEVLSDAEWVLHAADQDLPCLAEIGMRPPSLYDT
MAB_2988|M.abscessus_ATCC_1997 DPTNVPG----SLGPIVDALGADEWILHAADQDLPCLAELAMKPPSLYDT
Mb2700|M.bovis_AF2122/97 DPVSHGGDPLTVLAPVAEVLSTNEWILHSADQDLPCLAEVGMRPPALYDT
Rv2681|M.tuberculosis_H37Rv DPVSHGGDPLTVLAPVAEVLSTNEWILHSADQDLPCLAEVGMRPPALYDT
MLBr_01040|M.leprae_Br4923 DPVSHGNDPLTALRPVAEVISKDEWILHSADQDLPCLAEVGMRPPALYDT
MMAR_2035|M.marinum_M DPVSHGGDPLTVLQPLAEVLAKDEWILHSADQDLPCLAEVGMRPSALYDT
MUL_3315|M.ulcerans_Agy99 DPVSHGGDPLTVLQPLAEVLAKDEWILHSADQDLPCLAEVGMRPSALYDT
MAV_3576|M.avium_104 DPVSHGADPVRALRPVAEVLGSDEWILHSADQDLPCLAEVGMRPPALYDT
**.. : *:. .:. **:**:**********:.::* ****
MSMEG_2778|M.smegmatis_MC2_155 ELAGRLAGFERVNLAAMVQRLLGLQLMKGHGAADWSKRPLPDEWLNYAAL
TH_2208|M.thermoresistible__bu ELAGRLAGFARVNLATMVQQLLGLQLMKGHGAADWSKRPLPAEWLNYAAL
Mflv_3921|M.gilvum_PYR-GCK ELAGRLANFDRVNLAAMVQRLLGLQLTKGHGAADWSKRPLPDEWLNYAAL
Mvan_2479|M.vanbaalenii_PYR-1 ELAGRLANYERVNLAAMVQRLLGLQLTKGHGAADWSKRPLPQDWLNYAAL
MAB_2988|M.abscessus_ATCC_1997 ELAGRLAGFEKVNLASMVHRLLGLGLAKGHGAADWSKRPLPDDWLNYAAL
Mb2700|M.bovis_AF2122/97 ELAGRLAGFDRVNLAAMVERLLGLGLTKGHGAADWSKRPLPSAWLNYAAL
Rv2681|M.tuberculosis_H37Rv ELAGRLAGFDRVNLAAMVERLLGLGLTKGHGAADWSKRPLPSAWLNYAAL
MLBr_01040|M.leprae_Br4923 ELAGRLAGFDRVNLATMVQRLLGFELAKGHGAADWSKRPLPSDWLNYAAL
MMAR_2035|M.marinum_M ELAGRLAGYDRVNLATMVERLLGMGLVKGHGAADWSKRPLPSDWLNYAAL
MUL_3315|M.ulcerans_Agy99 ELAGRLAGYDRVNLATMVERLLGMGLVKGHGAADWSKRPLPSDWLNYAAL
MAV_3576|M.avium_104 ELAGRLAGFERVNLATMVERLLGFGLAKGHGAADWSKRPLPAEWLNYAAL
*******.: :****:**.:***: * ************** *******
MSMEG_2778|M.smegmatis_MC2_155 DVEVLLELRHAIAAVLEEQGKTEWAAQEFEHLRTYVAQ--------PTRR
TH_2208|M.thermoresistible__bu DVEVLLELRAAIAEVLDDQGKAEWAAEEFEYLRTYEAP--------PTRR
Mflv_3921|M.gilvum_PYR-GCK DVEVLTDLREAIAAVLDEQGKAEWARQEFEYLRTFEGS--------PTRR
Mvan_2479|M.vanbaalenii_PYR-1 DVEVLVDLRHAISEVLQEQGKEGWAAEEFEYLRTVEAT--------PTRR
MAB_2988|M.abscessus_ATCC_1997 DVEVLVELRDKIAEVLAEQGKTEWARQEFEHLAHTPVP--------ATRR
Mb2700|M.bovis_AF2122/97 DVELLIELRAVISRVLAEQGKTDWAAQEFEHLRSFESR----PPPAAARQ
Rv2681|M.tuberculosis_H37Rv DVELLIELRAAISRVLAEQGKTDWAAQEFEHLRSFESR----PPPAAARQ
MLBr_01040|M.leprae_Br4923 DVELLIELRTAISKVLAEQDKTDWATQEFNYLRTYATRGATTETIPPTRR
MMAR_2035|M.marinum_M DVELLIELRSAISGVLAEQGKSDWAAQEFEYLRTFESR----WVPATAKP
MUL_3315|M.ulcerans_Agy99 DVELLIELRSAISGVLAEQGKSDWAAQEFEYLRTFESR----WVPATAKP
MAV_3576|M.avium_104 DVELLIELRAAIADVLAEQGKTDWAAQEFDYLREAGSK----EPGPAARR
***:* :** *: ** :*.* ** :**::* .::
MSMEG_2778|M.smegmatis_MC2_155 DRWRRTSGIHKVRNPRALAAVRELWTTRDNIARSRDIAPGRILPDAAIIN
TH_2208|M.thermoresistible__bu DRWRRTSGIHKVRNGRALAAVRELWVTRDQIARRRDIAPGRILPDSAIID
Mflv_3921|M.gilvum_PYR-GCK DRWRRTSGIHKVRDPRALAAVRELWTTRDQIARRRDIAPGRILPDSAIIS
Mvan_2479|M.vanbaalenii_PYR-1 DRWRRTSGIHKVRDPRALAAVRELWTTRDQIARRRDIAPGRILPDSAIVN
MAB_2988|M.abscessus_ATCC_1997 DNWRRTSGIHKVRKPGQLAAVRELWLSRDELARARDVAPGRTLPDSAIVE
Mb2700|M.bovis_AF2122/97 DRWRRTSGIHKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPDSAIID
Rv2681|M.tuberculosis_H37Rv DRWRRTSGIHKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPDSAIID
MLBr_01040|M.leprae_Br4923 DRWRRTSGIRRVRDRRALAAVRELWATRDHIAQRRDIAPRRILPDTAIID
MMAR_2035|M.marinum_M DRWRRTSGIHKVRDRRGLAAVRELWITRDRIAERRDIAPRRILPDSAIID
MUL_3315|M.ulcerans_Agy99 DRWRRTSGIHKVRDRRGLAAVRELWITRDRIAERRDIAPRRILPDSAIID
MAV_3576|M.avium_104 DRWRRTSGIHRVRDQRGLAAVRELWLTRDRIAQRRDIAPRRILPDSAIIE
*.*******::*:. ******** :**.:*. **:** * ***:**:.
MSMEG_2778|M.smegmatis_MC2_155 AATVDPKTTAELTALPVFGGAKQRRSAQVWLDALNRARQNPDPPSASEAS
TH_2208|M.thermoresistible__bu AATTDPKTISELTALPVFGGAKQRRSAHIWLEALDRARKSTDVPDSKEPT
Mflv_3921|M.gilvum_PYR-GCK AATANPDTIEKLTALPVFGGSKQRRSAQVWLDALARARTN-DPPDAQEPS
Mvan_2479|M.vanbaalenii_PYR-1 AATANPDTIEKLTALPIFGGSKQRRSAAVWLDALARARTS-EPPDVQEPS
MAB_2988|M.abscessus_ATCC_1997 AALADPKTRAELIALPVFGGPRQKQQADRWLAALAKARSGTAPPPVNEPT
Mb2700|M.bovis_AF2122/97 AAIADPKSVDDLVALPVFGGRNQRRSAAVWWAALAAARESPDPPEIAEPA
Rv2681|M.tuberculosis_H37Rv AAIADPKSVDDLVALPVFGGRNQRRSAAVWWAALAAARESPDPPEIAEPA
MLBr_01040|M.leprae_Br4923 AAIADPKTIDELIAMPVFGGANQRRSAAMWLAALETARQSQDLPDEAEPS
MMAR_2035|M.marinum_M AALSDPKSVEDLVSLPVFGGRNQRRNATMWLGALDVARKSQHPPEVAEPS
MUL_3315|M.ulcerans_Agy99 AALSDPKSVEDLVSLPVFGGRNQRRNATMWLGALDVARKSQHPPEVAEPS
MAV_3576|M.avium_104 AALANPTTIEELVALPVFGGRNQRRSAATWLAALDAARQSENPPVDSEPP
** :* : .* ::*:*** .*::.* * ** ** . * *..
MSMEG_2778|M.smegmatis_MC2_155 NGPPPAARWARRKPEAAARLEAARAGLAELSERVSVPAENLITPEVVRRL
TH_2208|M.thermoresistible__bu NGPPPASRWARRKPEAAERLDAVRDALAKLSERVSVPAENLLSPDTVRRL
Mflv_3921|M.gilvum_PYR-GCK NGPPPASRWSRRKPEAAVRLEAARAELTALAQQVSVPVENLLSPETVRRL
Mvan_2479|M.vanbaalenii_PYR-1 NGPPPASRWARRKPEAAVRLEAARTELAALADRVSVPVENLLSPEIVRRL
MAB_2988|M.abscessus_ATCC_1997 TGPPPVSRWSRRKPEAYARLEAARTALAALSEQISVPVENIVTPEIVRRI
Mb2700|M.bovis_AF2122/97 NGPPPPGRWVRRKPAAAARLDAARAALTEVSQRVRVPTENLVSPDLVRRL
Rv2681|M.tuberculosis_H37Rv NGPPPPGRWVRRKPAAAARLDAARAALTEVSQRVRVPTENLVSPDLVRRL
MLBr_01040|M.leprae_Br4923 NVPPPPGRWARRKPDAAARLEAARAALATVSQRVGVPTENLVSPELVRRL
MMAR_2035|M.marinum_M NGPPVPARWSRRKPEAAARLEAARAALSEVSDSVGVPTENLVTPELVRRL
MUL_3315|M.ulcerans_Agy99 NGPPVPARWSRRKPEAAARLEAARAALSEVSDSVGVPTENLVTPELVRRL
MAV_3576|M.avium_104 NGPPPPARWSRRKPEAAARLEAARAALAEVSERVHVPTENLVAPDLVRRL
. ** .** **** * **:*.* *: ::: : **.**:::*: ***:
MSMEG_2778|M.smegmatis_MC2_155 CWDWQP----VADVASTVEEFLVDNQVRPWQRELTVPVLTVALAEN----
TH_2208|M.thermoresistible__bu CWDWKP----ADDPVAAIDEFLRAAGTRRWQRELVVPVLADALGSPTEQA
Mflv_3921|M.gilvum_PYR-GCK CWDWQPPA-DGDAT-AAVEAFLRDSTARQWQRELTVPALGRALSEPPVS-
Mvan_2479|M.vanbaalenii_PYR-1 CWDWKPVE-GVDATAAAVDAFLRDSAARRWQRELVVPALAKALAGAGQ--
MAB_2988|M.abscessus_ATCC_1997 CWDWDG--------HGDVDEQLAGHGARPWQRQLTVPLLTEALAD-----
Mb2700|M.bovis_AF2122/97 CWEWEDISQSSPDPIAAVEAYLRTGQARAWQLELVVPILTAALTGAPDAG
Rv2681|M.tuberculosis_H37Rv CWEWEDISQSSPDPIAAVEAYLRTGQARAWQLELVVPILTAALTGAPDAG
MLBr_01040|M.leprae_Br4923 CWDWEVLPESSVDPVNAVEEYLRVGQARAWQRELVVTILASAVKSS--AG
MMAR_2035|M.marinum_M CWDWAPVAAAEIT--STIDEFLATGQARVWQRELVVPALAAALANAAEPE
MUL_3315|M.ulcerans_Agy99 CWDWAPVAAAEIT--STIDEFLATGQARVWQRELVVPALAAALANAAEPE
MAV_3576|M.avium_104 CWDWEPTP----DPFAAVEAFLCAGHARPWQRELVDPVLARALQQPPPAV
**:* :: * .* ** :*. . * *:
MSMEG_2778|M.smegmatis_MC2_155 -------
TH_2208|M.thermoresistible__bu -------
Mflv_3921|M.gilvum_PYR-GCK -------
Mvan_2479|M.vanbaalenii_PYR-1 -------
MAB_2988|M.abscessus_ATCC_1997 -------
Mb2700|M.bovis_AF2122/97 AQGDDGS
Rv2681|M.tuberculosis_H37Rv AQGDDGS
MLBr_01040|M.leprae_Br4923 -------
MMAR_2035|M.marinum_M TEPGAR-
MUL_3315|M.ulcerans_Agy99 TEPGAR-
MAV_3576|M.avium_104 ADDDG--