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KVPPDQEAAMANATTSRIDQDLDAQSPAADLVRVYLNGIGKTALLNAADEVELAKRIEAGLYAQHLLDTR KRLGENRKRDLAAVVRDGEAARRHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYAKG FKFSTYATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQNLGREATDEELAAESGIPVEKI TDLLEHSRDPVSLDMPVGSDEEAPLGDFIEDAEAMSAENAVISELLHTDIRYVLATLDEREQQVIRLRFG LDDGQPRTLDQIGKLFGLSRERVRQIEREVMAKLRNGERADRLRSYAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2451 | - | - | 100% (329) | RNA polymerase sigma factor SigB |
| M. vanbaalenii PYR-1 | Mvan_2461 | - | e-105 | 61.59% (315) | RNA polymerase sigma factor |
| M. vanbaalenii PYR-1 | Mvan_1660 | - | 2e-20 | 31.12% (241) | RNA polymerase sigma factor SigF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2729 | sigB | 1e-168 | 93.75% (320) | RNA polymerase sigma factor SigB |
| M. gilvum PYR-GCK | Mflv_3948 | - | 1e-180 | 97.87% (329) | RNA polymerase sigma factor SigB |
| M. tuberculosis H37Rv | Rv2710 | sigB | 1e-168 | 93.75% (320) | RNA polymerase sigma factor SigB |
| M. leprae Br4923 | MLBr_01014 | - | 1e-168 | 93.73% (319) | RNA polymerase sigma factor SigB |
| M. abscessus ATCC 19977 | MAB_3028 | - | 1e-159 | 88.85% (323) | RNA polymerase sigma factor SigB |
| M. marinum M | MMAR_2003 | sigB | 1e-164 | 89.49% (333) | RNA polymerase sigma factor SigB |
| M. avium 104 | MAV_3603 | - | 1e-169 | 94.36% (319) | RNA polymerase sigma factor SigB |
| M. smegmatis MC2 155 | MSMEG_2752 | - | 1e-173 | 96.87% (319) | RNA polymerase sigma factor SigB |
| M. thermoresistible (build 8) | TH_0829 | sigB | 1e-131 | 72.87% (317) | RNA POLYMERASE SIGMA FACTOR SIGB |
| M. ulcerans Agy99 | MUL_3350 | sigB | 1e-164 | 92.16% (319) | RNA polymerase sigma factor SigB |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2451|M.vanbaalenii_PYR-1 ----MKVPPDQEAAMANATTSRIDQDLDAQSPAADLVRVYLNGIGKTALL
Mflv_3948|M.gilvum_PYR-GCK ----MNVPPDQEAAMANATTSRFDQDLDAQSPAADLVRVYLNGIGKTALL
MSMEG_2752|M.smegmatis_MC2_155 --------------MANATTSRVDTDLDAQSPAADLVRVYLNGIGKTALL
MMAR_2003|M.marinum_M MTAQADREGEMAQPIARGIVGRVDSDLDAQSPAADLVRVYLNGIGKTALL
MUL_3350|M.ulcerans_Agy99 ----------MAQPIARGIVGRVDSDLDAQSPAADLVRVYLNGIGKTALL
MLBr_01014|M.leprae_Br4923 --------------MAEATTNRVDSDLDAQSPAADLVRVYLNGIGKTALL
Mb2729|M.bovis_AF2122/97 ----------MADAPTRATTSRVDSDLDAQSPAADLVRVYLNGIGKTALL
Rv2710|M.tuberculosis_H37Rv ----------MADAPTRATTSRVDSDLDAQSPAADLVRVYLNGIGKTALL
MAV_3603|M.avium_104 ----------MAN----ASTSRFDGDLDAQSPAADLVRVYLNGIGKTALL
MAB_3028|M.abscessus_ATCC_1997 ----------MANATTRPARTTESEDLDAQSPAADLVRVYLNGIGKTALL
TH_0829|M.thermoresistible__bu --------------MANATTSRVDSDLDAQSPAADLVRVYLNGIGKTALL
. *************************
Mvan_2451|M.vanbaalenii_PYR-1 NAADEVELAKRIEAGLYAQHLLDTRKRLGENRKRDLAAVVRDGEAARRHL
Mflv_3948|M.gilvum_PYR-GCK TAADEVELAKRIEAGLYAQHLLATRKRLGENRKRDLAAVVRDGEAARRHL
MSMEG_2752|M.smegmatis_MC2_155 NAADEVELAKRIEAGLYAQHLLDTKKRLGEARKRDLQAVVRDGEAARRHL
MMAR_2003|M.marinum_M NAEGEVELAKRIEAGLYAEHLLATRKRLGDNRKRELAAVVRDGAEARRHL
MUL_3350|M.ulcerans_Agy99 NAEGEVELAKRIEAGLYAEHLLATRKRLGDNRKRELAAVVRDGAEARRHL
MLBr_01014|M.leprae_Br4923 NAADEVELAKRIEAGLYAEHLLQTRKRFGEGRKRALAAVARDGAAARRHL
Mb2729|M.bovis_AF2122/97 NAAGEVELAKRIEAGLYAEHLLETRKRLGENRKRDLAAVVRDGEAARRHL
Rv2710|M.tuberculosis_H37Rv NAAGEVELAKRIEAGLYAEHLLETRKRLGENRKRDLAAVVRDGEAARRHL
MAV_3603|M.avium_104 NAAGEVELAKRIEAGLYAEHLLETRKRLGENRKRDLEAVVRDGQAARRHL
MAB_3028|M.abscessus_ATCC_1997 TAEDEVELAKRIEAGLYAQHLLDTKKRLGEARKKDLAVIVREGNAARSHL
TH_0829|M.thermoresistible__bu DAAEEVELAKRIEAGLYAQHLLKTKKRLGQNRKRDLEAIVRDGEEARRHL
* **************:*** *:**:*: **: * .:.*:* ** **
Mvan_2451|M.vanbaalenii_PYR-1 LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYAKGFKFST
Mflv_3948|M.gilvum_PYR-GCK LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYAKGFKFST
MSMEG_2752|M.smegmatis_MC2_155 LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFST
MMAR_2003|M.marinum_M LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFST
MUL_3350|M.ulcerans_Agy99 LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFST
MLBr_01014|M.leprae_Br4923 LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFST
Mb2729|M.bovis_AF2122/97 LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFST
Rv2710|M.tuberculosis_H37Rv LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFST
MAV_3603|M.avium_104 LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFST
MAB_3028|M.abscessus_ATCC_1997 LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYAKGFKFST
TH_0829|M.thermoresistible__bu LEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFST
******************************************:*******
Mvan_2451|M.vanbaalenii_PYR-1 YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQNLGREAT
Mflv_3948|M.gilvum_PYR-GCK YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQNLGREAT
MSMEG_2752|M.smegmatis_MC2_155 YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQNLGREAT
MMAR_2003|M.marinum_M YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQNLGREAT
MUL_3350|M.ulcerans_Agy99 YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREIHQNLGREAT
MLBr_01014|M.leprae_Br4923 YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQNLGREAT
Mb2729|M.bovis_AF2122/97 YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQHLGREAT
Rv2710|M.tuberculosis_H37Rv YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQHLGREAT
MAV_3603|M.avium_104 YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQNLGREAT
MAB_3028|M.abscessus_ATCC_1997 YATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKRELHQRLGREAS
TH_0829|M.thermoresistible__bu YATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPT
************.****:****:***:** :***.**:**: * ****.:
Mvan_2451|M.vanbaalenii_PYR-1 DEELAAESGIPVEKITDLLEHSRDPVSLDMPVGSDEEAPLGDFIEDAEAM
Mflv_3948|M.gilvum_PYR-GCK DEELAEESGIPVEKINDLLEHSRDPVSLDMPVGSDEEAPLGDFIEDAEAM
MSMEG_2752|M.smegmatis_MC2_155 DEELAEESGIPVEKINDLLEHSRDPVSLDMPVGTDEEAPLGDFIEDSEAM
MMAR_2003|M.marinum_M DEELAAESGIPVEKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAM
MUL_3350|M.ulcerans_Agy99 DEELAAESGIPVEKINDLLEHSRDPVSLDMPVGSDEEAPLGDFIEDAEAM
MLBr_01014|M.leprae_Br4923 DEELAAESGIPIEKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAM
Mb2729|M.bovis_AF2122/97 DEELAAESGIPIDKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAM
Rv2710|M.tuberculosis_H37Rv DEELAAESGIPIDKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAM
MAV_3603|M.avium_104 DEELAAESGIPIDKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAM
MAB_3028|M.abscessus_ATCC_1997 DEELAEESGIPVEKIGDLLDHSRDPVSLDMPVGTDEEAPLGDFIEDTEAM
TH_0829|M.thermoresistible__bu PEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAV
**** * .*. :*: :: :::*:*:*** .:* : :: *******:**:
Mvan_2451|M.vanbaalenii_PYR-1 SAENAVISELLHTDIRYVLATLDEREQQVIRLRFGLDDGQPRTLDQIGKL
Mflv_3948|M.gilvum_PYR-GCK SAENAVISELLHTDIRYVLATLDEREQQVIRLRFGLDDGQPRTLDQIGKL
MSMEG_2752|M.smegmatis_MC2_155 SAENAVISELLHTDIRYVLATLDEREQQVIRLRFGLDDGQPRTLDQIGKL
MMAR_2003|M.marinum_M SAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKL
MUL_3350|M.ulcerans_Agy99 SAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKL
MLBr_01014|M.leprae_Br4923 SAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKL
Mb2729|M.bovis_AF2122/97 SAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKL
Rv2710|M.tuberculosis_H37Rv SAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKL
MAV_3603|M.avium_104 SAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKL
MAB_3028|M.abscessus_ATCC_1997 SAENAVIAELLHSDVRSVLATLDEREQQVIRLRYGLDDGQARTLDQIGKL
TH_0829|M.thermoresistible__bu VAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLDEIGQV
* :** **: ::: ** **.*** *:***:** ***.****:**::
Mvan_2451|M.vanbaalenii_PYR-1 FGLSRERVRQIEREVMAKLRNGERADRLRSYAS
Mflv_3948|M.gilvum_PYR-GCK FGLSRERVRQIEREVMAKLRNGDRADRLRSYAS
MSMEG_2752|M.smegmatis_MC2_155 FGLSRERVRQIEREVMAKLRNGERADRLRSYAS
MMAR_2003|M.marinum_M FGLSRERVRQIERDVMCKLRHGERADRLRSYAS
MUL_3350|M.ulcerans_Agy99 FGLSRERVRQIERDVMCKLRHGERADRLRSYAS
MLBr_01014|M.leprae_Br4923 FGLSRERVRQIERDVMCKLRNGERADRLRSYAS
Mb2729|M.bovis_AF2122/97 FGLSRERVRQIERDVMSKLRHGERADRLRSYAS
Rv2710|M.tuberculosis_H37Rv FGLSRERVRQIERDVMSKLRHGERADRLRSYAS
MAV_3603|M.avium_104 FGLSRERVRQIERDVMSKLRNGERADRLRSYAS
MAB_3028|M.abscessus_ATCC_1997 FGLSRERVRQIEREVMAKLRHGDRAERLRSYAS
TH_0829|M.thermoresistible__bu YGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
:*::***:**** ..*.***: .*:: **.* .