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TAVDPTRDHPEGITLALHDASPPDMVDAMRDDVVLELGWGRLIFGQTFADPEKLADVLREEAQGRRDICI YAREPHVLVARAPAELFIDPSHTYRLRFPDDEDHAAPPMTGFSVRTLRSRADADEMNRVYVRCGMVPAPT DVIWDNHRGQKSVDYLVAVSDEDGAVLGTVTGVDHKTLFSDPEEGSSLWTLAVDPTATLPGVGAALTRSL AALYRDRGRSYMDLSVAHDNAAAIALYEKLGFTRVPVMAVKRKNAINEPLFTHPPETVDDLNPYARIIAD EAMRRGIWVEVLDAEAGEMRLSHGGRSVVTRESLSEYTSAVAMARCDDKRLTRRIVAEAGIAVPRGRLAS FDQADHDFLTEVGDVVVKPTRGEQGKGITVGVDGPEELDAALARAREQHPEVLIEQRADGDDLRLVVIDG KVVAAALRMPAEVCGTGKHTIRELVETQSRRRAAATGGESRIPMDVVTETTVREAGYSFDDVLPEGERLR VRRTANLHQGGTIHDVTATVHPELCRVAVAAAQAIGIPVTGIDLLVPDVTRPEYVFIEANERPGLANHEP QPTAAAFVDFLFPGQPGLPQAWTPDEAPGPGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2275 | - | - | 100% (593) | GCN5-related N-acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4067 | - | 0.0 | 88.59% (587) | GCN5-related N-acetyltransferase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3286c | ddl | 6e-05 | 31.62% (117) | D-alanyl-alanine synthetase A |
| M. marinum M | MMAR_2406 | - | 2e-38 | 33.44% (317) | Mur family ligase |
| M. avium 104 | MAV_3054 | - | 0.0 | 76.69% (592) | gnat-family protein acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_2593 | - | 0.0 | 81.51% (584) | gnat-family protein acetyltransferase |
| M. thermoresistible (build 8) | TH_1390 | - | 0.0 | 82.10% (581) | gnat-family protein acetyltransferase |
| M. ulcerans Agy99 | MUL_1976 | ddl | 6e-06 | 32.74% (113) | D-alanyl-alanine synthetase A |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2275|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4067|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2593|M.smegmatis_MC2_155 ----------------------------------------------MTAL
MAV_3054|M.avium_104 --------------------------------------------------
TH_1390|M.thermoresistible__bu --------------------------------------------------
MAB_3286c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_1976|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2406|M.marinum_M MNIDSISVYVGPNVHALEAVIRLQVDVKPSYAETLRGLGAGVIDRLAAVL
Mvan_2275|M.vanbaalenii_PYR-1 -----------MTAVDP---TRDHP-EGITLALHDAS--------PPDMV
Mflv_4067|M.gilvum_PYR-GCK ------------MTADP---TADNP-EAITLALHEAA--------TADQL
MSMEG_2593|M.smegmatis_MC2_155 EPDAAAPAPAPASTPDPEPPVEDHT-EAITMGLHDAS--------PQHLV
MAV_3054|M.avium_104 -----------MTMTDP---AEDHPSEAITLGLHDAS--------PPEMV
TH_1390|M.thermoresistible__bu -----------MTKSES-PDSTDHT-EAITLSLHDAS--------PQHLV
MAB_3286c|M.abscessus_ATCC_199 --------------------------------MNDSV--------GRSRA
MUL_1976|M.ulcerans_Agy99 --------------------------------MSGSS--------RRG--
MMAR_2406|M.marinum_M PGLALEHAEWVAALHAGAGLSIGDLVARLALALEHAAGIDGTLAWSRSTD
: :
Mvan_2275|M.vanbaalenii_PYR-1 DAMRDDVVLELGWGRLIFGQTFADPEKLADVLREEA--------------
Mflv_4067|M.gilvum_PYR-GCK DSMADDVVLELGWGRLIFGQTFADPERLAEVLRQEG--------------
MSMEG_2593|M.smegmatis_MC2_155 DAMADDVELELGWGRLIFGQTFADPEKLAEALQQER--------------
MAV_3054|M.avium_104 DAMAKDVELELGWGRLIFGQTFANSQELVEALRREG--------------
TH_1390|M.thermoresistible__bu DVMAENVVLELGWGRLVFGQTFADPDDLAEVMRQER--------------
MAB_3286c|M.abscessus_ATCC_199 DQQRIKVALVFGGRSSEHAISCVSAGSILRNLDQAV--------------
MUL_1976|M.ulcerans_Agy99 --ERLRVAVVFGGRSNEHAISCVSAGSILRNLDPRR--------------
MMAR_2406|M.marinum_M DPDIVEVFYSYGNEDIGIEAGEVACDMLAAIARADSDDQEAPDLDKNVED
* * . :
Mvan_2275|M.vanbaalenii_PYR-1 --------------------------------------------QGRRDI
Mflv_4067|M.gilvum_PYR-GCK --------------------------------------------QGRRDI
MSMEG_2593|M.smegmatis_MC2_155 --------------------------------------------PGRRDI
MAV_3054|M.avium_104 --------------------------------------------PGRRDI
TH_1390|M.thermoresistible__bu --------------------------------------------SGRRDI
MAB_3286c|M.abscessus_ATCC_199 --------------------------------------------YEVVAV
MUL_1976|M.ulcerans_Agy99 --------------------------------------------FEVIAI
MMAR_2406|M.marinum_M FLTYADRRSLGPSAMELVRTAQARDIPVYRLNDASLIQIGQGKYQQRIEA
Mvan_2275|M.vanbaalenii_PYR-1 CIYAREPHVLVARAPAELFID--------PSHTYRLRFPDDEDHAAPPMT
Mflv_4067|M.gilvum_PYR-GCK CIYAREPHVLVSKAPAELFID--------PSHTYRLRFAEVEDSGSTP-T
MSMEG_2593|M.smegmatis_MC2_155 CIYARESHVLVARSPAELFID--------PSHTYRKRFTG-ELPPAEP-I
MAV_3054|M.avium_104 CIYARESHVVVAEAPTELFID--------PSHTYRLRFTGKEKSLAPTPL
TH_1390|M.thermoresistible__bu CIYAREAHVLVSLAPTELFID--------PSHTYRLRFHEHDEIAEPSPP
MAB_3286c|M.abscessus_ATCC_199 GVTPEGGWVLTDGDPAQLAIS--------DRTLPQVTDASGTELLLAT--
MUL_1976|M.ulcerans_Agy99 GITPQGSWVLTDGNPDALAIT--------DRRLPEVSSQSGTELALPA--
MMAR_2406|M.marinum_M ALTSKTSHIAVEIASDKNLANNLLADLGLPAPRQKLVYSVDEAVGAAERI
: .. : . . .
Mvan_2275|M.vanbaalenii_PYR-1 ---------------GFSVRTLRSRADADEMNRVYVRCGMVPAPTDVIWD
Mflv_4067|M.gilvum_PYR-GCK ---------------GFRVRTLAERADADEMNRVYLRCGMVPAPTDVLWD
MSMEG_2593|M.smegmatis_MC2_155 ---------------GFTVRTLESPEDADSMNRVYVRCGMVPAPVDVIWR
MAV_3054|M.avium_104 ---------------GVTVRTLNDPIDADAMNRVYVRCGMVPAGVDVIWE
TH_1390|M.thermoresistible__bu ---------------GITVRRPRAREEADEMNRVYVRCGMVPAPIDVIWD
MAB_3286c|M.abscessus_ATCC_199 ----------------------DPRRAGQLVNVDSSAAGQVLASVDVVFP
MUL_1976|M.ulcerans_Agy99 ----------------------DPRWGGQLVSLPP-GAGEVLASVDVVFP
MMAR_2406|M.marinum_M GYPVVIKPLDGNHGRGVTVNITSEDGIAEAFETADAEGSAVLVETMLRGD
.: .. . * . :
Mvan_2275|M.vanbaalenii_PYR-1 NHRGQKSVDYLVAVS--------DEDGAVLGTVTGVDHKTLFSDPEEGSS
Mflv_4067|M.gilvum_PYR-GCK NHREQPSVDYLVAVS--------DEDGTVLGTVTGVDHVALFSDPENGSS
MSMEG_2593|M.smegmatis_MC2_155 NHTENPAVIYLVAVR--------DDDGSIVGTVTGVDHKQLFDDPEDGSS
MAV_3054|M.avium_104 NHQHVPAVKYLLAVR--------DEDGAVVGTVTGVDHELLFNDPEHGSS
TH_1390|M.thermoresistible__bu NHLNAEAVEYLIAVR--------DDDGSVVGTVTGVDHKRLFSDPEDGSS
MAB_3286c|M.abscessus_ATCC_199 ---------VLHGPY--------GEDGTIQG-------------------
MUL_1976|M.ulcerans_Agy99 ---------VLHGPY--------GEDGTIQG-------------------
MMAR_2406|M.marinum_M DHRLLVVNGQLAAAARRVPGHVKGDGRHTIAELVNIVNQDPRRGVGHENV
* . .:. .
Mvan_2275|M.vanbaalenii_PYR-1 LWTLAVDPTAT------------LPGVG--------------------AA
Mflv_4067|M.gilvum_PYR-GCK LWTLAVDPTAA------------LPGVG--------------------AA
MSMEG_2593|M.smegmatis_MC2_155 LWSLAVDPAAS------------LPGVG--------------------AA
MAV_3054|M.avium_104 LWTLAVDPAAG------------LPGVG--------------------GA
TH_1390|M.thermoresistible__bu LWTLAVDPTAG------------LPGIG--------------------AA
MAB_3286c|M.abscessus_ATCC_199 -----LLELAG------------VPYVG--------------------AG
MUL_1976|M.ulcerans_Agy99 -----LLELAG------------VPYVG--------------------AG
MMAR_2406|M.marinum_M LTRLELDDQATRLLEEKGYTAETVPAEGEEVYLRKTANISTGGTAVDVTD
: * :* *
Mvan_2275|M.vanbaalenii_PYR-1 LTRSLAALYRDRGRSYMDLSVAHDNAAAIALYEKLGFTRVPVMAVKRKNA
Mflv_4067|M.gilvum_PYR-GCK LTRALASLYRDRGRAYMDLSVAHDNVAAIALYEKLGFARVPVMAVKRKNA
MSMEG_2593|M.smegmatis_MC2_155 LTRTLAGMLHARGRAYLDLSVAHDNAAAIGLYEKLGFQRVPVLAVKRKNA
MAV_3054|M.avium_104 LTRALAEHFRSAGRAYMDLSVAHDNAAAISLYEKLGFRRVPVLAIKRKNA
TH_1390|M.thermoresistible__bu LTRALAAIFRDRGRAYMDLSVAHDNTAAINLYEKLGFQRVPVLAVKRKNA
MAB_3286c|M.abscessus_ATCC_199 VLASAAG-------------------------------------------
MUL_1976|M.ulcerans_Agy99 VLASAAG-------------------------------------------
MMAR_2406|M.marinum_M TIHPDNKLMAERAIRAIGLDVGAVDFLTTDITKSYRETGGGICEINAGPG
.
Mvan_2275|M.vanbaalenii_PYR-1 INEPLFTHPPETVDDLNPYARIIADEAMRRGIWVEVLDAEAGEMRLS---
Mflv_4067|M.gilvum_PYR-GCK INEPLFTHPPETVDDLNPYARILADEAMRRGIWVEVLDAEAGEMRLS---
MSMEG_2593|M.smegmatis_MC2_155 INEPLFTHPPETVDDLNPYARIIADEAIRRGIWVEVLDAGAGEMRLS---
MAV_3054|M.avium_104 INEPLFSPPPETVDDLNPYARIIADEALRRGIWVEVLDAETGEMRLT---
TH_1390|M.thermoresistible__bu INEPLFTHPPETVDDLNPYARIIADEAMRRGIRVEVLDAETGEMRLT---
MAB_3286c|M.abscessus_ATCC_199 ------------------------------------MDKEFTKKLLA---
MUL_1976|M.ulcerans_Agy99 ------------------------------------MDKEFTKKLWS---
MMAR_2406|M.marinum_M LRMHIAPSEGTPRDVGGAIMDMLFPPGTQARVPIAALTGTNGKTTCSRML
: : :
Mvan_2275|M.vanbaalenii_PYR-1 -----------------------------HGGRSVVTRESLSEYTSAVAM
Mflv_4067|M.gilvum_PYR-GCK -----------------------------HGGRTVVTRESLSEYTSAVAM
MSMEG_2593|M.smegmatis_MC2_155 -----------------------------HGGRTVITRESLSEFTSAVAM
MAV_3054|M.avium_104 -----------------------------HGGRSVITRESLSEYTSAVAM
TH_1390|M.thermoresistible__bu -----------------------------HGGRSVVTRESLSEFTSAVAM
MAB_3286c|M.abscessus_ATCC_199 -----------------------------AEGLPIGKYAVIRPRDTTLTL
MUL_1976|M.ulcerans_Agy99 -----------------------------AAGLPIGPHAVLRPSRQSLDR
MMAR_2406|M.marinum_M AHILKMAGHVVGQTSTDAVLIDGNVTVKGDMTGPVSAKMVLRDPSVDIAV
.: : :
Mvan_2275|M.vanbaalenii_PYR-1 ARCDDKRLTRRIV------AEAGIAVPRGRLASFDQADHDFLTEVGDVVV
Mflv_4067|M.gilvum_PYR-GCK ARCDDKRLTRRIV------SEAGITVPKGRLATFDQADHDFLAEVGDVVV
MSMEG_2593|M.smegmatis_MC2_155 SRCDDKRQTRRIV------SDAGITVPKGRLATFDEADHKFLAEVGDVVV
MAV_3054|M.avium_104 CRCDDKRLTRRLV------SEAGITVPRARLATFDEGDFAFLKEVGEVVV
TH_1390|M.thermoresistible__bu ARCDDKRLTRRIV------SEAGIKVPRGRLASFDDADHAFLDEVGKVVV
MAB_3286c|M.abscessus_ATCC_199 DQREDLGLP--------------------------------------VFV
MUL_1976|M.ulcerans_Agy99 EELQRLGLP--------------------------------------AYV
MMAR_2406|M.marinum_M LETARGGIVRSGLGYNFCDVGAVLNVASDHLGLGGVDTLDDLARVKRVVA
. . .
Mvan_2275|M.vanbaalenii_PYR-1 KPTRGEQGKGITVG-------------VDG---PEELDAALARAREQHPE
Mflv_4067|M.gilvum_PYR-GCK KPTRGEQGKGITVG-------------VDS---AEELDAALARAREQHPE
MSMEG_2593|M.smegmatis_MC2_155 KPTRGEQGKGITVG-------------VGS---PEELDAALHRAREQHPE
MAV_3054|M.avium_104 KPTRGEQGKGITVG-------------VTAENGPDDLSAALARARAQYPD
TH_1390|M.thermoresistible__bu KPTRGEQGIGITVG-------------VQT---HEELDEALARAREQHPE
MAB_3286c|M.abscessus_ATCC_199 KPARA----GSSFG-------------VSRVTAWEELPAAIAHARQYDPK
MUL_1976|M.ulcerans_Agy99 KPARG----GSSIG-------------VSRVSSFDELPAAIAAARRHDPK
MMAR_2406|M.marinum_M EVTRGTVVLNADDEQTLKMAAFSPARQVMYVTRNPEHELVREHIRLGKLA
: :*. . * : . *
Mvan_2275|M.vanbaalenii_PYR-1 VLIEQRADGD----------------DLRLVVIDGKVVA-----------
Mflv_4067|M.gilvum_PYR-GCK VLIEQRAEGD----------------DLRLVVIDGKVVA-----------
MSMEG_2593|M.smegmatis_MC2_155 VLIEQRAKGD----------------DLRLVVIDGKVVA-----------
MAV_3054|M.avium_104 VLIEQRVPGD----------------DLRLVVIDGRVVA-----------
TH_1390|M.thermoresistible__bu VLIEECYPGD----------------DLRLVVIDGKVVA-----------
MAB_3286c|M.abscessus_ATCC_199 VIVEAAIVGR----------------ELECGVLE----------------
MUL_1976|M.ulcerans_Agy99 VIVEAAINGR----------------ELECGVLE----------------
MMAR_2406|M.marinum_M VVLEQGVNGDQIVIYDNGTQMPLMWTQLIPATLEGKALHNVENAMFATGM
*::* * :* .::
Mvan_2275|M.vanbaalenii_PYR-1 -AALRMPAEVCGTGKHTIRELVETQSRRRAAATGGESRIPMDVVTETTVR
Mflv_4067|M.gilvum_PYR-GCK -AALRMPAEITGTGRHTIRELIETQSRRRAAATGGESQIPIDAVTENTVR
MSMEG_2593|M.smegmatis_MC2_155 -AAIRRPAEIVGTGGHTIRELIETQSRRRAAATGGESRIPMDDVTASTVA
MAV_3054|M.avium_104 -AALRLPPEVIGTGEHSVRDLIAAESRRRSAATGGESRIPLDELTEATVA
TH_1390|M.thermoresistible__bu -AALRKPAEVIGTGQHTIQELIEAQSRRRAAATGGESKIPLDAITKSIVH
MAB_3286c|M.abscessus_ATCC_199 -----------------------FPDGDTRASVLGEIRVEG--------V
MUL_1976|M.ulcerans_Agy99 -----------------------FPDGRLEASTLGEIRVAG--------V
MMAR_2406|M.marinum_M AYALGKTLDQISAGLRTFDNSFFQSPGRMNVFDEHGFRVILDYGHNEAAV
. ::
Mvan_2275|M.vanbaalenii_PYR-1 EAGYSFDDVLPEGERLRVRRTAN-----------------------LHQG
Mflv_4067|M.gilvum_PYR-GCK EAGYTFDDVLPEGERLRVRRTAN-----------------------LHQG
MSMEG_2593|M.smegmatis_MC2_155 EAGWSLDDVLPEGQRLRVRRTAN-----------------------LHQG
MAV_3054|M.avium_104 EAGWKLDDVLPQGTRLRVRRTAN-----------------------LHQG
TH_1390|M.thermoresistible__bu DAGYSLDDVLPEGERLRVRRTAN-----------------------LHQG
MAB_3286c|M.abscessus_ATCC_199 NRDQTAAGAFYDFETKYLDDTAE-----------------------LDVP
MUL_1976|M.ulcerans_Agy99 RGRE---DGFYDFETKYLDDAAE-----------------------LDVP
MMAR_2406|M.marinum_M GAMVDLVDRLKPRGRRIVGLTCPGDRRDEDATAIAAKVAGHFDTYICHRD
. : : :. .
Mvan_2275|M.vanbaalenii_PYR-1 GTIHDVTATVHPELCR-------VAVAAAQAIGIPVTGIDLLVPDVTRPE
Mflv_4067|M.gilvum_PYR-GCK GTIHDVTATVHPELCR-------VAVAAAAAIGIPVTGIDLLVPDVTKPE
MSMEG_2593|M.smegmatis_MC2_155 GTIHDVTAEVNPELCR-------VGVRAAEAIGIPVTGIDLLVPDVRGTE
MAV_3054|M.avium_104 GTIHDVTAQVNSELCR-------VAVTAAEAIGIPVTGIDLLVPDVTGAD
TH_1390|M.thermoresistible__bu GTIHDVTAKVHPELCR-------VAVKAAEAIGIPVTGIDLLVPDVTRDD
MAB_3286c|M.abscessus_ATCC_199 AKVDDDVSDQIRELAV-------AAFRAIDCQGLAR--VDFFLAEDG---
MUL_1976|M.ulcerans_Agy99 AKVEDDVADAVRQLAI-------RAFEAIDCQGLAR--VDFFLTDDG---
MMAR_2406|M.marinum_M DNLRDREPDEVPELLRDALIAEGVAPDAISIIGEEEQALDAALEQAQPDD
.: * . :* . * * :* : :
Mvan_2275|M.vanbaalenii_PYR-1 YVFIEANER-----------PGLANHEPQPTAAAFVDFLFPGQPGLPQAW
Mflv_4067|M.gilvum_PYR-GCK YAFIEANER-----------PGLANHEPQPTAQAFVDFLFPNQPGLPQAW
MSMEG_2593|M.smegmatis_MC2_155 YVFIEANER-----------PGLANHEPQPTAAAFVDFLFPQQPGLPQAW
MAV_3054|M.avium_104 YAFIEANER-----------PGLANHEPQPTAAAFIDFLFPGHPGQPQAW
TH_1390|M.thermoresistible__bu YVFIEANER-----------PGLANHEPQPTAAAFVDFLFPGQPGLPQAW
MAB_3286c|M.abscessus_ATCC_199 PLINEINTM-----------PGFTTISMYPRMWDATGVDYPTLLDAMVRT
MUL_1976|M.ulcerans_Agy99 PVINELNTM-----------PGFTTISMYPRMWVASGVDYPTLLATMVET
MMAR_2406|M.marinum_M LVLYFCEAITRCWKQIIHFTPKFTAPEPESVAKRLATSIFDVPDGFALTS
: : * :: . . :
Mvan_2275|M.vanbaalenii_PYR-1 TPDEAPGPGA-
Mflv_4067|M.gilvum_PYR-GCK TPDEVQS----
MSMEG_2593|M.smegmatis_MC2_155 TPSETPIRPD-
MAV_3054|M.avium_104 TPEESRFARG-
TH_1390|M.thermoresistible__bu TPSEAPD----
MAB_3286c|M.abscessus_ATCC_199 ALARGTGLR--
MUL_1976|M.ulcerans_Agy99 ALSRGIGLR--
MMAR_2406|M.marinum_M DDRGVLIVPAK