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TMTDPAEDHPSEAITLGLHDASPPEMVDAMAKDVELELGWGRLIFGQTFANSQELVEALRREGPGRRDIC IYARESHVVVAEAPTELFIDPSHTYRLRFTGKEKSLAPTPLGVTVRTLNDPIDADAMNRVYVRCGMVPAG VDVIWENHQHVPAVKYLLAVRDEDGAVVGTVTGVDHELLFNDPEHGSSLWTLAVDPAAGLPGVGGALTRA LAEHFRSAGRAYMDLSVAHDNAAAISLYEKLGFRRVPVLAIKRKNAINEPLFSPPPETVDDLNPYARIIA DEALRRGIWVEVLDAETGEMRLTHGGRSVITRESLSEYTSAVAMCRCDDKRLTRRLVSEAGITVPRARLA TFDEGDFAFLKEVGEVVVKPTRGEQGKGITVGVTAENGPDDLSAALARARAQYPDVLIEQRVPGDDLRLV VIDGRVVAAALRLPPEVIGTGEHSVRDLIAAESRRRSAATGGESRIPLDELTEATVAEAGWKLDDVLPQG TRLRVRRTANLHQGGTIHDVTAQVNSELCRVAVTAAEAIGIPVTGIDLLVPDVTGADYAFIEANERPGLA NHEPQPTAAAFIDFLFPGHPGQPQAWTPEESRFARG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3054 | - | - | 100% (597) | gnat-family protein acetyltransferase |
| M. avium 104 | MAV_3830 | ddl | 6e-05 | 29.23% (130) | D-alanyl-alanine synthetase A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3005c | ddl | 2e-05 | 33.06% (124) | D-alanyl-alanine synthetase A |
| M. gilvum PYR-GCK | Mflv_4067 | - | 0.0 | 75.47% (587) | GCN5-related N-acetyltransferase |
| M. tuberculosis H37Rv | Rv2981c | ddl | 2e-05 | 33.06% (124) | D-alanyl-alanine synthetase A |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2406 | - | 8e-34 | 30.63% (320) | Mur family ligase |
| M. smegmatis MC2 155 | MSMEG_2593 | - | 0.0 | 77.72% (588) | gnat-family protein acetyltransferase |
| M. thermoresistible (build 8) | TH_1390 | - | 0.0 | 76.37% (584) | gnat-family protein acetyltransferase |
| M. ulcerans Agy99 | MUL_1976 | ddl | 9e-07 | 35.78% (109) | D-alanyl-alanine synthetase A |
| M. vanbaalenii PYR-1 | Mvan_2275 | - | 0.0 | 76.69% (592) | GCN5-related N-acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4067|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2275|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2593|M.smegmatis_MC2_155 --------------------------------------------------
TH_1390|M.thermoresistible__bu --------------------------------------------------
MAV_3054|M.avium_104 --------------------------------------------------
Mb3005c|M.bovis_AF2122/97 --------------------------------------------------
Rv2981c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1976|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2406|M.marinum_M MNIDSISVYVGPNVHALEAVIRLQVDVKPSYAETLRGLGAGVIDRLAAVL
Mflv_4067|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2275|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2593|M.smegmatis_MC2_155 --------------------------------------------------
TH_1390|M.thermoresistible__bu --------------------------------------------------
MAV_3054|M.avium_104 --------------------------------------------------
Mb3005c|M.bovis_AF2122/97 --------------------------------------------------
Rv2981c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1976|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2406|M.marinum_M PGLALEHAEWVAALHAGAGLSIGDLVARLALALEHAAGIDGTLAWSRSTD
Mflv_4067|M.gilvum_PYR-GCK ---------------------------MTADP---TADNP-EAITLALHE
Mvan_2275|M.vanbaalenii_PYR-1 --------------------------MTAVDP---TRDHP-EGITLALHD
MSMEG_2593|M.smegmatis_MC2_155 -----------MTALEPDAAAPAPAPASTPDPEPPVEDHT-EAITMGLHD
TH_1390|M.thermoresistible__bu ---------------------------MTKSESPDSTDHT-EAITLSLHD
MAV_3054|M.avium_104 --------------------------MTMTDP---AEDHPSEAITLGLHD
Mb3005c|M.bovis_AF2122/97 --------------------------------------------------
Rv2981c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1976|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2406|M.marinum_M DPDIVEVFYSYGNEDIGIEAGEVACDMLAAIARADSDDQEAPDLDKNVED
Mflv_4067|M.gilvum_PYR-GCK AATADQLDSM-ADDVVLELGWGRLIFGQTFADPERLAEVLRQEGQGRRDI
Mvan_2275|M.vanbaalenii_PYR-1 ASPPDMVDAM-RDDVVLELGWGRLIFGQTFADPEKLADVLREEAQGRRDI
MSMEG_2593|M.smegmatis_MC2_155 ASPQHLVDAM-ADDVELELGWGRLIFGQTFADPEKLAEALQQERPGRRDI
TH_1390|M.thermoresistible__bu ASPQHLVDVM-AENVVLELGWGRLVFGQTFADPDDLAEVMRQERSGRRDI
MAV_3054|M.avium_104 ASPPEMVDAM-AKDVELELGWGRLIFGQTFANSQELVEALRREGPGRRDI
Mb3005c|M.bovis_AF2122/97 -MSANDRR----VRVAVVFGGRSNEHAISCVSAGSILRNLDSRRFDVIAV
Rv2981c|M.tuberculosis_H37Rv -MSANDRRDR-RVRVAVVFGGRSNEHAISCVSAGSILRNLDSRRFDVIAV
MUL_1976|M.ulcerans_Agy99 -MSGSSRRGE-RLRVAVVFGGRSNEHAISCVSAGSILRNLDPRRFEVIAI
MMAR_2406|M.marinum_M FLTYADRRSLGPSAMELVRTAQARDIPVYRLNDASLIQIGQGKYQQRIEA
. : : . : .
Mflv_4067|M.gilvum_PYR-GCK CIYAREPHVLVSKAPA---------ELFIDPSHTYRLRFAEVEDSGSTP-
Mvan_2275|M.vanbaalenii_PYR-1 CIYAREPHVLVARAPA---------ELFIDPSHTYRLRFPDDEDHAAPPM
MSMEG_2593|M.smegmatis_MC2_155 CIYARESHVLVARSPA---------ELFIDPSHTYRKRFTG-ELPPAEP-
TH_1390|M.thermoresistible__bu CIYAREAHVLVSLAPT---------ELFIDPSHTYRLRFHEHDEIAEPSP
MAV_3054|M.avium_104 CIYARESHVVVAEAPT---------ELFIDPSHTYRLRFTGKEKSLAPTP
Mb3005c|M.bovis_AF2122/97 GITPAGSWVLTDANPD---------ALTIT----------NRELPQVKSG
Rv2981c|M.tuberculosis_H37Rv GITPAGSWVLTDANPD---------ALTIT----------NRELPQVKSG
MUL_1976|M.ulcerans_Agy99 GITPQGSWVLTDGNPD---------ALAIT----------DRRLPEVSSQ
MMAR_2406|M.marinum_M ALTSKTSHIAVEIASDKNLANNLLADLGLPAPRQKLVYSVDEAVGAAERI
: . . : . . * :
Mflv_4067|M.gilvum_PYR-GCK --------------TGFRVRTLAERADADEMNRVYLRCGMVPAPTDVLWD
Mvan_2275|M.vanbaalenii_PYR-1 --------------TGFSVRTLRSRADADEMNRVYVRCGMVPAPTDVIWD
MSMEG_2593|M.smegmatis_MC2_155 --------------IGFTVRTLESPEDADSMNRVYVRCGMVPAPVDVIWR
TH_1390|M.thermoresistible__bu --------------PGITVRRPRAREEADEMNRVYVRCGMVPAPIDVIWD
MAV_3054|M.avium_104 --------------LGVTVRTLNDPIDADAMNRVYVRCGMVPAGVDVIWE
Mb3005c|M.bovis_AF2122/97 --------------SGTELALPADPRRGGQLVSLPPGAGEVLESVDVVFP
Rv2981c|M.tuberculosis_H37Rv --------------SGTELALPADPRRGGQLVSLPPGAGEVLESVDVVFP
MUL_1976|M.ulcerans_Agy99 --------------SGTELALPADPRWGGQLVSLPPGAGEVLASVDVVFP
MMAR_2406|M.marinum_M GYPVVIKPLDGNHGRGVTVNITSEDGIAEAFETADAEGSAVLVETMLRGD
* : . : . * :
Mflv_4067|M.gilvum_PYR-GCK NHREQPSVDYLVAVS--------DEDGTVLGTVTGVDHVALFSDPENGSS
Mvan_2275|M.vanbaalenii_PYR-1 NHRGQKSVDYLVAVS--------DEDGAVLGTVTGVDHKTLFSDPEEGSS
MSMEG_2593|M.smegmatis_MC2_155 NHTENPAVIYLVAVR--------DDDGSIVGTVTGVDHKQLFDDPEDGSS
TH_1390|M.thermoresistible__bu NHLNAEAVEYLIAVR--------DDDGSVVGTVTGVDHKRLFSDPEDGSS
MAV_3054|M.avium_104 NHQHVPAVKYLLAVR--------DEDGAVVGTVTGVDHELLFNDPEHGSS
Mb3005c|M.bovis_AF2122/97 ---------VLHGPY--------GEDGTIQG-------------------
Rv2981c|M.tuberculosis_H37Rv ---------VLHGPY--------GEDGTIQG-------------------
MUL_1976|M.ulcerans_Agy99 ---------VLHGPY--------GEDGTIQG-------------------
MMAR_2406|M.marinum_M DHRLLVVNGQLAAAARRVPGHVKGDGRHTIAELVNIVNQDPRRGVGHENV
* . .:. .
Mflv_4067|M.gilvum_PYR-GCK LWTLAVDPTAA------------LPGVG--------------------AA
Mvan_2275|M.vanbaalenii_PYR-1 LWTLAVDPTAT------------LPGVG--------------------AA
MSMEG_2593|M.smegmatis_MC2_155 LWSLAVDPAAS------------LPGVG--------------------AA
TH_1390|M.thermoresistible__bu LWTLAVDPTAG------------LPGIG--------------------AA
MAV_3054|M.avium_104 LWTLAVDPAAG------------LPGVG--------------------GA
Mb3005c|M.bovis_AF2122/97 -----LLELAG------------VPYVG--------------------AG
Rv2981c|M.tuberculosis_H37Rv -----LLELAG------------VPYVG--------------------AG
MUL_1976|M.ulcerans_Agy99 -----LLELAG------------VPYVG--------------------AG
MMAR_2406|M.marinum_M LTRLELDDQATRLLEEKGYTAETVPAEGEEVYLRKTANISTGGTAVDVTD
: * :* *
Mflv_4067|M.gilvum_PYR-GCK LTRALASLYRDRGRAYMDLSVAHDNVAAIALYEKLGFARVPVMAVKRKNA
Mvan_2275|M.vanbaalenii_PYR-1 LTRSLAALYRDRGRSYMDLSVAHDNAAAIALYEKLGFTRVPVMAVKRKNA
MSMEG_2593|M.smegmatis_MC2_155 LTRTLAGMLHARGRAYLDLSVAHDNAAAIGLYEKLGFQRVPVLAVKRKNA
TH_1390|M.thermoresistible__bu LTRALAAIFRDRGRAYMDLSVAHDNTAAINLYEKLGFQRVPVLAVKRKNA
MAV_3054|M.avium_104 LTRALAEHFRSAGRAYMDLSVAHDNAAAISLYEKLGFRRVPVLAIKRKNA
Mb3005c|M.bovis_AF2122/97 VLASAVG-------------------------------------------
Rv2981c|M.tuberculosis_H37Rv VLASAVG-------------------------------------------
MUL_1976|M.ulcerans_Agy99 VLASAAG-------------------------------------------
MMAR_2406|M.marinum_M TIHPDNKLMAERAIRAIGLDVGAVDFLTTDITKSYRETGGGICEINAGPG
.
Mflv_4067|M.gilvum_PYR-GCK INEPLFTHPPETVDDLNPYARILADEAMRRGIWVEVLDAEAGEMRLS---
Mvan_2275|M.vanbaalenii_PYR-1 INEPLFTHPPETVDDLNPYARIIADEAMRRGIWVEVLDAEAGEMRLS---
MSMEG_2593|M.smegmatis_MC2_155 INEPLFTHPPETVDDLNPYARIIADEAIRRGIWVEVLDAGAGEMRLS---
TH_1390|M.thermoresistible__bu INEPLFTHPPETVDDLNPYARIIADEAMRRGIRVEVLDAETGEMRLT---
MAV_3054|M.avium_104 INEPLFSPPPETVDDLNPYARIIADEALRRGIWVEVLDAETGEMRLT---
Mb3005c|M.bovis_AF2122/97 ------------------------------------MDKEFTKKLLA---
Rv2981c|M.tuberculosis_H37Rv ------------------------------------MDKEFTKKLLA---
MUL_1976|M.ulcerans_Agy99 ------------------------------------MDKEFTKKLWS---
MMAR_2406|M.marinum_M LRMHIAPSEGTPRDVGGAIMDMLFPPGTQARVPIAALTGTNGKTTCSRML
: : :
Mflv_4067|M.gilvum_PYR-GCK -----------------------------HGGRTVVTRESLSEYTSAVAM
Mvan_2275|M.vanbaalenii_PYR-1 -----------------------------HGGRSVVTRESLSEYTSAVAM
MSMEG_2593|M.smegmatis_MC2_155 -----------------------------HGGRTVITRESLSEFTSAVAM
TH_1390|M.thermoresistible__bu -----------------------------HGGRSVVTRESLSEFTSAVAM
MAV_3054|M.avium_104 -----------------------------HGGRSVITRESLSEYTSAVAM
Mb3005c|M.bovis_AF2122/97 -----------------------------ADGLPVGAYAVLRPPRSTLHR
Rv2981c|M.tuberculosis_H37Rv -----------------------------ADGLPVGAYAVLRPPRSTLHR
MUL_1976|M.ulcerans_Agy99 -----------------------------AAGLPIGPHAVLRPSRQSLDR
MMAR_2406|M.marinum_M AHILKMAGHVVGQTSTDAVLIDGNVTVKGDMTGPVSAKMVLRDPSVDIAV
.: . * :
Mflv_4067|M.gilvum_PYR-GCK ARCDDKRLTRRIV------SEAGITVPKGRLATFDQADHDFLAEVGDVVV
Mvan_2275|M.vanbaalenii_PYR-1 ARCDDKRLTRRIV------AEAGIAVPRGRLASFDQADHDFLTEVGDVVV
MSMEG_2593|M.smegmatis_MC2_155 SRCDDKRQTRRIV------SDAGITVPKGRLATFDEADHKFLAEVGDVVV
TH_1390|M.thermoresistible__bu ARCDDKRLTRRIV------SEAGIKVPRGRLASFDDADHAFLDEVGKVVV
MAV_3054|M.avium_104 CRCDDKRLTRRLV------SEAGITVPRARLATFDEGDFAFLKEVGEVVV
Mb3005c|M.bovis_AF2122/97 QECERLGLP--------------------------------------VFV
Rv2981c|M.tuberculosis_H37Rv QECERLGLP--------------------------------------VFV
MUL_1976|M.ulcerans_Agy99 EELQRLGLP--------------------------------------AYV
MMAR_2406|M.marinum_M LETARGGIVRSGLGYNFCDVGAVLNVASDHLGLGGVDTLDDLARVKRVVA
. . .
Mflv_4067|M.gilvum_PYR-GCK KPTRGEQGK-------------GITVGVDS---AEELDAALARAREQHPE
Mvan_2275|M.vanbaalenii_PYR-1 KPTRGEQGK-------------GITVGVDG---PEELDAALARAREQHPE
MSMEG_2593|M.smegmatis_MC2_155 KPTRGEQGK-------------GITVGVGS---PEELDAALHRAREQHPE
TH_1390|M.thermoresistible__bu KPTRGEQGI-------------GITVGVQT---HEELDEALARAREQHPE
MAV_3054|M.avium_104 KPTRGEQGK-------------GITVGVTAENGPDDLSAALARARAQYPD
Mb3005c|M.bovis_AF2122/97 KPARGGSSI-------------GVSR-VSS---WDQLPAAVARARRHDPK
Rv2981c|M.tuberculosis_H37Rv KPARGGSSI-------------GVSR-VSS---WDQLPAAVARARRHDPK
MUL_1976|M.ulcerans_Agy99 KPARGGSSI-------------GVSR-VSS---FDELPAAIAAARRHDPK
MMAR_2406|M.marinum_M EVTRGTVVLNADDEQTLKMAAFSPARQVMYVTRNPEHELVREHIRLGKLA
: :** . : * : . *
Mflv_4067|M.gilvum_PYR-GCK VLIEQRAEGD---------------------DLRLVVIDGKVVAAALRMP
Mvan_2275|M.vanbaalenii_PYR-1 VLIEQRADGD---------------------DLRLVVIDGKVVAAALRMP
MSMEG_2593|M.smegmatis_MC2_155 VLIEQRAKGD---------------------DLRLVVIDGKVVAAAIRRP
TH_1390|M.thermoresistible__bu VLIEECYPGD---------------------DLRLVVIDGKVVAAALRKP
MAV_3054|M.avium_104 VLIEQRVPGD---------------------DLRLVVIDGRVVAAALRLP
Mb3005c|M.bovis_AF2122/97 VIVEAAISGR---------------------ELECGVLE-----------
Rv2981c|M.tuberculosis_H37Rv VIVEAAISGR---------------------ELECGVLE-----------
MUL_1976|M.ulcerans_Agy99 VIVEAAINGR---------------------ELECGVLE-----------
MMAR_2406|M.marinum_M VVLEQGVNGDQIVIYDNGTQMPLMWTQLIPATLEGKALHNVENAMFATGM
*::* * *. .:.
Mflv_4067|M.gilvum_PYR-GCK AEITGTGRHTIRELIETQSRRRAAATGGE---SQIPIDAVTENTVREAGY
Mvan_2275|M.vanbaalenii_PYR-1 AEVCGTGKHTIRELVETQSRRRAAATGGE---SRIPMDVVTETTVREAGY
MSMEG_2593|M.smegmatis_MC2_155 AEIVGTGGHTIRELIETQSRRRAAATGGE---SRIPMDDVTASTVAEAGW
TH_1390|M.thermoresistible__bu AEVIGTGQHTIQELIEAQSRRRAAATGGE---SKIPLDAITKSIVHDAGY
MAV_3054|M.avium_104 PEVIGTGEHSVRDLIAAESRRRSAATGGE---SRIPLDELTEATVAEAGW
Mb3005c|M.bovis_AF2122/97 -----------------------MPDGTL---EASTLGEIRVAGVRGR--
Rv2981c|M.tuberculosis_H37Rv -----------------------MPDGTL---EASTLGEIRVAGVRGR--
MUL_1976|M.ulcerans_Agy99 -----------------------FPDGRL---EASTLGEIRVAGVRGR--
MMAR_2406|M.marinum_M AYALGKTLDQISAGLRTFDNSFFQSPGRMNVFDEHGFRVILDYGHNEAAV
. * . : :
Mflv_4067|M.gilvum_PYR-GCK TFDDVLPEGERLRVRRTANLHQGGTIHDVTATVHP---------------
Mvan_2275|M.vanbaalenii_PYR-1 SFDDVLPEGERLRVRRTANLHQGGTIHDVTATVHP---------------
MSMEG_2593|M.smegmatis_MC2_155 SLDDVLPEGQRLRVRRTANLHQGGTIHDVTAEVNP---------------
TH_1390|M.thermoresistible__bu SLDDVLPEGERLRVRRTANLHQGGTIHDVTAKVHP---------------
MAV_3054|M.avium_104 KLDDVLPQGTRLRVRRTANLHQGGTIHDVTAQVNS---------------
Mb3005c|M.bovis_AF2122/97 --EDSFYDFATKYLDDAAELDVPAKVDDQVAEAIR---------------
Rv2981c|M.tuberculosis_H37Rv --EDSFYDFATKYLDDAAELDVPAKVDDQVAEAIR---------------
MUL_1976|M.ulcerans_Agy99 --EDGFYDFETKYLDDAAELDVPAKVEDDVADAVR---------------
MMAR_2406|M.marinum_M GAMVDLVDRLKPRGRRIVGLTCPGDRRDEDATAIAAKVAGHFDTYICHRD
: : . * . * * .
Mflv_4067|M.gilvum_PYR-GCK ---------ELCRVAVAAAAAIGIPVTGIDLLVPDVTKPEYAFIEANE--
Mvan_2275|M.vanbaalenii_PYR-1 ---------ELCRVAVAAAQAIGIPVTGIDLLVPDVTRPEYVFIEANE--
MSMEG_2593|M.smegmatis_MC2_155 ---------ELCRVGVRAAEAIGIPVTGIDLLVPDVRGTEYVFIEANE--
TH_1390|M.thermoresistible__bu ---------ELCRVAVKAAEAIGIPVTGIDLLVPDVTRDDYVFIEANE--
MAV_3054|M.avium_104 ---------ELCRVAVTAAEAIGIPVTGIDLLVPDVTGADYAFIEANE--
Mb3005c|M.bovis_AF2122/97 ---------QLAIRAFAAIDCRGLAR--VDFFLTDDG---PVINEINT--
Rv2981c|M.tuberculosis_H37Rv ---------QLAIRAFAAIDCRGLAR--VDFFLTDDG---PVINEINT--
MUL_1976|M.ulcerans_Agy99 ---------QLAIRAFEAIDCQGLAR--VDFFLTDDG---PVINELNT--
MMAR_2406|M.marinum_M DNLRDREPDEVPELLRDALIAEGVAPDAISIIGEEEQALDAALEQAQPDD
:: * . *:. :.:: : .: : :
Mflv_4067|M.gilvum_PYR-GCK -------------------RPGLANHEPQPTAQAFVDFLFPNQPGLPQAW
Mvan_2275|M.vanbaalenii_PYR-1 -------------------RPGLANHEPQPTAAAFVDFLFPGQPGLPQAW
MSMEG_2593|M.smegmatis_MC2_155 -------------------RPGLANHEPQPTAAAFVDFLFPQQPGLPQAW
TH_1390|M.thermoresistible__bu -------------------RPGLANHEPQPTAAAFVDFLFPGQPGLPQAW
MAV_3054|M.avium_104 -------------------RPGLANHEPQPTAAAFIDFLFPGHPGQPQAW
Mb3005c|M.bovis_AF2122/97 -------------------MPGFTTISMYPRMWAASGVDYPTLLATMIET
Rv2981c|M.tuberculosis_H37Rv -------------------MPGFTTISMYPRMWAASGVDYPTLLATMIET
MUL_1976|M.ulcerans_Agy99 -------------------MPGFTTISMYPRMWVASGVDYPTLLATMVET
MMAR_2406|M.marinum_M LVLYFCEAITRCWKQIIHFTPKFTAPEPESVAKRLATSIFDVPDGFALTS
* :: . . : .
Mflv_4067|M.gilvum_PYR-GCK TPDEVQS----
Mvan_2275|M.vanbaalenii_PYR-1 TPDEAPGPGA-
MSMEG_2593|M.smegmatis_MC2_155 TPSETPIRPD-
TH_1390|M.thermoresistible__bu TPSEAPD----
MAV_3054|M.avium_104 TPEESRFARG-
Mb3005c|M.bovis_AF2122/97 ALARGVGLH--
Rv2981c|M.tuberculosis_H37Rv TLARGVGLH--
MUL_1976|M.ulcerans_Agy99 ALSRGIGLR--
MMAR_2406|M.marinum_M DDRGVLIVPAK