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RRYRTGGGQHGRTPLLTTTPQHPVSPLSRHGRFVGRVGGLAVALGIGIAIANSPAVAAADDDTTSSEASS ASTADSDTISNTPNNTDSDSDSDSEESGDAGEPDQADEDDPAPDVEDEERRTRVTVDVPSPESEAEPDSK SESEPETETEPEADAESVDRDDSADDPVSPEPAAVWALAGSARRETAVESPSMTQDIQAAATASPLGTEQ QLEAEQIAAETVKTWPVRLMKFVLSVGWLATAHREYSEINGPDWDNLWQLHRAVDEYAMGTAFQQQLLNP MTPTVVTQVAPPHSWYGRDVEGSRILYDNPDTIYRFMGVNMTSTYVIKGQFVGVHPADTSFSVLTGLSGV TADYLSGRDIEIAPDGSFTITVSGAPAAPGQANHLQLTADTTLIAVRNTLSDWTTQDPMSLTIERLSGPR NSLFSQLGGFAIPGLGPMVTKSPLLTTLVSLIPPMKEPPRILRGAFAAVIMGLGLGMESKYIKVATTDPA TGDRVAPNHLPHPSRNAEFLATQLQSAGYFQLCDDQALVVTIVPGNARYFVVPVTNLWTVTGNYWDEQTS LNNAQAVANPDGSYTFVISPTDTGVHNWVSTGGLNKGTVSIRFQDLDLASSKTPTVTSAVVPVSDLAAVL PPTTAYVTAAERQSQLSVRRAGFDRRFAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1940 | - | - | 100% (660) | hypothetical protein Mvan_1940 |
| M. vanbaalenii PYR-1 | Mvan_5229 | - | 2e-21 | 29.18% (329) | hypothetical protein Mvan_5229 |
| M. vanbaalenii PYR-1 | Mvan_5180 | - | 3e-20 | 35.05% (214) | hypothetical protein Mvan_5180 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3561c | - | 3e-21 | 27.11% (332) | hypothetical protein Mb3561c |
| M. gilvum PYR-GCK | Mflv_4414 | - | 0.0 | 64.19% (673) | hypothetical protein Mflv_4414 |
| M. tuberculosis H37Rv | Rv3531c | - | 3e-21 | 27.11% (332) | hypothetical protein Rv3531c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4179c | - | 6e-25 | 28.13% (359) | hypothetical protein MAB_4179c |
| M. marinum M | MMAR_5019 | - | 2e-20 | 27.09% (358) | hypothetical protein MMAR_5019 |
| M. avium 104 | MAV_0629 | - | 4e-21 | 28.88% (329) | hypothetical protein MAV_0629 |
| M. smegmatis MC2 155 | MSMEG_5932 | - | 2e-20 | 26.20% (355) | hypothetical protein MSMEG_5932 |
| M. thermoresistible (build 8) | TH_3890 | - | 3e-19 | 25.14% (354) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4093 | - | 2e-20 | 26.54% (358) | hypothetical protein MUL_4093 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3561c|M.bovis_AF2122/97 --------------------------------------------------
Rv3531c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5019|M.marinum_M --------------------------------------------------
MUL_4093|M.ulcerans_Agy99 --------------------------------------------------
MAV_0629|M.avium_104 --------------------------------------------------
MSMEG_5932|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4179c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1940|M.vanbaalenii_PYR-1 --MRRYRTGGGQHGRTPLLTTTPQHPVSPLSRHGRFVGRVGGLAVALGIG
Mflv_4414|M.gilvum_PYR-GCK MQFRRWRRGGGATVRISTDRGPHGRTLLVAATHGRFIGRVGGLAVALGIG
TH_3890|M.thermoresistible__bu --------------------------------------------------
Mb3561c|M.bovis_AF2122/97 --------------------------------------------------
Rv3531c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5019|M.marinum_M --------------------------------------------------
MUL_4093|M.ulcerans_Agy99 --------------------------------------------------
MAV_0629|M.avium_104 --------------------------------------------------
MSMEG_5932|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4179c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1940|M.vanbaalenii_PYR-1 IAIANSPAVAAADDDTTSSEASSASTADSDTISNTPNNTDSDSDSDSEES
Mflv_4414|M.gilvum_PYR-GCK AAIAAASPTAAAED-TPSSAASTGTEASGTEASGT--EASSSPSSDSESP
TH_3890|M.thermoresistible__bu --------------------------------------------------
Mb3561c|M.bovis_AF2122/97 --------------------------------------------------
Rv3531c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5019|M.marinum_M --------------------------------------------------
MUL_4093|M.ulcerans_Agy99 --------------------------------------------------
MAV_0629|M.avium_104 --------------------------------------------------
MSMEG_5932|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4179c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1940|M.vanbaalenii_PYR-1 GDAGEPDQADEDDPAPDVEDEERRTRVTVDVPSPESEAEPDSKSESEPET
Mflv_4414|M.gilvum_PYR-GCK ARQRKPSRSE-----VETAGEDRDARASERSDGDADDAGADRLRADE-GP
TH_3890|M.thermoresistible__bu --------------------------------------------------
Mb3561c|M.bovis_AF2122/97 --------------------------------------------------
Rv3531c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5019|M.marinum_M --------------------------------------------------
MUL_4093|M.ulcerans_Agy99 --------------------------------------------------
MAV_0629|M.avium_104 --------------------------------------------------
MSMEG_5932|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4179c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1940|M.vanbaalenii_PYR-1 ETEPEADAESVDRDDSADDPVSPEPAAVWALAGSARRETAVESPSMTQDI
Mflv_4414|M.gilvum_PYR-GCK DDEDPADDERETPEPADEEPATAVAAATAPTATTSTAATPAKPS--DPDR
TH_3890|M.thermoresistible__bu --------------------------------------------------
Mb3561c|M.bovis_AF2122/97 --------MYSDPLREAIAEAEQLVAAAPHIETEADLLEGLQYLAG----
Rv3531c|M.tuberculosis_H37Rv --------MYSDPLREAIAEAEQLVAAAPHIETEADLLEGLQYLAG----
MMAR_5019|M.marinum_M ------MQPVSQPLTEAIAEAEKLVTAAPHIETEADLLEGLQYLAG----
MUL_4093|M.ulcerans_Agy99 ------MQPVSQPLTVAIAEAEKLVTAAPHIETEADLLEGLQYLAG----
MAV_0629|M.avium_104 --------MFSDPLTSAIAEAENLVAAAPHIETEADLLEGLQYLAG----
MSMEG_5932|M.smegmatis_MC2_155 --------MYSQPLVDAIAEAERLVAAAPFIESEADLTEGLQYLAG----
MAB_4179c|M.abscessus_ATCC_199 --------MYSEAFTAAIVEAEELIVAAPHIETEADLLEGLQYLAQ----
Mvan_1940|M.vanbaalenii_PYR-1 QAAATASPLGTEQQLEAEQIAAETVKTWPVRLMKFVLSVGWLATAHREYS
Mflv_4414|M.gilvum_PYR-GCK SPAAPVSPLATPQQLEAERIATETVGTWPVRLMKQVLSAGWRATAAREYR
TH_3890|M.thermoresistible__bu ---------MTGTATAVLAPPGNIGAATPEGDNIAEMMA-----------
: . . . : * :
Mb3561c|M.bovis_AF2122/97 --------CIAGCMHLAFDYERDHPFLQSGTGPFT---------------
Rv3531c|M.tuberculosis_H37Rv --------CIAGCMHLAFDYERDHPFLQSGTGPFT---------------
MMAR_5019|M.marinum_M --------CIAGCLHLAFDYERDHPFLQSGTGPFT---------------
MUL_4093|M.ulcerans_Agy99 --------CIAGCLHLAFDYERDHPFLQSGTGPFT---------------
MAV_0629|M.avium_104 --------CISACIHLAVDYERDHPFLQSGTGPFT---------------
MSMEG_5932|M.smegmatis_MC2_155 --------CVSGCLHLAFDYDRDHPFLQSGTGPFT---------------
MAB_4179c|M.abscessus_ATCC_199 --------GIAACTHMAFHTDRDHPFLLSGTGPFT---------------
Mvan_1940|M.vanbaalenii_PYR-1 EINGPDWDNLWQLHRAVDEYAMGTAFQQQLLNPMTPTVVTQVAPPHSWYG
Mflv_4414|M.gilvum_PYR-GCK QISGPDPENLVTLRRAVDEYALAAAFQQLLLNSMTPTVVAQVAPPHTWYR
TH_3890|M.thermoresistible__bu ---------LAQAQLLQQAADLVRPVWVPFLSKTI---------------
: .. .
Mb3561c|M.bovis_AF2122/97 ------KMGLDNPDTLYFGTRLQANRDYVVSGRRG--TTTDLSFQLLGG-
Rv3531c|M.tuberculosis_H37Rv ------KMGLDNPDTLYFGTRLQANRDYVVSGRRG--TTTDLSFQLLGG-
MMAR_5019|M.marinum_M ------KMGLDNPDTLYFGTRVHADRDYVVIGNRG--TTTDLSFQLLGG-
MUL_4093|M.ulcerans_Agy99 ------KMGLDNPDTLYFGTRVHADRDYVVIGNRG--TTTDLSFQLLGG-
MAV_0629|M.avium_104 ------KMGLDNPDTLYFGTRVHAGYDYVVTGRRG--TTTDLSFQLLGG-
MSMEG_5932|M.smegmatis_MC2_155 ------KMGLDNPDTLYFGTRVQPGHEYVVTGKRG--TTTDLSFQVLGG-
MAB_4179c|M.abscessus_ATCC_199 ------KMGLDNPDTLYFGARVSGEYEYVVTGKRG--TTTDLSFQVLGGG
Mvan_1940|M.vanbaalenii_PYR-1 RDVEGSRILYDNPDTIYRFMGVNMTSTYVIKGQFVGVHPADTSFSVLTG-
Mflv_4414|M.gilvum_PYR-GCK QSVSGSRILYDNPDTVYRFMGVNMTSTYVIRGRFTDAHPADTNFSVLTG-
TH_3890|M.thermoresistible__bu ------RSAGANADTTYGVALLEPGGSYRISGRRG--TVVFADLLVGAGL
: *.** * : * : *. . .: : *
Mb3561c|M.bovis_AF2122/97 EYTDYNVPASQAAFDDRELDIAADGSFEWRLRPS--------------AP
Rv3531c|M.tuberculosis_H37Rv EYTDYNVPASQAAFDDRELDIAADGSFEWRLRPS--------------AP
MMAR_5019|M.marinum_M EYTDNNVPVSQAAFDDRELEIASDGSFQWRLRPT--------------SN
MUL_4093|M.ulcerans_Agy99 EYTDDNVPVSQAAFDDRELEIASDGSFQWRLRPT--------------SN
MAV_0629|M.avium_104 EYTDDNVPASQAAFDDRELDIAPDGSFEWRVRPT--------------SN
MSMEG_5932|M.smegmatis_MC2_155 EYTDDNVPASQAAFDDRELDIAEDGTFEWRITPT--------------SP
MAB_4179c|M.abscessus_ATCC_199 DYTDKNVPGSAIAFDDREIHIDSDGSFEVRFGPAPADDSRPNYFTLGPGP
Mvan_1940|M.vanbaalenii_PYR-1 -----LSGVTADYLSGRDIEIAPDGSFTITVSGAPAAPGQANHLQLTADT
Mflv_4414|M.gilvum_PYR-GCK -----LSGITADNLSGRQIDVGPDGSFTITVSGAAAAPGQRNHLQLTPDS
TH_3890|M.thermoresistible__bu LGVVERQQPNVGVVDFTDLDLGDDDTVELILSAERPAGYDGHWFRLDPTA
. .. ::.: *.:. .
Mb3561c|M.bovis_AF2122/97 GQLVIREVYGDWSQQR-GTLAIARLDTVG---------------------
Rv3531c|M.tuberculosis_H37Rv GQLVIREVYGDWSQQR-GTLAIARLDTVG---------------------
MMAR_5019|M.marinum_M GQLVIREVYADWSAQR-GTLAISRLDTAG---------------------
MUL_4093|M.ulcerans_Agy99 GQLVIREVYADWSAQR-GTLAISRLDTAG---------------------
MAV_0629|M.avium_104 GQLVIREVYGDWAAQR-GTLAIAREDTAG---------------------
MSMEG_5932|M.smegmatis_MC2_155 SQLVIREVYNDWSAQR-GHLAIARTDTAG---------------------
MAB_4179c|M.abscessus_ATCC_199 AQLVMREVYSDWREQR-GSLAIARVDTAG---------------------
Mvan_1940|M.vanbaalenii_PYR-1 TLIAVRNTLSDWTTQDPMSLTIERLSGPRNSLFSQLGGFAIPGLGPMVTK
Mflv_4414|M.gilvum_PYR-GCK TLVAVRNTLSDWNTQSPMTLSIERLTGPRNSLFSQLGGFAIPGLGPLVTR
TH_3890|M.thermoresistible__bu DHVWLRQYFYDWETERPWSVTIERLDVAP---------------------
: :*: ** : ::* *
Mb3561c|M.bovis_AF2122/97 --------------TAPPPLTRELMEKRYATAGSQLVNRVKTWLQFPQWF
Rv3531c|M.tuberculosis_H37Rv --------------TAPPPLTRELMEKRYATAGSQLVNRVKTWLQFPQWF
MMAR_5019|M.marinum_M --------------TAPPPLTRETMQKRYTVAGKQLVDRVKTWLQFPQWF
MUL_4093|M.ulcerans_Agy99 --------------TAPPPLTRETMQKRYTVAGKQLVDRVKTWLQFPQWF
MAV_0629|M.avium_104 --------------TAPPPLTRETIEKRYATAGKQLVNRVKTWLQFPQWF
MSMEG_5932|M.smegmatis_MC2_155 --------------TAPPPLTKELIEKRYAVAGKQLVQRVKTWLQFPQWF
MAB_4179c|M.abscessus_ATCC_199 --------------TAPAPLTKEQIEKRYASAGKQLVNRVKTWLQFPKWF
Mvan_1940|M.vanbaalenii_PYR-1 SPLLTTLVSLIPPMKEPPRILRGAFAAVIMGLGLGMESKYIKVATTDPAT
Mflv_4414|M.gilvum_PYR-GCK SPLLTSLVSSIPPMKEPPPFLRGVFTAVIMALGLGQESKYIKVATTDAET
TH_3890|M.thermoresistible__bu -------------TDPPKPALRDVEINGFVDR------YVSMWQSHVAAM
* :
Mb3561c|M.bovis_AF2122/97 YLNIPVNTMVAPRL-TPGGLATQYSSAGHFELRPGQALVITVPVSD-APY
Rv3531c|M.tuberculosis_H37Rv YLNIPVNTMVAPRL-TPGGLATQYSSAGHFELRPGQALVITVPVSD-APY
MMAR_5019|M.marinum_M YLNIPVNTMVAPRL-TPGGLATQYSSAGHFDLRPDQALVITVPVSD-APY
MUL_4093|M.ulcerans_Agy99 YLNIPVNTMVVPRL-TPGGLATQYSSAGHFDLRPDQALVITVPVSD-APY
MAV_0629|M.avium_104 YFNIPVNTMVAPRL-TPGGLATQYSSAGHYELRPDQALLITIPVTD-APY
MSMEG_5932|M.smegmatis_MC2_155 YNNLPVNTMVAPRL-TPGGLATQYSSVGHFDLRPDQAMVITLPVTD-APY
MAB_4179c|M.abscessus_ATCC_199 YDNLPVNTMTEPRL-TPGGLATQFSSVGHYDLADDQAMIITVPKSD-APY
Mvan_1940|M.vanbaalenii_PYR-1 GDRVAPNHLPHPSR-NAEFLATQLQSAGYFQLCDDQALVVTIVPGN-ARY
Mflv_4414|M.gilvum_PYR-GCK GERVPPNVLRDPSR-NAEFLATQLQSAGYFHLADDQALVVTITPAN-ARY
TH_3890|M.thermoresistible__bu ADRGYVNRLETVGLPDTTGMVAQSYFQGVYEIAEDEALLLEVRPPRRCRY
. * : . :.:* * :.: .:*::: : . *
Mb3561c|M.bovis_AF2122/97 LGFQLGSMWYISLDYINHQTSLNASQAQADPDGKVRIVVAEQNPGVTNWV
Rv3531c|M.tuberculosis_H37Rv LGFQLGSMWYISLDYINHQTSLNASQAQADPDGKVRIVVAEQNPGVTNWV
MMAR_5019|M.marinum_M LGFQLGSMWYISLDYINHQTSLNNSQAQADPDGKVRIVVADRNPGVTNWV
MUL_4093|M.ulcerans_Agy99 LGFQLGSMWYISLDYINHQTSLNNSQAQADPDGKVRIVVADRNPGVTNWV
MAV_0629|M.avium_104 LGFQLGSLWYISLDYINHQTSLNNTQAQADPDGKVRIVVAEQNPGVTNWV
MSMEG_5932|M.smegmatis_MC2_155 LGFQLGSLWYISLDYINHQTSLNGTQAQEDPDGKIRIVVSDANPGVTNWC
MAB_4179c|M.abscessus_ATCC_199 QGFQLGSLWYISLDYINHQTSLNSSQAQIDPDGNIRMVVSNTNPGVTNWI
Mvan_1940|M.vanbaalenii_PYR-1 FVVPVTNLWTVTGNYWDEQTSLNNAQAVANPDGSYTFVISPTDTGVHNWV
Mflv_4414|M.gilvum_PYR-GCK FIVPVTDLWTVTGDYWHQQTSLNNAQAVPDPDGKYTFVISPTDPGVHNWV
TH_3890|M.thermoresistible__bu WSVQLTDDRYISLDWMWRQTSLNGHQARLDPDGVFRAVISHRDPGVHNWL
. : . :: :: .***** ** :*** *:: :.** **
Mb3561c|M.bovis_AF2122/97 ETLGHRRGFLQFRWQRVSRELTEADGPTVELVDFDAIPAALPHYQHNKIS
Rv3531c|M.tuberculosis_H37Rv ETLGHRRGFLQFRWQRVSRELTEADGPTVELVDFDAIPAALPHYQHNKIS
MMAR_5019|M.marinum_M ETLGHRRGFLQFRWQRVSRQLTDADGPSVELVDFDAVGSVLPYLEHNKIS
MUL_4093|M.ulcerans_Agy99 ETLGHRRGFLQFRWQRVSRQLTDADGPSVELVDFDAVGSVLPYLEHNKIS
MAV_0629|M.avium_104 ETVGHRKGFLQFRWQRVSRQLTEADGPTVELVDFDAVPAKLPYYEHNKIS
MSMEG_5932|M.smegmatis_MC2_155 ETLGHRKGYLQFRWQRLSRALTEADGPTVEVVDIDQVPEKLPYHESNKIS
MAB_4179c|M.abscessus_ATCC_199 ETLGHRRAYLQFRWQRADRQLTPADGPTVEVVAVGDIPAKLPHYSQNQIS
Mvan_1940|M.vanbaalenii_PYR-1 STGGLNKGTVSIRFQDLDLASSKTPTVTSAVVPVSDLAAVLPPTT-AYVT
Mflv_4414|M.gilvum_PYR-GCK STGGLNKGTVSIRFQDLDLASSQTPTLTSAVVAVSDLDSVLPPTT-VCVT
TH_3890|M.thermoresistible__bu DAAGWTRGTILGRWNRAD----ANPVPSVKLVDFADLPGFLPADV-PRIT
.: * :. : *:: . : :* . : ** ::
Mb3561c|M.bovis_AF2122/97 EDDWRARIALRQRQIATRMLG--
Rv3531c|M.tuberculosis_H37Rv EDDWRARIALRQRQIATRMLG--
MMAR_5019|M.marinum_M EEDWRARIALRQKQIAARMLG--
MUL_4093|M.ulcerans_Agy99 EEDWRARIALRQKQIAARMLG--
MAV_0629|M.avium_104 DDEWRARIALRQQQIAARMLG--
MSMEG_5932|M.smegmatis_MC2_155 EADWRARIALRQQQIQNRMVG--
MAB_4179c|M.abscessus_ATCC_199 EEGWRSRIAERQTAIGARMLG--
Mvan_1940|M.vanbaalenii_PYR-1 AAERQSQLSVRRAGFDRRFAD--
Mflv_4414|M.gilvum_PYR-GCK PAQRAAQLTERATGFARRFGSPV
TH_3890|M.thermoresistible__bu SDERRAQLRAR-AAAAQRMG---
::: * *: