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VTGRIVISGAGGLVGRVLAGQARRAGRDVVALTSAQWDITDRAQAERVIAAGDVVVNCAAFTKVDAAEAE PDRAHAVNAVGAGNVAQACARAGASLIHLSTDYVFSGSRRRPYEIDDETGPLSVYGRTKLAGEQAVLAAL PDAYVVRTAWIYEGGAGTDFAAVMRRAAQGDGTVEVVADQIGSPTYVGDLCRALLQIADGGVRGPVLHAA NLGAVSRFDQAQAVFAELGADPSRVRPVGSDRHPRPAPRPAYSALSPVKSAEAGLTPLRPWRDALAEALA TVAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1727 | - | - | 100% (284) | dTDP-4-dehydrorhamnose reductase |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 2e-06 | 35.19% (108) | dTDP-glucose 4,6-dehydratase |
| M. vanbaalenii PYR-1 | Mvan_4635 | - | 5e-06 | 24.62% (264) | 3-beta hydroxysteroid dehydrogenase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3294c | rmlD | 1e-99 | 66.20% (284) | dTDP-rhamnose modification protein RmlD |
| M. gilvum PYR-GCK | Mflv_4736 | - | 1e-117 | 77.21% (272) | dTDP-4-dehydrorhamnose reductase |
| M. tuberculosis H37Rv | Rv3266c | rmlD | 9e-99 | 65.85% (284) | dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD |
| M. leprae Br4923 | MLBr_00751 | rmlD | 1e-100 | 65.64% (291) | putative dTDP-rhamnose modification protein |
| M. abscessus ATCC 19977 | MAB_3613c | - | 9e-80 | 57.30% (281) | dTDP-rhamnose modification protein RmlD |
| M. marinum M | MMAR_1275 | rmlD | 4e-98 | 62.50% (288) | dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD |
| M. avium 104 | MAV_4231 | rfbD | 3e-98 | 64.79% (284) | dTDP-4-dehydrorhamnose reductase |
| M. smegmatis MC2 155 | MSMEG_1825 | rfbD | 1e-111 | 68.79% (282) | dTDP-4-dehydrorhamnose reductase |
| M. thermoresistible (build 8) | TH_0781 | rmlD | 1e-110 | 70.97% (279) | dTDP-6-DEOXY-L-LYXO-4-HEXULOSE REDUCTASE RMLD (dTDP-RHAMNOSE |
| M. ulcerans Agy99 | MUL_2612 | rmlD | 8e-98 | 62.15% (288) | dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1275|M.marinum_M ----------------------------MVGRSERLVITGAAGQLGGVLA
MUL_2612|M.ulcerans_Agy99 ----------------------------MVGRSERLVIAGAAGQLGGVLA
Mb3294c|M.bovis_AF2122/97 ----------------------------MAGRSERLVITGAGGQLGSHLT
Rv3266c|M.tuberculosis_H37Rv ----------------------------MAGRSERLVITGAGGQLGSHLT
MLBr_00751|M.leprae_Br4923 ----------------------------MSDRSGRLVITGAGGQLGSALA
MAV_4231|M.avium_104 ------------------------------------MIAGAGGQLGGYVS
MAB_3613c|M.abscessus_ATCC_199 ----------------------------------MLVITGAGGQLGTHLI
Mvan_1727|M.vanbaalenii_PYR-1 -------------------------------MTGRIVISGAGGLVGRVLA
Mflv_4736|M.gilvum_PYR-GCK -----------------------------------------------MLA
MSMEG_1825|M.smegmatis_MC2_155 MDLINGMGTSPGYWRTPREPGNDHRRARLDVMAQRIVITGAGGMVGRVLA
TH_0781|M.thermoresistible__bu ---------------------------MTNSSAKRIVIPGAGGMVGTVLA
:
MMAR_1275|M.marinum_M AQAVRAGRDVLAKTSSEWDITDAAATEEI----IGTGDVVINCAAYTDVD
MUL_2612|M.ulcerans_Agy99 AQAVRAGRDVLAKTSSEWDITDAAATEEI----IGTGDVVINCAAYTDVD
Mb3294c|M.bovis_AF2122/97 AQAAREGRDMLALTSSQWDITDPAAAERI----IRHGDVVINCAAYTDVD
Rv3266c|M.tuberculosis_H37Rv AQAAREGRDMLALTSSQWDITDPAAAERI----IRHGDVVINCAAYTDVD
MLBr_00751|M.leprae_Br4923 AQATAAGRDVLALTSSQWDITDAAVAERMGRSALKKNDVVVNCAAYTNVD
MAV_4231|M.avium_104 ALAADQGRDVVALTSAQWDITDPAAAERI----VRPGDVVINCAAYTDVD
MAB_3613c|M.abscessus_ATCC_199 ARAKLRDLPVRALTSSDWDITRDGTPDGV----VAEGDIVINCAAYTAVD
Mvan_1727|M.vanbaalenii_PYR-1 GQARRAGRDVVALTSAQWDITDRAQAERV----IAAGDVVVNCAAFTKVD
Mflv_4736|M.gilvum_PYR-GCK GQARRQGRDVVALTSRDWDITEQGSEPR-----LAAGDIVVNCAAITNVD
MSMEG_1825|M.smegmatis_MC2_155 DQAAAKGHTVLALTSSQCDITDEDAVRRF----VANGDVVINCAAYTQVD
TH_0781|M.thermoresistible__bu GQARTQGRDVAAFTSAQWDITDAAAAEHL----IRPGDVVINCAAYTDVD
* . : * ** : *** : .*:*:**** * **
MMAR_1275|M.marinum_M SAESDEARAYAVNATGPENLAKACARAGAALIHVSTDYVFDGDHADLPDG
MUL_2612|M.ulcerans_Agy99 SAESDEARAYAVNATGPENLAKACARAGAALIHVSTDYVFDGDHADLPDG
Mb3294c|M.bovis_AF2122/97 GAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFG----G
Rv3266c|M.tuberculosis_H37Rv GAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFG----G
MLBr_00751|M.leprae_Br4923 GAESNELAAYAVNATGPEYIARACRCAGAALIHVSTDYVFSGDFGSGANR
MAV_4231|M.avium_104 GAESDEAGAFAVNEAGPGHIARACARAGARLLHVSTDYVFGGESPAG-AP
MAB_3613c|M.abscessus_ATCC_199 AAEEDESRAYAVNAEGAERVARACRDVGARLIHISTDYVFDGEFG----D
Mvan_1727|M.vanbaalenii_PYR-1 AAEAEPDRAHAVNAVGAGNVAQACARAGASLIHLSTDYVFS--------G
Mflv_4736|M.gilvum_PYR-GCK LAEAVPERSRAVNAVGAGNVARACAQVGASLIHLSTDYVFSGVFG----G
MSMEG_1825|M.smegmatis_MC2_155 KAEDEPERAHAVNAVGPGNLAKACAAVDAGLIHISTDYVFG---A----V
TH_0781|M.thermoresistible__bu GAESDEDRAHLVNAVGPGHLARACARVGADLVHISTDYVFS--------G
** : ** *. :*:** ..* *:*:******.
MMAR_1275|M.marinum_M AQPQPYEPGDKTAPQGVYARSKFAGERAVLAALPD---AVVVRSAWVYTG
MUL_2612|M.ulcerans_Agy99 AQPQPYEPGDKTAPQGVYARSKFAGERAVLAALPD---AVVVRSAWVYTG
Mb3294c|M.bovis_AF2122/97 AEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPE---AAVVRTAWVYTG
Rv3266c|M.tuberculosis_H37Rv AEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPE---AAVVRTAWVYTG
MLBr_00751|M.leprae_Br4923 VAPRPYEPTDETGPLGVYGRSKLAGEQAVLAAMPE---ATVVRTAWVYTG
MAV_4231|M.avium_104 DRPRPYEPGDPVAPQGVYARSKVAGERAVLAALPDPAQGVVVRTAWVYTG
MAB_3613c|M.abscessus_ATCC_199 AGPRPYRPGDATAPQGVYARTKVAGELAVHGVLPS---AQVVRTAWVYTG
Mvan_1727|M.vanbaalenii_PYR-1 SRRRPYEIDDETGPLSVYGRTKLAGEQAVLAALPD---AYVVRTAWIYEG
Mflv_4736|M.gilvum_PYR-GCK DSTRPYDIDDEPAPLSVYGRTKLAGEHAVLAALPN---AYVVRTSWIFEG
MSMEG_1825|M.smegmatis_MC2_155 DRDTPYEVDDETGPVNIYGRTKLAGEQAVLAAKPD---AYVVRTAWVYRG
TH_0781|M.thermoresistible__bu DRREPFEIDDDTTPMNVYGRTKLAGEQAVLSALPS---ARVVRTSWVYRG
*: * * .:*.*:*.*** ** .. *. . ***::*:: *
MMAR_1275|M.marinum_M G-TGSDFVAIMRRLAAGEGPVDVVDDQTGSPTYVADLAAALLEVADAGVR
MUL_2612|M.ulcerans_Agy99 G-TGSDFVAIMRRLAAGEGPVDVVDDQTGSPTYVADLAAALLEVADAGVR
Mb3294c|M.bovis_AF2122/97 G-TGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVR
Rv3266c|M.tuberculosis_H37Rv G-TGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVR
MLBr_00751|M.leprae_Br4923 G-TGKDFVAVMRRLAAGDGPVYVVDDQIGSPTYVVDLAAALLQVADGSVH
MAV_4231|M.avium_104 G-TGKDFVAVMRRLAAGEGPVQVVDDQIGSPTYVGDLAAALLQIVDDRVP
MAB_3613c|M.abscessus_ATCC_199 V-NG-DFVGVMRRLAAGEGPVRVVTDQTGSPTYAVDLAEALLDLAASDVR
Mvan_1727|M.vanbaalenii_PYR-1 G-AGTDFAAVMRRAAQGDGTVEVVADQIGSPTYVGDLCRALLQIADGGVR
Mflv_4736|M.gilvum_PYR-GCK G-NGADFAAVMRRAAAGSGDIEMVADQIGSPTYVGDLCAALLQIADGGVR
MSMEG_1825|M.smegmatis_MC2_155 G-DGSDFVATMRRLAAGDGAIDVVADQVGSPTYTGDLVGALLQIVDGGVE
TH_0781|M.thermoresistible__bu DVDGKDFVAVMRRLAAGPDPVNVVADQVGSPTYAADLAAALLQVADGAVD
* **.. *** * * . : :* ** *****. ** *** :. *
MMAR_1275|M.marinum_M GRLLHAANGGAVSRFGLARAVFEECGTDPQRVRPVSTAQFPRPAVRPGYS
MUL_2612|M.ulcerans_Agy99 GRLLHAANGGAVSRFGLARAVFEECGTDPQRVRPVSTAQFPRPVVRPGYS
Mb3294c|M.bovis_AF2122/97 GRVLHAANEGVVSRFGQARAVFEECGADPQRVRPVSSAQFPRPAPRPSYS
Rv3266c|M.tuberculosis_H37Rv GRVLHAANEGVVSRFGQARAVFEECGADPQRVRPVSSAQFPRPAPRSSYS
MLBr_00751|M.leprae_Br4923 GSVLHAANEGEVSRFGQARAVFEECGADPLQVQPVSTAQNPRSAARPAYS
MAV_4231|M.avium_104 GPVLHAANEGAVSRFEQARAVFEECGADPARVRPVGTEHFPRPAPRPTYS
MAB_3613c|M.abscessus_ATCC_199 EPFLHAAGSGHVNRFEWAKAVFELVGADASRLQPCLSVDFPRPAPRPAYT
Mvan_1727|M.vanbaalenii_PYR-1 GPVLHAANLGAVSRFDQAQAVFAELGADPSRVRPVGSDRHPRPAPRPAYS
Mflv_4736|M.gilvum_PYR-GCK GPLLHAANAGSASRFDQAQAVFAELGADPGRVHPISGDRHPRPAPRPSYS
MSMEG_1825|M.smegmatis_MC2_155 PGILHAANAGVASRFDQARATFEAVGADPERVRPCGSDRHPRPAPRPSYT
TH_0781|M.thermoresistible__bu IPVLHAANAGAASRFEQARAVFELVGADPDRVRPVTSDQVPRPAPRPAYT
.****. * ..** *:*.* *:*. :::* **.. *. *:
MMAR_1275|M.marinum_M ALGGRQWAAAGLTPLRPWRSALVAALAAASDRALAGRPVPSTSD
MUL_2612|M.ulcerans_Agy99 ALGGRQWAAAGLTPLRPWRSALVAALAAASDRALAGRPVPSTSD
Mb3294c|M.bovis_AF2122/97 ALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLPSTRD
Rv3266c|M.tuberculosis_H37Rv ALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLPSTRD
MLBr_00751|M.leprae_Br4923 ALSGRQSVAAGLTPLRPWRSALVEALAVSR-SLPVDRPLPSTRD
MAV_4231|M.avium_104 ALGSRESAAAGLRPLRPWRPALVAALTNAGSPAAADRPLPSTRD
MAB_3613c|M.abscessus_ATCC_199 ALDGDHWADAGLPRLRPWRDALAEALATN---------------
Mvan_1727|M.vanbaalenii_PYR-1 ALSPVKSAEAGLTPLRPWRDALAEALATVAG-------------
Mflv_4736|M.gilvum_PYR-GCK ALAATKSTAAGLTPLRPWRAALAEALATMGGSLL----------
MSMEG_1825|M.smegmatis_MC2_155 VLSSQRSAQAGLTPLRDWREALQDAVAAVVGATTDGPLPSTP--
TH_0781|M.thermoresistible__bu VLSGRRSAEAGLTPLRPWREALASALASAGEPAG-YPLRRE---
.* . . *** ** ** ** *::