For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TIVDLLTERVALPPEGEIAIVDIGPLTLENGEVIDDVSIAVQRWGELSARRDNVVVVLHALTGDSHITGP AGPDHPTPGWWDGVAGPGAPIDTDRWCAISTNVLGGCRGSTGPSSLAPDGKAWGSRFPTISIRDQVAADV AALERFGITEVAAVIGGSMGGARALEWMMLHPDSVRAALVLAVGARATADQIGTQCTQVAAIKSDPNWRG GDYHGTGRSPDHGLEIARRFAHLTYRGETELDERFGNDAQPGEDPATGGRYSVQSYLEHQGRKLLARFDA GTYVTLTDALSSHDIGRGRGGVAAALQSCPVPTVVGGITSDRLYPLRLQAELAELLPGCDGLDVVDSACG HDGFLVETDAVGKLIRRTLELAAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1553 | metX | - | 100% (375) | homoserine O-acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4414 | - | 5e-06 | 33.94% (109) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3373 | metX | 1e-172 | 77.87% (375) | homoserine O-acetyltransferase |
| M. gilvum PYR-GCK | Mflv_4876 | metX | 0.0 | 87.47% (375) | homoserine O-acetyltransferase |
| M. tuberculosis H37Rv | Rv3341 | metX | 1e-172 | 77.87% (375) | homoserine O-acetyltransferase |
| M. leprae Br4923 | MLBr_00682 | metX | 1e-173 | 77.75% (373) | homoserine O-acetyltransferase |
| M. abscessus ATCC 19977 | MAB_3688 | metX | 1e-160 | 73.02% (367) | homoserine O-acetyltransferase |
| M. marinum M | MMAR_1184 | metX | 1e-169 | 75.60% (373) | homoserine O-acetyltransferase MetA |
| M. avium 104 | MAV_4316 | metX | 1e-170 | 77.75% (373) | homoserine O-acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_1651 | metX | 1e-174 | 80.55% (365) | homoserine O-acetyltransferase |
| M. thermoresistible (build 8) | TH_1969 | metA | 1e-177 | 78.93% (375) | PROBABLE HOMOSERINE O-ACETYLTRANSFERASE META (HOMOSERINE |
| M. ulcerans Agy99 | MUL_1437 | metX | 1e-169 | 75.87% (373) | homoserine O-acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1553|M.vanbaalenii_PYR-1 MTIVDLLTERVA-----LPPEGEIAIVDIGPLTLENGEVIDDVSIAVQRW
Mflv_4876|M.gilvum_PYR-GCK MTIVDILSERVA-----LPPEGEIGIVDIGTLTLESGEVIEDAFIAVQRW
MSMEG_1651|M.smegmatis_MC2_155 MTIIEERATDTGMATVPLPAEGEIGLVHIGALTLENGTVLPDVTIAVQRW
TH_1969|M.thermoresistible__bu VTILDVTRTPT------LPAEGELAVVDIGPLQLECGEVLDNVSIAVQRW
MMAR_1184|M.marinum_M MTISDVP-TQT------LPAEGEVRLVDIGSLRLESGAVIDNVCIALQRW
MUL_1437|M.ulcerans_Agy99 MTISDVP-TQT------LPAEGEVRLVDIGSLRLESGAVIDNVCIALQRW
MLBr_00682|M.leprae_Br4923 MTISKVP-TQK------LPAEGEVGLVDIGSLTTESGAVIDDVCIAVQRW
Mb3373|M.bovis_AF2122/97 MTISDVP-TQT------LPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRW
Rv3341|M.tuberculosis_H37Rv MTISDVP-TQT------LPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRW
MAV_4316|M.avium_104 MTIPDVP-TQT------LPDEGEIGFVHIGSLTTEAGAVIDDVHIAVQRW
MAB_3688|M.abscessus_ATCC_1997 MTIEQQLPVPHIA----LPQGDEIAYVPIGSITLESGAVIDDVTIAVQSW
:** . ** .*: : :*.: * * *: :. **:* *
Mvan_1553|M.vanbaalenii_PYR-1 GELSARRDNVVVVLHALTGDSHITGPAGPDHPTPGWWDGVAGPGAPIDTD
Mflv_4876|M.gilvum_PYR-GCK GELSPDRDNVVMVLHALTGDSHITGPAGPDHPTPGWWDGVAGPGAPIDTD
MSMEG_1651|M.smegmatis_MC2_155 GELAPDRGNVVMVLHALTGDSHVTGPAGDGHPTAGWWDGVAGPGAPIDTD
TH_1969|M.thermoresistible__bu GELSPNRDNVVMVLHALTGDSHITGPAGPQHPTPGWWDGVAGPGAPIDTD
MMAR_1184|M.marinum_M GELSPTRDNVVMVLHALTGDSHVTGPAGPGHSTPGWWDGMVGPGAPIDTN
MUL_1437|M.ulcerans_Agy99 GELSPTRDNVVMVLHALTGDSHVTGPAGPGHSTPGWWDGMVGPGAPIDTN
MLBr_00682|M.leprae_Br4923 GELSPTRDNVVMVLHALTGDSHITGPAGPGHPTPGWWDWIAGPGAPIDTN
Mb3373|M.bovis_AF2122/97 GKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTT
Rv3341|M.tuberculosis_H37Rv GKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTT
MAV_4316|M.avium_104 GELSPTRDNVVVVLHALTGDSHVTGPAGPGHPTGGWWDEMVGPGAPIDTD
MAB_3688|M.abscessus_ATCC_1997 GELSPRRDNVVFVCHALTADSHVVGPAGPDHITGGWWEGIIGPGAAIDTD
*:*:. *.***.* ****.***:.**** * * ***: : ****.***
Mvan_1553|M.vanbaalenii_PYR-1 RWCAISTNVLGGCRGSTGPSSLAPDGKAWGSRFPTISIRDQVAADVAALE
Mflv_4876|M.gilvum_PYR-GCK TWCAISTNVLGGCRGSIGPSSTAPDGKAWGSRFPVITVRDQVAADVAALA
MSMEG_1651|M.smegmatis_MC2_155 HWCAIATNVLGGCRGSTGPGSLAPDGKPWGSRFPQITIRDQVAADRAALA
TH_1969|M.thermoresistible__bu RWCAVATNALGGCRGSTGPGSIAPDGKPWGSRFPTVTVRDQVNADLAALA
MMAR_1184|M.marinum_M RWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISVRDQVEADMAALA
MUL_1437|M.ulcerans_Agy99 RWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISVRDQVEADMAALA
MLBr_00682|M.leprae_Br4923 RWCAIATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVEADIAALA
Mb3373|M.bovis_AF2122/97 RWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALA
Rv3341|M.tuberculosis_H37Rv RWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALA
MAV_4316|M.avium_104 RWCAVATNVLGGCRGSTGPSSRTRDGKPWGSRFPRISIRDQVEADIAALA
MAB_3688|M.abscessus_ATCC_1997 HWCAVATNVLGGCRGTTGPTSLARDGKPWGSRFPEVSVRDQVNADVAALA
***::**.******: ** * : ***.****** :::**** ** ***
Mvan_1553|M.vanbaalenii_PYR-1 RFGITEVAAVIGGSMGGARALEWMMLHPDSVRAALVLAVGARATADQIGT
Mflv_4876|M.gilvum_PYR-GCK RLGITEVAAVIGGSMGGARALEWAVTYPDSVRSALVLAVGARATADQIGT
MSMEG_1651|M.smegmatis_MC2_155 ALGITEVAAVVGGSMGGARALEWLVTHPDDVRAGLVLAVGARATADQIGT
TH_1969|M.thermoresistible__bu ALGITEVAAVVGGSLGGARALEWMVGHPDTVRAGLVLAVGARATADQIGT
MMAR_1184|M.marinum_M ALGITQVAAVVGGSMGGARALEWIVGHPDRVRSALLLAVGARATADQIGT
MUL_1437|M.ulcerans_Agy99 ALGITQVAAVVGGSMGGARALEWIVGHPDRVRSALLLAVGARATADQIGT
MLBr_00682|M.leprae_Br4923 AMGITKVAAVVGGSMGGARALEWIIGHPDQVRAGLLLAVGVRATADQIGT
Mb3373|M.bovis_AF2122/97 ALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGT
Rv3341|M.tuberculosis_H37Rv ALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGT
MAV_4316|M.avium_104 ALGIDEVAAVVGGSMGGARALEWIVGHPSRVRAGLLLAVGARATADQIGT
MAB_3688|M.abscessus_ATCC_1997 QLGITEVAAVVGGSMGGARALEWAVMHPDAVRAALVLAVGARATGDQIGT
:** :****:***:******** : :*. **:.*:****.***.*****
Mvan_1553|M.vanbaalenii_PYR-1 QCTQVAAIKSDPNWRGGDYHGTGRSPDHGLEIARRFAHLTYRGETELDER
Mflv_4876|M.gilvum_PYR-GCK QSTQVAAIKADPNWAGGDYHDTGRSPDAGLEIARRFAHLTYRGEAELDDR
MSMEG_1651|M.smegmatis_MC2_155 QSTQVAAIKADPDWQGGDYHGTGRAPTEGMEIARRFAHLTYRGEEELDDR
TH_1969|M.thermoresistible__bu QSTQIAAIKADPDWQGGDYYGTGRAPLTGMMIARRFAHLTYRGEVELDNR
MMAR_1184|M.marinum_M QTTQIAAIKADPNWRNGDYHETGCKPEAGLKVARRFAHLTYRGEIELDSR
MUL_1437|M.ulcerans_Agy99 QTTQIAAIKADPNWRNGDYHETGCRPEAGLKVARRFAHLTYRGEIELDSR
MLBr_00682|M.leprae_Br4923 QTTQIAAIKTDPNWQGGDYYETGRAPENGLTIARRFAHLTYRSEVELDTR
Mb3373|M.bovis_AF2122/97 QTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELDTR
Rv3341|M.tuberculosis_H37Rv QTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELDTR
MAV_4316|M.avium_104 QCTQIAAIKSDPNWQGGDYHDTGRTPDAGLAIARRFAHLTYRGEVELDTR
MAB_3688|M.abscessus_ATCC_1997 QSTQIAAIQTDPDWQGGDYHGSGRSPGKGLNLARRIAHLTYRGEVELDTR
* **:***::**:* .***: :* * *: :***:******.* *** *
Mvan_1553|M.vanbaalenii_PYR-1 FGNDAQPG----EDPATGGRYSVQSYLEHQGRKLLARFDAGTYVTLTDAL
Mflv_4876|M.gilvum_PYR-GCK FGNDAQTG----EDPTTGGRYAVQSYLEYQGRKLLARFDAGTYVLLTDAL
MSMEG_1651|M.smegmatis_MC2_155 FANTPQDD----EDPLTGGRYAVQSYLEYQGGKLARRFDPGTYVVLSDAL
TH_1969|M.thermoresistible__bu FGNKPQGD----EDPLAGGRYAVQSYLEHQGEKLAARFDPGTYVALTEAL
MMAR_1184|M.marinum_M FANDGQGG----EDPADGGRYAIQSYLEHQGDKLLARFDAGSYVILTEAL
MUL_1437|M.ulcerans_Agy99 FANDGQGG----EDPADGGRYAIQSYLEHQGDKLLARFDAGSYVILTEAL
MLBr_00682|M.leprae_Br4923 FANNNQGN----EDPATGGRYAVQSYLEHQGDKLLARFDAGSYVVLTETL
Mb3373|M.bovis_AF2122/97 FANHNQGN----EDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEAL
Rv3341|M.tuberculosis_H37Rv FANHNQGN----EDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEAL
MAV_4316|M.avium_104 FGNDAQLD----EDPANGGRYAVQSYLEYQGVKLVERFDAGSYVVLTEAL
MAB_3688|M.abscessus_ATCC_1997 FGNDPQVGPDGPEDPWADGRYAVQSYLEHQGNKFVRRFDAGSYVILTESL
*.* * . *** .***::*****:** *: ***.*:** *:::*
Mvan_1553|M.vanbaalenii_PYR-1 SSHDIGRGRGGVAAALQSCPVPTVVGGITSDRLYPLRLQAELAELLPGCD
Mflv_4876|M.gilvum_PYR-GCK SSHDVGRGRGGIAAALAGCPVPTVVGGITSDRLYPLRLQAELAELLPGCD
MSMEG_1651|M.smegmatis_MC2_155 SSHDVGRGRGGVEAALRSCPVPVVVGGITSDRLYPIRLQQELAELLPGCQ
TH_1969|M.thermoresistible__bu SSHDVGRGRGGVEAALRSCPVPALVGGITSDRLYPLRLQEELAERLPGCR
MMAR_1184|M.marinum_M NRHDVGRGRDGIHAALRGCPVPVVVGGITSDRLYPLRLQQELADLLPGCA
MUL_1437|M.ulcerans_Agy99 SRHDVGRGRDGIHAALRGCPVPVVVGGITSDRLYPLRLQQELADLLPGCA
MLBr_00682|M.leprae_Br4923 NSHDVGRGRGGIGTALRGCPVPVVVGGITSDRLYPLRLQQELAEMLPGCT
Mb3373|M.bovis_AF2122/97 NSHDVGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCA
Rv3341|M.tuberculosis_H37Rv NSHDVGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCA
MAV_4316|M.avium_104 NSHDVGRARGGVRKALRSCPVPVVVGGITSDRLYPLRLQQELAEQLPGCA
MAB_3688|M.abscessus_ATCC_1997 NRHDVGRGRGGVEKALRGCPVPVVVGGITSDRLYPLRLQEELADLLPGCT
. **:**.*.*: ** .****.:***********:*** ***: ****
Mvan_1553|M.vanbaalenii_PYR-1 GLDVVDSACGHDGFLVETDAVGKLIRRTLELAAR----------------
Mflv_4876|M.gilvum_PYR-GCK ALDVVESAYGHDGFLVETDAVGKLIRRTLDLAGK----------------
MSMEG_1651|M.smegmatis_MC2_155 GLDVVDSIYGHDGFLVETELVGKLIRRTLELAQR----------------
TH_1969|M.thermoresistible__bu DLDIIDSMYGHDGFLVETEAVGKLIRRTLELADR----------------
MMAR_1184|M.marinum_M GLEVVDSIRGHDGFLVESEAVGELIHKTLRLAEDRSSRPW----------
MUL_1437|M.ulcerans_Agy99 GLEVVDSIRGHDGFLVESEAVGELIHKTLRLAEDRSSRPW----------
MLBr_00682|M.leprae_Br4923 GLQVVDSTYGHDGFLVESEAVGKLIRQTLELADVGSKEDACSQ-------
Mb3373|M.bovis_AF2122/97 GLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR----------
Rv3341|M.tuberculosis_H37Rv GLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR----------
MAV_4316|M.avium_104 ELQVVDSICGHDGFLVESEAVGEMIRKTLLLAGSQSAGPGGAGPGSRKGT
MAB_3688|M.abscessus_ATCC_1997 GLRVVESVHGHDAFLIEFDAVSELVRETLALAKATQAS------------
* :::* ***.**:* : *.::::.** **
Mvan_1553|M.vanbaalenii_PYR-1 ---
Mflv_4876|M.gilvum_PYR-GCK ---
MSMEG_1651|M.smegmatis_MC2_155 ---
TH_1969|M.thermoresistible__bu ---
MMAR_1184|M.marinum_M ---
MUL_1437|M.ulcerans_Agy99 ---
MLBr_00682|M.leprae_Br4923 ---
Mb3373|M.bovis_AF2122/97 ---
Rv3341|M.tuberculosis_H37Rv ---
MAV_4316|M.avium_104 TRR
MAB_3688|M.abscessus_ATCC_1997 ---