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VFFQVVAADIDGTLTSSGELSVDALRAIRRARDGGVCVVFVTGRIAAELHTEFPGIAEHADALVLENGAV AVVDGQDILLAAPVESALDAELTRRHIPFRRGAALIATDGHHVAGVVEAIGVLGLDCQIIRNREALMVLP AGVTKGSGLRSLLSRINRSPHNTIAIGDAENDLSMMAAAELGVAVANAVASVKAHADLVMDDRDGKGVAG LLDGPILSGARRWCPPRRWVDIGVFDDHTPAQLPGSQGRIVVTGPPGSGKSHLIGLMAEQWILAGYGVLV VDPEGDHAELRELDNVVLVDSRHNLVEPPDLVEMLHPATSLVVDLSALDAEAKSGYAHRLRSVVEAHRER HGFPHWVIWDEAHLLGRQREERWVRRGGYVLSSFAPATLPADEVDASDVVVEAIRPDRAESVANPVQWAT IRYGTDASRPFTVARRRTAHIRHRHKYVDVALPRERRFYFQAEDGQPVTPAATMRDFGQAILQLTPESLQ FHLERGDFSRWLGHTIADTELAAEVACWEDEVAAHRAAEIERVRRQIADAVRTRYLEGRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1423 | - | - | 100% (550) | HAD family hydrolase |
| M. vanbaalenii PYR-1 | Mvan_5654 | - | 4e-08 | 25.93% (270) | Cof-like hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3843c | - | 7e-09 | 25.47% (267) | hypothetical protein Mb3843c |
| M. gilvum PYR-GCK | Mflv_1155 | - | 9e-09 | 25.09% (267) | Cof-like hydrolase |
| M. tuberculosis H37Rv | Rv3813c | - | 3e-09 | 25.47% (267) | hypothetical protein Rv3813c |
| M. leprae Br4923 | MLBr_00089 | - | 1e-07 | 31.00% (100) | hypothetical protein MLBr_00089 |
| M. abscessus ATCC 19977 | MAB_0167 | - | 3e-07 | 35.53% (76) | putative hydrolase |
| M. marinum M | MMAR_5376 | - | 2e-07 | 28.97% (107) | hypothetical protein MMAR_5376 |
| M. avium 104 | MAV_0205 | - | 5e-08 | 24.63% (268) | hypothetical protein MAV_0205 |
| M. smegmatis MC2 155 | MSMEG_6407 | - | 2e-08 | 24.72% (267) | Cof-like hydrolase |
| M. thermoresistible (build 8) | TH_0897 | - | 1e-05 | 33.33% (78) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4996 | - | 1e-07 | 28.97% (107) | hypothetical protein MUL_4996 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3843c|M.bovis_AF2122/97 --------MKPTVPALVACDVDGTLLDDGETVTKRTRDAVHAAVDAGTHF
Rv3813c|M.tuberculosis_H37Rv --------MKPTVPALVACDVDGTLLDDGETVTKRTRDAVHAAVDAGTHF
MMAR_5376|M.marinum_M ------------------------MLNDDEHVSGRTRDAVRAAVAGGATF
MUL_4996|M.ulcerans_Agy99 ------------------------MLNDDEHVSGRTRDAVRAAVAGGATF
MLBr_00089|M.leprae_Br4923 MTDTTRPAPTPTQPTLIACDVDGTLLDENETVTARTRAAVRSAVAGGAYF
MAV_0205|M.avium_104 ----------MTLPRLIACDVDGTLFDDDERITPRTRAAVRAAVAGGARF
Mflv_1155|M.gilvum_PYR-GCK -----------MTPLMIATDVDGTLLDNDENVTARTRSAVRAAVDAGVRF
MSMEG_6407|M.smegmatis_MC2_155 -------MTSDKTPGLIATDVDGTLLDEDERVTPRTRAAVRAAVAAGATF
TH_0897|M.thermoresistible__bu ----------VTLPSLIASDVDGTLLDDQERLTPRTRDAIYAARDAGAHF
MAB_0167|M.abscessus_ATCC_1997 ----------MTHPALIASDVDGTLIDSAEILSARTRAVITAAVESGSAF
Mvan_1423|M.vanbaalenii_PYR-1 -----------MFFQVVAADIDGTLTSSGE-LSVDALRAIRRARDGGVCV
: .. * :: : .: * .* .
Mb3843c|M.bovis_AF2122/97 ILATGRPPRWVRPIVDALG-FAPMAVCANGAVIYDPGTDRVTSVRTLP--
Rv3813c|M.tuberculosis_H37Rv ILATGRPPRWVRPIVDALG-FAPMAVCANGAVIYDPGTDRVMSVRTLP--
MMAR_5376|M.marinum_M ILATGRPPRWVRPVVEELG-FTPMAVCANGAVIYDPATDRVVSAHTLS--
MUL_4996|M.ulcerans_Agy99 ILATGRPPRWVRPVVEELG-FTPMAVCANGAVIYDPATDRVVSAHTLS--
MLBr_00089|M.leprae_Br4923 VLATGRPPRWVRPVVDALG-FPPMAVCANGAVIYDPATDRVVSARTLA--
MAV_0205|M.avium_104 VVATGRPPRWIRPVVDALG-FAPIAVCANGAVIYDPANDRVLSARTLD--
Mflv_1155|M.gilvum_PYR-GCK VLATGRPPRWVGPVVDQLG-FAPMAVCANGAVIYDPSTDRIVSARTLS--
MSMEG_6407|M.smegmatis_MC2_155 VLATGRPPRWIQPVVDGLG-LAPMAVCANGAVIYDPATDRIVSARTLS--
TH_0897|M.thermoresistible__bu VLATGRPPRWIAPVVDALG-FAPMAVCANGAVIYDPDTDRIVSARTLS--
MAB_0167|M.abscessus_ATCC_1997 VLATGRPPRWITPIVDALG-FAPISVCANGSVLYDAENDRIISAATLS--
Mvan_1423|M.vanbaalenii_PYR-1 VFVTGRIAAELHTEFPGIAEHADALVLENGAVAVVDGQDILLAAPVESAL
:..*** . : . . :. . * **:* * : :. .
Mb3843c|M.bovis_AF2122/97 -----------------------------------------VDALATLAE
Rv3813c|M.tuberculosis_H37Rv -----------------------------------------VDALATLAE
MMAR_5376|M.marinum_M -----------------------------------------VEALATLAE
MUL_4996|M.ulcerans_Agy99 -----------------------------------------VEALATLAE
MLBr_00089|M.leprae_Br4923 -----------------------------------------VDILGELVE
MAV_0205|M.avium_104 -----------------------------------------VDTLAELAE
Mflv_1155|M.gilvum_PYR-GCK -----------------------------------------TDVLAMLAE
MSMEG_6407|M.smegmatis_MC2_155 -----------------------------------------PEMLAELAD
TH_0897|M.thermoresistible__bu -----------------------------------------AATLQKLSD
MAB_0167|M.abscessus_ATCC_1997 -----------------------------------------PSELAVLAE
Mvan_1423|M.vanbaalenii_PYR-1 DAELTRRHIPFRRGAALIATDGHHVAGVVEAIGVLGLDCQIIRNREALMV
*
Mb3843c|M.bovis_AF2122/97 VATRVIPGAGLA--VERIGERAHDTATP--------------------QF
Rv3813c|M.tuberculosis_H37Rv VATRVIPGAGLA--VERIGERAHDTATP--------------------QF
MMAR_5376|M.marinum_M VSSRVIPGSGLA--VERIGERAHDTATP--------------------QF
MUL_4996|M.ulcerans_Agy99 VSSRVIPGSGLA--VERIGERAHDTAAP--------------------QF
MLBr_00089|M.leprae_Br4923 IATRVIPGAGLA--VERVGDRAHDSATP--------------------QF
MAV_0205|M.avium_104 LATRVIPGAGLA--VERIGERAHDTATP--------------------QF
Mflv_1155|M.gilvum_PYR-GCK IATRTIPGAGLA--VERVGSSAHDAATP--------------------QF
MSMEG_6407|M.smegmatis_MC2_155 IATHVIPGAGLA--VERVGRSAHDAATP--------------------QF
TH_0897|M.thermoresistible__bu LVSRLLPGAGLA--VERVGEQAHDAATP--------------------QF
MAB_0167|M.abscessus_ATCC_1997 VAQAAIPGVGLA--VERVGRSAHDAATP--------------------QF
Mvan_1423|M.vanbaalenii_PYR-1 LPAGVTKGSGLRSLLSRINRSPHNTIAIGDAENDLSMMAAAELGVAVANA
: * ** :.*:. .*:: : :
Mb3843c|M.bovis_AF2122/97 VSSPGYEHAWLNPDNTEVSIDHLLSAPAIK--------------------
Rv3813c|M.tuberculosis_H37Rv VSSPGYEHAWLNPDNTEVSIDHLLSAPAIK--------------------
MMAR_5376|M.marinum_M VSSPGYEHAWLNPDNTEVSIEDLLSAPAIK--------------------
MUL_4996|M.ulcerans_Agy99 VSSPGYEHAWLNPDNTEVSIEDLLSAPAIK--------------------
MLBr_00089|M.leprae_Br4923 VSSVGYEHAWLHPDNTEVSIEDLLSVPAIK--------------------
MAV_0205|M.avium_104 ISSPGYEHAWLNPDNTEVSIEDLLSAPAIK--------------------
Mflv_1155|M.gilvum_PYR-GCK VSSPGYEHAWLNPDNTEVSIEDLLSAPAVK--------------------
MSMEG_6407|M.smegmatis_MC2_155 VSSPGYEHAWLNPDNTEVSVEDLLSAPAVK--------------------
TH_0897|M.thermoresistible__bu VSSPGYEHAWLNPDNTEVSLEDLLSAPAIK--------------------
MAB_0167|M.abscessus_ATCC_1997 VSSPGYEHAWLNPDNTEVSLEDLLSFPAVK--------------------
Mvan_1423|M.vanbaalenii_PYR-1 VASVKAHADLVMDDRDGKGVAGLLDGPILSGARRWCPPRRWVDIGVFDDH
::* . : *. .: **. * :.
Mb3843c|M.bovis_AF2122/97 ------------LLIRKAGAASADMAAELAKHVGFEG-------------
Rv3813c|M.tuberculosis_H37Rv ------------LLIRKAGAASADMAAELAKHVGFEG-------------
MMAR_5376|M.marinum_M ------------LLIRKAGAASADMAAELAKHVGIEG-------------
MUL_4996|M.ulcerans_Agy99 ------------LLIRKAGAASADMAAELAKHVGIEG-------------
MLBr_00089|M.leprae_Br4923 ------------LLIRKSGARSADMAAELAKHVGIAG-------------
MAV_0205|M.avium_104 ------------LLIRRAGARSSDIAAELAKHVGLEG-------------
Mflv_1155|M.gilvum_PYR-GCK ------------LLVRKAGARSADMAEVLAQHIGTEG-------------
MSMEG_6407|M.smegmatis_MC2_155 ------------LLIRKAGAQSADMAAELVKHIGAQG-------------
TH_0897|M.thermoresistible__bu ------------LLIRKPGATSSEMAELLGEHIRPYG-------------
MAB_0167|M.abscessus_ATCC_1997 ------------LLVRKAGARSSEMAEVLAPLVTEAGA------------
Mvan_1423|M.vanbaalenii_PYR-1 TPAQLPGSQGRIVVTGPPGSGKSHLIGLMAEQWILAGYGVLVVDPEGDHA
:: .*: .:.: : *
Mb3843c|M.bovis_AF2122/97 ------------------------DITYSTNNGLVEIVPLGISKATGVDE
Rv3813c|M.tuberculosis_H37Rv ------------------------DITYSTNNGLVEIVPLGISKATGVDE
MMAR_5376|M.marinum_M ------------------------DITYSTNNGLVEIVPLGISKATGVRD
MUL_4996|M.ulcerans_Agy99 ------------------------DITYSTNNGLVEIVPLGISKATGVRD
MLBr_00089|M.leprae_Br4923 ------------------------DITYSTNNGLVEILPLGISKATGVEE
MAV_0205|M.avium_104 ------------------------DITYSTDNGLVEIVPLGISKATGIEE
Mflv_1155|M.gilvum_PYR-GCK ------------------------DITYSTNNGLIEIMPLGISKATGIEE
MSMEG_6407|M.smegmatis_MC2_155 ------------------------DITYSTNNGLIEIVPSGISKATGVAE
TH_0897|M.thermoresistible__bu ------------------------EITFSTDNGLLEVVSPGITKATGVEE
MAB_0167|M.abscessus_ATCC_1997 ------------------------AITYSTDNGLIEVMPTGISKASGIAI
Mvan_1423|M.vanbaalenii_PYR-1 ELRELDNVVLVDSRHNLVEPPDLVEMLHPATSLVVDLSALDAEAKSGYAH
: ..: . :::: . . :*
Mb3843c|M.bovis_AF2122/97 IARPLGISDAEVVAFG--------DMPNDVPMLLRAGLGVAMGNAHPDAL
Rv3813c|M.tuberculosis_H37Rv IARPLGISDAEVVAFG--------DMPNDVPMLLRAGLGVAMGNAHPDAL
MMAR_5376|M.marinum_M VAAPLGIADTDVVAFG--------DMPNDVPMLLRAGLGVAMGNAHPDAL
MUL_4996|M.ulcerans_Agy99 VAAPLGIADTDVVAFG--------DMPNDVPMLLRAGLGVAMGNAHPDAL
MLBr_00089|M.leprae_Br4923 VGRPLGIADGNAAAFG--------DMPNDVPMLLRAGHGVAMGNAHPAVL
MAV_0205|M.avium_104 IARPLEIAREEVVAFG--------DMPNDLPMLRWAGHGVAMGNAHPEVQ
Mflv_1155|M.gilvum_PYR-GCK LARPLGVDAADIVTFG--------DMPNDVPMLGWAGLGVAMGNAHPDAL
MSMEG_6407|M.smegmatis_MC2_155 LAGPLGLTDADIVAFG--------DMPNDVPMLSWAGRGVAMGNAHPEAK
TH_0897|M.thermoresistible__bu LARPLGLTAADVVAFG--------DMPNDIPMLRWAGLGVAMGNAHPKAI
MAB_0167|M.abscessus_ATCC_1997 VAKQAGVQPESIIAFG--------DMPNDVAMLRWAGHGVAMGNAHPEAR
Mvan_1423|M.vanbaalenii_PYR-1 RLRSVVEAHRERHGFPHWVIWDEAHLLGRQREERWVRRGGYVLSSFAPAT
. * .: . . * : .:.. .
Mb3843c|M.bovis_AF2122/97 AVADEVTAP-------NSEDGVARVLERWWS-------------------
Rv3813c|M.tuberculosis_H37Rv AVADEVTAP-------NSEDGVARVLERWWS-------------------
MMAR_5376|M.marinum_M AAANEVTAP-------NSEDGVAKVLERWWF-------------------
MUL_4996|M.ulcerans_Agy99 AAANEVTAP-------NSEDGVAKVLERWWF-------------------
MLBr_00089|M.leprae_Br4923 AAADEITAP-------NTDDGVARVLERWWS-------------------
MAV_0205|M.avium_104 AAADEITAA-------NNDDGVGRVLERWWL-------------------
Mflv_1155|M.gilvum_PYR-GCK AAADEVTGT-------NAEDGVARVLERWWR-------------------
MSMEG_6407|M.smegmatis_MC2_155 AAADEVTTT-------NAEDGVATVLERWWG-------------------
TH_0897|M.thermoresistible__bu EAADEVTAP-------NTDDGLARVLERWWM-------------------
MAB_0167|M.abscessus_ATCC_1997 AAANEVTAT-------NNDDGVAKVLERWWG-------------------
Mvan_1423|M.vanbaalenii_PYR-1 LPADEVDASDVVVEAIRPDRAESVANPVQWATIRYGTDASRPFTVARRRT
*:*: . . : . . . *
Mb3843c|M.bovis_AF2122/97 --------------------------------------------------
Rv3813c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5376|M.marinum_M --------------------------------------------------
MUL_4996|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00089|M.leprae_Br4923 --------------------------------------------------
MAV_0205|M.avium_104 --------------------------------------------------
Mflv_1155|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6407|M.smegmatis_MC2_155 --------------------------------------------------
TH_0897|M.thermoresistible__bu --------------------------------------------------
MAB_0167|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1423|M.vanbaalenii_PYR-1 AHIRHRHKYVDVALPRERRFYFQAEDGQPVTPAATMRDFGQAILQLTPES
Mb3843c|M.bovis_AF2122/97 --------------------------------------------------
Rv3813c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5376|M.marinum_M --------------------------------------------------
MUL_4996|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00089|M.leprae_Br4923 --------------------------------------------------
MAV_0205|M.avium_104 --------------------------------------------------
Mflv_1155|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6407|M.smegmatis_MC2_155 --------------------------------------------------
TH_0897|M.thermoresistible__bu --------------------------------------------------
MAB_0167|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1423|M.vanbaalenii_PYR-1 LQFHLERGDFSRWLGHTIADTELAAEVACWEDEVAAHRAAEIERVRRQIA
Mb3843c|M.bovis_AF2122/97 ------------
Rv3813c|M.tuberculosis_H37Rv ------------
MMAR_5376|M.marinum_M ------------
MUL_4996|M.ulcerans_Agy99 ------------
MLBr_00089|M.leprae_Br4923 ------------
MAV_0205|M.avium_104 ------------
Mflv_1155|M.gilvum_PYR-GCK ------------
MSMEG_6407|M.smegmatis_MC2_155 ------------
TH_0897|M.thermoresistible__bu ------------
MAB_0167|M.abscessus_ATCC_1997 ------------
Mvan_1423|M.vanbaalenii_PYR-1 DAVRTRYLEGRG