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MSGGSWLTTGNLGAEVHETHTGLVALVGDRAFKIKKPVVTDFLDFSTAQKRETACRREIELNRRLASSSY LGVGHFQPPSGDAEPVIVMRRYPDTERLAELVRSGVPVETWLTAIADLLARFHSRAERGDAIDREATARV LSDRWQQNLTELRRHAGTVVDDGQIAEVERLASAYLAGREPLYQARIAAHRVVDGHGDLLSQDIFCTAEG PMLLDCLEFDDRLRYVDGIDDAGFLAMDLEFLGRRDLADFFLDEYCRRADDPAAHSLRHFCIAYRAVVRA KVDCVRVDQGHAEAIPDAQRHLAIALAHLRSGRVQLVVVGGGPGTGKTTLARALAQCVDAQLISTDEVRR ELVGSGVVHGRAGELNTGLYTPENLSAVYDEVLSRARAWLGAGHSVIVDGTWRDAGHRQRAHAVAAQTYS SIVELRCTLPVAEAERRIAGRGATASDATPAMAAELSRWESDWPGAHPIDTAGPLADSVAAARQVCLDTV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1384 | - | - | 100% (490) | hypothetical protein Mvan_1384 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2027c | - | 1e-141 | 55.51% (472) | hypothetical protein Mb2027c |
| M. gilvum PYR-GCK | Mflv_0263 | - | 1e-151 | 57.62% (479) | hypothetical protein Mflv_0263 |
| M. tuberculosis H37Rv | Rv2004c | - | 1e-141 | 55.51% (472) | hypothetical protein Rv2004c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3902c | - | 1e-141 | 51.95% (487) | hypothetical protein MAB_3902c |
| M. marinum M | MMAR_3476 | - | 1e-142 | 56.05% (471) | hypothetical protein MMAR_3476 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_3942 | - | 1e-154 | 59.71% (479) | hypothetical protein MSMEG_3942 |
| M. thermoresistible (build 8) | TH_2244 | cysN | 2e-06 | 28.30% (212) | PROBABLE BIFUNCTIONAL ENZYME CYSN/CYSC: SULFATE |
| M. ulcerans Agy99 | MUL_1249 | - | 2e-05 | 29.09% (110) | hypothetical protein MUL_1249 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0263|M.gilvum_PYR-GCK ----------------MGTP-------------------GNLDAQIHET-
MSMEG_3942|M.smegmatis_MC2_155 ---------------MEDKPETAVA------QRDRVFAFGNLDAQIRET-
Mvan_1384|M.vanbaalenii_PYR-1 ---------------MSGGS---------------WLTTGNLGAEVHET-
Mb2027c|M.bovis_AF2122/97 ----------------MDSPTNDG-------TCDAHPVTDEPFIDVRET-
Rv2004c|M.tuberculosis_H37Rv ----------------MDSPTNDG-------TCDAHPVTDEPFIDVRET-
MMAR_3476|M.marinum_M ---------------------------------------------MHET-
MAB_3902c|M.abscessus_ATCC_199 ---------------MTGCPQLPPRNDEVMRSLRSTLSPTSVGAEIRET-
TH_2244|M.thermoresistible__bu MTQVLNQPTTLLRLATAGSVDDGKSTLIGRLLFDSKAVMEDQLAAVERTS
MUL_1249|M.ulcerans_Agy99 -----------------------------------MTPNRGIDAEFLDLP
.
Mflv_0263|M.gilvum_PYR-GCK ------HTGLVVLLGERAYKAKKAVKTDFLD--FSTVEQRARALHHEVTL
MSMEG_3942|M.smegmatis_MC2_155 ------HTGLVALIGDLAYKAKKPVRTDFLD--FTTAQQREAACLREVEL
Mvan_1384|M.vanbaalenii_PYR-1 ------HTGLVALVGDRAFKIKKPVVTDFLD--FSTAQKRETACRREIEL
Mb2027c|M.bovis_AF2122/97 ------HTAVVVLAGDRAFKAKKPVVTDFCD--FRTAEQRERACIREFEL
Rv2004c|M.tuberculosis_H37Rv ------HTAVVVLAGDRAFKAKKPVVTDFCD--FRTAEQRERACIREFEL
MMAR_3476|M.marinum_M ------HTGVVVLVGERAYKAKKPVLTDFLD--FRTAEQRERACAREVEL
MAB_3902c|M.abscessus_ATCC_199 ------HTGIVILVGGMAYKIKKPVITNFLD--FSTPELRERACAREVAL
TH_2244|M.thermoresistible__bu QERGHDYTDLALVTDGLRAEREQGITIDVAYRYFATAKRKFIIADTPGHL
MUL_1249|M.ulcerans_Agy99 RLALADAALSAATAAGASYADLRIQRIGTEIIHLRDGELETAILSRELGF
: . : . : : . :
Mflv_0263|M.gilvum_PYR-GCK NRRLAPQSYLGVGEFAMPGAQP-EPVIVMRR--------------YPDSA
MSMEG_3942|M.smegmatis_MC2_155 NSRLAPNSYLGVAHLVGPGDRPDEPVVVMRR--------------YRDAD
Mvan_1384|M.vanbaalenii_PYR-1 NRRLASSSYLGVGHFQPPSGDA-EPVIVMRR--------------YPDTE
Mb2027c|M.bovis_AF2122/97 NSRLAAQSYLGIAHLSDPSGGHAEPVVVMRR--------------YRDKQ
Rv2004c|M.tuberculosis_H37Rv NSRLAAQSYLGIAHLSDPSGGHAEPVVVMRR--------------YRDKQ
MMAR_3476|M.marinum_M NSRLAPTSYLGVAHCTDPTGGPAEPLVVMRR--------------YHDSD
MAB_3902c|M.abscessus_ATCC_199 NSRISQDSYLGVSHLTDPDGGSGEPVVVMRR--------------YPDAA
TH_2244|M.thermoresistible__bu QYTRNMVTGASTAHLVIVLVDARNGLLEQSRRHAFLASLLGVRHVVLAVN
MUL_1249|M.ulcerans_Agy99 AVRVIVNGTWGFASHAELSASAAADTARRAVR---------------VAT
. .
Mflv_0263|M.gilvum_PYR-GCK RLTSLVAQG---KPLTAELREIAGRLADFHRDARRGPDIDAQGRPE-AVW
MSMEG_3942|M.smegmatis_MC2_155 RLSTLVTRG---AEVNDQLDVIAEILARFHRDAGRGAVIDDQARAT-SVW
Mvan_1384|M.vanbaalenii_PYR-1 RLAELVRSG---VPVETWLTAIADLLARFHSRAERGDAIDREATAR-VLS
Mb2027c|M.bovis_AF2122/97 RLASMVTAG---LPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVG-AVA
Rv2004c|M.tuberculosis_H37Rv RLASMVTAG---LPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVG-AVA
MMAR_3476|M.marinum_M RLAYQISSGGSDESVRALLDTIATVLARFHEGAERSPTINTAGEPA-AIG
MAB_3902c|M.abscessus_ATCC_199 RLSAMAKSK---RVTKAHLDAIAEVLAGFHKRADRSPSIDEAGSLD-AIV
TH_2244|M.thermoresistible__bu KMDLIDWDRERFDAIREEFEAFATRLDLHDVRAIPLSALHGDNVVTKSDR
MUL_1249|M.ulcerans_Agy99 TLAALNTER-------VELAPEPVYTDAVWVSNYQIDPFSLPASEKIAVL
: : . :
Mflv_0263|M.gilvum_PYR-GCK ERWAQNLTELGRHADVVFDRADLDEIHALAQRFLAGRSV-------LMAQ
MSMEG_3942|M.smegmatis_MC2_155 ARWDENLTELARMSLVPPE--QLSEVRRLASQYLSGRAE-------LFAE
Mvan_1384|M.vanbaalenii_PYR-1 DRWQQNLTELRRHAGTVVDDGQIAEVERLASAYLAGREP-------LYQA
Mb2027c|M.bovis_AF2122/97 RRWHENLAELRHHADKVVSGDVIRRIEHMVDEFVSGREV-------LFAG
Rv2004c|M.tuberculosis_H37Rv RRWHENLAELRHHADKVVSGDVIRRIEHMVDEFVSGREV-------LFAG
MMAR_3476|M.marinum_M RRFGDNLAELHRYAGTSFPDESIGRIEDLVAAFISGRET-------LLAQ
MAB_3902c|M.abscessus_ATCC_199 DRWDDTLTALEKYAGTVLAADDVRLVRTLATQFISGRAV-------LFAQ
TH_2244|M.thermoresistible__bu APWYEGPALLEHLESIDVAGDRNLVDVRFPVQYVIRPHTREHQDHRSYAG
MUL_1249|M.ulcerans_Agy99 EDYSGRLLSADGVDHASASLNAVKEQTFYADTYGSSITQQR-----VRLH
: :
Mflv_0263|M.gilvum_PYR-GCK RIAQGRIVDGHADLLTD----DIFCMPDGPAMLDCLEFDDLLRYVDGVDD
MSMEG_3942|M.smegmatis_MC2_155 RIADGRIVDGHADLLAD----DIFCTPEGPAILDCLEFDDTLRYVDGVDD
Mvan_1384|M.vanbaalenii_PYR-1 RIAAHRVVDGHGDLLSQ----DIFCTAEGPMLLDCLEFDDRLRYVDGIDD
Mb2027c|M.bovis_AF2122/97 RIKEGCIVDGHADLLAD----DIFLVDGEPALLDCLEFEDELRYLDRIDD
Rv2004c|M.tuberculosis_H37Rv RIKEGCIVDGHADLLAD----DIFLVDGEPALLDCLEFEDELRYLDRIDD
MMAR_3476|M.marinum_M RIAQGCIVDGHGDLLAD----DIFCAEGGPALLDCLEFDDRLRYVDRVDD
MAB_3902c|M.abscessus_ATCC_199 RVADGRIIDGHGDLLAS----DIFCLPNGPVLLDCLEFDDRLRHVDGLDD
TH_2244|M.thermoresistible__bu TVASGVLRTGDEIVVLPSGKTSRITGIEGPSGPVTEAFPPMAISITLADD
MUL_1249|M.ulcerans_Agy99 PSLEAVTVDSGAGIFDS----MRTLAPPTARGWEVVAGDEIWNWTDELAQ
. :. . :
Mflv_0263|M.gilvum_PYR-GCK AAFLAMDLEFHG--RGNLGDEFLRE---YVARAADPAPRSLQNFYIAY--
MSMEG_3942|M.smegmatis_MC2_155 AAFLAMDLEFLG--SPELSAFFVDR---YRHHAHDTAPQSLMDFYVAY--
Mvan_1384|M.vanbaalenii_PYR-1 AGFLAMDLEFLG--RRDLADFFLDE---YCRRADDPAAHSLRHFCIAY--
Mb2027c|M.bovis_AF2122/97 AAFLAMDLEFLG--RKDLGDYFLAG---YAVRSGDTAPASLRDFYIAY--
Rv2004c|M.tuberculosis_H37Rv AAFLAMDLEFLG--RKDLGDYFLAG---YAVRSGDTAPASLRDFYIAY--
MMAR_3476|M.marinum_M AAFLAMDLEFLG--RKDLGEYFLDR---YLAHSGDVAPASLRDFYIAY--
MAB_3902c|M.abscessus_ATCC_199 AAFLAMDLEFLG--RPDLGDYFMNR---YVELSADTAPEPLRHFYIAY--
TH_2244|M.thermoresistible__bu IDISRGDMITRSDNRPQMTQDFDAT---VCWMADESALEPGRDYILKHTT
MUL_1249|M.ulcerans_Agy99 LPSLLAEKTKAPSVTAGPTDLVIDPTNLWLTIHESIGHATEYDRAIGYEA
: . . . . . : :
Mflv_0263|M.gilvum_PYR-GCK ---RAVVRAKVDCVRVEQGHPEAADDARRHLHLAADRLR-DGAVRLVIVG
MSMEG_3942|M.smegmatis_MC2_155 ---RAVVRAKVECIRVGQGRPEAATDACRHIDIALDRLR-AATVQLVIVG
Mvan_1384|M.vanbaalenii_PYR-1 ---RAVVRAKVDCVRVDQGHAEAIPDAQRHLAIALAHLR-SGRVQLVVVG
Mb2027c|M.bovis_AF2122/97 ---RAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQ-HATVRLALVG
Rv2004c|M.tuberculosis_H37Rv ---RAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQ-HATVRLALVG
MMAR_3476|M.marinum_M ---RAVVRAKTDCVRLSQGKPEAAADAARHLELATRHLE-TGAVRLALVG
MAB_3902c|M.abscessus_ATCC_199 ---RALVRAKVDCIRFTQGQRSAAGRAAKHVAMALSHLG-AATVRLVLVG
TH_2244|M.thermoresistible__bu RTTRVRITDLDYRLDVNTLERDKSATALKLNELGRISLRSQAPLLLDEYT
MUL_1249|M.ulcerans_Agy99 AYAGTSFATPDKLGSMRYGSPVMNVTADRTVEFGLASIGYDDEGVASQSW
. . . * : :. :
Mflv_0263|M.gilvum_PYR-GCK GGPGSG---------KTTVSRALAEVLGAQVISTDDVR------------
MSMEG_3942|M.smegmatis_MC2_155 GGPGTG---------KTTVSRALAEELGAVVISTDDVR------------
Mvan_1384|M.vanbaalenii_PYR-1 GGPGTG---------KTTLARALAQCVDAQLISTDEVR------------
Mb2027c|M.bovis_AF2122/97 GNPGTG---------KSTLARGVAELVGAQVISTDDVR------------
Rv2004c|M.tuberculosis_H37Rv GNPGTG---------KSTLARGVAELVGAQVISTDDVR------------
MMAR_3476|M.marinum_M GNPGTG---------KSTLARALAEQVGAQVISTDDVR------------
MAB_3902c|M.abscessus_ATCC_199 GGPGAG---------KSTLARRISEDIGAQVISTDEVR------------
TH_2244|M.thermoresistible__bu RNPATGSFILIDPVTNGTVGAGMVLRGRRQTASPDTVRHQSLVTAADRLS
MUL_1249|M.ulcerans_Agy99 DLVRDG----------VFVGYQLDRVFAPRLGQPRSNG------------
* :. : ..
Mflv_0263|M.gilvum_PYR-GCK -----------------------RELRDAG----VISGA---VGALDSGL
MSMEG_3942|M.smegmatis_MC2_155 -----------------------RYLQESG----VIGGA---AGELDTGL
Mvan_1384|M.vanbaalenii_PYR-1 -----------------------RELVGSG----VVHGR---AGELNTGL
Mb2027c|M.bovis_AF2122/97 -----------------------RRLRDCG----VITGE---PGVLDSGL
Rv2004c|M.tuberculosis_H37Rv -----------------------RRLRDCG----VITGE---PGVLDSGL
MMAR_3476|M.marinum_M -----------------------KELRDRG----DIHGE---SGVLDEGL
MAB_3902c|M.abscessus_ATCC_199 -----------------------QQLHRLG----VISGG---KGVLDAGL
TH_2244|M.thermoresistible__bu RGCTVWFTGLSGAGKSSVAMLVERKLLERGRPAYVLDGDNLRHGLNSDLG
MUL_1249|M.ulcerans_Agy99 -----------------------CSYADSP------------HHVPIQRM
Mflv_0263|M.gilvum_PYR-GCK YAPESVARVYDEVLRRAEAAVTGGCSVILDGTWRDEEETGRARRLADSTA
MSMEG_3942|M.smegmatis_MC2_155 YAPKNVAAVYDEVLARARHALTHGRSVILDGTWRDVGRRQRAHLLASETA
Mvan_1384|M.vanbaalenii_PYR-1 YTPENLSAVYDEVLSRARAWLGAGHSVIVDGTWRDAGHRQRAHAVAAQTY
Mb2027c|M.bovis_AF2122/97 YSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACARRLAADTH
Rv2004c|M.tuberculosis_H37Rv YSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACARRLAADTH
MMAR_3476|M.marinum_M YTRDNVTVVYDLVLSRARRCLQEGRSVILDGTWRDPQSRARAHHLGGQTH
MAB_3902c|M.abscessus_ATCC_199 YSTENVGAVYDAVLRRARLALAGGHTVILDGTWRSPRHRLRAHQLAYEAG
TH_2244|M.thermoresistible__bu FSMADRAENLRRLAHIATLLADSGQVVLVPAISPLEEHRQLARQIHAEAG
MUL_1249|M.ulcerans_Agy99 ANVSLQPGAEDLSTADLIGRVEDGIYIVGDKSWSIDMQR-YNFQFTGQRF
* :: . .
Mflv_0263|M.gilvum_PYR-GCK TPLIEFTCVLPVEEAGARIRARTQTTSDATPQIAEAL----AGR-TGVAG
MSMEG_3942|M.smegmatis_MC2_155 VPVVEFTCSLPVVAAGERIASRSGTTSDATPEIADAL----AEQGAGIVH
Mvan_1384|M.vanbaalenii_PYR-1 SSIVELRCTLPVAEAERRIAGRGATASDATPAMAAEL----SRWESDWPG
Mb2027c|M.bovis_AF2122/97 SAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAAL----AARQADWDT
Rv2004c|M.tuberculosis_H37Rv SAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAAL----AARQADWDT
MMAR_3476|M.marinum_M AALVELLCTLPVDMAADRISTRAPGNSEVTAEIAATM----AAQHAGWDT
MAB_3902c|M.abscessus_ATCC_199 APMVEFLCLAPLVTAQHRVAARHDGVSDATGDIAAALGAEFAGPDRGWGE
TH_2244|M.thermoresistible__bu FEFFEVFCDTPLEDCERRDP--KGLYAKARAGLITHF----TGIDSPYQR
MUL_1249|M.ulcerans_Agy99 FRIRDGRLDGQLRDIAYQATTTEFWNSMEAVGGPSTWR---LGGAINCGK
. : : : :
Mflv_0263|M.gilvum_PYR-GCK RHPLDTGRPLAESVAEAQRICRKVISPFTRG---
MSMEG_3942|M.smegmatis_MC2_155 GHSIDTSRPLRESVTEAQRVCCLAI---------
Mvan_1384|M.vanbaalenii_PYR-1 AHPIDTAGPLADSVAAARQVCLDTV---------
Mb2027c|M.bovis_AF2122/97 GHRIDTAGPRERSVGQAYHIWRSAI---------
Rv2004c|M.tuberculosis_H37Rv GHRIDTAGPRERSVGQAYHIWRSAI---------
MMAR_3476|M.marinum_M ALPMDTSRPIEFSLNEAHDAWCRAIYPE------
MAB_3902c|M.abscessus_ATCC_199 AHVIDTRLPLDRSTAEAEELCRQALYAPVPCHPR
TH_2244|M.thermoresistible__bu PKNPDLRLTPEHSLDELAQMVIDLLGERV-----
MUL_1249|M.ulcerans_Agy99 AQP-GQVAPVSHGCPSALFRGVNILNTRTEGGR-
. . . :