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M. vanbaalenii PYR-1 Mvan_1133 (-)

annotation: hypothetical protein Mvan_1133
coordinates: 1202906 - 1206277
length: 1123

MTESRCDATQPGAGYRLQYAEVYNWGTFDDHSWRFTPGTDTALLTGDIGSGKSTIVDALTTLLVPAHKAA
YNKAAGADAKERTLRSYVEGHYKSERNESTGRSRPKGLRENKRTYSVILGVFRNHGHDETVTLAQVFQQR
ESTGQPYRFFVTATKELSIATDFADFGTDLRELRRRLRGAGAEIFDEFPKYSTSLRRLLGIRSEQALELF
HQTVSMKSVGNLNDFVRDHMLEPSDSTERVREIIGHFEDLTKAHDAVKRAREQLEALQPIVDTAAKYDAA
LAERAGLELERAAVRLFIAELRSGLLTDEIARLEADGAALLTQLDTAEAEQRRLGRERDSLIEERAKAGG
DRIGELERLAADAREQAKTRSQTKALFDAAVAEAGLEPVADGDAFAALGAVVAGERPRLTGEKRDLDTAT
VDAIGREREHQRRCDVIAEEVASLEQRTDNLPQEQVVVRAELCAALGLTPDDLPYAGELLDVHDEHAQWR
GAAERVLRGFALSLLVPQRHYDAVTAWVNGRRLTVGGRGAKLVYERVPQHRVRLQPTAHDGLLLADCIEV
RDGQFEEYLRAELMKRADFRCAATLDEFRTERRAVTREGQVRSGDRHEKDDRHRVDDPRRWVLGWVNERK
IAAMRAELAELESQRDEAAAQAARLVKERDALQCRLDAFRSVEGFRSWGELDADEAESRAKAHDAERVRL
QAGSNRLAEITQALERNAENAVTVTDLIKKLTGMLATAQSRMNQAKQERSRDDEFVAAHAPDQREKARAS
YPALTARLADSPPARAADCADSEAALSDDLHRRIERLSGQLNGHALNLTQHMTAVLNRWQELRADMDVNV
ESRADFLAFRERVATDDLPRFESEFKEQLNKNAIQELAGFNNWLGRQASAIDERVDRINDALGAVPYNPG
RYIKLEKEPTSNQDVAQFRSDLRNLTNDTLTADGDQYSEQRFLDVKRIIERFRGRDGYAESDKNWTRRVT
DVRNWFVFSASERDVDTDLEWEHYSDSDGKSGGQKEKLAYTILAASLAYQFGLEWGVERSRDFRFAVIDE
AFGRGSDVSTRYALDLFATLGLQLLIVTPLQKVHVIEPYVKSIGIVDNPTGTYSRLQTMTIEEYRDRRDR
PLR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_1133--100% (1123)hypothetical protein Mvan_1133
M. vanbaalenii PYR-1Mvan_1172-5e-7525.18% (1140) hypothetical protein Mvan_1172

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97-----
M. gilvum PYR-GCKMflv_5159-9e-7826.11% (1145) hypothetical protein Mflv_5159
M. tuberculosis H37Rv-----
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_1492-4e-8125.88% (1132) hypothetical protein MAB_1492
M. marinum MMMAR_3068-1e-7826.11% (1153) hypothetical protein MMAR_3068
M. avium 104MAV_1428-1e-0524.38% (644) hypothetical protein MAV_1428
M. smegmatis MC2 155MSMEG_1281-0.081.80% (1077) hypothetical protein MSMEG_1281
M. thermoresistible (build 8)TH_2611-2e-8326.48% (1148) PUTATIVE conserved hypothetical protein
M. ulcerans Agy99MUL_2313-2e-7725.94% (1145) hypothetical protein MUL_2313

CLUSTAL 2.0.9 multiple sequence alignment


Mvan_1133|M.vanbaalenii_PYR-1       MTESRCDATQPGAGYRLQYAEVYNWGTFDDHSWRFTPGTDTALLTGDIGS
MSMEG_1281|M.smegmatis_MC2_155      ------------------------------------------MLTGDIGS
MMAR_3068|M.marinum_M               ----------MTEQFHLSRLQVINWGVFDGYHS-IPFSVGGALIAGASGS
MUL_2313|M.ulcerans_Agy99           ----------MTEQFHLSRLQVINWGVFDGYHS-IPFSVGGALIAGASGS
Mflv_5159|M.gilvum_PYR-GCK          ----------MTEQFHLSRLQVINWGVFDGYHD-IPFSEGGALIAGASGS
TH_2611|M.thermoresistible__bu      ----------LTEQFHLSRLQVINWGVFDGYHS-IPFSPGGALIAGASGS
MAB_1492|M.abscessus_ATCC_1997      ----MTTSDAATQQFWLSRLQVINWGVFDGYHS-IEFSRRGTLITGSSGS
MAV_1428|M.avium_104                --------------MKLHRLTLTNYRGIAHREIEFPDHG-VVVVCGANEI
                                                                              :: *    

Mvan_1133|M.vanbaalenii_PYR-1       GKSTIVDALTTLLVPAHKAAYNK-----AAGADAKERTLRSYVEGHYKSE
MSMEG_1281|M.smegmatis_MC2_155      GKSTIVDALTTLLVPSHKAAYNK-----AAGADAKERTLRSYVEGHYRSE
MMAR_3068|M.marinum_M               GKSSLLDAISLGFLPFNRRNFNASGDNTAAGSSAGRRTVDKYVRGAWG-Q
MUL_2313|M.ulcerans_Agy99           GKSSLLDAISLGFLPFNRRNFNASGDNTAAGSSAGRRTVDKYVRGAWG-Q
Mflv_5159|M.gilvum_PYR-GCK          GKSSLLDAISLGFLPFNRRNFNASGDNTAAGSSAGRRTVDKYVRGAWG-Q
TH_2611|M.thermoresistible__bu      GKSSLLDAISLGFLPFNRRNFNASGDQTAAGSSAGRRTVDKYVRGAWG-Q
MAB_1492|M.abscessus_ATCC_1997      GKSSLLDAISLAFLSSNRRNFNASSDTTAAGSSMGKRTVDKYVRGLWG-E
MAV_1428|M.avium_104                GKSSMIEALDLLLEAKDRSTKKEVKQVKPTHSDVGAEVSAEISCGPYR--
                                    ***::::*:   : . .:   :      .: :.   ..  .   * :   

Mvan_1133|M.vanbaalenii_PYR-1       RNESTGRSRPKGLRENKRTYSVILGVFRNHGHDETVTLAQVFQQRESTGQ
MSMEG_1281|M.smegmatis_MC2_155      RNEATGKSRPKGLRENRRTYSVILGVFRNHGHDETVTLAQVFQQRESTGQ
MMAR_3068|M.marinum_M               RSD-GGTSRVMYLRGDGTAWSAVAVTYASDSGRTVTGLVLKWLTGESRND
MUL_2313|M.ulcerans_Agy99           RSD-GGTSRVMYLRGDGTAWSAVAVTYASDSGRTVTGLVLKWLTGESRND
Mflv_5159|M.gilvum_PYR-GCK          RSD-GGTSRVMYLRGDGTAWSAVAVTYSSDSGRTVTGLVLKWLTGESRND
TH_2611|M.thermoresistible__bu      RSD-GGTNRVMYLRGEGTTWSAVAVTYTSDSGRTVTGLVLKWLTGESRSD
MAB_1492|M.abscessus_ATCC_1997      LKNPGERPKQMFLRGKGGAWSAIAVTYSGTDGRVITGLVLKWLAPGSDSD
MAV_1428|M.avium_104                -----FVYRKRFHKKCETELTVITPYREQLTGDEAHERVRAMLAETVDSD
                                            :    :      :.:               .         .:

Mvan_1133|M.vanbaalenii_PYR-1       PYRFFVTATKELSIATDFADFGTDLRELRRRLRGAG------AEIFDEFP
MSMEG_1281|M.smegmatis_MC2_155      PYRFFVTATKELSIAVDFADFGSDLRELRKRLRSAG------AEIFDEFP
MMAR_3068|M.marinum_M               SSSRFVLGDGDLDIEEVCNRWASGRFDAGVFKED-------WRFSTKVES
MUL_2313|M.ulcerans_Agy99           SSSRFVLGDGDLDIEEVCNRWASGRFDAGVFKED-------WRFSTKVES
Mflv_5159|M.gilvum_PYR-GCK          SSSRFVLGDGDLDIEDICNRWAAGRFDTGVFKEGQGERSDGWRFTTKVES
TH_2611|M.thermoresistible__bu      SSSRFVIGDGDLDIEEVCNRWAARRFDASVFKEG------GWRFTTKVES
MAB_1492|M.abscessus_ATCC_1997      SSSRYYLIDADADIRDLCNAWASKGYAGSVFEGAG------WRGH-KSER
MAV_1428|M.avium_104                LWHAQRVLQAASTAAVDLSGCDALSRALDVAAGDSG-------GLCGTEP
                                                          :                           

Mvan_1133|M.vanbaalenii_PYR-1       KYSTSLRRLLGIR-SEQALELFHQTVSMKSVGNLNDFVRDHMLEPSDSTE
MSMEG_1281|M.smegmatis_MC2_155      KYATSLRRLLGIR-SEQALELFHQTVSMKSVGNLNDFVRDHMLEPSDSTE
MMAR_3068|M.marinum_M               QYLAQLYAAIGIRASDAAQQLLGKAKSLKSVGGLEQFVREFMLDEPDSLA
MUL_2313|M.ulcerans_Agy99           QYLAQLYAAIGIRASDAAQQLLGKAKSLKSVGGLEQFVREFMLDEPDSLA
Mflv_5159|M.gilvum_PYR-GCK          QYLAQLYATIGIRASDAAQQLLGKAKSLKSVGGLEQFVREFMLDEPESLT
TH_2611|M.thermoresistible__bu      QYLAQLYATIGIRASDAAQQLLGKAKSLKSVGGLEQFVREFMLDEPESLA
MAB_1492|M.abscessus_ATCC_1997      WYLEQLYAAVGIQGSSAAQQLLGKAKSLKSVGGLEQFVREYMLDEPESMA
MAV_1428|M.avium_104                LLIERIDAEYARYFTPTGRPTGEWAAAIARLADAEAAVAECAAAVAEVDE
                                         :    .   :  .      : ::  :.. :  * :     .:   

Mvan_1133|M.vanbaalenii_PYR-1       RVREIIGHFEDLTKAHDAVKRAREQLEALQPIVDTAAKYDAALAERAGLE
MSMEG_1281|M.smegmatis_MC2_155      RIREIISHFDDLTRAHDAVKRAREQLEALEPIADTAAKYDAALAERDGLE
MMAR_3068|M.marinum_M               RLPEALKQIDPLVEARELLAVAQKKRKILGDIEQIQQRYASESSDLGIID
MUL_2313|M.ulcerans_Agy99           RLPEALKQIDPLVEARELLAVAQKKRKILGDIEQIQQRYASESSDLGIID
Mflv_5159|M.gilvum_PYR-GCK          RLPEALKQIDPLVEARELLAVAQKKRKILGDIEKIQQRYASESTDLGIID
TH_2611|M.thermoresistible__bu      RLPEALKQIDPLVEARELLAVAQRKRKILGDIEQIQQRYAAESSDLGIID
MAB_1492|M.abscessus_ATCC_1997      AISEALGQITPLVDARAALAIAQRQRQTLGDIEQIQQTYASDAAQLATVD
MAV_1428|M.avium_104                RVSRHAALTEQVADLSQRRIAAGPRVTAARQAADRIAELTAQRRE-----
                                     : .       :.        *  :        .      :   :     

Mvan_1133|M.vanbaalenii_PYR-1       LERA-AVRLFIAELRSGLLTDEIARLEADGAALLTQLDTAEAEQRRLGRE
MSMEG_1281|M.smegmatis_MC2_155      HERS-AVRLFIAELRSGLLADEIGRLEADGAALWQQQDAAEADQRRLNHE
MMAR_3068|M.marinum_M               LVDAPMVRAYTDHARLAQCPAQIATLDGTVDQLENEYEDVTRSLNLAKAE
MUL_2313|M.ulcerans_Agy99           LVDAPMVRAYTDHARLAQCPAQIATLDGTVDQLENEYEDVTRSLNLAKAE
Mflv_5159|M.gilvum_PYR-GCK          LVDLPMVRAYTDHVRLAQCPAHVSQLDTTIDQLDNEHEDITRSLNLAKAE
TH_2611|M.thermoresistible__bu      LVDMPTVRAYTDHVRLAQCPEQIAQLDSTIEQLDNEYQDITRQLNLAKAE
MAB_1492|M.abscessus_ATCC_1997      VVDHHTVRDYVDQQRLALAGPEIDLLDTEITRLGGECDEIQSRQDILTGE
MAV_1428|M.avium_104                --------AQLVAEAAAATKAAAAQAHSGRLQLLADIDTRAAAVTQTHAQ
                                                    .         .     *  : :           :

Mvan_1133|M.vanbaalenii_PYR-1       RDSLIEERAKAGGDRIGELERLAADAREQAKTRSQTKALFDAAVAEAG-L
MSMEG_1281|M.smegmatis_MC2_155      RDSLIEERAKAGGDRIGELERLAHEARAQAESRRQARTLFDSAVGEAG-L
MMAR_3068|M.marinum_M               ADSLNAQISGSSAN-IAPLQSQVTAAETEAEQVERRRTTYEDMLAAQG-I
MUL_2313|M.ulcerans_Agy99           ADSLNAQISGSSAN-IAPLQSQVTAAETQAEQVERRRTTYEDMLAAQG-I
Mflv_5159|M.gilvum_PYR-GCK          ADSLNAQISGSSAS-IGPLQSQVTAAETEAEQVSRRRNAYEDLLAAQG-L
TH_2611|M.thermoresistible__bu      ADSLTAQISGSSAS-LAPLQSQLTAAEAEAEQVSRRRTAYEDMLTAHG-L
MAB_1492|M.abscessus_ATCC_1997      RDKLLGRIAAADSN-LAPLKSELAHARARAEEVSRRRTAYDSALWDLGHE
MAV_1428|M.avium_104                VQQAAADHAVAQADAQACDTALQHATEALAELERRVQEAQRTVERSAG--
                                     :.     : : ..  .        :.  *:   : :          *  

Mvan_1133|M.vanbaalenii_PYR-1       EPVADGDAFAALGAVVAGERPRLTGEKRDLDTATVDAIGREREHQRRCDV
MSMEG_1281|M.smegmatis_MC2_155      TTVADEEAFLNLPTLVAAERTRLAAEKREVDAATVDAIGRERDCERKCTT
MMAR_3068|M.marinum_M               EIPDTADEFWNLREELLAQATELLAKVERNREASTDAEYAQKAARIARDD
MUL_2313|M.ulcerans_Agy99           EIPDTADEFWNLREELLAQATELLAKVERNREASTDAEYAQKATRIARDD
Mflv_5159|M.gilvum_PYR-GCK          DAPETADAFWNLREELLAQATDLLAKVERNREASTDAEYAQKSARLVRDE
TH_2611|M.thermoresistible__bu      EIPETAEEFWNLRERLLTEATESLAKAERRREESTDAEYAQKAARLARDE
MAB_1492|M.abscessus_ATCC_1997      DDIESAEEFEAMRVESLRAVTRINAELEAGHDAYVMAAGALSTARDQLRA
MAV_1428|M.avium_104                ----------------REEADRLAARLDKID-----------AIQRDRER
                                                            ..                  .     

Mvan_1133|M.vanbaalenii_PYR-1       IAEEVASLEQRTDNLPQEQVVVRAELCAALGLTPDDLPYAGELLDVHDEH
MSMEG_1281|M.smegmatis_MC2_155      LSAEIESLEQRTSNLPHEQVVMREELCAAIGLTPEQLPYAGELLDVYDER
MMAR_3068|M.marinum_M               VAKELKRVEHVGSALPEFALAMRDHICAAIKVDATELPYIAELLDLRPGQ
MUL_2313|M.ulcerans_Agy99           VAKELKRVEHVGSALPEFALAMRDHICAAIKVDAAELPYIAELLDLRPGQ
Mflv_5159|M.gilvum_PYR-GCK          AAKELKRVEHVGSALPEFALTMRDQICAAVGVDATDLPYVAELMDLKADQ
TH_2611|M.thermoresistible__bu      IAAELRRVEKVGSSLPEFALVMREQICAAIGVDPSELPYIAELMDLRPDQ
MAB_1492|M.abscessus_ATCC_1997      ASAEFKRVEHLGTPVPPDEDRMRGEIAAALGLTAKDLPYVCELMDLRPGQ
MAV_1428|M.avium_104                ISAELS------------TIAVTEELLRRIEDAAAAVDRIGDQLASTSAA
                                     : *.                :  .:   :   .  :    : :      

Mvan_1133|M.vanbaalenii_PYR-1       AQWRGAAERVLRGFALSLLVPQRHYDAVTAWVNGRRLTVGGRGAKLVYER
MSMEG_1281|M.smegmatis_MC2_155      AEWRGAAERVLRGFALSLLVPQPHYDAVTRWVNERRLTVAGRGAKLVYER
MMAR_3068|M.marinum_M               TRWRLAVEKVLRGVGLRLLVPDQHWEKVLRFVNETDMRG-----RLQLHH
MUL_2313|M.ulcerans_Agy99           TRWRLAVEKVLRGVGLRLLVPDQHWEKVLRFVNETDMRG-----RLQLHH
Mflv_5159|M.gilvum_PYR-GCK          TRWRTAVEKVLRGVGLRLMVPDQHWTEVLRFVNETNMRG-----RLQLHH
TH_2611|M.thermoresistible__bu      TRWRVAVEKVLRGAGLRLLVPDAYWGAVLRFVNETNMRG-----RLALHH
MAB_1492|M.abscessus_ATCC_1997      ERWRKSVEKVLRSTGLCLLVPDQHHRQVLRYVNENPMRG-----YLQMER
MAV_1428|M.avium_104                VEFTAVADIHLVIGDRQVSLPAGQSWSITAVG------------------
                                     .:   .:  *      : :*      :                      

Mvan_1133|M.vanbaalenii_PYR-1       VPQHRVRLQPTAHDGLLLADCIEVRD--GQFEEYLRAELMKRADFRCAAT
MSMEG_1281|M.smegmatis_MC2_155      VAARRVRLQPAESDGLLLADCIEVRE--GPFEEYLRNELMKRADFRCATT
MMAR_3068|M.marinum_M               VRAKFLGAEPAEPEPNTLAGKLFPVDPKHLCAAEAVDIITGAGDHVCVDT
MUL_2313|M.ulcerans_Agy99           VRAKFLGAEPAEPEPNTLAGKLFPVDPKHLCAAEAVDVITGAGDHVCVDT
Mflv_5159|M.gilvum_PYR-GCK          VRAKFLGATPVDPEPNTLAGKLFAVDPEHPCAAEAVDVVTAAGDHICVDT
TH_2611|M.thermoresistible__bu      VRARMYGAEPVEPEPNTLAGKLFVVDPNHPCAAEAADVIAAAGDHICVDD
MAB_1492|M.abscessus_ATCC_1997      VIP---SGTPRRAEPGTLADCLRLTNPNHECASAAMNLVAGVGDYVLVDS
MAV_1428|M.avium_104                --------PTAVEVPGVLTARVTPG----------ATTLDVQAKHAAAQQ
                                             .       *:  :                :   ...  .  

Mvan_1133|M.vanbaalenii_PYR-1       LDEFRTERRAVTREGQVRSGDRHEKDDRHRVDDPRRWVLGWVNERKIAAM
MSMEG_1281|M.smegmatis_MC2_155      LQEFRDLRRAVTREGQVRSGDRHEKDDRHRVDDPRRWVLGWVNERKLTAL
MMAR_3068|M.marinum_M               PDVFSRFRRAVTDTGLYKDSDRLAVKDDRRPVKLSEYLYQGDVTAKINAL
MUL_2313|M.ulcerans_Agy99           PDVFSRFRRAVTDTGLYKDSDRLAVKDDRRPVKLSEYLYQGDVTAKINAL
Mflv_5159|M.gilvum_PYR-GCK          PEVFARFRRAVTDTGLYKDSDRLAIKDDRRPLKQSEYLYQGDVSAKINAL
TH_2611|M.thermoresistible__bu      PNVFGRFRRAVTDTGLYKESDRLAIKDDRRPVRQSEYLFQGDVSAKINAL
MAB_1492|M.abscessus_ATCC_1997      PDEFSKHRRAVTDQGLRKDGDRRAVKDDRRELRASQYIYQGNAGDKRAAL
MAV_1428|M.avium_104                ELAAALTAGAVADLGAARSADQRRRELQGTRDQLGATLAGLCGDEPLDEL
                                             **:  *  :..*:   .           :           :

Mvan_1133|M.vanbaalenii_PYR-1       RAELAELESQRDEAAAQAARLVKERDALQCRLDAFRSVEG-FRSWGELDA
MSMEG_1281|M.smegmatis_MC2_155      RDEFADLERDRQEAAAVAAALSARREVLQHRLDALVRIEG-FRSWTELDA
MMAR_3068|M.marinum_M               TVELAAAEEAYQKARRTADDIAAQRQQWRDRAAACKAICEQYPQWSQIDT
MUL_2313|M.ulcerans_Agy99           TVELTAAEEAYQKARRTADDIAAQRQQWRDRAAACKAICEQYPQWSQIDT
Mflv_5159|M.gilvum_PYR-GCK          TVDLAAAEEAYQKARRVADDIAAQRQQWRDRAAACKAICEQYPQWSQIDT
TH_2611|M.thermoresistible__bu      TVELAAAEEAYQKARRVADEIAAQRQQWRDWAASCRAICEQFPQWSQIDV
MAB_1492|M.abscessus_ATCC_1997      SDDVVEAQQAVSDAEKFIGEMDTKREELRSEVVRWSKLHSQYEYWSQIDT
MAV_1428|M.avium_104                RSRLARLRAEHPEQPAAPTGGAADLAAARTELEALAQARACASAECVTRR
                                       ..  .    .               :                     

Mvan_1133|M.vanbaalenii_PYR-1       DEAESRAKAHDAERVRLQAGSNRLAEITQALERNAENAVTVTDLIKKLTG
MSMEG_1281|M.smegmatis_MC2_155      DEAVSRAGAHDAERARLQSGSSRLEEITRALERNAEEAGVVAERIRQLTG
MMAR_3068|M.marinum_M               ETADG-------HAERLREQYELLMADNPDIEALNARADECWSQIQKLMT
MUL_2313|M.ulcerans_Agy99           ETADG-------HAERLREQYELLMADNPDIEALNARADECWSQIQKLMT
Mflv_5159|M.gilvum_PYR-GCK          ETADG-------HADRLREQYELLLAEHPDIEALNARADECWSQIQKLMT
TH_2611|M.thermoresistible__bu      ETADG-------HADRLREQYELLLAEHPDLDALNARAEDCWAQIQKLMT
MAB_1492|M.abscessus_ATCC_1997      DSAEA-------AVARLQDQYDAMLEANPDLTGLQQQADSYLDEIKRLSE
MAV_1428|M.avium_104                QAATA--------------AAARLAETATAATVLQNRLDTLRAELDAATG
                                    : * .                  :            .       :     

Mvan_1133|M.vanbaalenii_PYR-1       MLATAQSRMNQAKQERSRDDEFVAAHAP-----------DQREKARASYP
MSMEG_1281|M.smegmatis_MC2_155      QLATTAAAVQRAQQDRKRDQEFVTAQSP-----------EQLEVARASYP
MMAR_3068|M.marinum_M               RRGAIQTRRDSLDERRTRLLELQERLSP----------AFVSEPLTELLQ
MUL_2313|M.ulcerans_Agy99           RR-------DSLDERRTRLLELQERLSP----------AFVSEPLTELLQ
Mflv_5159|M.gilvum_PYR-GCK          RRGAVQTRRDALDDRRTRLLELAERLQP----------AFVSEPLTELLH
TH_2611|M.thermoresistible__bu      RRGAVQTRRDELDTRRTRLLELAERLSPPADERSRGEHRFVSEPLTELLQ
MAB_1492|M.abscessus_ATCC_1997      RIGALRKQESEHDSRRTRLLDLLDNLSP----------REVGGHTRSGIE
MAV_1428|M.avium_104                RLAAERASVGDEELAASADAALRAEQAA-------------ERRVAELAD
                                                .   .    :     .                      

Mvan_1133|M.vanbaalenii_PYR-1       ALTARLADSPPARAADCADSEAALSDDLHRRIERLSGQLNGHALNLTQHM
MSMEG_1281|M.smegmatis_MC2_155      ALDRRLAASRPTRADDCAAAESALSEDLYRRIERLTRELGGYGQSLAQYM
MMAR_3068|M.marinum_M               RYAAQLPVA--LELLDPEPHRDALFAAIKKEREQLRESRRRSYDELARIL
MUL_2313|M.ulcerans_Agy99           RYAAQLPVA--LELLDPEPHRDALFAAIKKEREQLRESRRRSYDELARIL
Mflv_5159|M.gilvum_PYR-GCK          RYAGQLPVS--LELLEPEPHRDALFNAIKKEREQLRESRRRSYDELARIL
TH_2611|M.thermoresistible__bu      RFAAQVPVG--LELLDPEPHREALFAAIKREREQLRESRRRSYDELARIL
MAB_1492|M.abscessus_ATCC_1997      AYVPQLSSS--LDVLEPDAYRLELWRQIEKDQSVLRESVTRSRNELNRIL
MAV_1428|M.avium_104                ALAAASPDSVAAELADATQESESLRERYEEAAGALREVT-----------
                                          . .      :       *     .    *               

Mvan_1133|M.vanbaalenii_PYR-1       TAVLNRWQELR-ADMDVNVESRADFLAFRERVATDDLPRFESEFKEQLNK
MSMEG_1281|M.smegmatis_MC2_155      LEVLRRWPELR-ADMDATVEARGDFLAFRRRVATDDLPRFESEFKEQLNK
MMAR_3068|M.marinum_M               NTFDTSFPDAIPNDSDDFDERVHDYVALCRHIDERELPEAYERMMRLVTE
MUL_2313|M.ulcerans_Agy99           NTFDTSFPDAIPNDSDDFDERVHDYVALCRLIDERELPEAYERMMRLVTE
Mflv_5159|M.gilvum_PYR-GCK          NTFDTSFPDAIPNDSENFDERVHDYVALCRHIDERELPEAYERMMRLVTE
TH_2611|M.thermoresistible__bu      NTFDTTFPDAIPNDSDVFDERVHDYVALCRHIDERELPEAYERMMRLVTE
MAB_1492|M.abscessus_ATCC_1997      NAYDRDFPDSIPNDSENFDEKIHDYVALCRRIDERDLPAAYERMLRLITE
MAV_1428|M.avium_104                --------------------------------------------------
                                                                                      

Mvan_1133|M.vanbaalenii_PYR-1       NAIQELAGFNNWLGRQASAIDERVDRINDALGAVPYNPGRYIKLEKEPTS
MSMEG_1281|M.smegmatis_MC2_155      NAIQELAGFNNWLSRQASAIDERIDRINEALGAVPYNPGRFIRLEKEPTT
MMAR_3068|M.marinum_M               QAPDAILTLHRVAEQEARRISGQIDRVNTGLAAVEFNRGTRLTLRATPRH
MUL_2313|M.ulcerans_Agy99           QAPDAILTLHRVAEQEERRISGQIDRVNTGLAAVEFNRGTRLTLRATPRH
Mflv_5159|M.gilvum_PYR-GCK          QAPDAILTLHRVAEQEARRISDQIDRVNTGLGAVEFNRGTRLTLRATPRS
TH_2611|M.thermoresistible__bu      QAPDAILTLHRVAEQEARRIAEQIERVNTGLGAVEFNRGTRLTLRATPRQ
MAB_1492|M.abscessus_ATCC_1997      QAPTAVLRLHQLAEEEAHRITDQIDRVNSGLGSVEFNRGTRLTLRAEPKA
MAV_1428|M.avium_104                ------------IELSVFGSEGRQGKLDAAETEREHAASEHSQVGRRARA
                                                   .      :  ::: .     .  .    :   .  

Mvan_1133|M.vanbaalenii_PYR-1       NQDVAQFRSDLRNLTNDTLTADGDQYSEQRFLDVKRIIERFRGRDGYAES
MSMEG_1281|M.smegmatis_MC2_155      NQDVAQFRSDLRNLTNDALAVDGDQYSEQRFLDVKRIIERFRGREGYAES
MMAR_3068|M.marinum_M               LVAVDELTQIVRSISRRIAEVG--LGDKQAILDQYADILRLRNRLASTAP
MUL_2313|M.ulcerans_Agy99           LVAVDELTQIVRSISRRIAEVG--LGDKQAILDQYAEILRLRNRLASTAP
Mflv_5159|M.gilvum_PYR-GCK          LTAVSELTEIVRAISRRIAEVG--LGDKQAILDQYADILRLRNRLASTSP
TH_2611|M.thermoresistible__bu      LTAVAELTEIVRAISRRIAEVG--LGDKQAILDQYADILRLRNRLASTTP
MAB_1492|M.abscessus_ATCC_1997      LEAVGELNERARRISGRAVAVS--MGDEKAIHDQYQDILQLRNLLAAETP
MAV_1428|M.avium_104                AQLLRSVMTRHRDTTR------------QRYVEPYRAELQRLGRPVFGPT
                                       : ..    *  :             :   :      :  .      .

Mvan_1133|M.vanbaalenii_PYR-1       -DKNWTRRVTDVRNWFVFSASERDVDTDLEWEHYSDSDGKSGGQKEKLAY
MSMEG_1281|M.smegmatis_MC2_155      -DRNWTRRVTDVRNWFVFSASERDVDTGAEWEHYSDSDGKSGGQKEKLAY
MMAR_3068|M.marinum_M               EDKAWTRDALDVRNRFTFDCAEWDVDTEELIRTHSNAGDNSGGEQEKLMA
MUL_2313|M.ulcerans_Agy99           EDKAWTRDALDVRNRFTFDCAEWDVDTEELIRTHSNAGDNSGGEQEKLMA
Mflv_5159|M.gilvum_PYR-GCK          EDKAWTRDALDVRNRFTFDCAEWDVATEELIRTHSNAGDNSGGEQEKLMA
TH_2611|M.thermoresistible__bu      EDRAWTRDALDVRNRFTFDCAEWDVATGELIRTHSNAGDNSGGEQEKLMA
MAB_1492|M.abscessus_ATCC_1997      EARQWTRDALDVRNRFVLYCEERDARTGEPIRTYSNAGANSGGEQEKLMA
MAV_1428|M.avium_104                FEVDID--------------SDLCIRSRTLNGITVPYESLSGGAKEQLGI
                                                         :    :             *** :*:*  

Mvan_1133|M.vanbaalenii_PYR-1       TILAASLAYQFGLEWGVERSRDFRFAVIDEAFGRGSDVSTRYALDLFATL
MSMEG_1281|M.smegmatis_MC2_155      TILAASLAYQFGLEWGAEESRDFRFAVIDEAFGRGSDVSTRYALDLFATL
MMAR_3068|M.marinum_M               FCLAGALSFNLASPESDNNKPVFAQLMLDEAFSKSDPQFAQQALHAFRKF
MUL_2313|M.ulcerans_Agy99           FCLAGALSFNLASPESDNNKPVFAQLMLDEAFSKSDPQFAQQALHAFRKF
Mflv_5159|M.gilvum_PYR-GCK          FCLAGALSFNLAAPESSDNRPVFAQLMLDEAFSKSDPQFAQQALQAFRKF
TH_2611|M.thermoresistible__bu      FCLAGALSFNLASPDSRDNRPVFAQLMLDEAFSKSDPQFAQQALEAFRKF
MAB_1492|M.abscessus_ATCC_1997      FCLAGALSFNLANPETGDNRPVFAQLMLDEAFSKSDPQFAQQALSAFRKF
MAV_1428|M.avium_104                LARLAGAALVAKEDAVP--------VVVDDALGFTDPDRLAKMGQLFDSV
                                        .. :                  ::*:*:.  .          * ..

Mvan_1133|M.vanbaalenii_PYR-1       GLQLLIVTPLQKVHVIEPYVKSIGIVDNP------TGTYSRLQTMTIEEY
MSMEG_1281|M.smegmatis_MC2_155      GLQLLIVTPLQKVHVIEPYVKAIGIVDNP------TGTYSRLQTMTIEEY
MMAR_3068|M.marinum_M               GFQLVIVATVQNATTIEPYIDSVVMVSKTEPTGGNARPVASVATRTISEF
MUL_2313|M.ulcerans_Agy99           GFQLVIVATVQNATTIEPYIDSVVMVSKTEPTGGNARPVASVATRTISEF
Mflv_5159|M.gilvum_PYR-GCK          GFQLVIVATVQNATTIQPYIDSVVMVSKTEATGRNARPVATVSTRTISEF
TH_2611|M.thermoresistible__bu      GFQLVIVATVQNATTIQPYVDSVVMVSKTEATGRNPRPVASVATRTISEF
MAB_1492|M.abscessus_ATCC_1997      GFQLVIVATVQNTTTIQPYIDSVVMVSKPDGPG--VRPVASTRTVPIGEL
MAV_1428|M.avium_104                GSHGQVIVLTCSPDRYDGVKGAHRIDLSA---------------------
                                    * :  ::.   .    :    :  :  ..                     

Mvan_1133|M.vanbaalenii_PYR-1       RDRRDRPLR---------
MSMEG_1281|M.smegmatis_MC2_155      RARRNGTRP---------
MMAR_3068|M.marinum_M               TSLRQEMRKTAERVPAGV
MUL_2313|M.ulcerans_Agy99           TSLRQEMRKTAERVPAGV
Mflv_5159|M.gilvum_PYR-GCK          TDLRHAMRAEAK-VPAGV
TH_2611|M.thermoresistible__bu      TALREKMG--SSRVPAGV
MAB_1492|M.abscessus_ATCC_1997      GDVRKAVSAR--------
MAV_1428|M.avium_104                ------------------